Sftpc (surfactant associated protein C) - Rat Genome Database

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Gene: Sftpc (surfactant associated protein C) Mus musculus
Analyze
Symbol: Sftpc
Name: surfactant associated protein C
RGD ID: 733829
MGI Page MGI
Description: Predicted to enable identical protein binding activity. Located in cytoplasm and extracellular region. Is expressed in several structures, including lung and main bronchus epithelium. Used to study desquamative interstitial pneumonia. Human ortholog(s) of this gene implicated in asthma; lung disease (multiple); and respiratory syncytial virus infectious disease. Orthologous to human SFTPC (surfactant protein C).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Bric; Bricd6; pr; pro-SpC; pulmonary surfactant-associated protein C; pulmonary surfactant-associated proteolipid SPL(Val); S; Sft; Sftp; Sftp-2; Sftp2; SP; SP-C; SP5; SPC
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391470,758,381 - 70,761,521 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1470,758,389 - 70,761,521 (-)EnsemblGRCm39 Ensembl
GRCm381470,520,941 - 70,524,081 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1470,520,949 - 70,524,081 (-)EnsemblGRCm38mm10GRCm38
MGSCv371470,920,748 - 70,923,888 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361469,256,020 - 69,259,150 (-)NCBIMGSCv36mm8
Celera1468,062,491 - 68,065,631 (-)NCBICelera
Cytogenetic Map14D2NCBI
cM Map1436.32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (EXP)
17alpha-ethynylestradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
3,7-dihydropurine-6-thione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-phenylbutyric acid  (ISO)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (ISO)
amiodarone  (EXP)
ammonium chloride  (ISO)
ATP  (EXP,ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (ISO)
bleomycin A2  (ISO)
bosentan  (ISO)
carbon nanotube  (EXP)
CHIR 99021  (ISO)
chlorpyrifos  (EXP)
ciguatoxin CTX1B  (EXP)
colforsin daropate hydrochloride  (ISO)
cortisol  (ISO)
crocidolite asbestos  (EXP)
dexamethasone  (ISO)
fonofos  (ISO)
ionomycin  (EXP,ISO)
L-ascorbic acid  (ISO)
lead diacetate  (EXP)
lipopolysaccharide  (EXP,ISO)
LY294002  (EXP)
mercaptopurine  (ISO)
N-ethyl-5'-carboxamidoadenosine  (EXP,ISO)
nickel atom  (EXP)
nickel subsulfide  (ISO)
nickel sulfate  (EXP)
nicotine  (EXP)
nitric oxide  (ISO)
nitrofen  (EXP,ISO)
ozone  (EXP,ISO)
paraquat  (ISO)
parathion  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
protein kinase inhibitor  (ISO)
purine-6-thiol  (ISO)
pyrrolidine dithiocarbamate  (ISO)
resveratrol  (ISO)
Ro 31-8220  (ISO)
S-nitroso-N-acetyl-D-penicillamine  (ISO)
silicon carbide  (ISO)
silicon dioxide  (ISO)
sodium chlorate  (ISO)
terbufos  (ISO)
terbutaline  (EXP,ISO)
testosterone  (ISO)
titanium dioxide  (EXP)
tubocurarine  (EXP)
UTP  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vinyl carbamate  (EXP)
vitamin D  (EXP)
wortmannin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Surfactant protein deficiency in familial interstitial lung disease. Amin RS, etal., J Pediatr. 2001 Jul;139(1):85-92.
2. Pneumocystis carinii pneumonia alters expression and distribution of lung collectins SP-A and SP-D. Atochina EN, etal., J Lab Clin Med. 2001 Jun;137(6):429-39.
3. Attenuated allergic airway hyperresponsiveness in C57BL/6 mice is associated with enhanced surfactant protein (SP)-D production following allergic sensitization. Atochina EN, etal., Respir Res. 2003 Dec 8;4:15. Print 2003.
4. Two novel mutations in surfactant protein-C, lung function and obstructive lung disease. Baekvad-Hansen M, etal., Respir Med. 2010 Mar;104(3):418-25. Epub 2009 Nov 11.
