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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:nitric oxide
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Accession:CHEBI:16480 term browser browse the term
Definition:A nitrogen oxide which is a free radical, each molecule of which consists of one nitrogen and one oxygen atom.
Synonyms:exact_synonym: oxidonitrogen(.);   oxoazanyl
 related_synonym: EDRF;   Formula=NO;   InChI=1S/NO/c1-2;   InChIKey=MWUXSHHQAYIFBG-UHFFFAOYSA-N;   NO;   SMILES=[N]=O;   Stickstoff(II)-oxid;   Stickstoffmonoxid;   endothelium-derived relaxing factor;   mononitrogen monoxide;   monoxido de nitrogeno;   monoxyde d'azote;   nitrogen monooxide;   nitrogen monoxide;   nitrosyl;   oxido de nitrogeno(II);   oxido nitrico;   oxyde azotique;   oxyde nitrique
 alt_id: CHEBI:14657;   CHEBI:25546;   CHEBI:44452;   CHEBI:7583
 xref: CAS:10102-43-9;   DrugBank:DB00435;   Gmelin:451;   KEGG:C00533;   KEGG:D00074
 xref_mesh: MESH:D009569
 xref: MolBase:943;   PDBeChem:NO;   Reaxys:3587257;   Wikipedia:Nitric_oxide


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nitric oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP-binding cassette, sub-family C member 1 multiple interactions EXP ABCC1 protein affects the reaction [AGT protein results in decreased abundance of Nitric Oxide]; ABCC1 protein promotes the reaction [Nitric Oxide results in increased secretion of Glutathione]; ABCC1 protein promotes the reaction [Nitric Oxide results in increased secretion of Iron] CTD PMID:16679408 PMID:17272743 NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601 		JBrowse link
G Abcc2 ATP-binding cassette, sub-family member 2 multiple interactions ISO ABCC2 affects the reaction [Ursodeoxycholic Acid results in increased secretion of Nitric Oxide]
ABCC2 gene SNP affects the susceptibility to [Air Pollutants results in increased abundance of Nitric Oxide]		 CTD PMID:20683964 PMID:29681089 NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179 		JBrowse link
G Acbd3 acyl-Coenzyme A binding domain containing 3 multiple interactions ISO Nitric Oxide promotes the reaction [[RASD1 protein binds to ACBD3 protein binds to SLC11A2 protein] which results in increased uptake of Iron] CTD PMID:16908409 NCBI chr 1:180,553,608...180,581,769
Ensembl chr 1:180,553,608...180,581,769 		JBrowse link
G Ace angiotensin I converting enzyme multiple interactions
increases expression		 ISO Hydralazine inhibits the reaction [Nitric Oxide deficiency results in increased expression of ACE mRNA]; Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of ACE mRNA] CTD PMID:10948087 PMID:16326922 NCBI chr11:105,858,774...105,880,790
Ensembl chr11:105,858,771...105,880,790 		JBrowse link
G Aco1 aconitase 1 decreases expression
multiple interactions		 EXP Nitric Oxide results in decreased expression of ACO1 mRNA
STAT5A protein affects the reaction [Nitric Oxide results in decreased expression of ACO1 mRNA]; STAT5B protein affects the reaction [Nitric Oxide results in decreased expression of ACO1 mRNA]		 CTD PMID:16886906 NCBI chr 4:40,143,429...40,199,011
Ensembl chr 4:40,143,081...40,198,338 		JBrowse link
G Acta1 actin alpha 1, skeletal muscle multiple interactions
increases expression		 ISO Hydralazine inhibits the reaction [Nitric Oxide deficiency results in increased expression of ACTA1 mRNA]; Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of ACTA1 mRNA] CTD PMID:10397678 PMID:16326922 NCBI chr 8:124,618,497...124,621,514
Ensembl chr 8:124,618,508...124,621,490 		JBrowse link
G Actb actin, beta decreases expression EXP Nitric Oxide deficiency results in decreased expression of ACTB mRNA CTD PMID:15878706 NCBI chr 5:142,888,870...142,892,509
Ensembl chr 5:142,888,870...142,892,509 		JBrowse link
G Adm adrenomedullin increases expression ISO Nitric Oxide deficiency results in increased expression of ADM mRNA CTD PMID:16326922 NCBI chr 7:110,226,864...110,229,027
Ensembl chr 7:110,226,868...110,229,027 		JBrowse link
G Adm2 adrenomedullin 2 increases expression ISO Nitric Oxide deficiency results in increased expression of ADM2 mRNA CTD PMID:16326922 NCBI chr15:89,206,923...89,208,934
Ensembl chr15:89,206,923...89,208,934 		JBrowse link
G Adrb2 adrenergic receptor, beta 2 decreases abundance EXP ADRB2 protein results in decreased abundance of Nitric Oxide CTD PMID:10580815 NCBI chr18:62,310,784...62,313,052
Ensembl chr18:62,310,887...62,313,030 		JBrowse link
G Agt angiotensinogen decreases secretion
multiple interactions
decreases abundance
increases secretion
increases abundance
increases activity
increases chemical synthesis		 ISO
EXP		 AGT protein modified form results in decreased secretion of Nitric Oxide
candesartan inhibits the reaction [AGT protein results in increased chemical synthesis of Nitric Oxide]; Hydrogen Sulfide promotes the reaction [AGT protein modified form results in increased chemical synthesis of Nitric Oxide]; Losartan inhibits the reaction [AGT protein modified form results in decreased secretion of Nitric Oxide]; troglitazone inhibits the reaction [AGT protein modified form results in decreased secretion of Nitric Oxide]
ABCC1 protein affects the reaction [AGT protein results in decreased abundance of Nitric Oxide]
AGT protein alternative form promotes the reaction [NOS3 protein results in increased chemical synthesis of Nitric Oxide]; PD 123319 inhibits the reaction [AGT protein results in increased abundance of Nitric Oxide]; theaflavin-3,3'-digallate inhibits the reaction [AGT protein results in decreased abundance of Nitric Oxide]; Valsartan inhibits the reaction [AGT protein results in increased abundance of Nitric Oxide]; Valsartan inhibits the reaction [AGT protein results in increased secretion of Nitric Oxide]
AGT protein alternative form results in increased secretion of Nitric Oxide
Nitric Oxide deficiency results in increased activity of AGT protein modified form		 CTD PMID:12198334 PMID:14597853 PMID:14620932 PMID:17272743 PMID:17666345 More... NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a affects abundance ISO AGTR1A protein affects the abundance of Nitric Oxide CTD PMID:19151255 NCBI chr13:30,520,339...30,566,850
Ensembl chr13:30,520,424...30,566,850 		JBrowse link
G Agtr1b angiotensin II receptor, type 1b affects abundance ISO AGTR1B protein affects the abundance of Nitric Oxide CTD PMID:19151255 NCBI chr 3:20,368,637...20,421,341
Ensembl chr 3:20,368,637...20,421,341 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 affects response to substance ISO AGTR2 protein affects the susceptibility to Nitric Oxide CTD PMID:9374809 NCBI chr  X:21,350,863...21,355,072
Ensembl chr  X:21,350,783...21,355,403 		JBrowse link
G Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 affects localization ISO Nitric Oxide affects the localization of AIFM1 protein CTD PMID:15126337 NCBI chr  X:47,563,821...47,602,440
Ensembl chr  X:47,563,821...47,602,440 		JBrowse link
G Aimp1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 increases expression EXP Nitric Oxide deficiency results in increased expression of AIMP1 mRNA CTD PMID:15878706 NCBI chr 3:132,366,259...132,390,151
Ensembl chr 3:132,366,242...132,390,131 		JBrowse link
G Aip aryl-hydrocarbon receptor-interacting protein decreases expression EXP Nitric Oxide deficiency results in decreased expression of AIP mRNA CTD PMID:15878706 NCBI chr19:4,163,756...4,177,233
Ensembl chr19:4,164,446...4,175,858 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions ISO AKT1 protein inhibits the reaction [Carbon Tetrachloride results in decreased abundance of Nitric Oxide] CTD PMID:18245901 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2, mitochondrial multiple interactions EXP [ALDH2 protein affects the metabolism of and results in increased susceptibility to Pentaerythritol Tetranitrate] which results in increased abundance of Nitric Oxide CTD PMID:21156756 NCBI chr 5:121,704,090...121,731,887
Ensembl chr 5:121,704,090...121,731,887 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions ISO Nitric Oxide promotes the reaction [Reactive Oxygen Species results in decreased activity of ALOX5 protein] CTD PMID:12388339 NCBI chr 6:116,387,030...116,438,139
Ensembl chr 6:116,387,038...116,438,139 		JBrowse link
G Angptl2 angiopoietin-like 2 decreases chemical synthesis EXP ANGPTL2 gene mutant form results in decreased chemical synthesis of Nitric Oxide CTD PMID:27402837 NCBI chr 2:33,105,963...33,137,737
Ensembl chr 2:33,106,081...33,137,729 		JBrowse link
G Anxa5 annexin A5 increases expression ISO Nitric Oxide results in increased expression of ANXA5 protein CTD PMID:16024610 NCBI chr 3:36,503,072...36,530,036
Ensembl chr 3:36,503,072...36,530,043 		JBrowse link
G Apoe apolipoprotein E decreases chemical synthesis EXP APOE gene mutant form results in decreased chemical synthesis of Nitric Oxide CTD PMID:11397713 NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113 		JBrowse link
G App amyloid beta precursor protein multiple interactions EXP [APP protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide; Ibuprofen inhibits the reaction [[APP protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Indomethacin inhibits the reaction [[APP protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide] CTD PMID:11080519 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654 		JBrowse link
G Aqp2 aquaporin 2 decreases expression ISO Nitric Oxide deficiency results in decreased expression of AQP2 protein CTD PMID:17940347 NCBI chr15:99,476,937...99,482,426
Ensembl chr15:99,476,936...99,482,428 		JBrowse link
G Ass1 argininosuccinate synthetase 1 increases response to substance EXP ASS1 protein results in increased susceptibility to Nitric Oxide CTD PMID:25033204 NCBI chr 2:31,360,282...31,410,682
Ensembl chr 2:31,360,219...31,410,684 		JBrowse link
G Atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide multiple interactions ISO Nitric Oxide deficiency inhibits the reaction [Clofibrate results in increased expression of ATP1A1 protein] CTD PMID:15018640 NCBI chr 3:101,483,535...101,512,023
Ensembl chr 3:101,483,535...101,512,000 		JBrowse link
G Atp5f1b ATP synthase F1 subunit beta increases expression EXP Nitric Oxide deficiency results in increased expression of ATP5F1B mRNA CTD PMID:15878706 NCBI chr10:127,919,176...127,926,257
Ensembl chr10:127,919,142...127,926,260 		JBrowse link
G Avp arginine vasopressin affects metabolic processing
multiple interactions
increases expression		 ISO AVP protein affects the metabolism of Nitric Oxide
IL1B protein affects the reaction [AVP protein affects the metabolism of Nitric Oxide]
Nitric Oxide results in increased expression of AVP mRNA		 CTD PMID:10460269 PMID:21171372 NCBI chr 2:130,422,540...130,424,508
Ensembl chr 2:130,422,540...130,424,474 		JBrowse link
G Axl AXL receptor tyrosine kinase decreases expression EXP Nitric Oxide deficiency results in decreased expression of AXL mRNA CTD PMID:15878706 NCBI chr 7:25,455,925...25,488,502
Ensembl chr 7:25,456,698...25,488,130 		JBrowse link
G B2m beta-2 microglobulin increases expression ISO Nitric Oxide results in increased expression of B2M protein CTD PMID:15764486 NCBI chr 2:121,978,168...121,983,563
Ensembl chr 2:121,978,167...121,983,564 		JBrowse link
G Bax BCL2-associated X protein affects localization
multiple interactions
decreases expression		 EXP
ISO		 Nitric Oxide affects the localization of BAX protein
[S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in increased expression of BAX protein
Nitric Oxide results in decreased expression of BAX protein
[Nitroprusside results in increased abundance of Nitric Oxide] which affects the localization of BAX protein; SB 203580 inhibits the reaction [[Nitroprusside results in increased abundance of Nitric Oxide] which affects the localization of BAX protein]
Nitric Oxide inhibits the reaction [Hydrogen Peroxide results in increased expression of and affects the localization of BAX protein]		 CTD PMID:10828028 PMID:14634119 PMID:22878015 PMID:25726415 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bbc3 BCL2 binding component 3 increases expression ISO Nitric Oxide results in increased expression of BBC3 mRNA CTD PMID:15126337 NCBI chr 7:16,042,307...16,052,130
Ensembl chr 7:16,042,318...16,052,130 		JBrowse link
G Bcar1 breast cancer anti-estrogen resistance 1 multiple interactions
decreases phosphorylation		 ISO Nitric Oxide inhibits the reaction [BCAR1 protein binds to CRK protein]
Nitric Oxide results in decreased phosphorylation of BCAR1 protein		 CTD PMID:12714323 NCBI chr 8:112,437,106...112,470,481
Ensembl chr 8:112,437,106...112,470,441 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression
multiple interactions
affects expression		 ISO
EXP		 Nitric Oxide results in decreased expression of BCL2 protein
1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [Nitric Oxide results in increased nitrosation of and results in decreased degradation of BCL2 protein]; [S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in decreased expression of BCL2 protein; Nitric Oxide results in increased nitrosation of and results in decreased degradation of BCL2 protein; pimagedine inhibits the reaction [Nitric Oxide results in increased nitrosation of and results in decreased degradation of BCL2 protein]
[3,5-dimethoxy-4'-hydroxystilbene results in decreased expression of NOS2 mRNA] inhibits the reaction [Nitric Oxide results in increased expression of BCL2 mRNA]; [linsidomine results in increased abundance of Nitric Oxide] which results in increased expression of BCL2 mRNA; [linsidomine results in increased abundance of Nitric Oxide] which results in increased expression of BCL2 protein; [Quercetin results in decreased expression of NOS2 mRNA] inhibits the reaction [Nitric Oxide results in increased expression of BCL2 mRNA]
Nitric Oxide affects the expression of BCL2 mRNA		 CTD PMID:7706495 PMID:10828028 PMID:15126337 PMID:16980304 PMID:17135264 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bcl2l1 BCL2-like 1 decreases expression
multiple interactions
increases expression		 ISO Nitric Oxide results in decreased expression of BCL2L1 protein
GATA5 protein promotes the reaction [Nitric Oxide inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2L1 mRNA]]; GATA5 protein promotes the reaction [Nitric Oxide results in increased expression of BCL2L1 mRNA]; Nitric Oxide inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2L1 mRNA]; Nitric Oxide results in increased expression of and affects the localization of BCL2L1 protein		 CTD PMID:15126337 PMID:25726415 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648 		JBrowse link
G Bdkrb2 bradykinin receptor, beta 2 multiple interactions ISO [kallidin, des-Arg(10)- binds to and results in increased activity of BDKRB2 protein] which results in increased chemical synthesis of Nitric Oxide; [KNG1 protein modified form binds to and results in increased activity of BDKRB2 protein] which results in increased chemical synthesis of Nitric Oxide CTD PMID:29775649 NCBI chr12:105,529,431...105,561,503
Ensembl chr12:105,529,485...105,561,496 		JBrowse link
G Bdnf brain derived neurotrophic factor increases chemical synthesis
multiple interactions		 ISO BDNF protein results in increased chemical synthesis of Nitric Oxide
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [BDNF protein results in increased chemical synthesis of Nitric Oxide]		 CTD PMID:17172126 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352 		JBrowse link
G Bid BH3 interacting domain death agonist increases cleavage ISO Nitric Oxide results in increased cleavage of BID protein CTD PMID:15126337 NCBI chr 6:120,870,080...120,894,074
Ensembl chr 6:120,868,891...120,893,814 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 increases expression EXP Nitric Oxide results in increased expression of BIRC2 protein CTD PMID:14634119 NCBI chr 9:7,818,227...7,837,123
Ensembl chr 9:7,818,228...7,837,065 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 increases expression
decreases expression		 EXP
ISO		 Nitric Oxide results in increased expression of BIRC3 protein
Nitric Oxide results in decreased expression of BIRC3 mRNA		 CTD PMID:14634119 PMID:15126337 NCBI chr 9:7,848,698...7,873,199
Ensembl chr 9:7,848,700...7,873,187 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO
EXP		 Nitric Oxide results in decreased expression of BIRC5 mRNA
Nitric Oxide results in decreased expression of BIRC5 protein		 CTD PMID:15126337 PMID:16166326 NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569 		JBrowse link
G Bmp1 bone morphogenetic protein 1 decreases expression EXP Nitric Oxide deficiency results in decreased expression of BMP1 mRNA CTD PMID:15878706 NCBI chr14:70,711,998...70,758,280
Ensembl chr14:70,711,998...70,757,674 		JBrowse link
G Bnip3 BCL2/adenovirus E1B interacting protein 3 increases expression
decreases expression		 ISO
EXP		 Nitric Oxide results in increased expression of BNIP3 protein
Nitric Oxide results in decreased expression of BNIP3 mRNA		 CTD PMID:11592958 PMID:16002567 NCBI chr 7:138,492,565...138,511,235
Ensembl chr 7:138,492,565...138,511,248 		JBrowse link
G Cacna1a calcium channel, voltage-dependent, P/Q type, alpha 1A subunit multiple interactions ISO CACNA1A protein affects the reaction [Potassium Chloride results in increased abundance of Nitric Oxide] CTD PMID:12770949 NCBI chr 8:85,065,257...85,366,880
Ensembl chr 8:85,065,268...85,366,875 		JBrowse link
G Cacna1b calcium channel, voltage-dependent, N type, alpha 1B subunit multiple interactions ISO CACNA1B protein affects the reaction [Potassium Chloride results in increased abundance of Nitric Oxide] CTD PMID:12770949 NCBI chr 2:24,493,872...24,653,210
Ensembl chr 2:24,493,899...24,653,164 		JBrowse link
G Calcrl calcitonin receptor-like increases expression ISO Nitric Oxide deficiency results in increased expression of CALCRL mRNA; Nitric Oxide deficiency results in increased expression of CALCRL protein CTD PMID:16326922 NCBI chr 2:84,160,970...84,255,786
Ensembl chr 2:84,160,970...84,255,755 		JBrowse link
G Calm1 calmodulin 1 multiple interactions ISO [Calcium binds to CALM1 protein] promotes the reaction [NOS1 protein results in increased chemical synthesis of Nitric Oxide] CTD PMID:17098364 NCBI chr12:100,165,694...100,176,083
Ensembl chr12:100,165,694...100,176,073 		JBrowse link
G Casp1 caspase 1 multiple interactions EXP [S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] which results in increased activity of and results in increased cleavage of CASP1 protein CTD PMID:10903723 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290 		JBrowse link
G Casp12 caspase 12 multiple interactions ISO [Nitroprusside results in increased abundance of Nitric Oxide] which results in increased expression of CASP12 protein CTD PMID:18675883 NCBI chr 9:5,345,419...5,373,034
Ensembl chr 9:5,345,430...5,373,032 		JBrowse link
G Casp3 caspase 3 multiple interactions
decreases activity
decreases cleavage
increases activity
increases metabolic processing		 ISO
EXP		 [NOS2 protein results in increased abundance of Nitric Oxide] inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]; [NOS2 protein results in increased abundance of Nitric Oxide] which results in decreased activity of CASP3 protein; [NOS2 protein results in increased abundance of Nitric Oxide] which results in increased metabolism of CASP3 protein; [S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] inhibits the reaction [N-caproylsphingosine promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]]; [S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] inhibits the reaction [N-caproylsphingosine results in increased activity of CASP3 protein]; [S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in decreased activity of CASP3 protein; [S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in increased metabolism of CASP3 protein; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]]; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] which results in decreased activity of CASP3 protein]; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] which results in increased metabolism of CASP3 protein]; Dithiothreitol inhibits the reaction [Nitric Oxide results in decreased activity of CASP3 protein]; Nitric Oxide inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]
Nitric Oxide results in decreased cleavage of CASP3 protein
[Nitric Oxide Donors results in increased abundance of Nitric Oxide] inhibits the reaction [[TNF protein co-treated with Galactosamine] results in increased activity of CASP3 protein]; [Nitroprusside results in increased abundance of Nitric Oxide] which results in increased activity of CASP3 protein; SB 203580 inhibits the reaction [[Nitroprusside results in increased abundance of Nitric Oxide] which results in increased activity of CASP3 protein]; U 0126 inhibits the reaction [[Nitroprusside results in increased abundance of Nitric Oxide] which results in increased activity of CASP3 protein]
Nitric Oxide results in increased activity of CASP3 protein
[Nitric Oxide Donors results in increased abundance of Nitric Oxide] which results in decreased activity of CASP3 protein; Cyclic GMP affects the reaction [Nitric Oxide results in decreased activity of CASP3 protein]; Dithiothreitol inhibits the reaction [1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one inhibits the reaction [[Nitric Oxide Donors results in increased abundance of Nitric Oxide] which results in decreased activity of CASP3 protein]]; Nitric Oxide affects the activity of and affects the cleavage of CASP3 protein; Nitric Oxide results in decreased cleavage of and results in decreased activity of CASP3 protein
Nitric Oxide results in increased metabolism of CASP3 protein		 CTD PMID:9388267 PMID:9706149 PMID:9755104 PMID:10222263 PMID:10358093 More... NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp7 caspase 7 decreases cleavage ISO Nitric Oxide results in decreased cleavage of CASP7 protein CTD PMID:10222263 NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity		 ISO
EXP		 Nitric Oxide results in decreased cleavage of and results in decreased activity of CASP8 protein
Nitric Oxide results in increased activity of CASP8 protein
[Nitroprusside results in increased abundance of Nitric Oxide] which results in increased activity of CASP8 protein		 CTD PMID:10358093 PMID:15126337 PMID:22878015 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662 		JBrowse link
G Casp9 caspase 9 decreases activity
increases activity
multiple interactions		 EXP
ISO		 Nitric Oxide results in decreased activity of CASP9 protein
Nitric Oxide results in increased activity of CASP9 protein
[Nitroprusside results in increased abundance of Nitric Oxide] which results in increased activity of CASP9 protein		 CTD PMID:14634119 PMID:15126337 PMID:22878015 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Cat catalase multiple interactions ISO Nitric Oxide deficiency inhibits the reaction [Formaldehyde results in increased expression of CAT mRNA]; Nitric Oxide promotes the reaction [Sertraline inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein]]; Nitric Oxide promotes the reaction [Venlafaxine Hydrochloride inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein]] CTD PMID:20305041 PMID:21983654 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Cav1 caveolin 1, caveolae protein multiple interactions
increases expression		 ISO [resveratrol promotes the reaction [ESR1 protein binds to CAV1 protein binds to SRC protein]] which results in increased abundance of Nitric Oxide; Nitric Oxide results in decreased ubiquitination of and results in decreased degradation of CAV1 protein; Nitric Oxide results in increased metabolism of and results in increased stability of CAV1 protein
Nitric Oxide results in increased expression of CAV1 protein		 CTD PMID:18296501 PMID:19706615 NCBI chr 6:17,306,387...17,341,323
Ensembl chr 6:17,306,334...17,341,451 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases secretion
multiple interactions		 ISO
EXP		 Nitric Oxide results in decreased secretion of CCL5 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Nitric Oxide]; [CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Nitric Oxide; Disulfiram inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Nitric Oxide]; wortmannin inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Nitric Oxide]		 CTD PMID:13678430 PMID:19016906 NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344 		JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions EXP [[[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide] which results in decreased expression of CCN2 protein CTD PMID:24412304 NCBI chr10:24,471,340...24,474,581
Ensembl chr10:24,471,340...24,474,581 		JBrowse link
G Ccr5 C-C motif chemokine receptor 5 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Nitric Oxide]; [CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Nitric Oxide; Disulfiram inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Nitric Oxide]; wortmannin inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Nitric Oxide] CTD PMID:19016906 NCBI chr 9:123,921,557...123,934,153
Ensembl chr 9:123,921,580...123,947,736 		JBrowse link
G Cd14 CD14 antigen multiple interactions ISO CD14 protein affects the reaction [G(M1) Ganglioside results in increased secretion of Nitric Oxide]; CD14 protein affects the reaction [ganglioside, GD1a results in increased secretion of Nitric Oxide]; CD14 protein affects the reaction [Gangliosides results in increased secretion of Nitric Oxide]; CD14 protein affects the reaction [Lipopolysaccharides results in increased secretion of Nitric Oxide]; CD14 protein affects the reaction [trisialoganglioside GT1 results in increased secretion of Nitric Oxide] CTD PMID:16651628 NCBI chr18:36,858,117...36,859,868
Ensembl chr18:36,858,120...36,859,851 		JBrowse link
G Cd28 CD28 antigen multiple interactions
increases abundance		 ISO 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [CD28 protein results in increased abundance of Nitric Oxide]; 2-aminoethoxydiphenylborane inhibits the reaction [CD28 protein results in increased abundance of Nitric Oxide]; 5-diisopropoxyphosphoryl-5-methyl-1-pyrroline-N-oxide inhibits the reaction [CD28 protein results in increased abundance of Nitric Oxide]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [CD28 protein results in increased abundance of Nitric Oxide] CTD PMID:14607919 NCBI chr 1:60,785,547...60,812,521
Ensembl chr 1:60,755,959...60,812,518 		JBrowse link
G Cd86 CD86 antigen decreases expression ISO Nitric Oxide results in decreased expression of CD86 protein CTD PMID:13678430 NCBI chr16:36,389,318...36,486,439
Ensembl chr16:36,424,231...36,486,443 		JBrowse link
G Cdh1 cadherin 1 decreases expression ISO Nitric Oxide results in decreased expression of CDH1 mRNA CTD PMID:20179380 NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878 		JBrowse link
G Cdx2 caudal type homeobox 2 increases chemical synthesis EXP CDX2 gene mutant form results in increased chemical synthesis of Nitric Oxide CTD PMID:29439001 NCBI chr 5:147,237,710...147,244,059
Ensembl chr 5:147,237,615...147,244,080 		JBrowse link
G Cftr cystic fibrosis transmembrane conductance regulator multiple interactions ISO Nitric Oxide inhibits the reaction [CFTR protein promotes the reaction [Cyclic AMP results in increased transport of Chlorine]] CTD PMID:12612912 NCBI chr 6:18,170,686...18,322,769
Ensembl chr 6:18,170,686...18,322,767 		JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1, CNS multiple interactions ISO [(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride binds to CHRM1 protein] which results in increased abundance of Nitric Oxide; [muscarinic toxin 7 binds to and results in decreased activity of CHRM1 protein] inhibits the reaction [Amphetamine results in increased abundance of Nitric Oxide] CTD PMID:18991861 NCBI chr19:8,641,369...8,660,970
Ensembl chr19:8,641,153...8,660,951 		JBrowse link
G Cnr1 cannabinoid receptor 1 multiple interactions EXP
ISO		 [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]; [anandamide binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]; rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased transport of Nitric Oxide]]; rimonabant inhibits the reaction [[anandamide binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased transport of Nitric Oxide]]; SR 144528 inhibits the reaction [[anandamide binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased transport of Nitric Oxide]]
[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [IFNG protein affects the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]]; CNR1 protein affects the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in decreased abundance of Nitric Oxide]; rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [IFNG protein affects the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]]]; rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] which results in decreased abundance of Nitric Oxide]		 CTD PMID:10027878 PMID:11727767 PMID:11891798 NCBI chr 4:33,923,171...33,948,831
Ensembl chr 4:33,924,593...33,948,831 		JBrowse link
G Col1a2 collagen, type I, alpha 2 multiple interactions
increases expression		 ISO Amlodipine inhibits the reaction [Nitric Oxide deficiency results in increased expression of COL1A2 mRNA] CTD PMID:10445667 NCBI chr 6:4,505,618...4,541,543
Ensembl chr 6:4,504,814...4,541,544 		JBrowse link
G Col5a3 collagen, type V, alpha 3 decreases expression EXP Nitric Oxide deficiency results in decreased expression of COL5A3 mRNA CTD PMID:15878706 NCBI chr 9:20,681,353...20,726,363
Ensembl chr 9:20,681,346...20,726,363 		JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4I1 increases expression EXP Nitric Oxide deficiency results in increased expression of COX4I1 mRNA CTD PMID:15878706 NCBI chr 8:121,394,964...121,400,948
Ensembl chr 8:121,394,961...121,400,946 		JBrowse link
G Cpd carboxypeptidase D affects chemical synthesis
multiple interactions		 ISO CPD affects the chemical synthesis of Nitric Oxide
[PRL results in increased expression of CPD mRNA] which results in increased chemical synthesis of Nitric Oxide; [Testosterone results in increased expression of CPD mRNA] which results in increased chemical synthesis of Nitric Oxide		 CTD PMID:21688280 NCBI chr11:76,668,034...76,737,834
Ensembl chr11:76,669,250...76,737,844 		JBrowse link
G Cps1 carbamoyl-phosphate synthetase 1 affects abundance ISO CPS1 gene SNP affects the abundance of Nitric Oxide metabolite CTD PMID:14718356 NCBI chr 1:67,151,294...67,270,426
Ensembl chr 1:67,162,185...67,270,418 		JBrowse link
G Crh corticotropin releasing hormone multiple interactions
increases expression		 ISO CRH protein affects the reaction [Nitric Oxide results in increased secretion of POMC protein alternative form]
Nitric Oxide results in increased expression of CRH mRNA		 CTD PMID:10460269 NCBI chr 3:19,747,565...19,749,560
Ensembl chr 3:19,747,565...19,749,560 		JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 increases expression ISO Nitric Oxide results in increased expression of CRHR1 mRNA CTD PMID:10460269 NCBI chr11:104,021,289...104,066,349
Ensembl chr11:104,023,681...104,066,349 		JBrowse link
G Crk v-crk avian sarcoma virus CT10 oncogene homolog multiple interactions ISO Nitric Oxide inhibits the reaction [BCAR1 protein binds to CRK protein] CTD PMID:12714323 NCBI chr11:75,570,020...75,599,254
Ensembl chr11:75,570,085...75,597,734 		JBrowse link
G Csf1 colony stimulating factor 1 (macrophage) multiple interactions
decreases activity		 ISO
EXP		 [CSF1 protein co-treated with CSF2 protein] promotes the reaction [Lipopolysaccharides results in increased chemical synthesis of Nitric Oxide]; [Lipopolysaccharides co-treated with CSF1 protein] results in increased chemical synthesis of Nitric Oxide; Benzene promotes the reaction [[[Lipopolysaccharides co-treated with IFNG protein] co-treated with CSF1 protein] results in increased chemical synthesis of Nitric Oxide]; Benzene promotes the reaction [[Lipopolysaccharides co-treated with CSF1 protein] results in increased chemical synthesis of Nitric Oxide]; CSF1 protein promotes the reaction [IFNG protein results in increased chemical synthesis of Nitric Oxide]; CSF1 protein promotes the reaction [Lipopolysaccharides results in increased chemical synthesis of Nitric Oxide]; Enzyme Inhibitors inhibits the reaction [CSF1 protein promotes the reaction [Lipopolysaccharides results in increased chemical synthesis of Nitric Oxide]]; Enzyme Inhibitors inhibits the reaction [Nitric Oxide results in decreased activity of CSF1 protein]
[Benzene promotes the reaction [[CSF1 protein co-treated with Lipopolysaccharides] results in increased expression of NOS2 mRNA]] which results in increased chemical synthesis of Nitric Oxide		 CTD PMID:8193360 NCBI chr 3:107,648,364...107,668,048
Ensembl chr 3:107,648,364...107,667,785 		JBrowse link
G Csf1r colony stimulating factor 1 receptor multiple interactions ISO [CSF1R protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide; Benzene promotes the reaction [[CSF1R protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]; hydroquinone promotes the reaction [[CSF1R protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]; hydroxyhydroquinone promotes the reaction [[CSF1R protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]; quinone promotes the reaction [[CSF1R protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide] CTD PMID:7884313 NCBI chr18:61,238,644...61,264,211
Ensembl chr18:61,233,670...61,265,221 		JBrowse link
G Csf2 colony stimulating factor 2 (granulocyte-macrophage) multiple interactions ISO
EXP		 [CSF2 protein results in increased expression of ITGB2 protein] which results in increased abundance of Nitric Oxide; CSF2 protein promotes the reaction [ITGB2 protein results in increased abundance of Nitric Oxide]; Ozone promotes the reaction [[CSF2 protein results in increased expression of ITGB2 protein] which results in increased abundance of Nitric Oxide]
[Benzene co-treated with Enzyme Inhibitors] promotes the reaction [[Lipopolysaccharides co-treated with CSF2 protein] results in increased chemical synthesis of Nitric Oxide]; [CSF2 protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide; [Lipopolysaccharides co-treated with CSF2 protein] results in increased chemical synthesis of Nitric Oxide; Benzene promotes the reaction [[[Lipopolysaccharides co-treated with IFNG protein] co-treated with CSF2 protein] results in increased chemical synthesis of Nitric Oxide]; Benzene promotes the reaction [[CSF2 protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]; Benzene promotes the reaction [[Lipopolysaccharides co-treated with CSF2 protein] results in increased chemical synthesis of Nitric Oxide]; hydroquinone promotes the reaction [[CSF2 protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]; hydroxyhydroquinone promotes the reaction [[CSF2 protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]; quinone promotes the reaction [[CSF2 protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]
[CSF1 protein co-treated with CSF2 protein] promotes the reaction [Lipopolysaccharides results in increased chemical synthesis of Nitric Oxide]		 CTD PMID:7884313 PMID:8193360 PMID:8600936 NCBI chr11:54,138,096...54,140,725
Ensembl chr11:54,138,097...54,140,493 		JBrowse link
G Ctf1 cardiotrophin 1 increases chemical synthesis ISO CTF1 protein results in increased chemical synthesis of Nitric Oxide CTD PMID:11304496 NCBI chr 7:127,311,872...127,317,360
Ensembl chr 7:127,311,908...127,317,364 		JBrowse link
G Cth cystathionine gamma lyase decreases expression ISO Nitric Oxide deficiency results in decreased expression of CTH mRNA CTD PMID:14508194 NCBI chr 3:157,599,885...157,630,718
Ensembl chr 3:157,599,885...157,630,714 		JBrowse link
G Ctsd cathepsin D increases secretion ISO Nitric Oxide results in increased secretion of CTSD protein CTD PMID:15040013 NCBI chr 7:141,929,647...141,941,564
Ensembl chr 7:141,929,648...141,941,775 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases secretion ISO Nitric Oxide results in decreased secretion of CXCL10 protein CTD PMID:13678430 NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression EXP Nitric Oxide deficiency results in decreased expression of CXCL12 mRNA CTD PMID:15878706 NCBI chr 6:117,145,496...117,158,329
Ensembl chr 6:117,145,496...117,158,328 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 increases expression ISO Nitric Oxide results in increased expression of CXCL8 protein CTD PMID:10619828 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression EXP Nitric Oxide deficiency results in decreased expression of CXCR4 mRNA CTD PMID:15878706 NCBI chr 1:128,515,936...128,520,036
Ensembl chr 1:128,515,936...128,520,030 		JBrowse link
G Cycs cytochrome c, somatic decreases secretion
affects localization		 ISO Nitric Oxide results in decreased secretion of CYCS protein
Nitric Oxide affects the localization of CYCS protein		 CTD PMID:10222263 PMID:10356289 PMID:10358093 PMID:16024610 NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO [CYP2E1 protein results in increased metabolism of Ethanol] which results in increased abundance of Nitric Oxide CTD PMID:18845238 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900 		JBrowse link
G Dab1 disabled 1 decreases expression EXP Nitric Oxide deficiency results in decreased expression of DAB1 mRNA CTD PMID:15878706 NCBI chr 4:103,476,425...104,602,041
Ensembl chr 4:103,476,556...104,602,041 		JBrowse link
G Ddah2 DDAH family member 2, ADMA independent multiple interactions ISO DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in decreased abundance of Nitric Oxide]] CTD PMID:32135237 NCBI chr17:35,278,011...35,281,075
Ensembl chr17:35,278,011...35,281,071 		JBrowse link
G Ddc dopa decarboxylase increases activity ISO Nitric Oxide deficiency results in increased activity of DDC protein CTD PMID:7541690 NCBI chr11:11,764,101...11,848,144
Ensembl chr11:11,764,101...11,848,144 		JBrowse link
G Dffb DNA fragmentation factor, beta subunit increases activity ISO Nitric Oxide results in increased activity of DFFB protein CTD PMID:15040013 NCBI chr 4:154,048,904...154,059,578
Ensembl chr 4:154,048,906...154,059,583 		JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein affects localization ISO Nitric Oxide affects the localization of DIABLO protein CTD PMID:15126337 NCBI chr 5:123,649,393...123,664,825
Ensembl chr 5:123,647,828...123,662,239 		JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression ISO Nitric Oxide results in increased expression of DUSP1 mRNA CTD PMID:9699677 NCBI chr17:26,724,565...26,727,446
Ensembl chr17:26,724,564...26,781,102 		JBrowse link
G Ech1 enoyl coenzyme A hydratase 1, peroxisomal increases expression EXP Nitric Oxide deficiency results in increased expression of ECH1 mRNA CTD PMID:15878706 NCBI chr 7:28,524,763...28,531,664
Ensembl chr 7:28,524,642...28,531,672 		JBrowse link
G Edn1 endothelin 1 increases chemical synthesis
increases expression
decreases expression
increases abundance
multiple interactions
decreases activity
increases secretion		 ISO
EXP		 EDN1 protein results in increased chemical synthesis of Nitric Oxide
Nitric Oxide results in increased expression of EDN1 mRNA
Nitric Oxide results in increased expression of EDN1 protein
Nitric Oxide results in decreased expression of EDN1 protein
EDN1 protein results in increased abundance of Nitric Oxide
[EDN1 protein results in increased activity of EDNRB protein] which results in increased abundance of Nitric Oxide; [EDN1 protein results in increased activity of NOS1 protein] which results in increased abundance of Nitric Oxide; BQ 788 inhibits the reaction [EDN1 protein results in increased abundance of Nitric Oxide]; Hydralazine inhibits the reaction [Nitric Oxide deficiency results in increased expression of EDN1 mRNA]; Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of EDN1 mRNA]; Nitric Oxide inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]; Nitric Oxide inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK3 protein]; S-methylthiocitrulline inhibits the reaction [EDN1 protein results in increased abundance of Nitric Oxide]
Nitric Oxide deficiency results in decreased activity of EDN1 protein
Nitric Oxide results in increased secretion of EDN1 protein		 CTD PMID:11187978 PMID:15640287 PMID:15838368 PMID:16326922 PMID:16380457 More... NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466 		JBrowse link
G Ednrb endothelin receptor type B multiple interactions ISO [EDN1 protein results in increased activity of EDNRB protein] which results in increased abundance of Nitric Oxide CTD PMID:16380457 NCBI chr14:104,052,055...104,081,764
Ensembl chr14:104,052,061...104,081,838 		JBrowse link
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 increases expression EXP Nitric Oxide deficiency results in increased expression of EEF1A1 mRNA CTD PMID:15878706 NCBI chr 9:78,385,735...78,389,006
Ensembl chr 9:78,385,731...78,396,433 		JBrowse link
G Eef1b2 eukaryotic translation elongation factor 1 beta 2 increases expression EXP Nitric Oxide deficiency results in increased expression of EEF1B2 mRNA CTD PMID:15878706 NCBI chr 1:63,215,990...63,219,645
Ensembl chr 1:63,215,984...63,219,645 		JBrowse link
G Ehmt2 euchromatic histone lysine N-methyltransferase 2 decreases expression ISO Nitric Oxide results in decreased expression of EHMT2 protein CTD PMID:23546878 NCBI chr17:35,117,427...35,133,049
Ensembl chr17:35,117,445...35,133,028 		JBrowse link
G Eif1a eukaryotic translation initiation factor 1A decreases expression EXP Nitric Oxide deficiency results in decreased expression of EIF1A mRNA CTD PMID:15878706 NCBI chr18:46,730,771...46,743,292
Ensembl chr18:46,730,768...46,749,523 		JBrowse link
G Eif2ak1 eukaryotic translation initiation factor 2 alpha kinase 1 multiple interactions EXP Nitric Oxide inhibits the reaction [Mercury results in decreased activity of EIF2AK1 protein] CTD PMID:17689536 NCBI chr 5:143,803,586...143,839,535
Ensembl chr 5:143,803,543...143,841,069 		JBrowse link
G Eif2b4 eukaryotic translation initiation factor 2B, subunit 4 delta decreases expression EXP Nitric Oxide deficiency results in decreased expression of EIF2B4 mRNA CTD PMID:15878706 NCBI chr 5:31,344,902...31,350,483
Ensembl chr 5:31,344,902...31,350,774 		JBrowse link
G Eif3g eukaryotic translation initiation factor 3, subunit G increases expression EXP Nitric Oxide deficiency results in increased expression of EIF3G mRNA CTD PMID:15878706 NCBI chr 9:20,805,645...20,809,886
Ensembl chr 9:20,805,645...20,809,919 		JBrowse link
G Epas1 endothelial PAS domain protein 1 multiple interactions EXP EPAS1 protein affects the reaction [Cobalt results in increased abundance of Nitric Oxide]; EPAS1 protein affects the reaction [Nickel results in increased abundance of Nitric Oxide] CTD PMID:23788631 NCBI chr17:87,061,292...87,140,838
Ensembl chr17:87,061,128...87,140,838 		JBrowse link
G Epo erythropoietin decreases response to substance ISO EPO protein results in decreased susceptibility to Nitric Oxide CTD PMID:15816862 NCBI chr 5:137,481,282...137,484,078
Ensembl chr 5:137,481,282...137,531,504 		JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions ISO [resveratrol promotes the reaction [ESR1 protein binds to CAV1 protein binds to SRC protein]] which results in increased abundance of Nitric Oxide CTD PMID:18296501 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614 		JBrowse link
G Ezh1 enhancer of zeste 1 polycomb repressive complex 2 subunit decreases expression EXP Nitric Oxide deficiency results in decreased expression of EZH1 mRNA CTD PMID:15878706 NCBI chr11:101,081,941...101,117,268
Ensembl chr11:101,081,941...101,117,289 		JBrowse link
G Ezr ezrin increases phosphorylation ISO Nitric Oxide deficiency results in increased phosphorylation of EZR protein CTD PMID:14732730 NCBI chr17:7,005,530...7,050,179
Ensembl chr17:7,005,440...7,050,183 		JBrowse link
G F2 coagulation factor II multiple interactions
increases abundance		 ISO arsenite inhibits the reaction [F2 protein results in increased abundance of Nitric Oxide]; F2 protein promotes the reaction [Heparin results in increased abundance of Nitric Oxide] CTD PMID:8408661 PMID:22244921 NCBI chr 2:91,442,742...91,466,799
Ensembl chr 2:91,455,665...91,466,759 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO Nitric Oxide results in increased expression of FAS mRNA; Nitric Oxide results in increased expression of FAS protein CTD PMID:15126337 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172 		JBrowse link
G Fasl Fas ligand multiple interactions ISO [linsidomine results in increased abundance of Nitric Oxide] inhibits the reaction [Etoposide results in increased activity of FASLG promoter]; [linsidomine results in increased abundance of Nitric Oxide] inhibits the reaction [N-caproylsphingosine results in increased activity of FASLG promoter]; [S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] inhibits the reaction [Etoposide results in increased activity of FASLG promoter]; [S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] inhibits the reaction [N-caproylsphingosine results in increased activity of FASLG promoter]; [S-Nitrosoglutathione results in increased abundance of Nitric Oxide] inhibits the reaction [Etoposide results in increased activity of FASLG promoter]; [S-Nitrosoglutathione results in increased abundance of Nitric Oxide] inhibits the reaction [N-caproylsphingosine results in increased activity of FASLG promoter]; [spermine nitric oxide complex results in increased abundance of Nitric Oxide] inhibits the reaction [Etoposide results in increased activity of FASLG promoter]; [spermine nitric oxide complex results in increased abundance of Nitric Oxide] inhibits the reaction [N-caproylsphingosine results in increased activity of FASLG promoter]; Nitric Oxide inhibits the reaction [Etoposide results in increased activity of FASLG promoter] CTD PMID:10811113 NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064 		JBrowse link
