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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69014
Species: Homo sapiens
RGD Object: Gene
Symbol: SERPINE1
Name: serpin family E member 1
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SERPINE1affects expressionEXP 6480464CTDbisphenol A affects the expression of SERPINE1 mRNAPMID:30903817
SERPINE1decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of SERPINE1 mRNA; bisphenol A results in decreased expression of SERPINE1 proteinPMID:27685785 PMID:29275510 PMID:29718440 PMID:34186270
SERPINE1increases expressionEXP 6480464CTDbisphenol A results in increased expression of SERPINE1 mRNAPMID:31230753
SERPINE1increases secretionEXP 6480464CTDbisphenol A results in increased secretion of SERPINE1 proteinPMID:31230753
SERPINE1multiple interactionsEXP 6480464CTDFulvestrant inhibits the reaction [bisphenol A results in increased secretion of SERPINE1 protein]PMID:31230753
SERPINE1decreases expressionISOSerpine1 (Mus musculus)6480464CTDbisphenol A results in decreased expression of SERPINE1 mRNAPMID:33221593 PMID:37105096
SERPINE1decreases expressionISOSerpine1 (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of SERPINE1 mRNAPMID:30816183
SERPINE1increases expressionISOSerpine1 (Mus musculus)6480464CTDbisphenol A results in increased expression of SERPINE1 mRNAPMID:30951980
SERPINE1increases expressionISOSerpine1 (Rattus norvegicus)6480464CTDbisphenol A results in increased expression of SERPINE1 mRNAPMID:25181051 PMID:32145629
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