5. A common mutation in the surfactant protein C gene associated with lung disease. Cameron HS, etal., J Pediatr. 2005 Mar;146(3):370-5.
6. Surfactant protein levels in bronchoalveolar lavage after segmental allergen challenge in patients with asthma. Erpenbeck VJ, etal., Allergy. 2006 May;61(5):598-604.
7. Dynamic investigation of alveolar type II cell function in a long-term survival model of rat lung ischemia-reperfusion injury. Feng D, etal., Scand J Clin Lab Invest. 2010 Sep;70(5):364-73.
8. Serum surfactant protein D is increased in acute and chronic inflammation in mice. Fujita M, etal., Cytokine. 2005 Jul 7;31(1):25-33.
9. Surfactant protein C-deficient mice are susceptible to respiratory syncytial virus infection. Glasser SW, etal., Am J Physiol Lung Cell Mol Physiol. 2009 Jul;297(1):L64-72. Epub 2009 Mar 20.
10. Pneumonitis and emphysema in sp-C gene targeted mice. Glasser SW, etal., J Biol Chem. 2003 Apr 18;278(16):14291-8. Epub 2003 Jan 7.
11. Macrophage dysfunction and susceptibility to pulmonary Pseudomonas aeruginosa infection in surfactant protein C-deficient mice. Glasser SW, etal., J Immunol. 2008 Jul 1;181(1):621-8.
12. Pulmonary surfactant, lung function, and endobronchial inflammation in cystic fibrosis. Griese M, etal., Am J Respir Crit Care Med. 2004 Nov 1;170(9):1000-5. Epub 2004 Jul 21.
13. New surfactant protein C gene mutations associated with diffuse lung disease. Guillot L, etal., J Med Genet. 2009 Jul;46(7):490-4. Epub 2009 May 13.
14. Defective surfactant secretion in a mouse model of Hermansky-Pudlak syndrome. Guttentag SH, etal., Am J Respir Cell Mol Biol. 2005 Jul;33(1):14-21. Epub 2005 Mar 24.
15. Aspergillus fumigatus-induced allergic airway inflammation alters surfactant homeostasis and lung function in BALB/c mice. Haczku A, etal., Am J Respir Cell Mol Biol. 2001 Jul;25(1):45-50.
16. Effects of rSP-C surfactant on oxygenation and histology in a rat-lung-lavage model of acute lung injury. Hafner D, etal., Am J Respir Crit Care Med. 1998 Jul;158(1):270-8.
17. Comparison of rSP-C surfactant with natural and synthetic surfactants after late treatment in a rat model of the acute respiratory distress syndrome. Hafner D, etal., Br J Pharmacol. 1998 Jul;124(6):1083-90.
18. Lung epithelium is the major source of IL-33 and is regulated by IL-33-dependent and IL-33-independent mechanisms in pulmonary cryptococcosis. Heyen L, etal., Pathog Dis. 2016 Oct;74(7). pii: ftw086. doi: 10.1093/femspd/ftw086. Epub 2016 Sep 4.
19. Deficiency of SP-B reveals protective role of SP-C during oxygen lung injury. Ikegami M, etal., J Appl Physiol. 2002 Feb;92(2):519-26.
20. Increased and prolonged pulmonary fibrosis in surfactant protein C-deficient mice following intratracheal bleomycin. Lawson WE, etal., Am J Pathol. 2005 Nov;167(5):1267-77.
21. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
22. MGDs mouse GO annotations MGD data from the GO Consortium
23. MGD IEA MGD IEA
24. A mutation in the surfactant protein C gene associated with familial interstitial lung disease. Nogee LM, etal., N Engl J Med. 2001 Feb 22;344(8):573-9.
25. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
26. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
27. Haplotypes of surfactant protein C are associated with common paediatric lung diseases. Puthothu B, etal., Pediatr Allergy Immunol. 2006 Dec;17(8):572-7.