G Fgf1 fibroblast growth factor 1 increases abundance
multiple interactions		 ISO FGF1 protein results in increased abundance of Nitric Oxide
PD 166866 inhibits the reaction [FGF1 protein results in increased abundance of Nitric Oxide]		 CTD PMID:16524372 NCBI chr18:38,971,725...39,062,532
Ensembl chr18:38,971,726...39,062,525 		JBrowse link
G Fosb FBJ osteosarcoma oncogene B increases activity ISO Nitric Oxide results in increased activity of FOSB protein CTD PMID:15949472 NCBI chr 7:19,036,621...19,043,970
Ensembl chr 7:19,036,621...19,043,976 		JBrowse link
G Ftl1 ferritin light polypeptide 1 increases expression EXP Nitric Oxide deficiency results in increased expression of FTL1 mRNA CTD PMID:15878706 NCBI chr 7:45,107,368...45,109,310
Ensembl chr 7:45,107,368...45,109,308 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions
increases expression		 ISO
EXP		 [7-nitroindazole results in decreased chemical synthesis of Nitric Oxide] inhibits the reaction [Paraquat affects the localization of GAPDH protein]
Nitric Oxide deficiency results in increased expression of GAPDH mRNA		 CTD PMID:15878706 PMID:20478973 NCBI chr 6:125,138,812...125,143,450
Ensembl chr 6:125,138,678...125,143,430 		JBrowse link
G Gata5 GATA binding protein 5 multiple interactions
increases response to substance
increases expression		 ISO GATA5 protein promotes the reaction [Nitric Oxide inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2L1 mRNA]]; GATA5 protein promotes the reaction [Nitric Oxide results in increased expression of BCL2L1 mRNA]; Nitric Oxide inhibits the reaction [Hydrogen Peroxide results in decreased expression of GATA5 mRNA]; Nitric Oxide inhibits the reaction [Hydrogen Peroxide results in decreased expression of GATA5 protein]
GATA5 protein results in increased susceptibility to Nitric Oxide
Nitric Oxide results in increased expression of GATA5 mRNA; Nitric Oxide results in increased expression of GATA5 protein		 CTD PMID:25726415 NCBI chr 2:179,966,881...179,977,296
Ensembl chr 2:179,966,926...179,976,492 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit decreases expression ISO Nitric Oxide deficiency results in decreased expression of GCLC mRNA; Nitric Oxide deficiency results in decreased expression of GCLC protein CTD PMID:19631198 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767 		JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit multiple interactions ISO GCLM gene SNP affects the abundance of and affects the activity of and affects the susceptibility to Nitric Oxide CTD PMID:12975258 NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381 		JBrowse link
G Gdi2 GDP dissociation inhibitor 2 decreases expression EXP Nitric Oxide deficiency results in decreased expression of GDI2 mRNA CTD PMID:15878706 NCBI chr13:3,588,075...3,616,261
Ensembl chr13:3,588,063...3,617,871 		JBrowse link
G Gfap glial fibrillary acidic protein decreases expression ISO Nitric Oxide deficiency results in decreased expression of GFAP protein CTD PMID:15763998 NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738 		JBrowse link
G Gja1 gap junction protein, alpha 1 decreases expression ISO Nitric Oxide deficiency results in decreased expression of GJA1 mRNA; Nitric Oxide deficiency results in decreased expression of GJA1 protein; Nitric Oxide results in decreased expression of GJA1 protein CTD PMID:10397678 PMID:11856964 PMID:20004189 NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609 		JBrowse link
G Glb1 galactosidase, beta 1 decreases activity ISO Nitric Oxide results in decreased activity of GLB1 protein CTD PMID:17075048 NCBI chr 9:114,230,146...114,303,447
Ensembl chr 9:114,230,144...114,303,966 		JBrowse link
G Gltp glycolipid transfer protein increases expression EXP Nitric Oxide deficiency results in increased expression of GLTP mRNA CTD PMID:15878706 NCBI chr 5:114,807,551...114,828,996
Ensembl chr 5:114,807,459...114,829,045 		JBrowse link
G Gm20348 predicted gene, 20348 increases expression ISO Nitric Oxide results in increased expression of TP53I3 mRNA CTD PMID:15126337 NCBI chr12:4,860,475...4,867,155
Ensembl chr12:4,860,494...4,867,142 		JBrowse link
G Gpc1 glypican 1 increases nitrosation
multiple interactions		 EXP Nitric Oxide results in increased nitrosation of GPC1 protein
[Ascorbic Acid co-treated with Nitric Oxide] results in increased degradation of GPC1 protein modified form; Zinc promotes the reaction [[Ascorbic Acid co-treated with Nitric Oxide] results in increased degradation of GPC1 protein modified form]		 CTD PMID:15677459 PMID:16923158 NCBI chr 1:92,759,367...92,787,933
Ensembl chr 1:92,759,367...92,788,501 		JBrowse link
G Gpi1 glucose-6-phosphate isomerase 1 increases expression EXP Nitric Oxide deficiency results in increased expression of GPI1 mRNA CTD PMID:15878706 NCBI chr 7:33,900,752...33,929,761
Ensembl chr 7:33,900,755...33,929,761 		JBrowse link
G Gpx1 glutathione peroxidase 1 affects metabolic processing
multiple interactions		 EXP GPX1 protein affects the metabolism of Nitric Oxide
GPX1 protein affects the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased metabolism of Nitric Oxide]		 CTD PMID:11498278 NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542 		JBrowse link
G Gpx2 glutathione peroxidase 2 increases expression EXP Nitric Oxide deficiency results in increased expression of GPX2 mRNA CTD PMID:15878706 NCBI chr12:76,839,109...76,842,328
Ensembl chr12:76,839,107...76,842,273 		JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression
multiple interactions		 EXP
ISO		 Nitric Oxide deficiency results in increased expression of GPX3 mRNA
Nitric Oxide deficiency inhibits the reaction [Formaldehyde results in increased expression of GPX3 mRNA]		 CTD PMID:15878706 PMID:21983654 NCBI chr11:54,793,680...54,801,213
Ensembl chr11:54,793,279...54,801,203 		JBrowse link
G Grb2 growth factor receptor bound protein 2 decreases expression EXP Nitric Oxide deficiency results in decreased expression of GRB2 mRNA CTD PMID:15878706 NCBI chr11:115,534,871...115,599,423
Ensembl chr11:115,534,871...115,599,423 		JBrowse link
G Gsn gelsolin increases expression EXP Nitric Oxide deficiency results in increased expression of GSN mRNA CTD PMID:15878706 NCBI chr 2:35,146,371...35,197,914
Ensembl chr 2:35,146,392...35,197,904 		JBrowse link
G Gsr glutathione reductase increases expression
affects activity
multiple interactions		 ISO Nitric Oxide deficiency results in increased expression of GSR protein
Nitric Oxide deficiency affects the activity of GSR protein
tempol inhibits the reaction [Nitric Oxide deficiency results in increased expression of GSR protein]		 CTD PMID:15925750 PMID:19631198 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191 		JBrowse link
G Gstm1 glutathione S-transferase, mu 1 increases expression EXP Nitric Oxide deficiency results in increased expression of GSTM1 mRNA CTD PMID:15878706 NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289 		JBrowse link
G Gstm2 glutathione S-transferase, mu 2 increases expression EXP Nitric Oxide deficiency results in increased expression of GSTM2 mRNA CTD PMID:15878706 NCBI chr 3:107,889,018...107,893,736
Ensembl chr 3:107,889,018...107,893,769 		JBrowse link
G Gucy1a1 guanylate cyclase 1, soluble, alpha 1 multiple interactions
increases response to substance		 ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one affects the folding of [Nitric Oxide binds to [GUCY1A1 protein binds to GUCY1B1 protein]]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole affects the folding of [Nitric Oxide binds to [GUCY1A1 protein binds to GUCY1B1 protein]]
GUCY1A1 gene mutant form results in increased susceptibility to Nitric Oxide		 CTD PMID:11744065 PMID:25373139 NCBI chr 3:81,999,734...82,053,253
Ensembl chr 3:81,999,734...82,053,096 		JBrowse link
G Gucy1b1 guanylate cyclase 1, soluble, beta 1 multiple interactions ISO 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one affects the folding of [Nitric Oxide binds to [GUCY1A1 protein binds to GUCY1B1 protein]]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole affects the folding of [Nitric Oxide binds to [GUCY1A1 protein binds to GUCY1B1 protein]] CTD PMID:11744065 NCBI chr 3:81,939,311...81,982,018
Ensembl chr 3:81,939,313...81,981,996 		JBrowse link
G Gulo gulonolactone (L-) oxidase multiple interactions EXP [GULO protein co-treated with NOS3 protein] results in increased abundance of Nitric Oxide CTD PMID:16737683 NCBI chr14:66,224,235...66,246,703
Ensembl chr14:66,224,235...66,246,656 		JBrowse link
G H2-Eb1 histocompatibility 2, class II antigen E beta increases abundance ISO HLA-DRB1 protein results in increased abundance of Nitric Oxide CTD PMID:17075829 NCBI chr17:34,524,841...34,535,648
Ensembl chr17:34,524,841...34,535,648 		JBrowse link
G Hadh hydroxyacyl-Coenzyme A dehydrogenase increases expression EXP Nitric Oxide deficiency results in increased expression of HADH mRNA CTD PMID:15878706 NCBI chr 3:131,027,068...131,065,750
Ensembl chr 3:131,027,068...131,065,750 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 increases expression ISO Nitric Oxide deficiency results in increased expression of HAVCR1 protein CTD PMID:19834340 NCBI chr11:46,630,644...46,670,405
Ensembl chr11:46,625,907...46,670,405 		JBrowse link
G Hbs1l Hbs1-like (S. cerevisiae) decreases expression EXP Nitric Oxide deficiency results in decreased expression of HBS1L mRNA CTD PMID:15878706 NCBI chr10:21,171,876...21,244,788
Ensembl chr10:21,171,878...21,244,797 		JBrowse link
G Hcrt hypocretin increases abundance ISO HCRT results in increased abundance of Nitric Oxide CTD PMID:18378017 NCBI chr11:100,652,519...100,653,757
Ensembl chr11:100,651,895...100,653,757 		JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit multiple interactions ISO Nitric Oxide results in decreased stability of and results in decreased expression of HIF1A protein; U 0126 inhibits the reaction [Nitric Oxide results in decreased degradation of and results in increased activity of HIF1A protein] CTD PMID:16310922 PMID:18424783 NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304 		JBrowse link
G Hmox1 heme oxygenase 1 decreases response to substance
affects response to substance
multiple interactions
increases expression
affects activity		 ISO
EXP		 HMOX1 protein results in decreased susceptibility to Nitric Oxide
HMOX1 protein affects the susceptibility to Nitric Oxide
HMOX1 protein promotes the reaction [[Raloxifene Hydrochloride results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide]; Nitric Oxide results in increased stability of and results in increased expression of HMOX1 mRNA
Nitric Oxide results in increased expression of HMOX1 mRNA; Nitric Oxide results in increased expression of HMOX1 protein
Nitric Oxide affects the activity of HMOX1 protein		 CTD PMID:9699677 PMID:15220209 PMID:17020887 PMID:17401437 PMID:18178725 More... NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 increases mutagenesis ISO Nitric Oxide results in increased mutagenesis of HPRT1 gene CTD PMID:22303861 PMID:28454271 NCBI chr  X:52,076,955...52,110,537
Ensembl chr  X:52,077,014...52,110,536 		JBrowse link
G Hspa5 heat shock protein 5 multiple interactions ISO [NOS3 protein polymorphism results in decreased chemical synthesis of Nitric Oxide] which results in decreased expression of HSPA5 mRNA; [NOS3 protein polymorphism results in decreased chemical synthesis of Nitric Oxide] which results in decreased expression of HSPA5 protein
[Nitroprusside results in increased abundance of Nitric Oxide] which results in decreased expression of HSPA5 protein		 CTD PMID:18675883 PMID:19320461 NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559 		JBrowse link
G Hspa8 heat shock protein 8 multiple interactions ISO [sodium arsenite results in increased expression of HSPA8 protein] which results in decreased chemical synthesis of Nitric Oxide CTD PMID:10216529 NCBI chr 9:40,712,572...40,716,498
Ensembl chr 9:40,712,280...40,721,383 		JBrowse link
G Hyal2 hyaluronoglucosaminidase 2 decreases expression EXP Nitric Oxide deficiency results in decreased expression of HYAL2 mRNA CTD PMID:15878706 NCBI chr 9:107,445,096...107,449,975
Ensembl chr 9:107,445,144...107,449,978 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Nitric Oxide deficiency inhibits the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased expression of ICAM1 protein]] CTD PMID:14762100 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113 		JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 multiple interactions ISO Nitric Oxide binds to and affects the folding of and results in increased degradation of and results in decreased activity of IDO1 protein CTD PMID:16834326 NCBI chr 8:25,074,148...25,086,987
Ensembl chr 8:25,074,152...25,087,025 		JBrowse link
G Ifnb1 interferon beta 1, fibroblast multiple interactions EXP [IFNB1 protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide; Dexamethasone inhibits the reaction [[IFNB1 protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]; Quercetin inhibits the reaction [[IFNB1 protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]; tocotrienol, delta inhibits the reaction [[IFNB1 protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide] CTD PMID:22185406 NCBI chr 4:88,440,253...88,441,083
Ensembl chr 4:88,440,262...88,441,011 		JBrowse link
G Ifng interferon gamma increases secretion
increases abundance
multiple interactions
increases chemical synthesis		 ISO
EXP		 Nitric Oxide results in increased secretion of IFNG protein
IFNG protein results in increased abundance of Nitric Oxide; IFNG results in increased abundance of Nitric Oxide
(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Manganese inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]]; [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [IFNG protein affects the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]]; [IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased abundance of Nitric Oxide; [IFNG protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide; [IFNG protein co-treated with TNF protein] results in increased abundance of Nitric Oxide; [IFNG protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [IL1B protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide; [IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide; [Lipopolysaccharides co-treated with IFNG protein co-treated with Manganese] results in decreased abundance of Nitric Oxide; [Lipopolysaccharides co-treated with IFNG protein co-treated with TNF protein] results in increased abundance of Nitric Oxide; [Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide; [pyrazolanthrone co-treated with Manganese] inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; [SB 203580 co-treated with Manganese] inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; [TNF co-treated with IL1B co-treated with IFNG] results in increased abundance of Nitric Oxide; [TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide; [U 0126 co-treated with Manganese] inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Cannabinol inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Chenodeoxycholic Acid inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Deoxycholic Acid inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Genistein inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein co-treated with TNF protein] results in increased abundance of Nitric Oxide]; IFNG promotes the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]; IFNG protein affects the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]; Indomethacin inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]; Luteolin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Manganese inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Nitric Oxide affects the susceptibility to [IFNG protein co-treated with Lipopolysaccharides]; Ozone promotes the reaction [[IFNG protein results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide]; Ozone promotes the reaction [IFNG protein results in increased abundance of Nitric Oxide]; pimagedine inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]; Polyphenols inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein co-treated with TNF protein] results in increased abundance of Nitric Oxide]; pyrazolanthrone inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Quercetin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein co-treated with TNF protein] results in increased abundance of Nitric Oxide]; Rimonabant inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]]; Rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [IFNG protein affects the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]]]; Rimonabant inhibits the reaction [Cannabinol inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]]; S-methylisothiopseudouronium inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; SB 203580 inhibits the reaction [[IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased abundance of Nitric Oxide]; SB 203580 inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]; SB 203580 inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; U 0126 inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Ursodeoxycholic Acid inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]
[IFNG protein co-treated with TNF protein co-treated with IL1B protein] results in increased abundance of Nitric Oxide; [IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide; [IL1B protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide; [IL5 protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide; [Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide; [Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of Nitric Oxide; [NOS2 protein results in increased abundance of Nitric Oxide] affects the susceptibility to [IL1B protein co-treated with TNF protein co-treated with IFNG protein]; Benzene promotes the reaction [[[Lipopolysaccharides co-treated with IFNG protein] co-treated with CSF1 protein] results in increased chemical synthesis of Nitric Oxide]; Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Clofibrate inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; CSF1 protein promotes the reaction [IFNG protein results in increased chemical synthesis of Nitric Oxide]; deoxynivalenol inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with IL1B protein] results in increased abundance of Nitric Oxide]; Ditiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of Nitric Oxide]; Gemfibrozil inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; morin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of Nitric Oxide]; pterostilbene inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Quercetin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; wortmannin inhibits the reaction [Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]]
1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole inhibits the reaction [IFNG protein results in increased abundance of Nitric Oxide]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[IFNG protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [IFNG protein results in increased abundance of Nitric Oxide]; 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [IFNG protein results in increased metabolism of Nitric Oxide]; [[[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide] which results in decreased expression of CCN2 protein; [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA] which results in increased chemical synthesis of Nitric Oxide; [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide; [[TNF protein co-treated with IFNG protein] affects the expression of NOS2 mRNA] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]; [[TNF protein co-treated with IFNG protein] affects the expression of NOS2 protein] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]; [[TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [APP protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide; [IFNG protein co-treated with hydroxyhydroquinone] results in increased abundance of Nitric Oxide; [IFNG protein co-treated with Lipopolysaccharides co-treated with quinone] results in increased abundance of Nitric Oxide; [IFNG protein co-treated with Lipopolysaccharides] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]; [IFNG protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide; [IFNG protein co-treated with TNF protein] results in increased abundance of Nitric Oxide; [IFNG protein results in increased abundance of Nitric Oxide] which results in increased expression of NOS2 protein; [IFNG protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [lead acetate results in increased abundance of Lead] inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of Nitric Oxide]; [Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide; [Lipopolysaccharides co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide; [Lipopolysaccharides co-treated with IFNG protein] results in increased metabolism of Nitric Oxide; [Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of Nitric Oxide; [Lipopolysaccharides co-treated with IFNG] results in increased abundance of Nitric Oxide; [Lipopolysaccharides co-treated with TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide; [TNF co-treated with IL1B co-treated with IFNG] results in increased abundance of Nitric Oxide; [TNF protein co-treated with IFNG protein co-treated with IL1B protein] results in increased abundance of Nitric Oxide; [TNF protein co-treated with IFNG protein] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]; [TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide; [TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide; [TNF protein co-treated with IFNG protein] results in increased secretion of Nitric Oxide; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [IFNG protein results in increased abundance of Nitric Oxide]; Aminosalicylic Acids inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; aristolochic acid I inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Benzene promotes the reaction [[[Lipopolysaccharides co-treated with IFNG protein] co-treated with CSF2 protein] results in increased chemical synthesis of Nitric Oxide]; Benzene promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]; Benzene promotes the reaction [IFNG protein results in increased chemical synthesis of Nitric Oxide]; Capsaicin inhibits the reaction [[IFNG protein results in increased abundance of Nitric Oxide] which results in increased expression of NOS2 protein]; Capsaicin inhibits the reaction [IFNG protein results in increased abundance of Nitric Oxide]; capsazepine inhibits the reaction [[IFNG protein results in increased abundance of Nitric Oxide] which results in increased expression of NOS2 protein]; capsazepine inhibits the reaction [IFNG protein results in increased abundance of Nitric Oxide]; catalpol inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]; chromous chloride inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]; ciglitazone inhibits the reaction [[IFNG protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; cobaltiprotoporphyrin inhibits the reaction [IFNG protein results in increased abundance of Nitric Oxide]; cobaltous chloride promotes the reaction [[[TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; cupric chloride inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]; Dexamethasone inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]; Dexamethasone inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]; Diquat promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased metabolism of Nitric Oxide]; Ditiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased metabolism of Nitric Oxide]; Dronabinol inhibits the reaction [[Lipopolysaccharides co-treated with IFNG] results in increased abundance of Nitric Oxide]; Estriol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased abundance of Nitric Oxide]; Genistein inhibits the reaction [IFNG protein results in increased abundance of Nitric Oxide]; Glyburide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; GPX1 protein affects the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased metabolism of Nitric Oxide]; GW 1929 inhibits the reaction [[IFNG protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Ibuprofen inhibits the reaction [[APP protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; IFNG promotes the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]; IFNG protein inhibits the reaction [Cyclophosphamide results in increased abundance of Nitric Oxide]; IFNG protein promotes the reaction [[Lipopolysaccharides co-treated with Benzene] results in increased abundance of Nitric Oxide]; IFNG protein promotes the reaction [[Lipopolysaccharides co-treated with hydroquinone] results in increased abundance of Nitric Oxide]; IFNG protein promotes the reaction [[Lipopolysaccharides co-treated with hydroxyhydroquinone] results in increased abundance of Nitric Oxide]; IFNG protein promotes the reaction [Lipopolysaccharides results in increased secretion of Nitric Oxide]; IL4 protein inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]; Indomethacin inhibits the reaction [[APP protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; JAK2 protein promotes the reaction [IFNG protein results in increased abundance of Nitric Oxide]; lead chloride inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]; lead chloride inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]; Lipopolysaccharides promotes the reaction [[IFNG protein co-treated with hydroxyhydroquinone] results in increased abundance of Nitric Oxide]; Lipopolysaccharides promotes the reaction [IFNG protein results in increased abundance of Nitric Oxide]; manganese chloride promotes the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]; manganese chloride promotes the reaction [TNF protein co-treated with and results in increased chemical synthesis of IFNG protein co-treated with and results in increased chemical synthesis of Nitric Oxide]; Manganese promotes the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]; Manganese promotes the reaction [TNF protein co-treated with and results in increased chemical synthesis of IFNG protein co-treated with and results in increased chemical synthesis of Nitric Oxide]; Mangifera indica extract inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; MK 473 inhibits the reaction [IFNG protein results in increased metabolism of Nitric Oxide]; NFKBIA protein affects the reaction [manganese chloride promotes the reaction [TNF protein co-treated with and results in increased chemical synthesis of IFNG protein co-treated with and results in increased chemical synthesis of Nitric Oxide]]; NFKBIA protein affects the reaction [Manganese promotes the reaction [TNF protein co-treated with and results in increased chemical synthesis of IFNG protein co-treated with and results in increased chemical synthesis of Nitric Oxide]]; nickel chloride promotes the reaction [[[TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Nitric Oxide affects the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] affects the localization of Zinc]; Nitric Oxide affects the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of MT1 mRNA]; Nitric Oxide affects the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of MT2 mRNA]; NOS2 protein promotes the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]; NOS2 protein promotes the reaction [cobaltous chloride promotes the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]]; NOS2 protein promotes the reaction [nickel chloride promotes the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]]; NS 1652 inhibits the reaction [IFNG protein results in increased metabolism of Nitric Oxide]; NS-3728 inhibits the reaction [IFNG protein results in increased metabolism of Nitric Oxide]; peroxyvanadate inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased abundance of Nitric Oxide]]; peroxyvanadate promotes the reaction [IFNG protein results in increased abundance of Nitric Oxide]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased metabolism of Nitric Oxide]; pimagedine inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]; pimagedine inhibits the reaction [Lipopolysaccharides promotes the reaction [IFNG protein results in increased abundance of Nitric Oxide]]; PPARG protein affects the reaction [[IFNG protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Progesterone inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased abundance of Nitric Oxide]; Quercetin inhibits the reaction [[[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA] which results in increased chemical synthesis of Nitric Oxide]; Quercetin inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]; resiniferatoxin inhibits the reaction [[IFNG protein results in increased abundance of Nitric Oxide] which results in increased expression of NOS2 protein]; resiniferatoxin inhibits the reaction [IFNG protein results in increased abundance of Nitric Oxide]; Resveratrol inhibits the reaction [[[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA] which results in increased chemical synthesis of Nitric Oxide]; Resveratrol inhibits the reaction [IFNG protein results in increased abundance of Nitric Oxide]; sodium arsenite inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Tamoxifen inhibits the reaction [IFNG protein results in increased metabolism of Nitric Oxide]; TBE 31 inhibits the reaction [IFNG protein results in increased abundance of Nitric Oxide]; tocotrienol, delta inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]; U 0126 inhibits the reaction [IFNG protein results in increased abundance of Nitric Oxide]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; zinc chloride inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]		 CTD PMID:7519435 PMID:7689037 PMID:7884313 PMID:8193360 PMID:8341679 More... NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Il10 interleukin 10 decreases secretion ISO Nitric Oxide results in decreased secretion of IL10 protein CTD PMID:13678430 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il12b interleukin 12b decreases expression ISO Nitric Oxide results in decreased expression of IL12B protein CTD PMID:13678430 NCBI chr11:44,290,890...44,305,504
Ensembl chr11:44,290,890...44,304,860 		JBrowse link
G Il12rb2 interleukin 12 receptor, beta 2 increases expression EXP Nitric Oxide results in increased expression of IL12RB2 mRNA CTD PMID:12451176 NCBI chr 6:67,263,914...67,353,277
Ensembl chr 6:67,268,302...67,353,172 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions
increases abundance		 ISO [IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide; Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; wortmannin inhibits the reaction [Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]]
IL1A results in increased abundance of Nitric Oxide
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in increased abundance of Nitric Oxide]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in increased abundance of Nitric Oxide]]; Simvastatin inhibits the reaction [IL1A results in increased abundance of Nitric Oxide]; Y 27632 inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in increased abundance of Nitric Oxide]]		 CTD PMID:15705589 PMID:16968468 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases abundance
increases chemical synthesis		 ISO
EXP		 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased abundance of Nitric Oxide]; [IFNG protein co-treated with TNF protein co-treated with IL1B protein] results in increased abundance of Nitric Oxide; [IL1B protein co-treated with Fatty Acids, Nonesterified] results in increased chemical synthesis of Nitric Oxide; [IL1B protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide; [lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Nitric Oxide; [NOS2 protein results in increased abundance of Nitric Oxide] affects the susceptibility to [IL1B protein co-treated with TNF protein co-treated with IFNG protein]; Asbestos, Crocidolite promotes the reaction [IL1B protein results in increased abundance of Nitric Oxide]; Asbestos, Serpentine promotes the reaction [IL1B protein results in increased abundance of Nitric Oxide]; bisphenol A inhibits the reaction [IL1B protein results in increased abundance of Nitric Oxide]; Clofibrate inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; cordycepin inhibits the reaction [IL1B protein results in increased abundance of Nitric Oxide]; Cytochalasin B inhibits the reaction [Asbestos, Crocidolite promotes the reaction [IL1B protein results in increased abundance of Nitric Oxide]]; Cytochalasin B inhibits the reaction [Asbestos, Serpentine promotes the reaction [IL1B protein results in increased abundance of Nitric Oxide]]; Dactinomycin inhibits the reaction [IL1B results in increased abundance of Nitric Oxide]; deoxynivalenol inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with IL1B protein] results in increased abundance of Nitric Oxide]; Estradiol inhibits the reaction [IL1B protein results in increased abundance of Nitric Oxide]; Gemfibrozil inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Glucosamine analog affects the reaction [IL1B protein results in increased abundance of Nitric Oxide]; Glucosamine inhibits the reaction [IL1B results in increased abundance of Nitric Oxide]; Gold Sodium Thiomalate inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Hydroxychloroquine inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; IL1B protein promotes the reaction [NOS2 protein results in increased abundance of Nitric Oxide]; IL4 protein inhibits the reaction [IL1B protein results in increased abundance of Nitric Oxide]; Leflunomide inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; LEP protein affects the reaction [IL1B protein results in increased chemical synthesis of Nitric Oxide]; Methotrexate inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Nitric Oxide deficiency inhibits the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased expression of ICAM1 protein]]; Nitric Oxide deficiency inhibits the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased expression of SELE protein]]; nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Nitric Oxide]; pimagedine inhibits the reaction [Asbestos, Crocidolite promotes the reaction [IL1B protein results in increased abundance of Nitric Oxide]]; pimagedine inhibits the reaction [Asbestos, Serpentine promotes the reaction [IL1B protein results in increased abundance of Nitric Oxide]]; sauchinone inhibits the reaction [IL1B protein results in increased abundance of Nitric Oxide]; sodium arsenite inhibits the reaction [IL1B protein results in increased abundance of Nitric Oxide]; Triglycerides affects the reaction [IL1B protein results in increased chemical synthesis of Nitric Oxide]; Troglitazone inhibits the reaction [IL1B protein results in increased abundance of Nitric Oxide]; Troglitazone inhibits the reaction [IL1B protein results in increased chemical synthesis of Nitric Oxide]
[Enzyme Inhibitors results in decreased abundance of Nitric Oxide] inhibits the reaction [IL1B protein results in decreased secretion of INS1 protein]; [IL1B protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide; [IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide; [IL1B protein co-treated with TNF protein] results in increased chemical synthesis of Nitric Oxide; [IL1B protein results in increased expression of and results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [IL1B protein results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide; [IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [TNF co-treated with IL1B co-treated with IFNG] results in increased abundance of Nitric Oxide; Active Hexose Correlated Compound inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide]; Active Hexose Correlated Compound inhibits the reaction [IL1B protein results in increased abundance of Nitric Oxide]; Adenosine inhibits the reaction [IL1B protein results in increased abundance of Nitric Oxide]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Edaravone inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Glucosamine inhibits the reaction [IL1B protein results in increased abundance of Nitric Oxide]; IL1B protein affects the reaction [AVP protein affects the metabolism of Nitric Oxide]; Luteolin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Ozone promotes the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide]; Ozone promotes the reaction [IL1B protein results in increased abundance of Nitric Oxide]; Quercetin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Rotenone inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; SOD2 protein inhibits the reaction [IL1B protein results in increased chemical synthesis of Nitric Oxide]; Vitamin E inhibits the reaction [[IL1B protein co-treated with TNF protein] results in increased chemical synthesis of Nitric Oxide]
IL1B protein results in increased abundance of Nitric Oxide; IL1B results in increased abundance of Nitric Oxide
[TNF co-treated with IL1B co-treated with IFNG] results in increased abundance of Nitric Oxide; [TNF protein co-treated with IFNG protein co-treated with IL1B protein] results in increased abundance of Nitric Oxide; IL1B protein promotes the reaction [Cobalt results in increased abundance of Nitric Oxide]; IL1B protein promotes the reaction [Nickel results in increased abundance of Nitric Oxide]; Nitric Oxide affects the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] affects the localization of Zinc]; Nitric Oxide affects the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of MT1 mRNA]; Nitric Oxide affects the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of MT2 mRNA]		 CTD PMID:7519435 PMID:8903404 PMID:8982730 PMID:9312173 PMID:9576743 More... NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO
EXP		 IL4 protein inhibits the reaction [IL1B protein results in increased abundance of Nitric Oxide]
IL4 protein inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]		 CTD PMID:12115740 PMID:12612912 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496 		JBrowse link
G Il5 interleukin 5 multiple interactions
decreases secretion		 ISO [IL5 protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide
Nitric Oxide results in decreased secretion of IL5 protein		 CTD PMID:13678430 PMID:18206661 NCBI chr11:53,611,621...53,615,930
Ensembl chr11:53,611,621...53,615,933 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO		 Plant Extracts inhibits the reaction [[Lipopolysaccharides results in increased expression of IL6 protein] which results in increased chemical synthesis of Nitric Oxide]
Nitric Oxide deficiency inhibits the reaction [Formaldehyde results in increased expression of IL6 protein]		 CTD PMID:20708382 PMID:21983654 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Ins1 insulin I multiple interactions ISO [Enzyme Inhibitors results in decreased abundance of Nitric Oxide] inhibits the reaction [IL1B protein results in decreased secretion of INS1 protein] CTD PMID:24425765 NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914 		JBrowse link
G Ins2 insulin II increases secretion
increases chemical synthesis
multiple interactions
decreases secretion		 ISO INS protein results in increased secretion of Nitric Oxide
INS protein results in increased chemical synthesis of Nitric Oxide
[INS protein co-treated with Glucose] results in decreased chemical synthesis of Nitric Oxide; [Orotic Acid inhibits the reaction [INS protein results in increased phosphorylation of NOS3 protein]] which results in decreased abundance of Nitric Oxide; Glucose inhibits the reaction [INS protein results in increased secretion of Nitric Oxide]; Kynurenic Acid inhibits the reaction [[INS protein co-treated with Glucose] results in decreased chemical synthesis of Nitric Oxide]; Orotic Acid inhibits the reaction [INS protein results in increased abundance of Nitric Oxide]; Palmitates inhibits the reaction [INS protein results in increased chemical synthesis of Nitric Oxide]; PIK3CA protein inhibits the reaction [[Orotic Acid inhibits the reaction [INS protein results in increased phosphorylation of NOS3 protein]] which results in decreased abundance of Nitric Oxide]; quercetin 3-O-glucuronide inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased chemical synthesis of Nitric Oxide]]; Quercetin inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased chemical synthesis of Nitric Oxide]]; resveratrol inhibits the reaction [Glucose inhibits the reaction [INS protein results in increased secretion of Nitric Oxide]]; SIRT1 protein affects the reaction [INS protein results in increased secretion of Nitric Oxide]; SIRT1 protein affects the reaction [resveratrol inhibits the reaction [Glucose inhibits the reaction [INS protein results in increased secretion of Nitric Oxide]]]; Sodium Salicylate inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased chemical synthesis of Nitric Oxide]]
INS protein results in decreased secretion of Nitric Oxide		 CTD PMID:20960276 PMID:23504962 PMID:25601987 PMID:26364587 PMID:28951307 NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118 		JBrowse link
G Itga6 integrin alpha 6 decreases abundance
multiple interactions		 ISO ITGA6 protein results in decreased abundance of Nitric Oxide
AG 1879 inhibits the reaction [ITGA6 protein results in decreased abundance of Nitric Oxide]		 CTD PMID:36731809 NCBI chr 2:71,617,236...71,688,761
Ensembl chr 2:71,575,960...71,688,760 		JBrowse link
G Itgb2 integrin beta 2 multiple interactions
increases abundance		 ISO Nitric Oxide promotes the reaction [ITGB2 protein results in increased activity of RAP1A protein]; Nitric Oxide promotes the reaction [ITGB2 protein results in increased activity of RAP2A protein]
[CSF2 protein results in increased expression of ITGB2 protein] which results in increased abundance of Nitric Oxide; [ITGB2 protein results in increased susceptibility to Ozone] which results in increased abundance of Nitric Oxide; CSF2 protein promotes the reaction [ITGB2 protein results in increased abundance of Nitric Oxide]; Ozone promotes the reaction [[CSF2 protein results in increased expression of ITGB2 protein] which results in increased abundance of Nitric Oxide]		 CTD PMID:8600936 PMID:16963453 NCBI chr10:77,366,164...77,401,542
Ensembl chr10:77,366,086...77,401,542 		JBrowse link
G Itgb3 integrin beta 3 increases expression ISO Nitric Oxide results in increased expression of ITGB3 protein CTD PMID:21332719 NCBI chr11:104,498,826...104,561,302
Ensembl chr11:104,498,826...104,561,302 		JBrowse link
G Jak1 Janus kinase 1 decreases expression EXP Nitric Oxide deficiency results in decreased expression of JAK1 mRNA CTD PMID:15878706 NCBI chr 4:101,009,171...101,122,493
Ensembl chr 4:101,009,564...101,122,479 		JBrowse link
G Jak2 Janus kinase 2 multiple interactions
decreases expression		 EXP JAK2 protein promotes the reaction [IFNG protein results in increased abundance of Nitric Oxide]
Nitric Oxide deficiency results in decreased expression of JAK2 mRNA		 CTD PMID:12847270 PMID:15878706 NCBI chr19:29,229,006...29,290,495
Ensembl chr19:29,229,228...29,290,480 		JBrowse link
G Jun jun proto-oncogene increases activity ISO Nitric Oxide results in increased activity of JUN protein CTD PMID:15949472 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459 		JBrowse link
G Junb jun B proto-oncogene increases activity ISO Nitric Oxide results in increased activity of JUNB protein CTD PMID:15949472 NCBI chr 8:85,703,538...85,705,377
Ensembl chr 8:85,701,113...85,705,347 		JBrowse link
G Kdm1a lysine (K)-specific demethylase 1A increases expression ISO Nitric Oxide results in increased expression of KDM1A mRNA CTD PMID:23546878 NCBI chr 4:136,277,844...136,330,127
Ensembl chr 4:136,277,851...136,330,034 		JBrowse link
G Kdm3a lysine (K)-specific demethylase 3A increases expression ISO Nitric Oxide results in increased expression of KDM3A mRNA; Nitric Oxide results in increased expression of KDM3A protein CTD PMID:23546878 NCBI chr 6:71,565,954...71,609,963
Ensembl chr 6:71,565,956...71,609,974 		JBrowse link
G Kdm3b KDM3B lysine (K)-specific demethylase 3B increases expression ISO Nitric Oxide results in increased expression of KDM3B mRNA CTD PMID:23546878 NCBI chr18:34,910,061...34,972,423
Ensembl chr18:34,910,100...34,971,713 		JBrowse link
G Kdm4a lysine (K)-specific demethylase 4A increases expression ISO Nitric Oxide results in increased expression of KDM4A mRNA CTD PMID:23546878 NCBI chr 4:117,994,154...118,037,216
Ensembl chr 4:117,994,154...118,037,240 		JBrowse link
G Kdm4b lysine (K)-specific demethylase 4B increases expression ISO Nitric Oxide results in increased expression of KDM4B mRNA CTD PMID:23546878 NCBI chr17:56,632,975...56,710,774
Ensembl chr17:56,633,062...56,709,870 		JBrowse link
G Kdm4c lysine (K)-specific demethylase 4C increases expression ISO Nitric Oxide results in increased expression of KDM4C mRNA CTD PMID:23546878 NCBI chr 4:74,160,734...74,324,101
Ensembl chr 4:74,160,734...74,324,097 		JBrowse link
G Kdm4d lysine (K)-specific demethylase 4D increases expression ISO Nitric Oxide results in increased expression of KDM4D mRNA CTD PMID:23546878 NCBI chr 9:14,373,844...14,411,818
Ensembl chr 9:14,373,844...14,411,778 		JBrowse link
G Kdm7a lysine (K)-specific demethylase 7A increases expression ISO Nitric Oxide results in increased expression of KDM7A mRNA CTD PMID:23546878 NCBI chr 6:39,113,554...39,183,707
Ensembl chr 6:39,113,557...39,183,723 		JBrowse link
G Klk1 kallikrein 1 increases abundance
multiple interactions		 ISO KLK1 protein results in increased abundance of Nitric Oxide
icatibant inhibits the reaction [KLK1 protein results in increased abundance of Nitric Oxide]; KLK1 protein inhibits the reaction [Gentamicins results in decreased abundance of Nitric Oxide]		 CTD PMID:16401625 NCBI chr 7:43,874,784...43,879,046
Ensembl chr 7:43,874,784...43,879,042 		JBrowse link
G Kng1 kininogen 1 affects abundance
multiple interactions
increases secretion
increases abundance		 EXP
ISO		 KNG1 affects the abundance of Nitric Oxide
[KNG1 protein modified form binds to and results in increased activity of BDKRB2 protein] which results in increased chemical synthesis of Nitric Oxide; Lipopolysaccharides promotes the reaction [KNG1 protein modified form results in increased chemical synthesis of Nitric Oxide]
KNG1 protein results in increased secretion of Nitric Oxide
KNG1 protein results in increased abundance of Nitric Oxide
PD 123319 affects the reaction [KNG1 affects the abundance of Nitric Oxide]		 CTD PMID:10535458 PMID:16514058 PMID:16733097 PMID:29775649 NCBI chr16:22,876,970...22,900,828
Ensembl chr16:22,876,615...22,900,828 		JBrowse link
G Lep leptin multiple interactions ISO LEP protein affects the reaction [IL1B protein results in increased chemical synthesis of Nitric Oxide] CTD PMID:9312173 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876 		JBrowse link
G Lif leukemia inhibitory factor multiple interactions EXP LIF protein affects the reaction [Progesterone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased abundance of Nitric Oxide]]; LIF protein inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased abundance of Nitric Oxide] CTD PMID:23409146 NCBI chr11:4,207,587...4,222,514
Ensembl chr11:4,207,557...4,222,514 		JBrowse link
G Ltf lactotransferrin increases chemical synthesis
decreases activity		 ISO LTF protein results in increased chemical synthesis of Nitric Oxide
Nitric Oxide deficiency results in decreased activity of LTF protein		 CTD PMID:14563657 NCBI chr 9:110,848,360...110,871,834
Ensembl chr 9:110,848,339...110,871,835 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
decreases expression
decreases phosphorylation		 ISO Nitric Oxide affects the reaction [Ditiocarb results in increased phosphorylation of MAPK1 protein]; Nitric Oxide affects the reaction [NGF protein results in increased activity of MAPK1 protein]; Nitric Oxide inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]
Nitric Oxide results in decreased expression of MAPK1 protein
Nitric Oxide results in decreased phosphorylation of MAPK1 protein		 CTD PMID:14713289 PMID:15640287 PMID:16389725 PMID:16575906 PMID:16603213 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
decreases expression
decreases phosphorylation		 ISO Nitric Oxide affects the reaction [Ditiocarb results in increased phosphorylation of MAPK3 protein]; Nitric Oxide affects the reaction [NGF protein results in increased activity of MAPK3 protein]; Nitric Oxide inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK3 protein]
Nitric Oxide results in decreased expression of MAPK3 protein
Nitric Oxide results in decreased phosphorylation of MAPK3 protein		 CTD PMID:14713289 PMID:15640287 PMID:16389725 PMID:16575906 PMID:16603213 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mbp myelin basic protein increases abundance
multiple interactions		 ISO MBP protein results in increased abundance of Nitric Oxide
Testosterone inhibits the reaction [MBP protein results in increased abundance of Nitric Oxide]		 CTD PMID:18579221 NCBI chr18:82,492,883...82,603,762
Ensembl chr18:82,493,271...82,603,762 		JBrowse link
G Mef2a myocyte enhancer factor 2A decreases expression EXP Nitric Oxide deficiency results in decreased expression of MEF2A mRNA CTD PMID:15878706 NCBI chr 7:66,880,911...67,026,435
Ensembl chr 7:66,880,911...67,022,606 		JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 multiple interactions ISO [1-hydroxy-2-oxo-3-(3-aminopropyl)-3-isopropyl-1-triazene results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein; [S-nitrosocysteine results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein; [S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein; Dithiothreitol inhibits the reaction [[1-hydroxy-2-oxo-3-(3-aminopropyl)-3-isopropyl-1-triazene results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein]; Dithiothreitol inhibits the reaction [[S-nitrosocysteine results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein]; Dithiothreitol inhibits the reaction [[S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein] CTD PMID:16386761 NCBI chr 6:138,117,525...138,133,753
Ensembl chr 6:138,117,314...138,133,753 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression
multiple interactions		 ISO Nitric Oxide results in decreased expression of MMP2 protein
Nitric Oxide results in increased expression of and results in increased activity of MMP2 protein		 CTD PMID:16575906 PMID:18796497 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048 		JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression EXP Nitric Oxide results in increased expression of MMP9 mRNA CTD PMID:20197249 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Mpo myeloperoxidase increases expression
multiple interactions
increases oxidation		 ISO Nitric Oxide results in increased expression of MPO protein
[Paraquat co-treated with Nitric Oxide] results in increased activity of MPO protein
MPO protein results in increased oxidation of Nitric Oxide
4-amino-TEMPO inhibits the reaction [MPO protein results in increased oxidation of Nitric Oxide]; [1,6-diaminohexane binds to TEMPO] inhibits the reaction [MPO protein results in increased oxidation of Nitric Oxide]; [Cadaverine binds to TEMPO] inhibits the reaction [MPO protein results in increased oxidation of Nitric Oxide]; [ethylenediamine binds to TEMPO] inhibits the reaction [MPO protein results in increased oxidation of Nitric Oxide]; [Putrescine binds to TEMPO] inhibits the reaction [MPO protein results in increased oxidation of Nitric Oxide]; [Spermine binds to TEMPO] inhibits the reaction [MPO protein results in increased oxidation of Nitric Oxide]; [trimethylenediamine binds to TEMPO] inhibits the reaction [MPO protein results in increased oxidation of Nitric Oxide]		 CTD PMID:10706834 PMID:15820443 PMID:34085520 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
G Mrps7 mitchondrial ribosomal protein S7 decreases expression EXP Nitric Oxide deficiency results in decreased expression of MRPS7 mRNA CTD PMID:15878706 NCBI chr11:115,494,966...115,498,862
Ensembl chr11:115,494,751...115,498,862 		JBrowse link
G Msn moesin increases phosphorylation ISO Nitric Oxide deficiency results in increased phosphorylation of MSN protein CTD PMID:14732730 NCBI chr  X:95,139,651...95,212,159
Ensembl chr  X:95,139,648...95,212,158 		JBrowse link
G mt-Co1 cytochrome c oxidase I, mitochondrial affects activity
affects expression		 ISO Nitric Oxide affects the activity of COX1 protein
Nitric Oxide affects the expression of COX1 mRNA		 CTD PMID:17936468 NCBI chr MT:5,328...6,872
Ensembl chr MT:5,328...6,872 		JBrowse link
G Mt1 metallothionein 1 multiple interactions EXP Nitric Oxide affects the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of MT1 mRNA] CTD PMID:14617770 NCBI chr 8:94,905,214...94,906,955
Ensembl chr 8:94,905,710...94,906,955 		JBrowse link
G Mt2 metallothionein 2 multiple interactions EXP Nitric Oxide affects the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of MT2 mRNA] CTD PMID:14617770 NCBI chr 8:94,899,246...94,900,195
Ensembl chr 8:94,899,292...94,900,196 		JBrowse link
G Mt3 metallothionein 3 decreases response to substance ISO MT3 protein results in decreased susceptibility to Nitric Oxide CTD PMID:10854270 NCBI chr 8:94,879,235...94,880,776
Ensembl chr 8:94,879,235...94,880,774 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions EXP [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]] CTD PMID:22363816 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140 		JBrowse link
G Myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha decreases expression ISO Nitric Oxide deficiency results in decreased expression of MYH6 mRNA CTD PMID:16326922 NCBI chr14:55,179,378...55,205,553
Ensembl chr14:55,179,378...55,204,384 		JBrowse link
G Myh7 myosin, heavy polypeptide 7, cardiac muscle, beta increases expression
multiple interactions		 ISO Nitric Oxide deficiency results in increased expression of MYH7 mRNA
Hydralazine inhibits the reaction [Nitric Oxide deficiency results in increased expression of MYH7 mRNA]; Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of MYH7 mRNA]		 CTD PMID:16326922 NCBI chr14:55,208,141...55,232,083
Ensembl chr14:55,208,141...55,232,083 		JBrowse link
G Ndn necdin, MAGE family member decreases expression EXP Nitric Oxide deficiency results in decreased expression of NDN mRNA CTD PMID:15878706 NCBI chr 7:61,998,025...61,999,676
Ensembl chr 7:61,996,317...62,000,010 		JBrowse link
G Ndrg1 N-myc downstream regulated gene 1 increases expression ISO Nitric Oxide results in increased expression of NDRG1 mRNA; Nitric Oxide results in increased expression of NDRG1 protein CTD PMID:21976667 NCBI chr15:66,801,167...66,841,490
Ensembl chr15:66,801,167...66,841,489 		JBrowse link
G Ndufa13 NADH:ubiquinone oxidoreductase subunit A13 increases expression EXP Nitric Oxide deficiency results in increased expression of NDUFA13 mRNA CTD PMID:15878706 NCBI chr 8:70,346,813...70,355,208
Ensembl chr 8:70,346,830...70,355,208 		JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions EXP NFKB1 protein promotes the reaction [[Ozone results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide] CTD PMID:12162464 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions EXP NFKBIA protein affects the reaction [manganese chloride promotes the reaction [TNF protein co-treated with and results in increased chemical synthesis of IFNG protein co-treated with and results in increased chemical synthesis of Nitric Oxide]]; NFKBIA protein affects the reaction [Manganese promotes the reaction [TNF protein co-treated with and results in increased chemical synthesis of IFNG protein co-treated with and results in increased chemical synthesis of Nitric Oxide]] CTD PMID:16168523 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432 		JBrowse link
G Ngf nerve growth factor multiple interactions ISO Nitric Oxide affects the reaction [NGF protein results in increased activity of MAPK1 protein]; Nitric Oxide affects the reaction [NGF protein results in increased activity of MAPK3 protein] CTD PMID:14713289 NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329 		JBrowse link
G Nos1 nitric oxide synthase 1, neuronal multiple interactions
decreases expression
increases chemical synthesis		 EXP
ISO		 7-nitroindazole inhibits the reaction [[N-isopropylbenzylamine results in increased expression of NOS1 protein] which results in increased abundance of Nitric Oxide]; [N-isopropylbenzylamine results in increased expression of NOS1 protein] which results in increased abundance of Nitric Oxide; PLAT protein affects the reaction [NOS1 protein results in increased chemical synthesis of Nitric Oxide]
[Calcium binds to CALM1 protein] promotes the reaction [NOS1 protein results in increased chemical synthesis of Nitric Oxide]; [Cisplatin results in increased expression of NOS1 mRNA] which results in increased abundance of Nitric Oxide; [EDN1 protein results in increased activity of NOS1 protein] which results in increased abundance of Nitric Oxide; [Formaldehyde results in increased expression of NOS1 protein] which results in increased abundance of Nitric Oxide; [NOS1 protein results in increased reduction of Trinitrotoluene] which results in decreased chemical synthesis of Nitric Oxide
Nitric Oxide deficiency results in decreased expression of NOS1 protein		 CTD PMID:15223068 PMID:15249212 PMID:16380457 PMID:17098364 PMID:18195371 More... NCBI chr 5:118,004,904...118,096,905
Ensembl chr 5:117,919,097...118,096,905 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible increases abundance
increases expression
multiple interactions
increases chemical synthesis
affects expression
decreases expression
affects abundance		 ISO
EXP		 NOS2 protein results in increased abundance of Nitric Oxide
Nitric Oxide results in increased expression of NOS2 mRNA; Nitric Oxide results in increased expression of NOS2 protein
[[Fluvastatin results in increased expression of NOS2] which results in increased abundance of Nitric Oxide] which results in decreased expression of TFRC; [[Particulate Matter results in increased abundance of Ammonium Compounds] which results in decreased methylation of NOS2 promoter] which results in increased abundance of Nitric Oxide; [[Particulate Matter results in increased abundance of Carbon] which results in decreased methylation of NOS2 promoter] which results in increased abundance of Nitric Oxide; [[Particulate Matter results in increased abundance of Nitrates] which results in decreased methylation of NOS2 promoter] which results in increased abundance of Nitric Oxide; [Acetaldehyde results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide; [Ethanol results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide; [Fluvastatin results in increased expression of NOS2] which results in increased abundance of Nitric Oxide; [Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide; [Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [N-(3-(aminomethyl)benzyl)acetamidine results in decreased activity of NOS2 protein] inhibits the reaction [Fluvastatin results in increased abundance of Nitric Oxide]; [Nitroprusside results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [NOS2 protein results in increased abundance of Nitric Oxide] affects the susceptibility to [IL1B protein co-treated with TNF protein co-treated with IFNG protein]; [NOS2 protein results in increased abundance of Nitric Oxide] inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]; [NOS2 protein results in increased abundance of Nitric Oxide] which results in decreased activity of CASP3 protein; [NOS2 protein results in increased abundance of Nitric Oxide] which results in increased metabolism of CASP3 protein; [Raloxifene Hydrochloride results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide; [Resveratrol results in decreased expression of NOS2 protein] which results in decreased abundance of Nitric Oxide; [Tobacco Smoke Pollution results in increased expression of and results in increased activity of NOS2 protein] which results in increased abundance of Nitric Oxide; [Trichloroethylene results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [Vehicle Emissions results in increased abundance of Air Pollutants] inhibits the reaction [NOS2 promoter polymorphism affects the abundance of Nitric Oxide]; Bee Venoms inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Bee Venoms inhibits the reaction [[Nitroprusside results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Cyclosporine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]]; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] which results in decreased activity of CASP3 protein]; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] which results in increased metabolism of CASP3 protein]; Gold Sodium Thiomalate inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; HMOX1 protein promotes the reaction [[Raloxifene Hydrochloride results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide]; Hydroxychloroquine inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; IL1B protein promotes the reaction [NOS2 protein results in increased abundance of Nitric Oxide]; Leflunomide inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; lornoxicam inhibits the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]; Melitten inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Melitten inhibits the reaction [[Nitroprusside results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Methotrexate inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Nicotine promotes the reaction [NOS2 protein results in increased abundance of Nitric Oxide]; Peptides inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide]; pyrazolanthrone inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; pyrazolanthrone inhibits the reaction [[Nitroprusside results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Tacrolimus inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; XDH protein promotes the reaction [[Raloxifene Hydrochloride results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide]
1,2-naphthoquinone inhibits the reaction [[lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[IFNG protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; 3-methylquercetin inhibits the reaction [[Lipopolysaccharides results in increased expression of and results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide]; [3,5-dimethoxy-4'-hydroxystilbene results in decreased expression of NOS2 mRNA] inhibits the reaction [Nitric Oxide results in increased expression of BCL2 mRNA]; [5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]] which results in decreased abundance of Nitric Oxide; [[[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide] which results in decreased expression of CCN2 protein; [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA] which results in increased chemical synthesis of Nitric Oxide; [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide; [[TNF protein co-treated with IFNG protein] affects the expression of NOS2 mRNA] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]; [[TNF protein co-treated with IFNG protein] affects the expression of NOS2 protein] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]; [[TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [[TNF protein results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide] which results in decreased expression of RETN mRNA; [Acetaminophen results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide; [Aspirin results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide; [Benzene promotes the reaction [[CSF1 protein co-treated with Lipopolysaccharides] results in increased expression of NOS2 mRNA]] which results in increased chemical synthesis of Nitric Oxide; [Cisplatin results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [cobaltous chloride results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [Deferoxamine results in increased expression of NOS2 mRNA] which results in increased abundance of Nitric Oxide; [diferuloylputrescine results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide; [ferulic acid results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide; [IFNG protein co-treated with Lipopolysaccharides] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]; [IFNG protein results in increased abundance of Nitric Oxide] which results in increased expression of NOS2 protein; [IFNG protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA] which results in increased chemical synthesis of Nitric Oxide; [Lipopolysaccharides results in increased abundance of Nitric Oxide] which results in increased expression of NOS2 protein; [Lipopolysaccharides results in increased expression of and results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [Lipopolysaccharides results in increased expression of NOS2 mRNA] which results in increased abundance of Nitric Oxide; [Lipopolysaccharides results in increased expression of NOS2 mRNA] which results in increased chemical synthesis of Nitric Oxide; [Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide; [Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [Lipopolysaccharides results in increased expression of NOS2] which results in increased abundance of Nitric Oxide; [Lipopolysaccharides results in increased expression of NOS2] which results in increased chemical synthesis of Nitric Oxide; [Mycoplasma arthritidis mitogen results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [Nicotine results in decreased expression of NOS2 protein] which results in decreased abundance of Nitric Oxide; [Nitroprusside results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [NOS2 protein results in increased chemical synthesis of Nitric Oxide] which results in decreased expression of TJP1 mRNA; [Ozone results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [p-coumaric acid results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide; [pimobendan results in decreased expression of NOS2 protein] which results in decreased abundance of Nitric Oxide; [Plant Extracts results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide; [prunetin results in decreased expression of NOS2 mRNA] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased chemical synthesis of Nitric Oxide]; [Putrescine metabolite results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide; [Quercetin results in decreased expression of NOS2 mRNA] inhibits the reaction [Nitric Oxide results in increased expression of BCL2 mRNA]; [S100B protein results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide; [Selenium inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 mRNA]] which results in decreased chemical synthesis of Nitric Oxide; [Sodium Salicylate results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide; [Thiourea analog results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide; [TNF protein co-treated with IFNG protein] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]; [TNF protein results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide; [TNF protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [Zoledronic Acid results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; Arsenic Trioxide inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Bee Venoms inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Bee Venoms inhibits the reaction [[Nitroprusside results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Bee Venoms inhibits the reaction [[TNF protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; bepafant