SERPINE1 (serpin family E member 1) - Rat Genome Database
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Gene: SERPINE1 (serpin family E member 1) Pan paniscus
Symbol: SERPINE1
Name: serpin family E member 1
RGD ID: 11771999
Description: ENCODES a protein that exhibits protease binding (ortholog); serine-type endopeptidase inhibitor activity (ortholog); signaling receptor binding (ortholog); INVOLVED IN angiogenesis (ortholog); cellular response to aldosterone (ortholog); cellular response to angiotensin (ortholog); PARTICIPATES IN fibrinolysis pathway; hypoxia inducible factor pathway; oxygen homeostasis pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); Acquired Protein C Deficiency (ortholog); Acute Lung Injury (ortholog); FOUND IN chromaffin granule (ortholog); collagen-containing extracellular matrix (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOC100973457; LOC106634989; plasminogen activator inhibitor 1; plasminogen activator inhibitor 1 pseudogene; plasminogen activator inhibitor 1-like; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.17106,511,539 - 106,518,605 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7106,510,130 - 106,518,450 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0793,267,517 - 93,279,728 (+)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acquired Protein C Deficiency  (ISO)
Acute Lung Injury  (ISO)
Acute Necrotizing Pancreatitis  (ISO)
adult respiratory distress syndrome  (ISO)
Aggressive Fibromatosis  (ISO)
Albuminuria  (ISO)
Alcoholic Fatty Liver  (ISO)
alcoholic liver cirrhosis  (ISO)
allergic rhinitis  (ISO)
amyloidosis  (ISO)
Animal Disease Models  (ISO)
anterolateral myocardial infarction  (ISO)
aortic aneurysm  (ISO)
Aortic Remodeling  (ISO)
Arterial Thrombosis  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
autistic disorder  (ISO)
bacterial pneumonia  (ISO)
Banti's Syndrome  (ISO)
Behcet's disease  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
Bronchopulmonary Dysplasia  (ISO)
Cardiac Fibrosis  (ISO)
Carotid Artery Injuries  (ISO)
Central Serous Chorioretinopathy  (ISO)
cerebral infarction  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (ISO)
Choroidal Neovascularization, Experimental  (ISO)
Chronic Allograft Nephropathy  (ISO)
chronic obstructive pulmonary disease  (ISO)
Chronic Relapsing Experimental Autoimmune Encephalomyelitis  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
Dermal Fibrosis  (ISO)
diabetes mellitus  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
disseminated intravascular coagulation  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
familial combined hyperlipidemia  (ISO)
familial hypercholesterolemia  (ISO)
familial Mediterranean fever  (ISO)
fatty liver disease  (ISO)
Fetal Growth Retardation  (ISO)
Fever  (ISO)
fibrosarcoma  (ISO)
focal segmental glomerulosclerosis  (ISO)
glaucoma  (ISO)
glomerulonephritis  (ISO)
glomerulosclerosis  (ISO)
Graft vs Host Disease  (ISO)
Graves Ophthalmopathy  (ISO)
Graves' disease  (ISO)
head and neck squamous cell carcinoma  (ISO)
hematopoietic system disease  (ISO)
Hemorrhage  (ISO)
hemorrhagic disease  (ISO)
high grade glioma  (ISO)
Hyaline Membrane Disease  (ISO)
hypertension  (ISO)
hyperthyroidism  (ISO)
Hypoxia-Ischemia, Brain  (ISO)
Insulin Resistance  (ISO)
interstitial lung disease  (ISO)
Intestinal Polyps  (ISO)
Intestinal Reperfusion Injury  (ISO)
ischemic colitis  (ISO)
limited scleroderma  (ISO)
liver cirrhosis  (ISO)
liver disease  (ISO)
Liver Neoplasms  (ISO)
Liver Reperfusion Injury  (ISO)
lung disease  (ISO)
Lung Reperfusion Injury  (ISO)
macular degeneration  (ISO)
Metabolic Syndrome  (ISO)
middle cerebral artery infarction  (ISO)
Multiple Organ Failure  (ISO)
Multiple Trauma  (ISO)
muscular atrophy  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neointima  (ISO)
Neovascularization, Pathologic  (ISO)
nephrotic syndrome  (ISO)
nervous system disease  (ISO)
neurilemmoma  (ISO)
non-alcoholic fatty liver disease  (ISO)
Noonan syndrome  (ISO)
obesity  (ISO)
obstructive sleep apnea  (ISO)
oral squamous cell carcinoma  (ISO)
Oxygen-Induced Retinopathy  (ISO)
peripheral artery disease  (ISO)
Peritoneal Adhesions  (ISO)
Peritoneal Fibrosis  (ISO)
placental insufficiency  (ISO)
Plasminogen Activator Inhibitor-1 Deficiency  (ISO)
platelet-type bleeding disorder 10  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