28. Mouse MP Annotation Import Pipeline RGD automated import pipeline
29. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
30. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
31. Total extracellular surfactant is increased but abnormal in a rat model of gram-negative bacterial pneumonia. Russo TA, etal., Am J Physiol Lung Cell Mol Physiol. 2002 Sep;283(3):L655-63.
32. Respiratory distress after intratracheal bleomycin: selective deficiency of surfactant proteins B and C. Savani RC, etal., Am J Physiol Lung Cell Mol Physiol. 2001 Sep;281(3):L685-96.
33. Time-dependent changes in pulmonary surfactant function and composition in acute respiratory distress syndrome due to pneumonia or aspiration. Schmidt R, etal., Respir Res. 2007 Jul 27;8:55.
34. Clinical features and genetic analysis of surfactant protein C in adult-onset familial interstitial pneumonia. Setoguchi Y, etal., Respirology. 2006 Jan;11 Suppl:S41-5.
35. [Genetic basis in chronic interstitial familial pneumopathy. Familial study of SFTPC] Somaschini M, etal., Pediatr Med Chir. 2005 May-Aug;27(3-4):103-7.
36. Overexpression of surfactant protein SP-A, SP-B, and SP-C mRNA in rat lungs with lipopolysaccharide-induced injury. Sugahara K, etal., Lab Invest. 1996 Jan;74(1):209-20.
37. [Polymorphic variants of a surfactant protein C gene in patients with chronic obstructive pulmonary disease]. Tsvetkova OA and Veselovskaia MV, Ter Arkh. 2007;79(9):65-9.
38. SFTPC Mutations are the Basis of a Significant Portion of Adult Familial Pulmonary Fibrosis in a Dutch Cohort. van Moorsel CH, etal., Am J Respir Crit Care Med. 2010 Jul 23.
39. Aberrant processing of surfactant protein C in hereditary SP-B deficiency. Vorbroker DK, etal., Am J Physiol. 1995 Apr;268(4 Pt 1):L647-56.
40. Elevated expression of surfactant proteins in newborn rats during adaptation to hyperoxia. White CW, etal., Am J Respir Cell Mol Biol. 2001 Jul;25(1):51-9.
Additional References at PubMed
PMID:1346779   PMID:1733280   PMID:2254341   PMID:7543410   PMID:7628695   PMID:7644495   PMID:7913017   PMID:8001981   PMID:8622914   PMID:8674409   PMID:8813084   PMID:9006067  
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PMID:12361974   PMID:12477932   PMID:12495930   PMID:12496149   PMID:12761850   PMID:12812790   PMID:12819125   PMID:12829717   PMID:12885771   PMID:12941618   PMID:14517255   PMID:14525980  
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PMID:20060823   PMID:20147383   PMID:20223754   PMID:20228843   PMID:20303366   PMID:20407208   PMID:20530543   PMID:20553735   PMID:20595636   PMID:20727874   PMID:20852037   PMID:21049041  
PMID:21129374   PMID:21169555   PMID:21257925   PMID:21267068   PMID:21270055   PMID:21303850   PMID:21350014   PMID:21385574   PMID:21408140   PMID:21438071   PMID:21482757   PMID:21503901  
PMID:21505443   PMID:21513708   PMID:21515253   PMID:21659474   PMID:21682884   PMID:21701069   PMID:21704616   PMID:21791528   PMID:21826198   PMID:21865055   PMID:21873635   PMID:21896782  
PMID:21985298   PMID:22001906   PMID:22014525   PMID:22096492   PMID:22096573   PMID:22123957   PMID:22162244   PMID:22194995   PMID:22331706   PMID:22411169   PMID:22411819   PMID:22421361  
PMID:22493501   PMID:22675208   PMID:22730381   PMID:22821687   PMID:22876201   PMID:22878413   PMID:22916088   PMID:22917924   PMID:23023706   PMID:23028652   PMID:23063659   PMID:23139760  
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PMID:23590306   PMID:23620511   PMID:23637629   PMID:23637738   PMID:23696835   PMID:23701443   PMID:23742148   PMID:23795648   PMID:23836893   PMID:23884445   PMID:23895934   PMID:23921127  
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PMID:25912685   PMID:25978641   PMID:26001956   PMID:26146081   PMID:26178733   PMID:26235626   PMID:26252542   PMID:26329601   PMID:26402555   PMID:26416771   PMID:26439735   PMID:26488883  
PMID:26511927   PMID:26555052   PMID:26567140   PMID:26743624   PMID:26816051   PMID:26878215   PMID:26921474   PMID:26984772   PMID:27035511   PMID:27106761   PMID:27141870   PMID:27150575  
PMID:27190064   PMID:27312374   PMID:27335464   PMID:27341756   PMID:27355685   PMID:27364009   PMID:27412481   PMID:27481995   PMID:27498861   PMID:27578791   PMID:27645581   PMID:27654891  
PMID:27694932   PMID:27699234   PMID:27748998   PMID:27770432   PMID:27861515   PMID:27864284   PMID:27880906   PMID:27913639   PMID:27967234   PMID:27979858   PMID:28002412   PMID:28216153  
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PMID:29999500   PMID:30022023   PMID:30183330   PMID:30194919   PMID:30305289   PMID:30389913   PMID:30389914   PMID:30578393   PMID:30604742   PMID:30643263   PMID:30651296   PMID:30655340  
PMID:30721158   PMID:30728831   PMID:30778223   PMID:30782824   PMID:30865885   PMID:30887098   PMID:30910861   PMID:30944105   PMID:30985294   PMID:30996081   PMID:31028085   PMID:31028279  
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PMID:31462798   PMID:31467330   PMID:31486675   PMID:31548395   PMID:31562139   PMID:31582725   PMID:31685810   PMID:31738079   PMID:31767619   PMID:31771978   PMID:31776260   PMID:31792060  
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PMID:33979629   PMID:33998997   PMID:34079126   PMID:34138759   PMID:34230964   PMID:34237032   PMID:34431978   PMID:34497269   PMID:34626771   PMID:34671097   PMID:34789718   PMID:34793600  
PMID:34927678   PMID:34931663   PMID:34932949   PMID:35050901   PMID:35303432   PMID:35351885   PMID:35512705   PMID:35676931   PMID:35682694   PMID:35705813   PMID:35765931   PMID:35803279  
PMID:36098964   PMID:36115458   PMID:36414616   PMID:36433959  


Genomics

Comparative Map Data
Sftpc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391470,758,381 - 70,761,521 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1470,758,389 - 70,761,521 (-)EnsemblGRCm39 Ensembl
GRCm381470,520,941 - 70,524,081 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1470,520,949 - 70,524,081 (-)EnsemblGRCm38mm10GRCm38
MGSCv371470,920,748 - 70,923,888 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361469,256,020 - 69,259,150 (-)NCBIMGSCv36mm8
Celera1468,062,491 - 68,065,631 (-)NCBICelera
Cytogenetic Map14D2NCBI
cM Map1436.32NCBI
SFTPC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38822,157,383 - 22,164,479 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl822,156,913 - 22,164,479 (+)EnsemblGRCh38hg38GRCh38
GRCh37822,014,896 - 22,021,992 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36822,075,129 - 22,077,937 (+)NCBINCBI36Build 36hg18NCBI36
Build 34822,075,112 - 22,077,928NCBI
Celera820,981,168 - 20,983,976 (+)NCBICelera
Cytogenetic Map8p21.3NCBI
HuRef820,561,488 - 20,564,296 (+)NCBIHuRef
CHM1_1822,220,843 - 22,223,651 (+)NCBICHM1_1
T2T-CHM13v2.0822,431,328 - 22,438,424 (+)NCBIT2T-CHM13v2.0
Sftpc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21545,596,565 - 45,599,615 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1545,596,574 - 45,610,777 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1549,714,437 - 49,717,379 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01550,825,943 - 50,828,885 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01547,685,234 - 47,688,176 (-)NCBIRnor_WKY
Rnor_6.01552,211,538 - 52,214,480 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1552,211,544 - 52,214,616 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01555,935,055 - 55,937,997 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41550,923,105 - 50,926,047 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11550,938,884 - 50,941,827 (-)NCBI
Celera1545,274,971 - 45,277,913 (-)NCBICelera
Cytogenetic Map15p11NCBI
Sftpc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540345,649,122 - 45,651,837 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540345,649,149 - 45,651,421 (+)NCBIChiLan1.0ChiLan1.0
SFTPC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1818,343,007 - 18,348,764 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl818,345,940 - 18,348,764 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0821,402,060 - 21,409,438 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
SFTPC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12535,088,295 - 35,090,995 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2535,088,279 - 35,091,457 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2535,677,864 - 35,680,614 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02535,299,616 - 35,302,366 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2535,299,694 - 35,302,250 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12535,245,093 - 35,247,843 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02535,099,613 - 35,102,363 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02535,255,134 - 35,257,884 (-)NCBIUU_Cfam_GSD_1.0
Sftpc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494312,588,481 - 12,596,579 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365555,979,417 - 5,982,011 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365555,966,610 - 5,982,083 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SFTPC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl146,440,309 - 6,443,095 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1146,440,309 - 6,443,104 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2146,868,096 - 6,880,564 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SFTPC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1820,229,756 - 20,233,568 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl820,230,870 - 20,234,020 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605222,002,517 - 22,009,591 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sftpc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475817,742,415 - 17,744,655 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475817,742,439 - 17,744,664 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:168
Count of miRNA genes:145
Interacting mature miRNAs:161
Transcripts:ENSMUST00000022692
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
1357527Epfpq1_mepididymal fat percentage QTL 1 (mouse)Not determined142106245071885801Mouse
27226774Tibl15_mtibia length 15, 10 week (mouse)143032195787937436Mouse
10043887Cia50_mcollagen induced arthritis QTL 50 (mouse)Not determined143743018571430320Mouse
4142419Tgq26_mtriglyceride QTL 26 (mouse)Not determined4033731974337319Mouse
1301777Bglq15_mbody growth late QTL 15 (mouse)Not determined144296241676962593Mouse
1301424Skull21_mskull morphology 21 (mouse)Not determined144296241676962593Mouse
1300805Mors3_mmodifier of obesity related sterility 3 (mouse)Not determined144303727077037418Mouse
1301091Bbaa21_mB.burgdorferi-associated arthritis 21 (mouse)Not determined144306584777066045Mouse
4141400Nilac8_mnicotine induced locomotor activity 8 (mouse)Not determined144306584777066045Mouse
1300605El5_mepilepsy 5 (mouse)Not determined144945542583455556Mouse
4142364Pbwg18_mpostnatal body weight growth 18 (mouse)Not determined145228198486282125Mouse
1301489Lbm10_mlean body mass 10 (mouse)Not determined145376129687761529Mouse
12880432Fgf23lq3_mFGF23 serum level QTL 3 (mouse)145393744087937440Mouse
10043889Cia52_mcollagen induced arthritis QTL 52 (mouse)Not determined145608238190082509Mouse
1301562Hwq1_mheart weight quantitative locus 1 (mouse)Not determined145654674590546941Mouse
1357565wrmod1_mwobbler modifier 1 (mouse)Not determined1458179640101859473Mouse
11039527Ccc2_mcolitis susceptibility in the Collaborative Cross 2 (mouse)145991861294138217Mouse
1300666Fembm2_mfemoral bone morphometry 2 (mouse)Not determined146239746096397680Mouse
14747006Mancz12_mmandible centroid size 12 (mouse)1470071977104071977Mouse

Markers in Region
D14Mit33  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381470,523,236 - 70,523,528UniSTSGRCm38
MGSCv371470,923,043 - 70,923,335UniSTSGRCm37
Celera1468,064,786 - 68,065,078UniSTS
Cytogenetic Map14D2UniSTS
cM Map1432.5UniSTS
Whitehead Genetic1440.4UniSTS
Whitehead_YAC14 UniSTS