inhibits the reaction [[Mycoplasma arthritidis mitogen results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; bisphenol A inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA] which results in increased chemical synthesis of Nitric Oxide]; Caffeine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide]; Capsaicin inhibits the reaction [[IFNG protein results in increased abundance of Nitric Oxide] which results in increased expression of NOS2 protein]; Capsaicin inhibits the reaction [[Lipopolysaccharides results in increased abundance of Nitric Oxide] which results in increased expression of NOS2 protein]; capsazepine inhibits the reaction [[IFNG protein results in increased abundance of Nitric Oxide] which results in increased expression of NOS2 protein]; capsazepine inhibits the reaction [[Lipopolysaccharides results in increased abundance of Nitric Oxide] which results in increased expression of NOS2 protein]; Carthamus yellow inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Chalcone analog inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2] which results in increased abundance of Nitric Oxide]; chromous chloride inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]; ciglitazone inhibits the reaction [[IFNG protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Cilostazol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; cobaltiprotoporphyrin inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; cobaltous chloride promotes the reaction [[[TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; cupric chloride inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]; Cyclosporine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; diphenylmethyl selenocyanate inhibits the reaction [[Cisplatin results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Drugs, Chinese Herbal inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 mRNA] which results in increased chemical synthesis of Nitric Oxide]; ent-1,3,6,11-tetrahydroxykaur-16-ene-15-one 3,11-diacetate inhibits the reaction [Lipopolysaccharides promotes the reaction [NOS2 protein results in increased chemical synthesis of and results in increased abundance of Nitric Oxide]]; erythraline inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; ethyl N-allyl-N-(2-methyl-3-(4-(4-amidinophenoxycarbonyl)phenyl)propenoyl)aminoacetate methanesulfonate inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; flavokawain A inhibits the reaction [Lipopolysaccharides promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]; Fluoxetine analog inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Ginkgo biloba extract inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; GW 1929 inhibits the reaction [[IFNG protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; hinokiresinol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; lead chloride inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]; Lipopolysaccharides promotes the reaction [NOS2 protein results in increased chemical synthesis of and results in increased abundance of Nitric Oxide]; Lipopolysaccharides promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]; manganese chloride promotes the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]; Manganese promotes the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]; matairesinol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide]; Melitten inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Melitten inhibits the reaction [[Nitroprusside results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Melitten inhibits the reaction [[TNF protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; naringenin inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; NFKB1 protein promotes the reaction [[Ozone results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; nickel chloride promotes the reaction [[[TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; nimesulide inhibits the reaction [bepafant inhibits the reaction [[Mycoplasma arthritidis mitogen results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]]; Nitroprusside inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; NOS2 protein promotes the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]; NOS2 protein promotes the reaction [cobaltous chloride promotes the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]]; NOS2 protein promotes the reaction [nickel chloride promotes the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]]; NOS2 protein results in increased chemical synthesis of and results in increased abundance of Nitric Oxide; panaxytriol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide]; Plant Extracts inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; PPARG protein affects the reaction [[IFNG protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; praeruptorin A inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Pyrazines inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 mRNA] which results in increased chemical synthesis of Nitric Oxide]; pyrazolanthrone inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide]; pyrazolanthrone inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; pyrazolanthrone inhibits the reaction [[Nitroprusside results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Quercetin analog inhibits the reaction [Lipopolysaccharides promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]; Quercetin inhibits the reaction [[[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA] which results in increased chemical synthesis of Nitric Oxide]; Quercetin inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 mRNA] which results in increased chemical synthesis of Nitric Oxide]; Quercetin inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Quercetin inhibits the reaction [Lipopolysaccharides promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]; quercetin pentaacetate inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; resiniferatoxin inhibits the reaction [[IFNG protein results in increased abundance of Nitric Oxide] which results in increased expression of NOS2 protein]; resiniferatoxin inhibits the reaction [[Lipopolysaccharides results in increased abundance of Nitric Oxide] which results in increased expression of NOS2 protein]; Resveratrol inhibits the reaction [[[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA] which results in increased chemical synthesis of Nitric Oxide]; Resveratrol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 mRNA] which results in increased abundance of Nitric Oxide]; Resveratrol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 mRNA] which results in increased chemical synthesis of Nitric Oxide]; Resveratrol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Resveratrol inhibits the reaction [Lipopolysaccharides promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]; Resveratrol metabolite inhibits the reaction [Lipopolysaccharides promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]; Rutin inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; SB 203580 inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide]; SB 203580 inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; STAT1 protein promotes the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Tacrolimus inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; timosaponin BIII inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; zinc chloride inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]
[Endotoxins results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [Ethanol results in decreased expression of and results in decreased activity of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide; [Formaldehyde results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide; [Fructose results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [Gentamicins results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide; [IFNG protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [IL1B protein results in increased expression of and results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [IL1B protein results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide; [IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [Indomethacin results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [Isoproterenol results in increased expression of NOS2] which results in increased chemical synthesis of Nitric Oxide; [Lipopolysaccharides results in increased expression of and results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [NOS2 protein results in increased abundance of Nitric Oxide] which results in increased expression of TP53 protein; [NOS2 protein results in increased chemical synthesis of Nitric Oxide] which results in decreased susceptibility to endothelium-dependent hyperpolarization factor; [notoginsenoside R1 results in increased phosphorylation of and results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [Ozone results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [S100B protein results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide; [Taurocholic Acid results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide; Active Hexose Correlated Compound inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide]; Edaravone inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Endotoxins inhibits the reaction [[Ozone results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Lipopolysaccharides promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]; natakalim inhibits the reaction [[Isoproterenol results in increased expression of NOS2] which results in increased chemical synthesis of Nitric Oxide]; Nitric Oxide deficiency inhibits the reaction [Formaldehyde results in increased expression of NOS2 mRNA]; NOS2 protein affects the reaction [Adenosine Triphosphate results in increased abundance of Nitric Oxide]; Ozone promotes the reaction [[IFNG protein results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide]; Ozone promotes the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide]; pyrrolidine dithiocarbamic acid inhibits the reaction [[Ozone results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Resveratrol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Resveratrol inhibits the reaction [[Taurocholic Acid results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide]; Rotenone inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; wuzi yanzong analog inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]
Nitric Oxide deficiency affects the expression of NOS2 protein
Nitric Oxide deficiency results in decreased expression of NOS2 protein		 CTD PMID:7519435 PMID:7705308 PMID:8193360 PMID:8652180 PMID:8975779 More... NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell decreases chemical synthesis
increases abundance
multiple interactions
affects expression
decreases expression
increases chemical synthesis
affects chemical synthesis		 ISO
EXP		 NOS3 gene mutant form results in decreased chemical synthesis of Nitric Oxide
NOS3 protein results in increased abundance of Nitric Oxide
[Sildenafil Citrate results in increased expression of NOS3 protein] which results in increased secretion of Nitric Oxide; AGT protein alternative form promotes the reaction [NOS3 protein results in increased chemical synthesis of Nitric Oxide]; Enalapril inhibits the reaction [Nitric Oxide deficiency results in decreased expression of NOS3 protein]; Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in decreased expression of NOS3 protein]; Nitric Oxide deficiency inhibits the reaction [Formaldehyde results in increased expression of NOS3 mRNA]; Thioacetamide promotes the reaction [NOS3 protein results in increased chemical synthesis of Nitric Oxide]
Nitric Oxide deficiency affects the expression of NOS3 protein
Nitric Oxide deficiency results in decreased expression of NOS3 mRNA; Nitric Oxide deficiency results in decreased expression of NOS3 protein
[Bezafibrate results in increased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide; [GULO protein co-treated with NOS3 protein] results in increased abundance of Nitric Oxide; [Resveratrol results in increased expression of NOS3 protein] which results in increased chemical synthesis of Nitric Oxide; dorsomorphin inhibits the reaction [[Bezafibrate results in increased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide]
NOS3 protein affects the chemical synthesis of Nitric Oxide
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[puerarin results in increased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[puerarin results in increased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[resveratrol results in increased phosphorylation of and results in increased activity of NOS3 protein] which results in increased abundance of Nitric Oxide]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rosiglitazone inhibits the reaction [[Glucose results in decreased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide]]; [[resveratrol results in increased activity of PPARA protein] which results in increased expression of NOS3 protein] which results in increased chemical synthesis of Nitric Oxide; [Estradiol results in increased phosphorylation of and results in increased activity of NOS3 protein] which results in increased chemical synthesis of Nitric Oxide; [Glucose results in decreased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide; [Glycochenodeoxycholic Acid results in decreased expression of NOS3 protein] which results in decreased abundance of Nitric Oxide; [Hydrogen Peroxide results in decreased activity of NOS3 protein] which results in decreased chemical synthesis of Nitric Oxide; [Hydrogen Peroxide results in decreased expression of NOS3 protein] which results in decreased secretion of Nitric Oxide; [NOS3 protein polymorphism results in decreased chemical synthesis of Nitric Oxide] which affects the expression of RCN1 protein; [NOS3 protein polymorphism results in decreased chemical synthesis of Nitric Oxide] which affects the expression of TXNDC5 protein; [NOS3 protein polymorphism results in decreased chemical synthesis of Nitric Oxide] which results in decreased expression of HSPA5 mRNA; [NOS3 protein polymorphism results in decreased chemical synthesis of Nitric Oxide] which results in decreased expression of HSPA5 protein; [NOS3 protein polymorphism results in decreased chemical synthesis of Nitric Oxide] which results in increased expression of SOD2 mRNA; [NOS3 protein polymorphism results in decreased chemical synthesis of Nitric Oxide] which results in increased expression of SOD2 protein; [Orotic Acid inhibits the reaction [INS protein results in increased phosphorylation of NOS3 protein]] which results in decreased abundance of Nitric Oxide; [Orotic Acid inhibits the reaction [Metformin results in increased phosphorylation of NOS3 protein]] which results in decreased abundance of Nitric Oxide; [puerarin results in increased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide; [resveratrol results in increased activity of NOS3 protein] which results in increased chemical synthesis of Nitric Oxide; [resveratrol results in increased expression of NOS3 protein] which results in increased chemical synthesis of Nitric Oxide; [resveratrol results in increased phosphorylation of and results in increased activity of NOS3 protein] which results in increased abundance of Nitric Oxide; [resveratrol results in increased phosphorylation of and results in increased activity of NOS3 protein] which results in increased chemical synthesis of Nitric Oxide; [Trichloroethylene results in increased activity of NOS3 protein] which results in increased chemical synthesis of Nitric Oxide; Amiodarone promotes the reaction [NOS3 protein results in increased chemical synthesis of Nitric Oxide]; desethylamiodarone promotes the reaction [NOS3 protein results in increased chemical synthesis of Nitric Oxide]; fulvestrant inhibits the reaction [[puerarin results in increased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide]; icariin promotes the reaction [NOS3 protein results in increased chemical synthesis of Nitric Oxide]; Nifedipine inhibits the reaction [[Hydrogen Peroxide results in decreased expression of NOS3 protein] which results in decreased secretion of Nitric Oxide]; Nifedipine promotes the reaction [Simvastatin inhibits the reaction [[Hydrogen Peroxide results in decreased expression of NOS3 protein] which results in decreased secretion of Nitric Oxide]]; NOX5 protein promotes the reaction [NOS3 protein results in increased chemical synthesis of Nitric Oxide]; PIK3CA protein inhibits the reaction [[Orotic Acid inhibits the reaction [INS protein results in increased phosphorylation of NOS3 protein]] which results in decreased abundance of Nitric Oxide]; resveratrol inhibits the reaction [[Hydrogen Peroxide results in decreased activity of NOS3 protein] which results in decreased chemical synthesis of Nitric Oxide]; rosiglitazone inhibits the reaction [[Glucose results in decreased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide]; Simvastatin inhibits the reaction [[Hydrogen Peroxide results in decreased expression of NOS3 protein] which results in decreased secretion of Nitric Oxide]; Simvastatin promotes the reaction [Nifedipine inhibits the reaction [[Hydrogen Peroxide results in decreased expression of NOS3 protein] which results in decreased secretion of Nitric Oxide]]; SOD1 protein inhibits the reaction [Nitric Oxide results in decreased activity of NOS3 protein]; Stilbenes inhibits the reaction [[Hydrogen Peroxide results in decreased activity of NOS3 protein] which results in decreased chemical synthesis of Nitric Oxide]; Tretinoin promotes the reaction [NOS3 protein results in increased chemical synthesis of Nitric Oxide]; U 0126 inhibits the reaction [[resveratrol results in increased phosphorylation of and results in increased activity of NOS3 protein] which results in increased abundance of Nitric Oxide]; W 7 inhibits the reaction [[puerarin results in increased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide]; wortmannin inhibits the reaction [rosiglitazone inhibits the reaction [[Glucose results in decreased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide]]		 CTD PMID:10445667 PMID:11740345 PMID:12270858 PMID:12489993 PMID:15207323 More... NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472 		JBrowse link
G Npc1 NPC intracellular cholesterol transporter 1 decreases expression EXP Nitric Oxide deficiency results in decreased expression of NPC1 mRNA CTD PMID:15878706 NCBI chr18:12,322,751...12,369,851
Ensembl chr18:12,322,749...12,369,457 		JBrowse link
G Nppa natriuretic peptide type A multiple interactions
increases expression		 ISO Losartan inhibits the reaction [Nitric Oxide deficiency results in increased expression of NPPA mRNA]
Nitric Oxide deficiency results in increased expression of NPPA mRNA; Nitric Oxide deficiency results in increased expression of NPPA protein		 CTD PMID:10397678 PMID:12198334 PMID:14700747 PMID:15177930 NCBI chr 4:148,085,179...148,086,531
Ensembl chr 4:148,085,179...148,086,536 		JBrowse link
G Nppb natriuretic peptide type B multiple interactions
increases expression		 ISO Hydralazine inhibits the reaction [Nitric Oxide deficiency results in increased expression of NPPB mRNA]; Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of NPPB mRNA]; Losartan inhibits the reaction [Nitric Oxide deficiency results in increased expression of NPPB mRNA]
Nitric Oxide deficiency results in increased expression of NPPB mRNA; Nitric Oxide deficiency results in increased expression of NPPB protein		 CTD PMID:12198334 PMID:16326922 NCBI chr 4:148,070,264...148,071,662
Ensembl chr 4:148,070,245...148,071,662 		JBrowse link
G Nr2f2 nuclear receptor subfamily 2, group F, member 2 decreases expression EXP Nitric Oxide deficiency results in decreased expression of NR2F2 mRNA CTD PMID:15878706 NCBI chr 7:70,001,694...70,016,494
Ensembl chr 7:70,001,692...70,016,483 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO [ginsenoside Re results in increased activity of NR3C1 protein] which results in increased abundance of Nitric Oxide CTD PMID:17490654 NCBI chr18:39,543,598...39,652,485
Ensembl chr18:39,543,598...39,652,474 		JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 increases expression ISO Nitric Oxide results in increased expression of NR4A1 mRNA CTD PMID:10460269 NCBI chr15:101,151,783...101,172,676
Ensembl chr15:101,152,150...101,172,676 		JBrowse link
G Nupr1 nuclear protein transcription regulator 1 decreases expression EXP Nitric Oxide deficiency results in decreased expression of NUPR1 mRNA CTD PMID:15878706 NCBI chr 7:126,222,418...126,224,642
Ensembl chr 7:126,222,421...126,230,033 		JBrowse link
G Ocln occludin decreases expression ISO Nitric Oxide deficiency results in decreased expression of OCLN protein CTD PMID:15763998 NCBI chr13:100,633,012...100,689,226
Ensembl chr13:100,633,015...100,689,226 		JBrowse link
G P4ha1 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide decreases expression EXP Nitric Oxide deficiency results in decreased expression of P4HA1 mRNA CTD PMID:15878706 NCBI chr10:59,159,019...59,209,126
Ensembl chr10:59,159,118...59,209,126 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions
increases cleavage		 ISO
EXP		 [S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] inhibits the reaction [N-caproylsphingosine promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]]
Nitric Oxide results in increased cleavage of PARP1 protein
PARP1 gene mutant form inhibits the reaction [S100B protein results in increased secretion of Nitric Oxide]		 CTD PMID:10811113 PMID:15126337 PMID:16024610 PMID:27444121 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Pdcd6ip programmed cell death 6 interacting protein decreases expression EXP Nitric Oxide deficiency results in decreased expression of PDCD6IP mRNA CTD PMID:15878706 NCBI chr 9:113,480,812...113,537,457
Ensembl chr 9:113,480,812...113,537,327 		JBrowse link
G Pde5a phosphodiesterase 5A, cGMP-specific increases expression
affects response to substance		 ISO Nitric Oxide results in increased expression of PDE5A mRNA; Nitric Oxide results in increased expression of PDE5A protein
PDE5A protein affects the susceptibility to Nitric Oxide		 CTD PMID:19374906 NCBI chr 3:122,522,822...122,653,023
Ensembl chr 3:122,522,596...122,653,023 		JBrowse link
G Phf8 PHD finger protein 8 increases expression ISO Nitric Oxide results in increased expression of PHF8 mRNA CTD PMID:23546878 NCBI chr  X:150,303,621...150,416,855
Ensembl chr  X:150,303,668...150,416,855 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha multiple interactions ISO PIK3CA protein inhibits the reaction [[Orotic Acid inhibits the reaction [INS protein results in increased phosphorylation of NOS3 protein]] which results in decreased abundance of Nitric Oxide] CTD PMID:25601987 NCBI chr 3:32,451,203...32,520,256
Ensembl chr 3:32,451,820...32,522,635 		JBrowse link
G Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) multiple interactions ISO Nitric Oxide affects the reaction [Ditiocarb results in increased expression of PLA2G4A mRNA]; Nitric Oxide affects the reaction [Ditiocarb results in increased expression of PLA2G4A protein] CTD PMID:16603213 NCBI chr 1:149,705,369...149,837,041
Ensembl chr 1:149,705,369...149,837,041 		JBrowse link
G Plat plasminogen activator, tissue multiple interactions
increases secretion		 EXP PLAT protein affects the reaction [NOS1 protein results in increased chemical synthesis of Nitric Oxide]
PLAT protein results in increased secretion of Nitric Oxide		 CTD PMID:18195371 NCBI chr 8:23,247,655...23,272,864
Ensembl chr 8:23,247,743...23,272,860 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO Nitric Oxide results in increased expression of PMAIP1 mRNA CTD PMID:15126337 NCBI chr18:66,591,675...66,598,629
Ensembl chr18:66,591,604...66,598,636 		JBrowse link
G Pms2 PMS1 homolog2, mismatch repair system component increases expression EXP Nitric Oxide deficiency results in increased expression of PMS2 mRNA CTD PMID:15878706 NCBI chr 5:143,846,379...143,922,538
Ensembl chr 5:143,846,782...143,870,786
Ensembl chr 5:143,846,782...143,870,786 		JBrowse link
G Pnoc prepronociceptin decreases activity ISO Nitric Oxide deficiency results in decreased activity of PNOC protein CTD PMID:10794074 NCBI chr14:65,638,931...65,662,908
Ensembl chr14:65,638,122...65,662,921 		JBrowse link
G Pomc pro-opiomelanocortin-alpha multiple interactions
increases secretion
decreases abundance		 ISO CRH protein affects the reaction [Nitric Oxide results in increased secretion of POMC protein alternative form]
POMC protein results in decreased abundance of Nitric Oxide		 CTD PMID:10460269 PMID:11193135 PMID:11703388 NCBI chr12:4,004,945...4,010,643
Ensembl chr12:4,004,951...4,010,642 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha affects activity
increases expression
multiple interactions		 ISO Nitric Oxide affects the activity of PPARA protein
Nitric Oxide deficiency results in increased expression of PPARA mRNA; Nitric Oxide deficiency results in increased expression of PPARA protein
[Bezafibrate binds to and results in increased activity of PPARA protein] which results in increased abundance of Nitric Oxide; [Clofibrate binds to and results in increased activity of PPARA protein] which results in increased abundance of Nitric Oxide; Nitric Oxide deficiency inhibits the reaction [Clofibrate results in increased expression of PPARA protein]
[[resveratrol results in increased activity of PPARA protein] which results in increased expression of NOS3 protein] which results in increased chemical synthesis of Nitric Oxide		 CTD PMID:15018640 PMID:16054168 PMID:16411023 PMID:19834340 PMID:21791144 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions
increases expression		 ISO
EXP		 [rosiglitazone binds to and affects the activity of PPARG protein] which results in increased abundance of Nitric Oxide
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]]; ciglitazone inhibits the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]]; GW 1929 inhibits the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]]; PPARG protein affects the reaction [[IFNG protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; PPARG protein affects the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]
Nitric Oxide deficiency results in increased expression of PPARG protein
[1,1-bis(3'-indolyl)-1-(4-trifluoromethylphenyl)methane binds to and results in increased activity of PPARG protein] inhibits the reaction [Manganese results in increased chemical synthesis of Nitric Oxide]		 CTD PMID:12847270 PMID:16527820 PMID:17063326 PMID:18041089 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Ppm1d protein phosphatase 1D magnesium-dependent, delta isoform increases expression ISO Nitric Oxide results in increased expression of PPM1D mRNA CTD PMID:15126337 NCBI chr11:85,202,080...85,237,897
Ensembl chr11:85,202,070...85,237,892 		JBrowse link
G Ppm1g protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform decreases expression EXP Nitric Oxide deficiency results in decreased expression of PPM1G mRNA CTD PMID:15878706 NCBI chr 5:31,360,012...31,377,889
Ensembl chr 5:31,360,008...31,378,031 		JBrowse link
G Ppp3ca protein phosphatase 3, catalytic subunit, alpha isoform decreases expression EXP Nitric Oxide deficiency results in decreased expression of PPP3CA mRNA CTD PMID:15878706 NCBI chr 3:136,375,778...136,643,488
Ensembl chr 3:136,375,885...136,643,488 		JBrowse link
G Ppp5c protein phosphatase 5, catalytic subunit decreases expression EXP Nitric Oxide deficiency results in decreased expression of PPP5C mRNA CTD PMID:15878706 NCBI chr 7:16,738,575...16,761,812
Ensembl chr 7:16,738,565...16,761,849 		JBrowse link
G Prdm2 PR domain containing 2, with ZNF domain increases expression ISO Nitric Oxide results in increased expression of PRDM2 mRNA CTD PMID:23546878 NCBI chr 4:142,833,961...142,939,560
Ensembl chr 4:142,833,961...142,939,565 		JBrowse link
G Prim2 DNA primase, p58 subunit decreases expression EXP Nitric Oxide deficiency results in decreased expression of PRIM2 mRNA CTD PMID:15878706 NCBI chr 1:33,492,889...33,708,867
Ensembl chr 1:33,492,891...33,708,876 		JBrowse link
G Prkaa1 protein kinase, AMP-activated, alpha 1 catalytic subunit multiple interactions ISO PRKAA1 protein affects the reaction [Fenofibrate results in increased abundance of Nitric Oxide] CTD PMID:20580385 NCBI chr15:5,172,641...5,211,380
Ensembl chr15:5,173,343...5,211,380 		JBrowse link
G Prkca protein kinase C, alpha multiple interactions ISO Nitric Oxide deficiency promotes the reaction [Brimonidine Tartrate affects the localization of PRKCA protein] CTD PMID:12388232 NCBI chr11:107,824,213...108,237,360
Ensembl chr11:107,824,213...108,234,754 		JBrowse link
G Prkcd protein kinase C, delta multiple interactions ISO Nitric Oxide deficiency inhibits the reaction [Brimonidine Tartrate affects the localization of PRKCD protein] CTD PMID:12388232 NCBI chr14:30,317,310...30,348,637
Ensembl chr14:30,317,311...30,348,167 		JBrowse link
G Prl prolactin multiple interactions ISO 2-mercaptomethyl-3-guanidinoethylthiopropionic acid inhibits the reaction [[PRL co-treated with furylacryloylalanylarginine co-treated with Testosterone] results in increased abundance of Nitric Oxide]; [PRL co-treated with furylacryloylalanylarginine co-treated with Testosterone] results in increased abundance of Nitric Oxide; [PRL co-treated with furylacryloylalanylarginine] results in increased abundance of Nitric Oxide; [PRL results in increased expression of CPD mRNA] which results in increased chemical synthesis of Nitric Oxide CTD PMID:21688280 NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions ISO Nitric Oxide deficiency inhibits the reaction [Formaldehyde results in increased expression of PTGS1 mRNA] CTD PMID:21983654 NCBI chr 2:36,106,758...36,142,287
Ensembl chr 2:36,120,438...36,142,284 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression		 ISO [Ouabain results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Nitric Oxide
Nitric Oxide deficiency results in decreased expression of PTGS2 mRNA		 CTD PMID:18976649 PMID:21983654 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Ptk2 PTK2 protein tyrosine kinase 2 decreases expression EXP Nitric Oxide deficiency results in decreased expression of PTK2 mRNA CTD PMID:15878706 NCBI chr15:73,076,951...73,297,192
Ensembl chr15:73,076,951...73,295,129 		JBrowse link
G Pttg1 pituitary tumor-transforming gene 1 increases expression EXP Nitric Oxide deficiency results in increased expression of PTTG1 mRNA CTD PMID:15878706 NCBI chr11:43,311,097...43,317,417
Ensembl chr11:43,311,077...43,317,078 		JBrowse link
G Raf1 v-raf-leukemia viral oncogene 1 multiple interactions ISO [Lipopolysaccharides results in increased activity of RAF1 protein] which results in decreased secretion of Nitric Oxide CTD PMID:19039081 NCBI chr 6:115,595,530...115,653,596
Ensembl chr 6:115,595,028...115,653,596 		JBrowse link
G Ramp1 receptor (calcitonin) activity modifying protein 1 increases expression ISO Nitric Oxide deficiency results in increased expression of RAMP1 mRNA; Nitric Oxide deficiency results in increased expression of RAMP1 protein CTD PMID:16326922 NCBI chr 1:91,107,544...91,152,918
Ensembl chr 1:91,107,544...91,152,918 		JBrowse link
G Ramp2 receptor (calcitonin) activity modifying protein 2 multiple interactions
increases expression		 ISO Hydralazine inhibits the reaction [Nitric Oxide deficiency results in increased expression of RAMP2 protein]; Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of RAMP2 protein]
Nitric Oxide deficiency results in increased expression of RAMP2 mRNA; Nitric Oxide deficiency results in increased expression of RAMP2 protein		 CTD PMID:16326922 NCBI chr11:101,137,160...101,139,076
Ensembl chr11:101,136,854...101,150,372 		JBrowse link
G Ramp3 receptor (calcitonin) activity modifying protein 3 multiple interactions
increases expression		 ISO Hydralazine inhibits the reaction [Nitric Oxide deficiency results in increased expression of RAMP3 protein]; Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of RAMP3 protein]
Nitric Oxide deficiency results in increased expression of RAMP3 mRNA; Nitric Oxide deficiency results in increased expression of RAMP3 protein		 CTD PMID:16326922 NCBI chr11:6,608,507...6,627,478
Ensembl chr11:6,608,521...6,627,475 		JBrowse link
G Rap1a RAS-related protein 1a multiple interactions ISO Nitric Oxide promotes the reaction [ITGB2 protein results in increased activity of RAP1A protein] CTD PMID:16963453 NCBI chr 3:105,634,576...105,708,740
Ensembl chr 3:105,634,583...105,708,652 		JBrowse link
G Rap2a RAS related protein 2a multiple interactions ISO Nitric Oxide promotes the reaction [ITGB2 protein results in increased activity of RAP2A protein] CTD PMID:16963453 NCBI chr14:120,715,873...120,744,606
Ensembl chr14:120,715,856...120,744,606 		JBrowse link
G Rasd1 RAS, dexamethasone-induced 1 multiple interactions ISO Nitric Oxide promotes the reaction [[RASD1 protein binds to ACBD3 protein binds to SLC11A2 protein] which results in increased uptake of Iron] CTD PMID:16908409 NCBI chr11:59,854,007...59,855,770
Ensembl chr11:59,854,007...59,855,770 		JBrowse link
G Rbbp6 retinoblastoma binding protein 6, ubiquitin ligase decreases expression EXP Nitric Oxide deficiency results in decreased expression of RBBP6 mRNA CTD PMID:15878706 NCBI chr 7:122,568,980...122,601,780
Ensembl chr 7:122,564,909...122,601,780 		JBrowse link
G Rcn1 reticulocalbin 1 multiple interactions ISO [NOS3 protein polymorphism results in decreased chemical synthesis of Nitric Oxide] which affects the expression of RCN1 protein CTD PMID:19320461 NCBI chr 2:105,216,293...105,229,664
Ensembl chr 2:105,216,636...105,229,664 		JBrowse link
G Rdx radixin increases phosphorylation ISO Nitric Oxide deficiency results in increased phosphorylation of RDX protein CTD PMID:14732730 NCBI chr 9:51,958,450...52,000,038
Ensembl chr 9:51,958,473...52,011,763 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) affects localization ISO Nitric Oxide deficiency affects the localization of RELA protein CTD PMID:19631198 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Ren1 renin 1 structural multiple interactions
increases expression		 ISO [Nitric Oxide deficiency co-treated with Sodium Chloride, Dietary] results in increased expression of REN protein; Nebivolol inhibits the reaction [Nitric Oxide deficiency results in increased expression of REN protein] CTD PMID:7541960 PMID:10679504 PMID:12806161 PMID:15123544 NCBI chr 1:133,278,412...133,288,058
Ensembl chr 1:133,278,248...133,288,063 		JBrowse link
G Retn resistin multiple interactions
increases expression		 EXP
ISO		 [[TNF protein results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide] which results in decreased expression of RETN mRNA
Nitric Oxide deficiency results in increased expression of RETN mRNA		 CTD PMID:17063326 PMID:18369347 NCBI chr 8:3,705,770...3,709,818
Ensembl chr 8:3,705,770...3,710,110 		JBrowse link
G Rhoa ras homolog family member A multiple interactions ISO Nitric Oxide deficiency affects the localization of and results in increased activity of RHOA protein CTD PMID:14732730 NCBI chr 9:108,183,359...108,215,142
Ensembl chr 9:108,183,328...108,215,133 		JBrowse link
G Rpl10a ribosomal protein L10A increases expression EXP Nitric Oxide deficiency results in increased expression of RPL10A mRNA CTD PMID:15878706 NCBI chr17:28,547,557...28,550,007
Ensembl chr17:28,547,445...28,550,007 		JBrowse link
G Rpl12 ribosomal protein L12 increases expression EXP Nitric Oxide deficiency results in increased expression of RPL12 mRNA CTD PMID:15878706 NCBI chr 2:32,851,724...32,854,057
Ensembl chr 2:32,851,571...32,855,357 		JBrowse link
G Rpl3 ribosomal protein L3 decreases expression EXP Nitric Oxide deficiency results in decreased expression of RPL3 mRNA CTD PMID:15878706 NCBI chr15:79,961,993...79,967,553
Ensembl chr15:79,961,992...79,976,069 		JBrowse link
G Rpl8 ribosomal protein L8 increases expression EXP Nitric Oxide deficiency results in increased expression of RPL8 mRNA CTD PMID:15878706 NCBI chr15:76,788,271...76,790,518
Ensembl chr15:76,788,278...76,790,514 		JBrowse link
G Rplp0 ribosomal protein lateral stalk subunit P0 increases expression EXP Nitric Oxide deficiency results in increased expression of RPLP0 mRNA CTD PMID:15878706 NCBI chr 5:115,697,526...115,701,788
Ensembl chr 5:115,697,526...115,701,786 		JBrowse link
G Rplp1 ribosomal protein lateral stalk subunit P1 increases expression EXP Nitric Oxide deficiency results in increased expression of RPLP1 mRNA CTD PMID:15878706 NCBI chr 9:61,820,565...61,821,792
Ensembl chr 9:61,820,566...61,821,824 		JBrowse link
G Rps12 ribosomal protein S12 increases expression EXP Nitric Oxide deficiency results in increased expression of RPS12 mRNA CTD PMID:15878706 NCBI chr10:23,661,042...23,664,297
Ensembl chr10:23,661,081...23,663,173 		JBrowse link
G Rps14 ribosomal protein S14 increases expression EXP Nitric Oxide deficiency results in increased expression of RPS14 mRNA CTD PMID:15878706 NCBI chr18:60,907,668...60,911,618
Ensembl chr18:60,880,170...60,911,618 		JBrowse link
G Rps15 ribosomal protein S15 increases expression EXP Nitric Oxide deficiency results in increased expression of RPS15 mRNA CTD PMID:15878706 NCBI chr10:80,128,265...80,129,948
Ensembl chr10:80,128,287...80,129,948 		JBrowse link
G Rps20 ribosomal protein S20 increases expression EXP Nitric Oxide deficiency results in increased expression of RPS20 mRNA CTD PMID:15878706 NCBI chr 4:3,831,334...3,835,600
Ensembl chr 4:3,831,334...3,835,665 		JBrowse link
G Rps26 ribosomal protein S26 increases expression EXP Nitric Oxide deficiency results in increased expression of RPS26 mRNA CTD PMID:15878706 NCBI chr10:128,460,398...128,462,375
Ensembl chr10:128,460,403...128,462,616 		JBrowse link
G Rps6 ribosomal protein S6 increases expression EXP Nitric Oxide deficiency results in increased expression of RPS6 mRNA CTD PMID:15878706 NCBI chr 4:86,772,336...86,775,604
Ensembl chr 4:86,772,897...86,775,649 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase, polypeptide 1 multiple interactions ISO [resveratrol results in decreased activity of RPS6KB1 protein] which results in increased abundance of Nitric Oxide; [Sirolimus results in decreased activity of RPS6KB1 protein] which results in increased abundance of Nitric Oxide CTD PMID:21544240 NCBI chr11:86,389,695...86,435,711
Ensembl chr11:86,389,697...86,435,631 		JBrowse link
G Rps7 ribosomal protein S7 increases expression EXP Nitric Oxide deficiency results in increased expression of RPS7 mRNA CTD PMID:15878706 NCBI chr12:28,680,846...28,685,952
Ensembl chr12:28,680,853...28,685,952 		JBrowse link
G Rps8 ribosomal protein S8 increases expression EXP Nitric Oxide deficiency results in increased expression of RPS8 mRNA CTD PMID:15878706 NCBI chr 4:117,011,033...117,013,329
Ensembl chr 4:117,011,024...117,013,440 		JBrowse link
G S100b S100 protein, beta polypeptide, neural multiple interactions
increases secretion		 EXP
ISO		 [S100B protein results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide; PARP1 gene mutant form inhibits the reaction [S100B protein results in increased secretion of Nitric Oxide] CTD PMID:16376947 PMID:27444121 NCBI chr10:76,089,670...76,097,153
Ensembl chr10:76,089,687...76,096,993 		JBrowse link
G Sap30bp SAP30 binding protein decreases expression EXP Nitric Oxide deficiency results in decreased expression of SAP30BP mRNA CTD PMID:15878706 NCBI chr11:115,824,477...115,857,547
Ensembl chr11:115,824,108...115,857,551 		JBrowse link
G Scgb1a1 secretoglobin, family 1A, member 1 decreases expression ISO Nitric Oxide results in decreased expression of SCGB1A1 protein CTD PMID:15764486 NCBI chr19:9,061,006...9,065,320
Ensembl chr19:9,061,000...9,065,322 		JBrowse link
G Sdc2 syndecan 2 increases expression EXP Nitric Oxide deficiency results in increased expression of SDC2 mRNA CTD PMID:15878706 NCBI chr15:32,920,869...33,034,867
Ensembl chr15:32,920,869...33,035,081 		JBrowse link
G Sele selectin, endothelial cell multiple interactions ISO Nitric Oxide deficiency inhibits the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased expression of SELE protein]] CTD PMID:14762100 NCBI chr 1:163,867,200...163,886,056
Ensembl chr 1:163,875,773...163,885,246 		JBrowse link
G Setdb2 SET domain, bifurcated 2 increases expression ISO Nitric Oxide results in increased expression of SETDB2 mRNA CTD PMID:23546878 NCBI chr14:59,639,458...59,678,329
Ensembl chr14:59,639,458...59,678,333 		JBrowse link
G Sftpa1 surfactant associated protein A1 multiple interactions
decreases expression		 ISO bosentan inhibits the reaction [Nitric Oxide results in decreased expression of SFTPA1 mRNA]; PD 156707 inhibits the reaction [Nitric Oxide results in decreased expression of SFTPA1 mRNA] CTD PMID:15640287 NCBI chr14:40,853,745...40,858,330
Ensembl chr14:40,853,739...40,858,409 		JBrowse link
G Sftpb surfactant associated protein B multiple interactions
decreases expression		 ISO bosentan inhibits the reaction [Nitric Oxide results in decreased expression of SFTPB mRNA]; PD 156707 inhibits the reaction [Nitric Oxide results in decreased expression of SFTPB mRNA] CTD PMID:15640287 NCBI chr 6:72,281,594...72,291,354
Ensembl chr 6:72,281,594...72,291,354 		JBrowse link
G Sftpc surfactant associated protein C multiple interactions
decreases expression		 ISO bosentan inhibits the reaction [Nitric Oxide results in decreased expression of SFTPC mRNA]; PD 156707 inhibits the reaction [Nitric Oxide results in decreased expression of SFTPC mRNA] CTD PMID:15640287 NCBI chr14:70,758,381...70,761,521
Ensembl chr14:70,758,389...70,761,521 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO SIRT1 protein affects the reaction [INS protein results in increased secretion of Nitric Oxide]; SIRT1 protein affects the reaction [resveratrol inhibits the reaction [Glucose inhibits the reaction [INS protein results in increased secretion of Nitric Oxide]]] CTD PMID:20960276 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483 		JBrowse link
G Slc11a2 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 multiple interactions
affects expression		 ISO
EXP		 Nitric Oxide promotes the reaction [[RASD1 protein binds to ACBD3 protein binds to SLC11A2 protein] which results in increased uptake of Iron]
Nitric Oxide affects the expression of SLC11A2 protein alternative form		 CTD PMID:16232120 PMID:16908409 NCBI chr15:100,285,779...100,322,090
Ensembl chr15:100,285,779...100,322,953 		JBrowse link
G Slc40a1 solute carrier family 40 (iron-regulated transporter), member 1 decreases expression ISO Nitric Oxide deficiency results in decreased expression of SLC40A1 protein CTD PMID:24184442 NCBI chr 1:45,947,230...45,965,690
Ensembl chr 1:45,947,228...45,965,683 		JBrowse link
G Slc4a2 solute carrier family 4 (anion exchanger), member 2 multiple interactions ISO Nitric Oxide inhibits the reaction [SLC4A2 protein promotes the reaction [Cyclic AMP results in increased transport of Bicarbonates]] CTD PMID:12612912 NCBI chr 5:24,628,834...24,645,945
Ensembl chr 5:24,628,835...24,645,948 		JBrowse link
G Slc5a2 solute carrier family 5 (sodium/glucose cotransporter), member 2 decreases activity ISO Nitric Oxide deficiency results in decreased activity of SLC5A2 protein CTD PMID:17940347 NCBI chr 7:127,864,855...127,871,602
Ensembl chr 7:127,864,829...127,871,602 		JBrowse link
G Slc7a7 solute carrier family 7 (cationic amino acid transporter, y+ system), member 7 decreases abundance ISO SLC7A7 protein results in decreased abundance of Nitric Oxide CTD PMID:11544277 NCBI chr14:54,606,899...54,657,525
Ensembl chr14:54,606,899...54,655,237 		JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO [SMAD4 protein co-treated with SMAD3 protein] affects the susceptibility to Nitric Oxide; Nitric Oxide results in increased activity of [SMAD4 protein binds to SMAD3 protein] CTD PMID:15949472 NCBI chr 9:63,554,048...63,665,276
Ensembl chr 9:63,554,049...63,665,276 		JBrowse link
G Smad4 SMAD family member 4 multiple interactions ISO [SMAD4 protein co-treated with SMAD3 protein] affects the susceptibility to Nitric Oxide; Nitric Oxide results in increased activity of [SMAD4 protein binds to SMAD3 protein] CTD PMID:15949472 NCBI chr18:73,767,861...73,836,862
Ensembl chr18:73,772,080...73,836,851 		JBrowse link
G Snca synuclein, alpha multiple interactions ISO [Maneb promotes the reaction [SNCA gene mutant form results in increased susceptibility to Paraquat]] which results in increased abundance of Nitric Oxide; [Paraquat promotes the reaction [SNCA gene mutant form results in increased susceptibility to Maneb]] which results in increased abundance of Nitric Oxide CTD PMID:24290359 NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839 		JBrowse link
G Snta1 syntrophin, acidic 1 decreases expression EXP Nitric Oxide deficiency results in decreased expression of SNTA1 mRNA CTD PMID:15878706 NCBI chr 2:154,218,234...154,250,004
Ensembl chr 2:154,218,233...154,250,019 		JBrowse link
G Sod1 superoxide dismutase 1, soluble increases abundance
decreases response to substance
multiple interactions		 EXP
ISO		 SOD1 protein results in increased abundance of Nitric Oxide
Nitric Oxide deficiency results in decreased susceptibility to SOD1 protein mutant form
SOD1 protein inhibits the reaction [[spermine nitric oxide complex results in increased abundance of Nitric Oxide] which results in increased abundance of Superoxides]; SOD1 protein inhibits the reaction [Nitric Oxide results in decreased activity of NOS3 protein]; SOD1 protein inhibits the reaction [Nitric Oxide results in increased abundance of Peroxynitrous Acid]
Nitric Oxide deficiency inhibits the reaction [Formaldehyde results in increased expression of SOD1 mRNA]		 CTD PMID:12489993 PMID:19845829 PMID:21443684 PMID:21983654 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial increases expression
multiple interactions
affects abundance
decreases abundance		 ISO Nitric Oxide deficiency results in increased expression of SOD2 protein
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [[2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased abundance of Nitric Oxide] which results in increased expression of and results in increased activity of SOD2 protein]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [[2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased abundance of Nitric Oxide] which results in increased expression of SOD2 mRNA]; [2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased abundance of Nitric Oxide] which results in increased expression of and results in increased activity of SOD2 protein; [2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased abundance of Nitric Oxide] which results in increased expression of SOD2 mRNA; [S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] which results in increased expression of and results in increased activity of SOD2 protein; [S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] which results in increased expression of SOD2 mRNA; Dactinomycin inhibits the reaction [[2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased abundance of Nitric Oxide] which results in increased expression of SOD2 mRNA]; Nitric Oxide deficiency inhibits the reaction [Formaldehyde results in increased expression of SOD2 mRNA]; SOD2 protein inhibits the reaction [IL1B protein results in increased chemical synthesis of Nitric Oxide]; tempol inhibits the reaction [Nitric Oxide deficiency results in increased expression of SOD2 protein]
[NOS3 protein polymorphism results in decreased chemical synthesis of Nitric Oxide] which results in increased expression of SOD2 mRNA; [NOS3 protein polymorphism results in decreased chemical synthesis of Nitric Oxide] which results in increased expression of SOD2 protein
SOD2 protein affects the abundance of Nitric Oxide
SOD2 protein results in decreased abundance of Nitric Oxide		 CTD PMID:9576743 PMID:14996425 PMID:15925750 PMID:19320461 PMID:20110409 More... NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950 		JBrowse link
G Spp1 secreted phosphoprotein 1 decreases expression EXP Nitric Oxide deficiency results in decreased expression of SPP1 mRNA CTD PMID:15878706 NCBI chr 5:104,582,977...104,588,919
Ensembl chr 5:104,582,984...104,588,916 		JBrowse link
G Src Rous sarcoma oncogene multiple interactions ISO [resveratrol promotes the reaction [ESR1 protein binds to CAV1 protein binds to SRC protein]] which results in increased abundance of Nitric Oxide CTD PMID:18296501 NCBI chr 2:157,265,828...157,313,758
Ensembl chr 2:157,260,364...157,313,782 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions EXP STAT1 protein promotes the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide] CTD PMID:23106696 NCBI chr 1:52,158,588...52,201,024
Ensembl chr 1:52,158,599...52,201,024 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A decreases expression
multiple interactions		 EXP Nitric Oxide results in decreased expression of STAT5A protein
STAT5A protein affects the reaction [Nitric Oxide results in decreased expression of ACO1 mRNA]		 CTD PMID:16886906 NCBI chr11:100,750,177...100,775,995
Ensembl chr11:100,750,177...100,775,995 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B multiple interactions
decreases expression		 EXP STAT5B protein affects the reaction [Nitric Oxide results in decreased expression of ACO1 mRNA]
Nitric Oxide results in decreased expression of STAT5B protein		 CTD PMID:16886906 NCBI chr11:100,671,557...100,741,407
Ensembl chr11:100,671,557...100,741,550 		JBrowse link
G Suv39h2 suppressor of variegation 3-9 2 increases expression ISO Nitric Oxide results in increased expression of SUV39H2 mRNA CTD PMID:23546878 NCBI chr 2:3,456,852...3,476,085
Ensembl chr 2:3,456,852...3,476,068 		JBrowse link
G Syn1 synapsin I increases expression EXP Nitric Oxide deficiency results in increased expression of SYN1 mRNA CTD PMID:15878706 NCBI chr  X:20,726,750...20,787,157
Ensembl chr  X:20,726,750...20,787,243 		JBrowse link
G Taldo1 transaldolase 1 multiple interactions
decreases abundance		 EXP Acetylcysteine inhibits the reaction [TALDO1 gene mutant form results in decreased abundance of Nitric Oxide] CTD PMID:19436114 NCBI chr 7:140,972,073...140,982,889
Ensembl chr 7:140,972,112...140,982,881 		JBrowse link
G Tbca tubulin cofactor A increases expression EXP Nitric Oxide deficiency results in increased expression of TBCA mRNA CTD PMID:15878706 NCBI chr13:94,925,428...94,979,431
Ensembl chr13:94,925,418...94,979,430 		JBrowse link
G Tfrc transferrin receptor multiple interactions
decreases expression		 ISO [[fluvastatin results in increased expression of NOS2] which results in increased abundance of Nitric Oxide] which results in decreased expression of TFRC
Nitric Oxide deficiency results in decreased expression of TFRC protein		 CTD PMID:24184442 PMID:24964743 NCBI chr16:32,427,714...32,451,612
Ensembl chr16:32,427,738...32,451,612 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
increases expression		 ISO candesartan inhibits the reaction [Nitric Oxide deficiency results in increased expression of TGFB1 mRNA]; Nitric Oxide inhibits the reaction [Paraquat results in increased expression of TGFB1 protein] CTD PMID:15820443 PMID:16778335 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Thbd thrombomodulin multiple interactions
decreases expression		 ISO candesartan inhibits the reaction [Nitric Oxide deficiency results in decreased expression of THBD protein]; Hydralazine inhibits the reaction [Nitric Oxide deficiency results in decreased expression of THBD protein] CTD PMID:16778335 NCBI chr 2:148,246,391...148,250,108
Ensembl chr 2:148,246,386...148,250,108 		JBrowse link
G Timp2 tissue inhibitor of metalloproteinase 2 decreases expression ISO Nitric Oxide results in decreased expression of TIMP2 mRNA; Nitric Oxide results in decreased expression of TIMP2 protein CTD PMID:18796497 NCBI chr11:118,191,887...118,246,237
Ensembl chr11:118,191,887...118,246,566 		JBrowse link
G Tinf2 Terf1 (TRF1)-interacting nuclear factor 2 increases expression EXP Nitric Oxide deficiency results in increased expression of TINF2 mRNA CTD PMID:15878706 NCBI chr14:55,912,120...55,919,265
Ensembl chr14:55,912,146...55,919,277 		JBrowse link
G Tjp1 tight junction protein 1 decreases expression
multiple interactions		 ISO
EXP		 Nitric Oxide deficiency results in decreased expression of TJP1 protein
[NOS2 protein results in increased chemical synthesis of Nitric Oxide] which results in decreased expression of TJP1 mRNA		 CTD PMID:15763998 PMID:25870319 NCBI chr 7:64,945,913...65,177,629
Ensembl chr 7:64,945,913...65,177,529 		JBrowse link
G Tk1 thymidine kinase 1 increases mutagenesis ISO Nitric Oxide results in increased mutagenesis of TK1 gene CTD PMID:22303861 PMID:28454271 NCBI chr11:117,706,345...117,716,913
Ensembl chr11:117,706,352...117,716,918 		JBrowse link
G Tle5 TLE family member 5, transcriptional modulator increases expression EXP Nitric Oxide deficiency results in increased expression of TLE5 mRNA CTD PMID:15878706 NCBI chr10:81,395,278...81,402,205
Ensembl chr10:81,395,322...81,402,196 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP TLR4 gene mutant form inhibits the reaction [Fungal Polysaccharides results in increased abundance of Nitric Oxide]; TLR4 protein affects the reaction [Plant Extracts results in increased chemical synthesis of Nitric Oxide]; TLR4 protein affects the reaction [Polysaccharides results in increased chemical synthesis of Nitric Oxide] CTD PMID:22687552 PMID:23246459 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion
decreases abundance
increases abundance
increases metabolic processing
increases expression		 ISO
EXP		 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [rhodojaponin II inhibits the reaction [TNF protein results in increased secretion of Nitric Oxide]]; [IFNG protein co-treated with TNF protein co-treated with IL1B protein] results in increased abundance of Nitric Oxide; [IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide; [IL5 protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide; [NOS2 protein results in increased abundance of Nitric Oxide] affects the susceptibility to [IL1B protein co-treated with TNF protein co-treated with IFNG protein]; Acetylcysteine inhibits the reaction [TNF results in increased abundance of Nitric Oxide]; Alginic Acid inhibits the reaction [TNF protein results in increased abundance of Nitric Oxide]; allicin inhibits the reaction [TNF protein results in increased abundance of Nitric Oxide]; Ascorbic Acid inhibits the reaction [TNF protein results in increased abundance of Nitric Oxide]; Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Dactinomycin inhibits the reaction [TNF results in increased abundance of Nitric Oxide]; deoxynivalenol inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with IL1B protein] results in increased abundance of Nitric Oxide]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate promotes the reaction [rhodojaponin II inhibits the reaction [TNF protein results in increased secretion of Nitric Oxide]]; martentoxin, Buthus martensi inhibits the reaction [TNF protein results in increased abundance of Nitric Oxide]; N,N-diacetylcystine inhibits the reaction [TNF protein results in decreased abundance of Nitric Oxide]; pyrrolidine dithiocarbamic acid promotes the reaction [rhodojaponin II inhibits the reaction [TNF protein results in increased secretion of Nitric Oxide]]; rhodojaponin II inhibits the reaction [TNF protein results in increased secretion of Nitric Oxide]; Wortmannin inhibits the reaction [Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]]
Nitric Oxide results in increased secretion of TNF protein; TNF protein results in increased secretion of Nitric Oxide
TNF protein results in increased abundance of Nitric Oxide; TNF results in increased abundance of Nitric Oxide
7-(2-(4-(4-nitrobenzene)piperazinyl)ethyl)-1,3-dimethylxanthine inhibits the reaction [TNF protein results in increased abundance of Nitric Oxide]; [IFNG protein co-treated with TNF protein] results in increased abundance of Nitric Oxide; [IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide; [IL1B protein co-treated with TNF protein] results in increased chemical synthesis of Nitric Oxide; [Lipopolysaccharides co-treated with IFNG protein co-treated with TNF protein] results in increased abundance of Nitric Oxide; [TNF co-treated with IL1B co-treated with IFNG] results in increased abundance of Nitric Oxide; [TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide; Acetylcysteine inhibits the reaction [Nitric Oxide deficiency results in increased expression of TNF protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Genistein inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein co-treated with TNF protein] results in increased abundance of Nitric Oxide]; KMUP 1 inhibits the reaction [TNF protein results in increased abundance of Nitric Oxide]; Polyphenols inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein co-treated with TNF protein] results in increased abundance of Nitric Oxide]; resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein co-treated with TNF protein] results in increased abundance of Nitric Oxide]; S-methylisothiopseudouronium inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; TNF protein affects the reaction [Lipopolysaccharides results in increased secretion of Nitric Oxide]; Vitamin E inhibits the reaction [[IL1B protein co-treated with TNF protein] results in increased chemical synthesis of Nitric Oxide]; zaprinast inhibits the reaction [TNF protein results in increased abundance of Nitric Oxide]
TNF protein results in increased metabolism of Nitric Oxide
Nitric Oxide deficiency results in increased expression of TNF protein; Nitric Oxide results in increased expression of TNF protein
[[TNF protein co-treated with IFNG protein] affects the expression of NOS2 mRNA] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]; [[TNF protein co-treated with IFNG protein] affects the expression of NOS2 protein] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]; [[TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [[TNF protein results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide] which results in decreased expression of RETN mRNA; [IFNG protein co-treated with TNF protein] results in increased abundance of Nitric Oxide; [Lipopolysaccharides co-treated with TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide; [Lipopolysaccharides co-treated with TNF] results in increased abundance of Nitric Oxide; [Nitric Oxide Donors results in increased abundance of Nitric Oxide] inhibits the reaction [[TNF protein co-treated with Galactosamine] results in increased activity of CASP3 protein]; [TNF co-treated with IL1B co-treated with IFNG] results in increased abundance of Nitric Oxide; [TNF protein co-treated with IFNG protein co-treated with IL1B protein] results in increased abundance of Nitric Oxide; [TNF protein co-treated with IFNG protein] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]; [TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide; [TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide; [TNF protein co-treated with IFNG protein] results in increased secretion of Nitric Oxide; [TNF protein results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide; [TNF protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; Bee Venoms inhibits the reaction [[TNF protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; cobaltous chloride promotes the reaction [[[TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Dexamethasone inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]; Estriol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased abundance of Nitric Oxide]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased abundance of Nitric Oxide]]; Guanidines analog inhibits the reaction [[Lipopolysaccharides co-treated with TNF] results in increased abundance of Nitric Oxide]; Guanidines inhibits the reaction [Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased abundance of Nitric Oxide]]; IL4 protein inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]; lead chloride inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]; manganese chloride promotes the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]; manganese chloride promotes the reaction [TNF protein co-treated with and results in increased chemical synthesis of IFNG protein co-treated with and results in increased chemical synthesis of Nitric Oxide]; Manganese promotes the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]; Manganese promotes the reaction [TNF protein co-treated with and results in increased chemical synthesis of IFNG protein co-treated with and results in increased chemical synthesis of Nitric Oxide]; Melitten inhibits the reaction [[TNF protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased abundance of Nitric Oxide]]; NFKBIA protein affects the reaction [manganese chloride promotes the reaction [TNF protein co-treated with and results in increased chemical synthesis of IFNG protein co-treated with and results in increased chemical synthesis of Nitric Oxide]]; NFKBIA protein affects the reaction [Manganese promotes the reaction [TNF protein co-treated with and results in increased chemical synthesis of IFNG protein co-treated with and results in increased chemical synthesis of Nitric Oxide]]; nickel chloride promotes the reaction [[[TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Nitric Oxide affects the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] affects the localization of Zinc]; Nitric Oxide affects the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of MT1 mRNA]; Nitric Oxide affects the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of MT2 mRNA]; NOS2 protein promotes the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]; NOS2 protein promotes the reaction [cobaltous chloride promotes the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]]; NOS2 protein promotes the reaction [nickel chloride promotes the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]]; pimagedine inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]; Plant Extracts inhibits the reaction [[Lipopolysaccharides results in increased expression of TNF protein] which results in increased chemical synthesis of Nitric Oxide]; Pravastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased abundance of Nitric Oxide]; Progesterone inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased abundance of Nitric Oxide]; Quercetin inhibits the reaction [TNF protein results in increased abundance of Nitric Oxide]; Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased abundance of Nitric Oxide]; sodium arsenite inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Y 27632 promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased abundance of Nitric Oxide]		 CTD PMID:7519435 PMID:8341679 PMID:8903404 PMID:8975779 PMID:9388267 More... NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Trp53 transformation related protein 53 multiple interactions
increases expression
increases glutathionylation
affects response to substance
decreases expression
increases phosphorylation		 ISO
EXP		 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nitric Oxide results in increased phosphorylation of TP53 protein]; [Nitric Oxide Donors results in increased abundance of Nitric Oxide] which results in increased expression of TP53 protein; Caffeine inhibits the reaction [Nitric Oxide results in increased phosphorylation of TP53 protein]; wortmannin inhibits the reaction [Nitric Oxide results in increased phosphorylation of TP53 protein]
Nitric Oxide results in increased expression of TP53 protein
Nitric Oxide results in increased glutathionylation of TP53 protein
TP53 protein affects the susceptibility to Nitric Oxide
[7-nitroindazole results in decreased chemical synthesis of Nitric Oxide] inhibits the reaction [Paraquat results in increased phosphorylation of TP53 protein]; [NOS2 protein results in increased abundance of Nitric Oxide] which results in increased expression of TP53 protein; [S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in increased expression of TP53 protein
Nitric Oxide results in decreased expression of TRP53 protein
[S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] which results in increased expression of TRP53 mRNA		 CTD PMID:7673702 PMID:8982730 PMID:9743513 PMID:10608825 PMID:14634119 More... NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Trp53bp1 transformation related protein 53 binding protein 1 decreases expression EXP Nitric Oxide deficiency results in decreased expression of TRP53BP1 mRNA CTD PMID:15878706 NCBI chr 2:121,025,316...121,126,830
Ensembl chr 2:121,023,762...121,101,888 		JBrowse link
G Txndc5 thioredoxin domain containing 5 multiple interactions ISO [NOS3 protein polymorphism results in decreased chemical synthesis of Nitric Oxide] which affects the expression of TXNDC5 protein CTD PMID:19320461 NCBI chr13:38,684,242...38,712,800
Ensembl chr13:38,684,055...38,712,800 		JBrowse link
G Ubc ubiquitin C increases expression EXP Nitric Oxide deficiency results in increased expression of UBC mRNA CTD PMID:15878706 NCBI chr 5:125,463,029...125,467,081
Ensembl chr 5:125,463,029...125,467,266 		JBrowse link
G Ube2l3 ubiquitin-conjugating enzyme E2L 3 decreases expression EXP Nitric Oxide deficiency results in decreased expression of UBE2L3 mRNA CTD PMID:15878706 NCBI chr16:16,969,879...17,019,363
Ensembl chr16:16,969,877...17,020,513 		JBrowse link
G Ucn urocortin increases abundance ISO UCN protein results in increased abundance of Nitric Oxide CTD PMID:20237592 NCBI chr 5:31,295,333...31,296,239
Ensembl chr 5:31,295,407...31,296,173 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression
increases secretion		 ISO Nitric Oxide deficiency results in decreased expression of VEGFA mRNA
VEGFA protein results in increased secretion of Nitric Oxide		 CTD PMID:15249212 PMID:16733097 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
G Wt1 WT1 transcription factor increases expression ISO Nitric Oxide results in increased expression of WT1 mRNA CTD PMID:21443142 NCBI chr 2:104,956,874...105,003,959
Ensembl chr 2:104,956,874...105,003,961 		JBrowse link
G Xdh xanthine dehydrogenase multiple interactions ISO XDH protein promotes the reaction [[Raloxifene Hydrochloride results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide] CTD PMID:20888885 NCBI chr17:74,190,890...74,257,191
Ensembl chr17:74,190,890...74,257,191 		JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression
increases expression		 ISO
EXP		 Nitric Oxide results in decreased expression of XIAP mRNA
Nitric Oxide results in increased expression of XIAP protein		 CTD PMID:14634119 PMID:15126337 NCBI chr  X:41,148,483...41,198,541
Ensembl chr  X:41,148,556...41,198,533 		JBrowse link
G Zfp422 zinc finger protein 422 decreases expression EXP Nitric Oxide deficiency results in decreased expression of ZFP422 mRNA CTD PMID:15878706 NCBI chr 6:116,600,977...116,605,960
Ensembl chr 6:116,600,977...116,605,960 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22327
    role 22313
      biological role 22312
        molecular messenger 19501
          signalling molecule 10845
            nitric oxide 324
Path 2
Term Annotations click to browse term
  CHEBI ontology 22327
    subatomic particle 22322
      composite particle 22322
        hadron 22322
          baryon 22322
            nucleon 22322
              atomic nucleus 22322
                atom 22322
                  main group element atom 22204
                    p-block element atom 22204
                      chalcogen 21551
                        oxygen atom 21529
                          oxygen molecular entity 21529
                            oxide 13516
                              inorganic oxide 8074
                                nitrogen oxide 447
                                  nitric oxide 324
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