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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69014
Species: Homo sapiens
RGD Object: Gene
Symbol: SERPINE1
Name: serpin family E member 1
Acc ID: CHEBI:34317
Term: 3,3',4,4',5-pentachlorobiphenyl
Definition: A pentachlorobiphenyl in which the chlorines are located at the 3, 4, 5, 3', and 4' positions.
Chemical ID: MESH:C023035
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SERPINE1affects expressionEXP 6480464CTD3,4,5,3',4'-pentachlorobiphenyl affects the expression of SERPINE1 mRNAPMID:21703328
SERPINE1increases expressionISOSerpine1 (Mus musculus)6480464CTD3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SERPINE1 mRNA; 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SERPINE1 proteinPMID:28163111 PMID:28973532
SERPINE1increases expressionISOSerpine1 (Rattus norvegicus)6480464CTD3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SERPINE1 mRNAPMID:19692669
SERPINE1increases secretionISOSerpine1 (Mus musculus)6480464CTD3,4,5,3',4'-pentachlorobiphenyl results in increased secretion of SERPINE1 proteinPMID:29216392
SERPINE1multiple interactionsISOSerpine1 (Mus musculus)6480464CTD3,4,5,3',4'-pentachlorobiphenyl promotes the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SERPINE1 protein]; [3,4,5,3',4'-pentachlorobiphenyl co-treated with Methionine deficiency co-treated with Choline deficiency] results in increased expression of SERPINE1 mRNA; [Methionine deficiency co-treated with Choline deficiency co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in increased expression of SERPINE1 mRNA; [perfluorooctane sulfonic acid co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in increased expression of SERPINE1 mRNA; [perfluorooctane sulfonic acid co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in increased expression of SERPINE1 proteinPMID:28163111 PMID:28973532 PMID:33096110
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