GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | SERPINE1 | decreases expression | ISO | Serpine1 (Rattus norvegicus) | 6480464 | CTD | Carbon Tetrachloride results in decreased expression of SERPINE1 mRNA | PMID:16239168 | SERPINE1 | increases expression | ISO | Serpine1 (Mus musculus) | 6480464 | CTD | Carbon Tetrachloride results in increased expression of SERPINE1 mRNA; Carbon Tetrachloride results in increased expression of SERPINE1 protein | PMID:25566828 PMID:27151496 PMID:27339419 PMID:31919559 | SERPINE1 | increases expression | ISO | Serpine1 (Rattus norvegicus) | 6480464 | CTD | Carbon Tetrachloride results in increased expression of SERPINE1 mRNA | PMID:12445421 | SERPINE1 | multiple interactions | ISO | Serpine1 (Mus musculus) | 6480464 | CTD | 3-methylquercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of SERPINE1 protein]; ABCB11 inhibits the reaction [NR1H4 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of SERPINE1 mRNA]]; NR1H4 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of SERPINE1 mRNA] | PMID:27151496 PMID:28505368 | SERPINE1 | multiple interactions | ISO | Serpine1 (Rattus norvegicus) | 6480464 | CTD | pirfenidone inhibits the reaction [Carbon Tetrachloride results in increased expression of SERPINE1 mRNA] | PMID:12445421 | | ||||||||||||||||||||||
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