Ppm1g (protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Ppm1g (protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform) Mus musculus
Analyze
Symbol: Ppm1g
Name: protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform
RGD ID: 732735
MGI Page MGI
Description: Enables phosphoprotein phosphatase activity. Acts upstream of or within regulation of cell cycle. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and immune system. Used to study schizophrenia. Orthologous to human PPM1G (protein phosphatase, Mg2+/Mn2+ dependent 1G).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: AI385652; fibroblast growth factor inducible 13; fibroblast growth factor-inducible protein 13; Fin; Fin13; PP2C-gamma; protein phosphatase 1C; protein phosphatase 1G; protein phosphatase 2C isoform gamma; protein phosphatase magnesium-dependent 1 gamma
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39531,360,012 - 31,377,889 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl531,360,008 - 31,378,031 (-)EnsemblGRCm39 Ensembl
GRCm38531,202,668 - 31,220,545 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl531,202,664 - 31,220,687 (-)EnsemblGRCm38mm10GRCm38
MGSCv37531,505,041 - 31,522,918 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36531,479,249 - 31,497,126 (-)NCBIMGSCv36mm8
Celera528,681,717 - 28,699,620 (-)NCBICelera
Cytogenetic Map5B1NCBI
cM Map517.27NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)
nucleoplasm  (IBA,ISO)
nucleus  (IDA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. FIN13, a novel growth factor-inducible serine-threonine phosphatase which can inhibit cell cycle progression. Guthridge MA, etal., Mol Cell Biol 1997 Sep;17(9):5485-98.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. MGD IEA MGD IEA
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8649829   PMID:12477932   PMID:12520002   PMID:14610273   PMID:15489334   PMID:15782199   PMID:16602821   PMID:18799693   PMID:19521500   PMID:21873635   PMID:23055941   PMID:23088624  
PMID:23723158   PMID:26365490   PMID:28378742   PMID:29669786   PMID:31040226   PMID:32325033   PMID:36417873   PMID:37839992   PMID:38372470  


Genomics

Comparative Map Data
Ppm1g
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39531,360,012 - 31,377,889 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl531,360,008 - 31,378,031 (-)EnsemblGRCm39 Ensembl
GRCm38531,202,668 - 31,220,545 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl531,202,664 - 31,220,687 (-)EnsemblGRCm38mm10GRCm38
MGSCv37531,505,041 - 31,522,918 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36531,479,249 - 31,497,126 (-)NCBIMGSCv36mm8
Celera528,681,717 - 28,699,620 (-)NCBICelera
Cytogenetic Map5B1NCBI
cM Map517.27NCBI
PPM1G
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38227,381,199 - 27,409,591 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl227,381,195 - 27,409,591 (-)EnsemblGRCh38hg38GRCh38
GRCh37227,604,066 - 27,632,458 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36227,457,565 - 27,486,000 (-)NCBINCBI36Build 36hg18NCBI36
Build 34227,515,712 - 27,544,147NCBI
Celera227,450,727 - 27,478,104 (-)NCBICelera
Cytogenetic Map2p23.3NCBI
HuRef227,346,069 - 27,374,440 (-)NCBIHuRef
CHM1_1227,534,014 - 27,562,499 (-)NCBICHM1_1
T2T-CHM13v2.0227,423,594 - 27,451,985 (-)NCBIT2T-CHM13v2.0
Ppm1g
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8630,873,531 - 30,893,735 (+)NCBIGRCr8
mRatBN7.2625,153,556 - 25,173,763 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl625,153,556 - 25,173,761 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx625,454,397 - 25,474,600 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0625,770,290 - 25,790,493 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0625,249,656 - 25,269,625 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0626,517,840 - 26,537,292 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl626,517,840 - 26,537,290 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0636,336,359 - 36,355,555 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4625,145,569 - 25,149,811 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1625,148,980 - 25,152,355NCBI
Celera624,645,573 - 24,665,067 (+)NCBICelera
Cytogenetic Map6q14NCBI
Ppm1g