pleurisy  (ISO)
pneumonia  (ISO)
polycystic ovary syndrome  (ISO)
polycythemia  (ISO)
polyneuropathy  (ISO)
portal vein thrombosis  (ISO)
Postoperative Atrial Fibrillation  (ISO)
pre-eclampsia  (ISO)
Pregnancy Complications  (ISO)
proliferative diabetic retinopathy  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
Radiation Nephropathy  (ISO)
relapsing-remitting multiple sclerosis  (ISO)
renal fibrosis  (ISO)
respiratory allergy  (ISO)
retinal vein occlusion  (ISO)
retinopathy of prematurity  (ISO)
rhinitis  (ISO)
Rhinosinusitis  (ISO)
sciatic neuropathy  (ISO)
Sepsis  (ISO)
sleep apnea  (ISO)
Stomach Neoplasms  (ISO)
Stroke  (ISO)
Sudden Hearing Loss  (ISO)
systemic scleroderma  (ISO)
thoracic aortic aneurysm  (ISO)
thrombosis  (ISO)
toxic shock syndrome  (ISO)
transient cerebral ischemia  (ISO)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (ISO)
urinary bladder cancer  (ISO)
uveal melanoma  (ISO)
Vascular Depression  (ISO)
Vascular Remodeling  (ISO)
Venous Thromboembolism  (ISO)
Venous Thrombosis  (ISO)
Ventilator-Induced Lung Injury  (ISO)
Wounds, Penetrating  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
cellular response to aldosterone  (ISO)
cellular response to angiotensin  (ISO)
cellular response to ATP  (ISO)
cellular response to cAMP  (ISO)
cellular response to cGMP  (ISO)
cellular response to cycloheximide  (ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to drug  (ISO)
cellular response to fibroblast growth factor stimulus  (ISO)
cellular response to follicle-stimulating hormone stimulus  (ISO)
cellular response to glucagon stimulus  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to gravity  (ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to hypoxia  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to leukemia inhibitory factor  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to low-density lipoprotein particle stimulus  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to metal ion  (ISO)
cellular response to nerve growth factor stimulus  (ISO)
cellular response to nicotine  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to platelet-derived growth factor stimulus  (ISO)
cellular response to potassium ion  (ISO)
cellular response to resveratrol  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
decidualization  (ISO)
defense response to Gram-negative bacterium  (ISO)
dentinogenesis  (ISO)
female gonad development  (ISO)
glucose homeostasis  (ISO)
mast cell activation  (ISO)
negative regulation of cell adhesion mediated by integrin  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of endopeptidase activity  (ISO)
negative regulation of endothelial cell apoptotic process  (ISO)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
negative regulation of fibrinolysis  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of plasminogen activation  (ISO)
negative regulation of smooth muscle cell migration  (ISO)
negative regulation of smooth muscle cell-matrix adhesion  (ISO)
negative regulation of vascular wound healing  (ISO)
placenta development  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of blood coagulation  (ISO)
positive regulation of calcium ion import  (ISO)
positive regulation of coagulation  (ISO)
positive regulation of collagen biosynthetic process  (ISO)
positive regulation of epithelium regeneration  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of keratinocyte migration  (ISO)
positive regulation of leukotriene production involved in inflammatory response  (ISO)
positive regulation of monocyte chemotaxis  (ISO)
positive regulation of odontoblast differentiation  (ISO)
positive regulation of receptor-mediated endocytosis  (ISO)
regulation of angiogenesis  (ISO)
regulation of cell population proliferation  (ISO)
regulation of signaling receptor activity  (ISO)
replicative senescence  (ISO)
response to cytokine  (ISO)
response to epidermal growth factor  (ISO)
response to estrogen  (ISO)
response to hyperoxia  (ISO)
response to laminar fluid shear stress  (ISO)
response to lipopolysaccharide  (ISO)
response to nutrient levels  (ISO)
response to reactive oxygen species  (ISO)
response to starvation  (ISO)
response to transforming growth factor beta  (ISO)
tissue regeneration  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View


Comparative Map Data
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.17106,511,539 - 106,518,605 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7106,510,130 - 106,518,450 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0793,267,517 - 93,279,728 (+)NCBIMhudiblu_PPA_v0panPan3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl7101,127,089 - 101,139,266 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl7101,127,104 - 101,139,247 (+)EnsemblGRCh38hg38GRCh38
GRCh387101,127,104 - 101,139,247 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh377100,770,385 - 100,782,528 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367100,557,172 - 100,569,026 (+)NCBINCBI36hg18NCBI36
Build 347100,363,886 - 100,375,741NCBI
Celera795,778,744 - 95,790,926 (+)NCBI
Cytogenetic Map7q22.1NCBI
HuRef795,363,553 - 95,375,745 (+)NCBIHuRef
CHM1_17100,700,705 - 100,712,867 (+)NCBICHM1_1
CRA_TCAGchr7v27100,128,757 - 100,140,934 (+)NCBI
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm395137,090,358 - 137,101,126 (-)NCBIGRCm39mm39
GRCm39 Ensembl5137,090,358 - 137,101,122 (-)Ensembl
GRCm385137,061,504 - 137,072,272 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5137,061,504 - 137,072,268 (-)EnsemblGRCm38mm10GRCm38
MGSCv375137,537,374 - 137,548,142 (-)NCBIGRCm37mm9NCBIm37
MGSCv365137,346,135 - 137,356,886 (-)NCBImm8
Celera5134,078,340 - 134,089,224 (-)NCBICelera
Cytogenetic Map5G2NCBI
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21219,601,272 - 19,611,657 (+)NCBI
Rnor_6.0 Ensembl1222,641,104 - 22,651,482 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01222,641,104 - 22,651,482 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01224,653,385 - 24,663,763 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41220,931,996 - 20,942,374 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11220,921,607 - 20,931,986 (-)NCBI
Celera1221,377,028 - 21,387,410 (+)NCBICelera
RH 3.4 Map12277.5RGD
Cytogenetic Map12q12NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495545616,145,944 - 16,157,142 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545616,147,523 - 16,157,040 (-)NCBIChiLan1.0ChiLan1.0
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1 Ensembl68,720,825 - 8,726,301 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.168,719,547 - 8,727,160 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
SpeTri2.0NW_0049365431,032,543 - 1,040,956 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl38,863,695 - 8,871,564 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.138,863,738 - 8,871,572 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12812,047,520 - 12,060,662 (-)NCBI
ChlSab1.1 Ensembl2812,047,529 - 12,060,202 (-)Ensembl
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_00462474016,128,145 - 16,136,696 (-)NCBI



Nucleotide Sequences
RefSeq Transcripts XM_034964639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide SSBP01000046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSPPAT00000065583   ⟹   ENSPPAP00000042653
RefSeq Status:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl7106,510,130 - 106,518,450 (+)Ensembl
RefSeq Acc Id: XM_034964639   ⟹   XP_034820530
RefSeq Status:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v0793,267,517 - 93,279,728 (+)NCBI
Protein Sequences
Protein RefSeqs XP_034820530 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_034820530   ⟸   XM_034964639
RefSeq Acc Id: ENSPPAP00000042653   ⟸   ENSPPAT00000065583
Protein Domains

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000043881 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000042653 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000065583 UniProtKB/TrEMBL
Gene3D-CATH 3.30.497.10 UniProtKB/TrEMBL
InterPro Serpin_CS UniProtKB/TrEMBL
  Serpin_dom UniProtKB/TrEMBL
  Serpin_fam UniProtKB/TrEMBL
  Serpin_sf UniProtKB/TrEMBL
  Serpin_sf_1 UniProtKB/TrEMBL
Pfam Serpin UniProtKB/TrEMBL
Superfamily-SCOP SSF56574 UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-06-11 SERPINE1  serpin family E member 1  LOC106634989  plasminogen activator inhibitor 1-like  Data Merged 737654 PROVISIONAL
2018-05-08 SERPINE1  serpin family E member 1  LOC100973457  plasminogen activator inhibitor 1  Symbol and/or name change 5135510 APPROVED
2018-05-08 LOC106634989  plasminogen activator inhibitor 1-like    plasminogen activator inhibitor 1 pseudogene  Symbol and/or name change 5135510 APPROVED