Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Cd28 (CD28 antigen) Mus musculus
Analyze
Symbol: Cd28
Name: CD28 antigen
Description: Exhibits protein kinase binding activity. Involved in several processes, including positive regulation of immune response; positive regulation of intracellular signal transduction; and regulation of lymphocyte activation. Localizes to the external side of plasma membrane and immunological synapse. Human ortholog(s) of this gene implicated in multiple sclerosis and type 1 diabetes mellitus. Orthologous to human CD28 (CD28 molecule); PARTICIPATES IN allograft rejection pathway; autoimmune thyroiditis pathway; graft-versus-host disease pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetohydrazide; acrolein.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: T-cell-specific surface glycoprotein CD28
Orthologs:
Homo sapiens (human) : CD28 (CD28 molecule)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cd28 (Cd28 molecule)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cd28 (CD28 molecule)
Pan paniscus (bonobo/pygmy chimpanzee) : CD28 (CD28 molecule)
Canis lupus familiaris (dog) : CD28 (CD28 molecule)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cd28 (CD28 molecule)
Sus scrofa (pig) : CD28 (CD28 molecule)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38160,746,388 - 60,773,359 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37160,803,232 - 60,830,203 (+)NCBIGRCm37mm9NCBIm37
MGSCv36160,691,012 - 60,717,905 (+)NCBImm8
Celera161,261,669 - 61,288,639 (+)NCBICelera
Cytogenetic Map1 C2NCBI
cM Map130.52NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Cd28
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10307
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.