Gene: Trp53bp1 (transformation related protein 53 binding protein 1) Mus musculus
Analyze
Symbol:
Trp53bp1
Name:
transformation related protein 53 binding protein 1
Description:
Exhibits damaged DNA binding activity; methylated histone binding activity; and telomeric DNA binding activity. Involved in double-strand break repair via nonhomologous end joining; negative regulation of double-strand break repair via homologous recombination; and positive regulation of isotype switching. Localizes to the DNA repair complex; chromosome; and nuclear body. Predicted to colocalize with the chromosome, telomeric region. Is expressed in ileum; lung; metanephros; nervous system; and sensory organ. Orthologous to human TP53BP1 (tumor protein p53 binding protein 1); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; histone modification pathway; non-homologous end joining pathway of double-strand break repair; INTERACTS WITH 1H-pyrazole; 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
53BP1; m53BP1; MGC100303; murine p53-binding protein; p53-binding protein 1; p53BP1; TP53-binding protein 1; Tp53bp1; transformation related protein 53 binding-protein 1; tumor suppressor p53-binding protein 1
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
TP53BP1 (tumor protein p53 binding protein 1) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Tp53bp1 (tumor protein p53 binding protein 1) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Tp53bp1 (tumor protein p53 binding protein 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
TP53BP1 (tumor protein p53 binding protein 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
TP53BP1 (tumor protein p53 binding protein 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Tp53bp1 (tumor protein p53 binding protein 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
TP53BP1 (tumor protein p53 binding protein 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Tp53bp1 (tumor protein p53 binding protein 1)
Alliance
DIOPT (Ensembl Compara, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Homo sapiens (human):
TP53BP1 (tumor protein p53 binding protein 1)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
tp53bp1 (tumor protein p53 binding protein, 1)
Alliance
DIOPT (Ensembl Compara, Hieranoid, OMA, OrthoFinder, PANTHER, PhylomeDB, TreeFam, ZFIN)
Caenorhabditis elegans (roundworm):
hsr-9
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OrthoInspector, PANTHER, Roundup, TreeFam)
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 Ensembl 2 121,193,281 - 121,271,407 (-) Ensembl GRCm38 2 121,194,835 - 121,296,354 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 2 121,022,463 - 121,097,122 (-) NCBI GRCm37 mm9 NCBIm37 MGSCv36 2 120,889,692 - 120,962,561 (-) NCBI mm8 Celera 2 122,346,827 - 122,423,056 (-) NCBI Celera Cytogenetic Map 2 E5 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
Imported Annotations - ClinVar
microcephaly and chorioretinopathy 3 ISO RGD:1317577 8554872 ClinVar Annotator: match by term: Microcephaly and chorioretinopathy, autosomal recessive, 3 ClinVar PMID:24033266 more ...
Imported Annotations - CTD
Breast Neoplasms ISO RGD:1317577 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:30705370 Colonic Neoplasms ISO RGD:1317577 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:30705370 glioblastoma multiforme ISO RGD:1317577 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:30705370 lung non-small cell carcinoma ISO RGD:1317577 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:30705370 Lymphatic Metastasis ISO RGD:1317577 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:30705370 Ovarian Neoplasms ISO RGD:1317577 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:30705370
(-)-epigallocatechin 3-gallate multiple interactions ISO RGD:1317577 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TP53BP1 mRNA CTD PMID:22079256 1H-pyrazole increases expression EXP 6480464 pyrazole results in increased expression of TRP53BP1 mRNA CTD PMID:17945193 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of TRP53BP1 mRNA CTD PMID:21570461 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:1317577 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of TP53BP1 mRNA CTD PMID:28628672 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one increases expression ISO RGD:1317577 6480464 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of TP53BP1 protein CTD PMID:26231820 4-hydroxyphenyl retinamide increases expression ISO RGD:1317577 6480464 Fenretinide results in increased expression of TP53BP1 mRNA CTD PMID:16570282 aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of TRP53BP1 mRNA CTD PMID:19770486 aflatoxin B1 increases methylation ISO RGD:1317577 6480464 Aflatoxin B1 results in increased methylation of TP53BP1 intron CTD PMID:30157460 all-trans-retinoic acid decreases expression ISO RGD:1308039 6480464 Tretinoin results in decreased expression of TP53BP1 mRNA CTD PMID:24977338 arsane decreases expression ISO RGD:1317577 6480464 Arsenic results in decreased expression of TP53BP1 mRNA CTD PMID:29161537 arsenic atom decreases expression ISO RGD:1317577 6480464 Arsenic results in decreased expression of TP53BP1 mRNA CTD PMID:29161537 atrazine increases expression ISO RGD:1317577 6480464 Atrazine results in increased expression of TP53BP1 mRNA CTD PMID:22378314 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of TRP53BP1 mRNA CTD PMID:22228805 benzo[a]pyrene affects methylation ISO RGD:1317577 6480464 Benzo(a)pyrene affects the methylation of TP53BP1 intron CTD PMID:30157460 bis(2-chloroethyl) sulfide increases phosphorylation ISO RGD:1317577 6480464 Mustard Gas results in increased phosphorylation of TP53BP1 protein CTD PMID:19845377 bisphenol A increases expression ISO RGD:1317577 6480464 bisphenol A results in increased expression of TP53BP1 mRNA, bisphenol A results in increased expression of TP53BP1 protein CTD PMID:29275510 bisphenol A affects expression ISO RGD:1308039 6480464 bisphenol A affects the expression of TP53BP1 mRNA CTD PMID:30816183 bisphenol F multiple interactions ISO RGD:1317577 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of TP53BP1 mRNA CTD PMID:28628672 bortezomib multiple interactions ISO RGD:1317577 6480464 TP53BP1 protein affects the reaction [[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in increased cleavage of PARP1 protein], TP53BP1 protein affects the reaction [[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in increased phosphorylation of RB1 protein] CTD PMID:25522274 brefeldin A increases expression ISO RGD:1317577 6480464 Brefeldin A results in increased expression of TP53BP1 protein CTD PMID:27358234 chromium(6+) decreases expression ISO RGD:1317577 6480464 chromium hexavalent ion results in decreased expression of TP53BP1 mRNA CTD PMID:27793765 cisplatin increases phosphorylation EXP 6480464 Cisplatin results in increased phosphorylation of TRP53BP1 protein CTD PMID:22006019 cisplatin increases expression ISO RGD:1317577 6480464 Cisplatin results in increased expression of TP53BP1 protein CTD PMID:27358234 crocidolite asbestos affects expression ISO RGD:1317577 6480464 Asbestos, Crocidolite affects the expression of TP53BP1 mRNA CTD PMID:17331233 cyclosporin A increases expression ISO RGD:1317577 6480464 Cyclosporine results in increased expression of TP53BP1 mRNA CTD PMID:20106945 dexamethasone multiple interactions ISO RGD:1317577 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of TP53BP1 mRNA CTD PMID:28628672 doxorubicin decreases expression ISO RGD:1317577 6480464 Doxorubicin results in decreased expression of TP53BP1 mRNA CTD PMID:29803840 enzyme inhibitor multiple interactions ISO RGD:1317577 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of TP53BP1 protein CTD PMID:23301498 ethanol affects splicing EXP 6480464 Ethanol affects the splicing of TRP53BP1 mRNA CTD PMID:30319688 etoposide multiple interactions ISO RGD:1317577 6480464 pifithrin inhibits the reaction [Etoposide results in increased expression of and affects the localization of TP53BP1 protein] CTD PMID:26259609 etoposide increases expression ISO RGD:1317577 6480464 Etoposide results in increased expression of TP53BP1 protein CTD PMID:26259609 , PMID:27358234 geldanamycin increases expression ISO RGD:1317577 6480464 geldanamycin results in increased expression of TP53BP1 mRNA CTD PMID:26705709 gemcitabine increases expression ISO RGD:1317577 6480464 gemcitabine results in increased expression of TP53BP1 mRNA CTD PMID:17039268 hexadecanoic acid affects phosphorylation ISO RGD:1317577 6480464 Palmitic Acid affects the phosphorylation of TP53BP1 protein CTD PMID:28073184 indometacin multiple interactions ISO RGD:1317577 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of TP53BP1 mRNA CTD PMID:28628672 mercury dichloride decreases expression ISO RGD:1317577 6480464 Mercuric Chloride results in decreased expression of TP53BP1 mRNA CTD PMID:27188386 methylmercury chloride increases expression ISO RGD:1317577 6480464 methylmercuric chloride results in increased expression of TP53BP1 mRNA CTD PMID:28001369 nitric oxide decreases expression EXP 6480464 Nitric Oxide deficiency results in decreased expression of TRP53BP1 mRNA CTD PMID:15878706 oxaliplatin increases expression ISO RGD:1317577 6480464 oxaliplatin results in increased expression of TP53BP1 protein CTD PMID:21285347 oxaliplatin multiple interactions ISO RGD:1317577 6480464 MSH3 protein promotes the reaction [oxaliplatin results in increased expression of TP53BP1 protein] CTD PMID:21285347 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of TRP53BP1 mRNA CTD PMID:17562736 paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of TRP53BP1 protein CTD PMID:29540258 pentachlorophenol increases expression EXP 6480464 Pentachlorophenol results in increased expression of TRP53BP1 mRNA CTD PMID:23892564 phenobarbital affects expression EXP 6480464 Phenobarbital affects the expression of TRP53BP1 mRNA CTD PMID:23091169 potassium chromate decreases expression ISO RGD:1317577 6480464 potassium chromate(VI) results in decreased expression of TP53BP1 mRNA CTD PMID:22079256 potassium chromate multiple interactions ISO RGD:1317577 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TP53BP1 mRNA CTD PMID:22079256 rac-1,2-dichloropropane affects localization ISO RGD:1317577 6480464 propylene dichloride affects the localization of TP53BP1 protein CTD PMID:28300663 sodium arsenate increases expression EXP 6480464 sodium arsenate results in increased expression of TRP53BP1 mRNA CTD PMID:21795629 sodium arsenite decreases expression ISO RGD:1317577 6480464 sodium arsenite results in decreased expression of TP53BP1 mRNA CTD PMID:29161537 tamoxifen affects expression EXP 6480464 Tamoxifen affects the expression of TRP53BP1 mRNA CTD PMID:20937368 tert-butyl hydroperoxide decreases expression ISO RGD:1317577 6480464 tert-Butylhydroperoxide results in decreased expression of TP53BP1 mRNA CTD PMID:27509014 tert-butyl hydroperoxide decreases methylation ISO RGD:1317577 6480464 tert-Butylhydroperoxide results in decreased methylation of TP53BP1 gene CTD PMID:27509014 thimerosal decreases expression ISO RGD:1317577 6480464 Thimerosal results in decreased expression of TP53BP1 mRNA CTD PMID:27188386 thioacetamide increases expression ISO RGD:1308039 6480464 Thioacetamide results in increased expression of TP53BP1 mRNA CTD PMID:23411599 torcetrapib increases expression ISO RGD:1317577 6480464 torcetrapib results in increased expression of TP53BP1 mRNA CTD PMID:23228038 trichostatin A decreases expression ISO RGD:1317577 6480464 trichostatin A results in decreased expression of TP53BP1 mRNA CTD PMID:24935251 tungsten decreases expression EXP 6480464 Tungsten results in decreased expression of TRP53BP1 mRNA CTD PMID:30912803 valproic acid decreases expression ISO RGD:1317577 6480464 Valproic Acid results in decreased expression of TP53BP1 mRNA CTD PMID:24935251 vorinostat decreases expression ISO RGD:1317577 6480464 vorinostat results in decreased expression of TP53BP1 mRNA CTD PMID:27188386
Biological Process cellular response to DNA damage stimulus ISO UniProtKB:Q12888 2290270 (MGI:MGI:3718866, PMID:17500065) MGI GO_REF:0000096 more ... DNA damage checkpoint IBA PANTHER:PTN001809041 , SGD:S000002625 2290270 (PMID:21873635) GO_Central PMID:21873635 DNA repair IDA 2290270 (MGI:MGI:3053255, PMID:15364958) MGI MGI:MGI:3053255 , PMID:15364958 double-strand break repair via nonhomologous end joining ISO UniProtKB:Q12888 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 double-strand break repair via nonhomologous end joining IDA 2290270 (MGI:MGI:5887194, PMID:20362325) UniProtKB MGI:MGI:5887194 , PMID:20362325 double-strand break repair via nonhomologous end joining IMP 2290270 (MGI:MGI:5476381, PMID:23333305) UniProtKB MGI:MGI:5476381 , PMID:23333305 negative regulation of double-strand break repair via homologous recombination ISO UniProtKB:Q12888 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 negative regulation of double-strand break repair via homologous recombination IMP 2290270 (MGI:MGI:5476381, PMID:23333305) UniProtKB MGI:MGI:5476381 , PMID:23333305 negative regulation of double-strand break repair via homologous recombination IDA 2290270 (MGI:MGI:5887194, PMID:20362325) UniProtKB MGI:MGI:5887194 , PMID:20362325 positive regulation of isotype switching ISO UniProtKB:Q12888 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 positive regulation of isotype switching IMP 2290270 (MGI:MGI:3041657 more ... UniProtKB MGI:MGI:3041657 more ... positive regulation of transcription by RNA polymerase II ISO UniProtKB:Q12888 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 positive regulation of transcription by RNA polymerase II IBA PANTHER:PTN001809041 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 protein homooligomerization ISO UniProtKB:Q12888 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 regulation of transcription, DNA-templated TAS 2290270 (MGI:MGI:84329, PMID:8910340) MGI MGI:MGI:84329 , PMID:8910340 Cellular Component chromosome IEA UniProtKB-KW:KW-0158 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 chromosome, centromeric region IEA UniProtKB-KW:KW-0137 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 chromosome, telomeric region colocalizes_with ISO UniProtKB:Q12888 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 cytoplasm ISO UniProtKB:Q12888 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 DNA repair complex IDA 2290270 (MGI:MGI:5562615, PMID:24217620) MGI MGI:MGI:5562615 , PMID:24217620 kinetochore IDA 2290270 (MGI:MGI:2158030, PMID:11801725) MGI MGI:MGI:2158030 , PMID:11801725 nuclear body ISO UniProtKB:Q12888 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 nuclear body IDA 2290270 (MGI:MGI:5139938, PMID:21746928) MGI MGI:MGI:5139938 , PMID:21746928 nuclear chromosome, telomeric region IDA 2290270 (MGI:MGI:3831647, PMID:19001091) MGI MGI:MGI:3831647 , PMID:19001091 nucleoplasm ISO UniProtKB:Q12888 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 nucleus IDA 2290270 (MGI:MGI:5547894, PMID:24001775) MGI MGI:MGI:5547894 , PMID:24001775 nucleus IBA MGI:MGI:1351320 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 nucleus ISO RGD:1308039 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 nucleus ISO UniProtKB:Q12888 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 replication fork IDA 2290270 (MGI:MGI:3053255, PMID:15364958) MGI MGI:MGI:3053255 , PMID:15364958 site of double-strand break ISO UniProtKB:Q12888 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 site of double-strand break IDA 2290270 (MGI:MGI:5476381 more ... UniProtKB MGI:MGI:5476381 more ... Molecular Function damaged DNA binding IDA 2290270 (MGI:MGI:2179182, PMID:11934988) MGI MGI:MGI:2179182 , PMID:11934988 DNA binding IEA UniProtKB-KW:KW-0238 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 histone binding IBA PANTHER:PTN001809041 , SGD:S000002625 2290270 (PMID:21873635) GO_Central PMID:21873635 methylated histone binding ISO UniProtKB:Q12888 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 methylated histone binding IDA 2290270 (MGI:MGI:5887191, PMID:23209566) UniProtKB MGI:MGI:5887191 , PMID:23209566 p53 binding ISO UniProtKB:Q12888 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 protein binding IPI UniProtKB:P15091 2290270 (MGI:MGI:84329, PMID:8910340) MGI MGI:MGI:84329 , PMID:8910340 protein binding IPI UniProtKB:P53350 2290270 (MGI:MGI:5915058, PMID:20126263) IntAct MGI:MGI:5915058 , PMID:20126263 protein binding IPI UniProtKB:Q6PR54 2290270 (MGI:MGI:5468036 more ... UniProtKB MGI:MGI:5468036 more ... protein binding IPI UniProtKB:O88700 , UniProtKB:P02340 2290270 (MGI:MGI:3053255, PMID:15364958) MGI MGI:MGI:3053255 , PMID:15364958 RNA polymerase II activating transcription factor binding ISO UniProtKB:Q12888 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 sequence-specific DNA binding IDA 2290270 (MGI:MGI:5462481, PMID:23241889) MGI MGI:MGI:5462481 , PMID:23241889 telomeric DNA binding IDA 2290270 (MGI:MGI:3692019, PMID:17053789) MGI MGI:MGI:3692019 , PMID:17053789 transcription coregulator activity ISO UniProtKB:Q12888 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 transcription factor binding TAS 2290270 (MGI:MGI:84329, PMID:8910340) MGI MGI:MGI:84329 , PMID:8910340 ubiquitin modification-dependent histone binding ISO UniProtKB:Q12888 2290270 MGI GO_REF:0000096, MGI:MGI:4834177
Gene-Chemical Interaction Annotations