D14Mit32  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381470,523,856 - 70,524,089UniSTSGRCm38
MGSCv371470,923,663 - 70,923,896UniSTSGRCm37
Celera1468,065,406 - 68,065,639UniSTS
Cytogenetic Map14D2UniSTS
cM Map1432.5UniSTS
Whitehead Genetic1440.4UniSTS
Whitehead_YAC14 UniSTS
Sftpc  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381470,521,402 - 70,522,178UniSTSGRCm38
MGSCv371470,921,209 - 70,921,985UniSTSGRCm37
Celera1468,062,952 - 68,063,728UniSTS
Cytogenetic Map14D2UniSTS
cM Map1432.5UniSTS
cM Map1432.5UniSTS
Sftpc  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381470,522,232 - 70,522,679UniSTSGRCm38
MGSCv371470,922,039 - 70,922,486UniSTSGRCm37
Celera1468,063,782 - 68,064,229UniSTS
Cytogenetic Map14D2UniSTS
Sftpc  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381470,521,432 - 70,522,703UniSTSGRCm38
MGSCv371470,921,239 - 70,922,510UniSTSGRCm37
Celera1468,062,982 - 68,064,253UniSTS
Cytogenetic Map14D2UniSTS
cM Map1432.5UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000022692   ⟹   ENSMUSP00000022692
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1470,758,393 - 70,761,521 (-)Ensembl
GRCm38.p6 Ensembl1470,520,953 - 70,524,081 (-)Ensembl
RefSeq Acc Id: ENSMUST00000227152
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1470,758,389 - 70,759,616 (-)Ensembl
GRCm38.p6 Ensembl1470,520,949 - 70,522,176 (-)Ensembl
RefSeq Acc Id: NM_011359   ⟹   NP_035489
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391470,758,381 - 70,761,521 (-)NCBI
GRCm381470,520,941 - 70,524,081 (-)ENTREZGENE
MGSCv371470,920,748 - 70,923,888 (-)RGD
Celera1468,062,491 - 68,065,631 (-)RGD
cM Map14 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_035489 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40010 (Get FASTA)   NCBI Sequence Viewer  
  AAH61137 (Get FASTA)   NCBI Sequence Viewer  
  EDL35896 (Get FASTA)   NCBI Sequence Viewer  
  P21841 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_035489   ⟸   NM_011359
- UniProtKB: Q6P8P8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000022692   ⟸   ENSMUST00000022692
Protein Domains
BRICHOS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P21841-F1-model_v2 AlphaFold P21841 1-193 view protein structure

Promoters
RGD ID:8682920
Promoter ID:EPDNEW_M19491
Type:multiple initiation site
Name:Sftpc_1
Description:Mus musculus surfactant associated protein C , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381470,524,076 - 70,524,136EPDNEW
RGD ID:6847139
Promoter ID:MM_ACW:16518
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:SFTPC.BSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361470,921,621 - 70,922,672 (-)MPROMDB
RGD ID:6825409
Promoter ID:MM_KWN:17386
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:NM_011359_SFTPC
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361470,923,371 - 70,923,871 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:109517 AgrOrtholog
Ensembl Genes ENSMUSG00000022097 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000022692 ENTREZGENE
  ENSMUSP00000022692.4 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000022692 ENTREZGENE
  ENSMUST00000022692.5 UniProtKB/TrEMBL
InterPro BRICHOS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SP-C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SP-C_palmitoylation_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Surfactant_protein_propep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:20389 UniProtKB/TrEMBL
MGD MGI:109517 ENTREZGENE
NCBI Gene 20389 ENTREZGENE
PANTHER PTHR10800 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BRICHOS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SP_C-Propep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sftpc PhenoGen
PROSITE BRICHOS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SURFACT_PALMITOYL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BRICHOS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SF_P UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt P21841 ENTREZGENE, UniProtKB/Swiss-Prot
  Q6P8P8 ENTREZGENE, UniProtKB/TrEMBL