Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Trp53bp1 (transformation related protein 53 binding protein 1) Mus musculus
Symbol: Trp53bp1
Name: transformation related protein 53 binding protein 1
Description: Exhibits damaged DNA binding activity; methylated histone binding activity; and telomeric DNA binding activity. Involved in double-strand break repair via nonhomologous end joining; negative regulation of double-strand break repair via homologous recombination; and positive regulation of isotype switching. Localizes to the DNA repair complex; chromosome; and nuclear body. Predicted to colocalize with the chromosome, telomeric region. Is expressed in ileum; lung; metanephros; nervous system; and sensory organ. Orthologous to human TP53BP1 (tumor protein p53 binding protein 1); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; histone modification pathway; non-homologous end joining pathway of double-strand break repair; INTERACTS WITH 1H-pyrazole; 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 53BP1; m53BP1; MGC100303; murine p53-binding protein; p53-binding protein 1; p53BP1; TP53-binding protein 1; Tp53bp1; transformation related protein 53 binding-protein 1; tumor suppressor p53-binding protein 1
Homo sapiens (human) : TP53BP1 (tumor protein p53 binding protein 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Tp53bp1 (tumor protein p53 binding protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tp53bp1 (tumor protein p53 binding protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TP53BP1 (tumor protein p53 binding protein 1)
Canis lupus familiaris (dog) : TP53BP1 (tumor protein p53 binding protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tp53bp1 (tumor protein p53 binding protein 1)
Sus scrofa (pig) : TP53BP1 (tumor protein p53 binding protein 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl2121,193,281 - 121,271,407 (-)Ensembl
GRCm382121,194,835 - 121,296,354 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372121,022,463 - 121,097,122 (-)NCBIGRCm37mm9NCBIm37
MGSCv362120,889,692 - 120,962,561 (-)NCBImm8
Celera2122,346,827 - 122,423,056 (-)NCBICelera
Cytogenetic Map2 E5NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Trp53bp1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1317578
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.