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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11329
Species: Mus musculus
RGD Object: Gene
Symbol: Sod1
Name: superoxide dismutase 1, soluble
Acc ID: CHEBI:16480
Term: nitric oxide
Definition: A nitrogen oxide which is a free radical, each molecule of which consists of one nitrogen and one oxygen atom.
Chemical ID: MESH:D009569
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod1increases abundanceEXP 6480464CTDSOD1 protein results in increased abundance of Nitric OxidePMID:21443684
Sod1decreases response to substanceISOSOD1 (Homo sapiens)6480464CTDNitric Oxide deficiency results in decreased susceptibility to SOD1 protein mutant formPMID:19845829
Sod1multiple interactionsISOSod1 (Rattus norvegicus)6480464CTDNitric Oxide deficiency inhibits the reaction [Formaldehyde results in increased expression of SOD1 mRNA]PMID:21983654
Sod1multiple interactionsISOSOD1 (Homo sapiens)6480464CTDSOD1 protein inhibits the reaction [[spermine nitric oxide complex results in increased abundance of Nitric Oxide] which results in increased abundance of Superoxides]; SOD1 protein inhibits the reaction [Nitric Oxide results in decreased activity of NOS3 protein]; SOD1 protein inhibits the reaction [Nitric Oxide results in increased abundance of Peroxynitrous Acid]PMID:12489993
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