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554699,344,968 - 9,350,125 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554699,344,968 - 9,350,123 (-)NCBIChiLan1.0ChiLan1.0
PPM1G
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21299,098,418 - 99,129,448 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A99,102,386 - 99,133,411 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A27,385,072 - 27,413,475 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A27,473,480 - 27,502,384 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A27,473,480 - 27,502,384 (-)Ensemblpanpan1.1panPan2
PPM1G
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11721,336,319 - 21,356,278 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1721,336,604 - 21,356,283 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1721,228,084 - 21,248,046 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01721,657,649 - 21,677,648 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1721,657,652 - 21,677,623 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11721,344,295 - 21,364,251 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01721,354,011 - 21,374,011 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01721,402,010 - 21,421,995 (-)NCBIUU_Cfam_GSD_1.0
Ppm1g
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629265,636,528 - 65,656,720 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364935,182,818 - 5,203,072 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364935,182,829 - 5,203,037 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPM1G
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3111,748,105 - 111,770,901 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13111,748,012 - 111,770,868 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23118,703,500 - 118,726,303 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PPM1G
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11480,205,359 - 80,230,391 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1480,205,458 - 80,230,424 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604531,921,834 - 31,947,912 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppm1g
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247389,454,798 - 9,479,141 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ppm1g
628 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:206
Count of miRNA genes:169
Interacting mature miRNAs:189
Transcripts:ENSMUST00000031032
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10401122Pgia41_mproteoglycan induced arthritis 41 (mouse)Not determined582314434823280Mouse
15039371Nmrs21_mNAFLD-associated magnetic resonance shift 21 (mouse)5350482337504823Mouse
1301806Actd2_mactivity-distance traveled 2 (mouse)Not determined5538452039384652Mouse
4141207Imrfq1_mimmune response to Factor IX QTL 1 (mouse)Not determined5812411742124239Mouse
7394748Mom5_mmodifier of Min 5 (mouse)Not determined5884767233475637Mouse
1301693Sle6_msystemic lupus erythematosus susceptibility 6 (mouse)Not determined5889069387841837Mouse
1357478Kdnw1_mkidney weight 1 (mouse)Not determined5891594940529869Mouse
14696730Kidlq1_mkidney weight, left QTL 1 (mouse)51356315247563152Mouse
1301685Estq2_mestradiol regulated response QTL 2 (mouse)Not determined51563408449634190Mouse
1300719Iba5_minduction of brown adipocytes 5 (mouse)Not determined52068699354687134Mouse
1301776Skts3_mskin tumor susceptibility 3 (mouse)Not determined52166729555667403Mouse
11537368Hmtb10_mhemostasis and thrombosis 10 (mouse)52210082354500318Mouse
11537367Hmtb11_mhemostasis and thrombosis 11 (mouse)52210082364806579Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
1300701Cd8ts1_mCD8 T cell subset 1 (mouse)Not determined52721534861215451Mouse
1301555Alcp10_malcohol preference locus 10 (mouse)Not determined53102427565024480Mouse
1301403Alcp9_malcohol preference locus 9 (mouse)Not determined53102427565024480Mouse

Markers in Region
PPM1G_7857  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38531,202,701 - 31,203,237UniSTSGRCm38
MGSCv37531,505,074 - 31,505,610UniSTSGRCm37
Celera528,681,750 - 28,682,286UniSTS
Cytogenetic Map5B1UniSTS
cM Map519.0UniSTS
Ppm1g  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38531,202,716 - 31,202,848UniSTSGRCm38
MGSCv37531,505,089 - 31,505,221UniSTSGRCm37
Celera528,681,765 - 28,681,897UniSTS
Cytogenetic Map5B1UniSTS
cM Map519.0UniSTS
G54114  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38531,202,829 - 31,202,994UniSTSGRCm38
MGSCv37531,505,202 - 31,505,367UniSTSGRCm37
Celera528,681,878 - 28,682,043UniSTS
Cytogenetic Map5B1UniSTS
cM Map519.0UniSTS
Ppm1g  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38531,204,038 - 31,204,128UniSTSGRCm38
MGSCv37531,506,411 - 31,506,501UniSTSGRCm37
Celera528,683,087 - 28,683,177UniSTS
Cytogenetic Map5B1UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000031032   ⟹   ENSMUSP00000031032
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl531,360,012 - 31,378,031 (-)Ensembl
GRCm38.p6 Ensembl531,202,668 - 31,220,687 (-)Ensembl
RefSeq Acc Id: ENSMUST00000200740
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl531,376,113 - 31,377,909 (-)Ensembl
GRCm38.p6 Ensembl531,218,769 - 31,220,565 (-)Ensembl
RefSeq Acc Id: ENSMUST00000200778   ⟹   ENSMUSP00000144094
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl531,362,434 - 31,377,663 (-)Ensembl
GRCm38.p6 Ensembl531,205,090 - 31,220,319 (-)Ensembl
RefSeq Acc Id: ENSMUST00000201407   ⟹   ENSMUSP00000144556
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl531,362,436 - 31,365,009 (-)Ensembl
GRCm38.p6 Ensembl531,205,092 - 31,207,665 (-)Ensembl
RefSeq Acc Id: ENSMUST00000202294   ⟹   ENSMUSP00000144644
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl531,360,008 - 31,377,909 (-)Ensembl
GRCm38.p6 Ensembl531,202,664 - 31,220,565 (-)Ensembl
RefSeq Acc Id: ENSMUST00000202402
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl531,360,446 - 31,362,427 (-)Ensembl
GRCm38.p6 Ensembl531,203,102 - 31,205,083 (-)Ensembl
RefSeq Acc Id: NM_008014   ⟹   NP_032040
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39531,360,012 - 31,377,889 (-)NCBI
GRCm38531,202,668 - 31,220,545 (-)ENTREZGENE
MGSCv37531,505,041 - 31,522,918 (-)RGD
Celera528,681,717 - 28,699,620 (-)RGD
cM Map5 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_032040   ⟸   NM_008014
- UniProtKB: Q61074 (UniProtKB/Swiss-Prot),   A0A0J9YVG0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000144644   ⟸   ENSMUST00000202294
RefSeq Acc Id: ENSMUSP00000031032   ⟸   ENSMUST00000031032
RefSeq Acc Id: ENSMUSP00000144556   ⟸   ENSMUST00000201407
RefSeq Acc Id: ENSMUSP00000144094   ⟸   ENSMUST00000200778
Protein Domains
PPM-type phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q61074-F1-model_v2 AlphaFold Q61074 1-542 view protein structure

Promoters
RGD ID:6886356
Promoter ID:EPDNEW_M6629
Type:initiation region
Name:Ppm1g_1
Description:Mus musculus protein phosphatase 1G , magnesium-dependent, gammaisoform , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38531,220,565 - 31,220,625EPDNEW
RGD ID:6838081
Promoter ID:MM_KWN:41828
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_008014
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36531,522,796 - 31,523,296 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:106065 AgrOrtholog
Ensembl Genes ENSMUSG00000029147 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000031032 ENTREZGENE
  ENSMUST00000031032.11 UniProtKB/Swiss-Prot
  ENSMUST00000200778.5 UniProtKB/TrEMBL
  ENSMUST00000201407.2 UniProtKB/TrEMBL
  ENSMUST00000202294.4 UniProtKB/TrEMBL
Gene3D-CATH 3.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro PP2C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PP2C_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PPM-type_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PPM-type_phosphatase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14208 UniProtKB/Swiss-Prot
MGD MGI:106065 ENTREZGENE
NCBI Gene 14208 ENTREZGENE
PANTHER PROTEIN PHOSPHATASE 1G UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR13832 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PP2C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ppm1g PhenoGen
PROSITE PPM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PPM_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PP2Cc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF81606 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0J9YUB0_MOUSE UniProtKB/TrEMBL
  A0A0J9YV96_MOUSE UniProtKB/TrEMBL
  A0A0J9YVG0 ENTREZGENE, UniProtKB/TrEMBL
  PPM1G_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE