Pms2 (PMS1 homolog2, mismatch repair system component) - Rat Genome Database
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Gene: Pms2 (PMS1 homolog2, mismatch repair system component) Mus musculus
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Symbol: Pms2
Name: PMS1 homolog2, mismatch repair system component
RGD ID: 1313537
Description: Predicted to contribute to MutSalpha complex binding activity and single-stranded DNA binding activity. Involved in mismatch repair; positive regulation of isotype switching; and somatic diversification of immunoglobulins. Localizes to MutLalpha complex. Is expressed in cerebellum; genitourinary system; and retina. Human ortholog(s) of this gene implicated in Lynch syndrome; hereditary nonpolyposis colorectal cancer type 4; ovarian cancer; and urinary bladder cancer. Orthologous to human PMS2 (PMS1 homolog 2, mismatch repair system component); PARTICIPATES IN altered mismatch repair pathway; colorectal cancer pathway; mismatch repair pathway; INTERACTS WITH 1,2-dichloroethane; 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AW555130; DNA mismatch repair protein PMS2; mismatch repair endonuclease PMS2; PMS1 protein homolog 2; Pmsl2; postmeiotic segregation increased 2; postmeiotic segregation increased 2 (S. cerevisiae)
Orthologs:
Homo sapiens (human) : PMS2 (PMS1 homolog 2, mismatch repair system component)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Pms2 (PMS1 homolog 2, mismatch repair system component)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pms2 (PMS1 homolog 2, mismatch repair system component)
Pan paniscus (bonobo/pygmy chimpanzee) : LOC100976787 (mismatch repair endonuclease PMS2)
Canis lupus familiaris (dog) : PMS2 (PMS1 homolog 2, mismatch repair system component)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pms2 (PMS1 homolog 2, mismatch repair system component)
Sus scrofa (pig) : PMS2 (PMS1 homolog 2, mismatch repair system component)
Chlorocebus sabaeus (African green monkey) : PMS2 (PMS1 homolog 2, mismatch repair system component)
Heterocephalus glaber (naked mole-rat) : Pms2 (PMS1 homolog 2, mismatch repair system component)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395143,846,379 - 143,922,538 (+)NCBI
GRCm385143,909,901 - 143,972,745 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5143,909,964 - 143,933,968 (+)EnsemblGRCm38mm10GRCm38
MGSCv375144,670,870 - 144,692,625 (+)NCBIGRCm37mm9NCBIm37
MGSCv365144,163,492 - 144,184,971 (+)NCBImm8
Celera5140,892,468 - 140,914,240 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map582.82NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:7628019   PMID:7661930   PMID:9096356   PMID:9192668   PMID:9286595   PMID:9469811   PMID:9500552   PMID:9515784   PMID:9618520   PMID:9697842   PMID:10349636   PMID:10359802  
PMID:10429667   PMID:10430621   PMID:10439048   PMID:10469609   PMID:10753224   PMID:10809667   PMID:10837019   PMID:10874005   PMID:10922068   PMID:10987303   PMID:11042159   PMID:11076861  
PMID:11223406   PMID:11313994   PMID:11325851   PMID:11544199   PMID:11717399   PMID:11805062   PMID:11828012   PMID:12195036   PMID:12477932   PMID:12520002   PMID:12531009   PMID:12697830  
PMID:12725522   PMID:12840110   PMID:12882965   PMID:12967659   PMID:14610273   PMID:15226823   PMID:15480418   PMID:15491631   PMID:15533837   PMID:16141072   PMID:16141073   PMID:16204034  
PMID:16260499   PMID:16336979   PMID:16713580   PMID:16728433   PMID:17785530   PMID:17947680   PMID:18264106   PMID:18551179   PMID:18768816   PMID:18799693   PMID:20624957   PMID:20864418  
PMID:21062905   PMID:21677750   PMID:21873635   PMID:21892206   PMID:22145025   PMID:22289650   PMID:22628407   PMID:23071719   PMID:23920106   PMID:23996931   PMID:24710273   PMID:26753533  
PMID:26850462   PMID:27791005   PMID:28283534   PMID:32325033  


Genomics

Comparative Map Data
Pms2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395143,846,379 - 143,922,538 (+)NCBI
GRCm385143,909,901 - 143,972,745 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5143,909,964 - 143,933,968 (+)EnsemblGRCm38mm10GRCm38
MGSCv375144,670,870 - 144,692,625 (+)NCBIGRCm37mm9NCBIm37
MGSCv365144,163,492 - 144,184,971 (+)NCBImm8
Celera5140,892,468 - 140,914,240 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map582.82NCBI
PMS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl75,970,925 - 6,009,106 (-)EnsemblGRCh38hg38GRCh38
GRCh3875,970,925 - 6,009,106 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3776,012,870 - 6,048,737 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3675,979,396 - 6,015,263 (-)NCBINCBI36hg18NCBI36
Build 3475,786,113 - 5,821,915NCBI
Celera760,142,236 - 60,149,112 (-)NCBI
Celera75,957,552 - 5,958,444 (-)NCBI
Cytogenetic Map7p22.1NCBI
HuRef75,894,376 - 5,920,472 (-)NCBIHuRef
CHM1_176,774,489 - 6,793,088 (+)NCBICHM1_1
CRA_TCAGchr7v276,059,215 - 6,095,082 (-)NCBI
Pms2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01212,714,394 - 12,738,654 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1212,714,394 - 12,738,641 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01214,757,747 - 14,781,994 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41211,004,507 - 11,028,754 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11211,034,447 - 11,058,818 (-)NCBI
Celera1212,474,260 - 12,498,506 (-)NCBICelera
Cytogenetic Map12p11NCBI
Pms2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495546013,762,854 - 13,791,462 (+)NCBIChiLan1.0ChiLan1.0
LOC100976787
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.176,175,913 - 6,203,094 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl76,167,403 - 6,202,984 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v077,433,031 - 7,459,560 (+)NCBIMhudiblu_PPA_v0panPan3
PMS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl611,349,453 - 11,438,940 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1611,411,062 - 11,438,767 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Pms2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936750439,396 - 468,747 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PMS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl35,113,230 - 5,145,634 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.135,118,002 - 5,145,634 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.235,179,132 - 5,206,754 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PMS2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl2815,172,100 - 15,209,852 (-)Ensembl
ChlSab1.12815,174,359 - 15,209,962 (-)NCBI
Pms2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474031,315,121 - 31,345,137 (+)NCBI

Position Markers
U28724  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385143,931,249 - 143,931,401UniSTSGRCm38
MGSCv375144,692,118 - 144,692,270UniSTSGRCm37
Celera5140,913,758 - 140,913,910UniSTS
Cytogenetic Map5G2UniSTS
cM Map582.0UniSTS
Whitehead_YAC5 UniSTS
AW555130  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385143,931,157 - 143,931,306UniSTSGRCm38
MGSCv375144,692,026 - 144,692,175UniSTSGRCm37
Celera5140,913,666 - 140,913,815UniSTS
Cytogenetic Map5G2UniSTS
cM Map582.0UniSTS
Whitehead/MRC_RH51711.51UniSTS
PMC153206P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385143,925,418 - 143,925,811UniSTSGRCm38
MGSCv375144,686,287 - 144,686,680UniSTSGRCm37
Celera5140,907,927 - 140,908,320UniSTS
Cytogenetic Map5G2UniSTS
cM Map582.0UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301362Prnr1_mprion resistance 1 (mouse)Not determined589271017146851125Mouse
1300827Cora1_mcorrelation in cytokine production 1 (mouse)Not determined5115128044149128176Mouse
1301226Bbaa2_mB.burgdorferi-associated arthritis 2 (mouse)Not determined5115128044149128176Mouse
1301857Bglq14_mbody growth late QTL 14 (mouse)Not determined5118920110151834684Mouse
4141081Nidd7k_mNidd7 on KK-A (mouse)Not determined119806972149423861Mouse
11528552Scram1_mspinal cord resistance to astrocytoma modifier 1 (mouse)5121457140151834684Mouse
1301986Bpq4_mblood pressure QTL 4 (mouse)Not determined5121556974151834684Mouse
1302079Lbw3_mlupus NZB x NZW 3 (mouse)Not determined5124714580151834684Mouse
1301363Pbwg13_mpostnatal body weight growth 13 (mouse)Not determined5125147702151834684Mouse
4141218Ath24_matherosclerosis 24 (mouse)Not determined129583274151834684Mouse
12880406Jcdq2_mjoint cartilage degeneration QTL 2 (mouse)5129851021151834684Mouse
11049557Lmr26_mleishmaniasis resistance 26 (mouse)5134002093151834684Mouse
13504734Ifvrq4_minfluenza virus resistance QTL 4 (mouse)5140000000153000000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2307
Count of miRNA genes:817
Interacting mature miRNAs:1120
Transcripts:ENSMUST00000031618, ENSMUST00000110707, ENSMUST00000110709, ENSMUST00000110710, ENSMUST00000126331, ENSMUST00000128153, ENSMUST00000128207, ENSMUST00000141942, ENSMUST00000147910, ENSMUST00000148011, ENSMUST00000154781, ENSMUST00000164604, ENSMUST00000164999, ENSMUST00000166847, ENSMUST00000168085, ENSMUST00000169758, ENSMUST00000170083, ENSMUST00000172367
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_008886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006504812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017320710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017320712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030254201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030254202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030254203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030254204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036164879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036164880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036164881 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036164882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036164883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036164884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036164885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036164886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036164887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036164888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036164889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036164890 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001784634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001784636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001784637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003955592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003955593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003955594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003955595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003955596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004942443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004942444 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004942445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004942446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004942447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004942448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004942449 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004942450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004942451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004942452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004942453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004942454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_377191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC121917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC166900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK014190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK017847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK034866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK083049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK163045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC022179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC058189 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC066110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC083502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC086637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC110684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC139774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC141287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000110707
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl5143,909,990 - 143,931,442 (+)Ensembl
RefSeq Acc Id: ENSMUST00000110709   ⟹   ENSMUSP00000106337
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl5143,910,057 - 143,931,159 (+)Ensembl
RefSeq Acc Id: ENSMUST00000110710
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl5143,909,990 - 143,931,205 (+)Ensembl
RefSeq Acc Id: ENSMUST00000126331
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl5143,910,025 - 143,926,870 (+)Ensembl
RefSeq Acc Id: ENSMUST00000128153
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl5143,910,161 - 143,913,460 (+)Ensembl
RefSeq Acc Id: ENSMUST00000128207
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl5143,913,318 - 143,913,912 (+)Ensembl
RefSeq Acc Id: ENSMUST00000141942
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl5143,909,964 - 143,933,968 (+)Ensembl
RefSeq Acc Id: ENSMUST00000147910
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl5143,909,999 - 143,917,658 (+)Ensembl
RefSeq Acc Id: ENSMUST00000148011   ⟹   ENSMUSP00000119875
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl5143,909,964 - 143,933,968 (+)Ensembl
RefSeq Acc Id: ENSMUST00000154781
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl5143,910,025 - 143,914,291 (+)Ensembl
RefSeq Acc Id: ENSMUST00000164999   ⟹   ENSMUSP00000133062
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl5143,919,579 - 143,925,479 (+)Ensembl
RefSeq Acc Id: ENSMUST00000168085
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl5143,910,004 - 143,914,754 (+)Ensembl
RefSeq Acc Id: ENSMUST00000170083
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl5143,909,964 - 143,933,968 (+)Ensembl
RefSeq Acc Id: NM_008886   ⟹   NP_032912
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395143,846,819 - 143,868,574 (+)NCBI
GRCm385143,910,001 - 143,931,756 (+)NCBI
MGSCv375144,670,870 - 144,692,625 (+)RGD
Celera5140,892,468 - 140,914,240 (+)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006504812   ⟹   XP_006504875
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395143,846,800 - 143,868,809 (+)NCBI
GRCm385143,909,991 - 143,931,991 (+)NCBI
Sequence: