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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69014
Species: Homo sapiens
RGD Object: Gene
Symbol: SERPINE1
Name: serpin family E member 1
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SERPINE1increases expressionISOSerpine1 (Mus musculus)6480464CTDStreptozocin results in increased expression of SERPINE1; Streptozocin results in increased expression of SERPINE1 mRNA; Streptozocin results in increased expression of SERPINE1 proteinPMID:16731828 PMID:21778425 PMID:22744176 PMID:24967692
SERPINE1increases expressionISOSerpine1 (Rattus norvegicus)6480464CTDStreptozocin results in increased expression of SERPINE1 mRNA; Streptozocin results in increased expression of SERPINE1 proteinPMID:15322501 PMID:16973718 PMID:19369054
SERPINE1multiple interactionsISOSerpine1 (Mus musculus)6480464CTDSIRT1 protein inhibits the reaction [Streptozocin results in increased expression of SERPINE1 mRNA]; SIRT1 protein inhibits the reaction [Streptozocin results in increased expression of SERPINE1]; Streptozocin promotes the reaction [MAP3K5 protein results in increased expression of SERPINE1 protein]; sulforaphane inhibits the reaction [Streptozocin results in increased expression of SERPINE1 protein]PMID:16731828 PMID:21778425 PMID:22744176 PMID:24967692
SERPINE1multiple interactionsISOSerpine1 (Rattus norvegicus)6480464CTDbenazepril inhibits the reaction [Streptozocin results in increased expression of SERPINE1 mRNA]; Trientine inhibits the reaction [Streptozocin results in increased expression of SERPINE1 mRNA]; Zinc inhibits the reaction [Streptozocin results in increased expression of SERPINE1 protein]PMID:15322501 PMID:16973718 PMID:19369054
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