GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Edn1 | increases expression | EXP | | 6480464 | CTD | Nitric Oxide results in increased expression of EDN1 mRNA | PMID:20197249 | Edn1 | decreases activity | ISO | Edn1 (Rattus norvegicus) | 6480464 | CTD | Nitric Oxide deficiency results in decreased activity of EDN1 protein | PMID:16810074 | Edn1 | decreases expression | ISO | EDN1 (Homo sapiens) | 6480464 | CTD | Nitric Oxide results in decreased expression of EDN1 protein | PMID:15838368 | Edn1 | increases abundance | ISO | Edn1 (Rattus norvegicus) | 6480464 | CTD | EDN1 protein results in increased abundance of Nitric Oxide | PMID:16380457 | Edn1 | increases chemical synthesis | ISO | EDN1 (Homo sapiens) | 6480464 | CTD | EDN1 protein results in increased chemical synthesis of Nitric Oxide | PMID:11187978 | Edn1 | increases expression | ISO | Edn1 (Rattus norvegicus) | 6480464 | CTD | Nitric Oxide deficiency results in increased expression of EDN1 mRNA | PMID:16326922 | Edn1 | increases expression | ISO | EDN1 (Homo sapiens) | 6480464 | CTD | Nitric Oxide results in increased expression of EDN1 protein | PMID:20929026 | Edn1 | increases secretion | ISO | Edn1 (Rattus norvegicus) | 6480464 | CTD | Nitric Oxide results in increased secretion of EDN1 protein | PMID:15640287 | Edn1 | multiple interactions | ISO | Edn1 (Rattus norvegicus) | 6480464 | CTD | [EDN1 protein results in increased activity of EDNRB protein] which results in increased abundance of Nitric Oxide; [EDN1 protein results in increased activity of NOS1 protein] which results in increased abundance of Nitric Oxide; BQ 788 inhibits the reaction [EDN1 protein results in increased abundance of Nitric Oxide]; Hydralazine inhibits the reaction [Nitric Oxide deficiency results in increased expression of EDN1 mRNA]; Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of EDN1 mRNA]; Nitric Oxide inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]; Nitric Oxide inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK3 protein]; S-methylthiocitrulline inhibits the reaction [EDN1 protein results in increased abundance of Nitric Oxide] | PMID:16326922 PMID:16380457 PMID:16389725 | | ||||||||||||||||||||||
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