Cd28 (CD28 antigen) - Rat Genome Database
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Gene: Cd28 (CD28 antigen) Mus musculus
Analyze
Symbol: Cd28
Name: CD28 antigen
RGD ID: 10307
Description: Exhibits protein kinase binding activity. Involved in several processes, including positive regulation of immune response; positive regulation of intracellular signal transduction; and regulation of lymphocyte activation. Localizes to external side of plasma membrane and immunological synapse. Human ortholog(s) of this gene implicated in multiple sclerosis and type 1 diabetes mellitus. Orthologous to human CD28 (CD28 molecule); PARTICIPATES IN allograft rejection pathway; autoimmune thyroiditis pathway; graft-versus-host disease pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetohydrazide; acrolein.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: T-cell-specific surface glycoprotein CD28
Orthologs:
Homo sapiens (human) : CD28 (CD28 molecule)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cd28 (Cd28 molecule)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cd28 (CD28 molecule)
Pan paniscus (bonobo/pygmy chimpanzee) : CD28 (CD28 molecule)
Canis lupus familiaris (dog) : CD28 (CD28 molecule)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cd28 (CD28 molecule)
Sus scrofa (pig) : CD28 (CD28 molecule)
Chlorocebus sabaeus (African green monkey) : CD28 (CD28 molecule)
Heterocephalus glaber (naked mole-rat) : Cd28 (CD28 molecule)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39160,785,547 - 60,812,521 (+)NCBI
GRCm38160,746,388 - 60,773,359 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl160,716,800 - 60,773,359 (+)EnsemblGRCm38mm10GRCm38
MGSCv37160,803,232 - 60,830,203 (+)NCBIGRCm37mm9NCBIm37
MGSCv36160,691,012 - 60,717,905 (+)NCBImm8
Celera161,261,669 - 61,288,639 (+)NCBICelera
Cytogenetic Map1C2NCBI
cM Map130.52NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal CD4-positive, alpha-beta T cell physiology  (IAGP)
abnormal CD8-positive, alpha beta T cell morphology  (IAGP)
abnormal class switch recombination  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal cytotoxic T cell physiology  (IAGP)
abnormal esophageal epithelium morphology  (IAGP)
abnormal eyelid morphology  (IAGP)
abnormal germinal center B cell physiology  (IAGP)
abnormal immunoglobulin level  (IAGP)
abnormal interferon level  (IAGP)
abnormal interleukin secretion  (IAGP)
abnormal lymphopoiesis  (IAGP)
abnormal NK cell physiology  (IAGP)
abnormal regulatory T cell physiology  (IAGP)
abnormal response to transplant  (IAGP)
abnormal T cell activation  (IAGP)
abnormal T cell anergy  (IAGP)
abnormal T cell clonal deletion  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal T cell proliferation  (IAGP)
abnormal T-helper 1 physiology  (IAGP)
abnormal T-helper 2 physiology  (IAGP)
abnormal thymocyte activation  (IAGP)
brain inflammation  (IAGP)
decreased B cell number  (IAGP)
decreased CD4-positive, alpha beta T cell number  (IAGP)
decreased circulating interferon-gamma level  (IAGP)
decreased circulating interleukin-4 level  (IAGP)
decreased cytotoxic T cell cytolysis  (IAGP)
decreased IgG1 level  (IAGP)
decreased IgG2a level  (IAGP)
decreased IgG2b level  (IAGP)
decreased IgM level  (IAGP)
decreased immunoglobulin level  (IAGP)
decreased interferon-gamma secretion  (IAGP)
decreased interleukin-12 secretion  (IAGP)
decreased interleukin-2 secretion  (IAGP)
decreased interleukin-4 secretion  (IAGP)
decreased lymphoma incidence  (IAGP)
decreased regulatory T cell number  (IAGP)
decreased spleen germinal center number  (IAGP)
decreased splenocyte proliferation  (IAGP)
decreased susceptibility to experimental autoimmune encephalomyelitis  (IAGP)
decreased susceptibility to type IV hypersensitivity reaction  (IAGP)
decreased T cell number  (IEA)
decreased T cell proliferation  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged spleen  (IAGP)
enlarged thymus  (IAGP)
esophageal inflammation  (IAGP)
focal hair loss  (IAGP)
hunched posture  (IAGP)
hypoactivity  (IAGP)
increased activated T cell number  (IAGP)
increased B cell number  (IAGP)
increased CD4-positive, alpha beta T cell number  (IAGP)
increased CD8-positive, alpha-beta T cell number  (IAGP)
increased eosinophil cell number  (IAGP)
increased IgG2a level  (IAGP)
increased interferon-gamma secretion  (IAGP)
increased interleukin-2 secretion  (IAGP)
increased interleukin-4 secretion  (IAGP)
increased length of allograft survival  (IAGP)
increased leukocyte cell number  (IEA)
increased memory T cell number  (IAGP)
increased splenocyte proliferation  (IAGP)
increased susceptibility to autoimmune diabetes  (IAGP)
increased susceptibility to autoimmune disorder  (IAGP)
increased susceptibility to experimental autoimmune encephalomyelitis  (IAGP)
increased susceptibility to parasitic infection  (IAGP)
increased susceptibility to type I hypersensitivity reaction  (IAGP)
increased T cell apoptosis  (IAGP)
increased T cell derived lymphoma incidence  (IAGP)
increased T cell proliferation  (IAGP)
insulitis  (IAGP)
no abnormal phenotype detected  (IAGP)
ruffled hair  (IAGP)
skin inflammation  (IAGP)
skin lesions  (IAGP)
References

References - curated
1. Arreaza GA, etal., J Clin Invest. 1997 Nov 1;100(9):2243-53.
2. Bachmaier K, etal., J Immunol. 1996 Aug 15;157(4):1752-7.
3. Bantsimba-Malanda C, etal., Am J Respir Crit Care Med. 2010 Aug 1;182(3):385-95. Epub 2010 Apr 15.
4. Barcelo B, etal., Eur Respir J. 2008 Mar;31(3):555-62. Epub 2007 Dec 5.
5. Beyersdorf N, etal., J Exp Med. 2005 Aug 1;202(3):445-55.
6. Botturi K, etal., Respir Res. 2011 Feb 28;12:25.
7. Chen X, etal., Blood. 2009 Apr 2;113(14):3226-34. Epub 2008 Dec 15.
8. Dolfi DV, etal., J Immunol. 2011 Apr 15;186(8):4599-608. Epub 2011 Mar 9.
9. Elflein K, etal., Blood. 2003 Sep 1;102(5):1764-70. Epub 2003 May 15.
10. Felonato M, etal., Infect Immun. 2010 Nov;78(11):4922-35. Epub 2010 Aug 16.
11. Heidema J, etal., J Immunol. 2007 Dec 15;179(12):8410-7.
12. Heron M, etal., Clin Exp Immunol. 2010 May;160(2):256-65. Epub 2009 Dec 17.
13. Ihara K, etal., Immunogenetics. 2001 Aug;53(6):447-54.
14. Lambers C, etal., Clin Exp Immunol. 2009 Mar;155(3):466-75.
15. Liu H, etal., Zhong Xi Yi Jie He Xue Bao. 2008 Jul;6(7):744-7.
16. Lorusso L, etal., Autoimmun Rev. 2009 Feb;8(4):287-91. Epub 2008 Sep 16.
17. MGD and Homologene mouse data transfer
18. MGD data from the GO Consortium
19. MGD IEA
20. Nolan A, etal., Am J Respir Crit Care Med. 2008 Feb 1;177(3):301-8. Epub 2007 Nov 7.
21. Pawlowski P, etal., Endokrynol Diabetol Chor Przemiany Materii Wieku Rozw. 2004;10(2):81-5.
22. Pechhold K, etal., J Immunol. 2001 Feb 15;166(4):2531-9.
23. Pipeline to import KEGG annotations from KEGG into RGD
24. RGD automated import pipeline
25. RGD automated import pipeline for gene-chemical interactions
26. Schmidt J, etal., J Neuroimmunol. 2003 Jul;140(1-2):143-52.
27. Teutsch SM, etal., J Neuroimmunol 2004 Mar;148(1-2):218-30.
28. Wang S, etal., Cardiology. 2010;115(2):107-13. doi: 10.1159/000256660. Epub 2009 Nov 10.
Additional References at PubMed
PMID:1281186   PMID:1320641   PMID:1347472   PMID:1431091   PMID:1671668   PMID:1713603   PMID:2157764   PMID:7515723   PMID:7525726   PMID:7534617   PMID:7539104   PMID:7544393  
PMID:7545666   PMID:7642234   PMID:7688139   PMID:7751626   PMID:7790813   PMID:7822814   PMID:7882171   PMID:7989745   PMID:8125140   PMID:8384947   PMID:8610339   PMID:8648099  
PMID:8649453   PMID:8676068   PMID:8676089   PMID:8683128   PMID:8717514   PMID:8751373   PMID:8752911   PMID:8808683   PMID:8898959   PMID:8934574   PMID:8943384   PMID:8992981  
PMID:9075933   PMID:9126966   PMID:9144484   PMID:9199871   PMID:9208839   PMID:9294148   PMID:9295036   PMID:9317105   PMID:9368605   PMID:9379007   PMID:9414285   PMID:9436464  
PMID:9498765   PMID:9529332   PMID:9541582   PMID:9647206   PMID:9653096   PMID:9653097   PMID:9732701   PMID:9759851   PMID:9886387   PMID:9973382   PMID:10078224   PMID:10201986  
PMID:10229827   PMID:10349636   PMID:10415007   PMID:10429671   PMID:10477557   PMID:10477582   PMID:10477604   PMID:10477605   PMID:10502560   PMID:10510372   PMID:10528184   PMID:10586076  
PMID:10605004   PMID:10605050   PMID:10679081   PMID:10693874   PMID:10725709   PMID:10725714   PMID:10725727   PMID:10742150   PMID:10748232   PMID:10779746   PMID:10791997   PMID:10795741  
PMID:10878386   PMID:10880049   PMID:10880526   PMID:10899917   PMID:10953030   PMID:11016460   PMID:11042159   PMID:11046015   PMID:11052947   PMID:11076861   PMID:11086053   PMID:11092808  
PMID:11120807   PMID:11120867   PMID:11145712   PMID:11157849   PMID:11160311   PMID:11217851   PMID:11238558   PMID:11238622   PMID:11247636   PMID:11276203   PMID:11285307   PMID:11329056  
PMID:11342617   PMID:11342622   PMID:11350825   PMID:11489978   PMID:11509650   PMID:11526404   PMID:11544297   PMID:11567634   PMID:11696572   PMID:11698427   PMID:11698433   PMID:11698438  
PMID:11698463   PMID:11707574   PMID:11723074   PMID:11801669   PMID:11826754   PMID:11837936   PMID:11861872   PMID:11884443   PMID:11908941   PMID:11929778   PMID:11937529   PMID:11937538  
PMID:11937552   PMID:11958588   PMID:11970987   PMID:12044964   PMID:12047751   PMID:12055251   PMID:12070288   PMID:12077322   PMID:12096029   PMID:12097399   PMID:12142553   PMID:12147624  
PMID:12193687   PMID:12193694   PMID:12218136   PMID:12239309   PMID:12391201   PMID:12432568   PMID:12444136   PMID:12466851   PMID:12471093   PMID:12477932   PMID:12496383   PMID:12515810  
PMID:12525576   PMID:12538664   PMID:12538715   PMID:12574364   PMID:12574376   PMID:12591901   PMID:12594842   PMID:12626553   PMID:12663542   PMID:12672399   PMID:12707299   PMID:12752681  
PMID:12759417   PMID:12829795   PMID:12835481   PMID:12867038   PMID:12874832   PMID:12902500   PMID:12923072   PMID:12925852   PMID:12937416   PMID:12946999   PMID:12960172   PMID:12960297  
PMID:14500627   PMID:14500690   PMID:14501867   PMID:14523041   PMID:14581610   PMID:14586728   PMID:14625545   PMID:14634147   PMID:14701943   PMID:14707048   PMID:14707071   PMID:14734751  
PMID:14973438   PMID:15004555   PMID:15016653   PMID:15024044   PMID:15034031   PMID:15039422   PMID:15100324   PMID:15128741   PMID:15128767   PMID:15128772   PMID:15135297   PMID:15187121  
PMID:15210771   PMID:15210777   PMID:15210826   PMID:15213110   PMID:15240667   PMID:15294937   PMID:15314039   PMID:15356139   PMID:15357951   PMID:15385476   PMID:15467837   PMID:15488732  
PMID:15494542   PMID:15514586   PMID:15536066   PMID:15539158   PMID:15585831   PMID:15585834   PMID:15611240   PMID:15629449   PMID:15634900   PMID:15634938   PMID:15640801   PMID:15657954  
PMID:15661893   PMID:15661906   PMID:15689402   PMID:15703298   PMID:15728451   PMID:15808517   PMID:15809349   PMID:15814667   PMID:15814687   PMID:15994233   PMID:16081804   PMID:16091384  
PMID:16116168   PMID:16141072   PMID:16141073   PMID:16148116   PMID:16239544   PMID:16239547   PMID:16301632   PMID:16301634   PMID:16311599   PMID:16365402   PMID:16369024   PMID:16424156  
PMID:16424201   PMID:16424212   PMID:16462800   PMID:16463658   PMID:16493028   PMID:16493033   PMID:16495554   PMID:16517696   PMID:16546096   PMID:16585571   PMID:16600196   PMID:16635747  
PMID:16724117   PMID:16751384   PMID:16771859   PMID:16791878   PMID:16809611   PMID:16908623   PMID:16934307   PMID:16940527   PMID:17015685   PMID:17055754   PMID:17056536   PMID:17114448  
PMID:17114476   PMID:17119120   PMID:17122127   PMID:17128276   PMID:17202836   PMID:17215523   PMID:17339461   PMID:17371988   PMID:17376197   PMID:17463170   PMID:17494743   PMID:17513738  
PMID:17548606   PMID:17617592   PMID:17617602   PMID:17618911   PMID:17629517   PMID:17635872   PMID:17641007   PMID:17690315   PMID:17702861   PMID:17720157   PMID:17873878   PMID:17947665  
PMID:17956982   PMID:17982038   PMID:18006698   PMID:18031697   PMID:18056348   PMID:18097000   PMID:18172933   PMID:18178855   PMID:18205792   PMID:18250436   PMID:18259608   PMID:18270248  
PMID:18287017   PMID:18310064   PMID:18328742   PMID:18331719   PMID:18354169   PMID:18354182   PMID:18390727   PMID:18523243   PMID:18606642   PMID:18606681   PMID:18628995   PMID:18641318  
PMID:18684917   PMID:18780833   PMID:18792405   PMID:18829987   PMID:18832683   PMID:18835195   PMID:18848473   PMID:19017952   PMID:19035513   PMID:19050242   PMID:19050251   PMID:19060239  
PMID:19077085   PMID:19109140   PMID:19122654   PMID:19179471   PMID:19188497   PMID:19190244   PMID:19217324   PMID:19234153   PMID:19234186   PMID:19249753   PMID:19268606   PMID:19326996  
PMID:19333372   PMID:19398542   PMID:19398586   PMID:19418202   PMID:19454657   PMID:19535626   PMID:19646680   PMID:19672303   PMID:19682930   PMID:19721011   PMID:19770391   PMID:19949106  
PMID:19950180   PMID:19966302   PMID:20007249   PMID:20065109   PMID:20137986   PMID:20215643   PMID:20228198   PMID:20421644   PMID:20471291   PMID:20601595   PMID:20601598   PMID:20628601  
PMID:20870175   PMID:20956339   PMID:21040905   PMID:21183789   PMID:21245484   PMID:21262800   PMID:21267068   PMID:21277900   PMID:21346228   PMID:21357256   PMID:21447398   PMID:21490618  
PMID:21530327   PMID:21606508   PMID:21690252   PMID:21745657   PMID:21844387   PMID:21873635   PMID:21931534   PMID:21949024   PMID:22068237   PMID:22156342   PMID:22231701   PMID:22285481  
PMID:22393155   PMID:22522653   PMID:22585421   PMID:22585681   PMID:22700722   PMID:22732586   PMID:22733595   PMID:22768209   PMID:22896637   PMID:22908331   PMID:22949644   PMID:23006848  
PMID:23047820   PMID:23065717   PMID:23102920   PMID:23144170   PMID:23281398   PMID:23300712   PMID:23348953   PMID:23487421   PMID:23589618   PMID:23671671   PMID:23690575   PMID:23716674  
PMID:23793062   PMID:23851689   PMID:23896981   PMID:23908246   PMID:23918985   PMID:23966623   PMID:24042341   PMID:24048955   PMID:24098053   PMID:24270545   PMID:24280042   PMID:24336670  
PMID:24487434   PMID:24493803   PMID:24516382   PMID:24633226   PMID:24639356   PMID:24688023   PMID:24711580   PMID:24752446   PMID:24909888   PMID:25029551   PMID:25054224   PMID:25180634  
PMID:25318356   PMID:25347065   PMID:25347469   PMID:25355918   PMID:25377239   PMID:25455592   PMID:25533288   PMID:25548162   PMID:25637021   PMID:25680271   PMID:25725801   PMID:25801976  
PMID:25825447   PMID:25833397   PMID:26002824   PMID:26146074   PMID:26249010   PMID:26301814   PMID:26408668   PMID:26485613   PMID:26507712   PMID:26711629   PMID:26773151   PMID:27122236  
PMID:27180986   PMID:27183621   PMID:27396441   PMID:27432861   PMID:27460989   PMID:27521344   PMID:27647348   PMID:28053234   PMID:28248972   PMID:28550204   PMID:28783663   PMID:28798231  
PMID:28919076   PMID:29042364   PMID:29058713   PMID:29093061   PMID:29425339   PMID:29661826   PMID:29773802   PMID:29862277   PMID:29909367   PMID:30007439   PMID:30148845   PMID:30320878  
PMID:31010850   PMID:31565151   PMID:31636135   PMID:31885821   PMID:32414925  


Genomics

Comparative Map Data
Cd28
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39160,785,547 - 60,812,521 (+)NCBI
GRCm38160,746,388 - 60,773,359 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl160,716,800 - 60,773,359 (+)EnsemblGRCm38mm10GRCm38
MGSCv37160,803,232 - 60,830,203 (+)NCBIGRCm37mm9NCBIm37
MGSCv36160,691,012 - 60,717,905 (+)NCBImm8
Celera161,261,669 - 61,288,639 (+)NCBICelera
Cytogenetic Map1C2NCBI
cM Map130.52NCBI
CD28
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2203,706,475 - 203,738,912 (+)EnsemblGRCh38hg38GRCh38
GRCh382203,706,509 - 203,739,756 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372204,571,198 - 204,603,635 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362204,279,443 - 204,310,801 (+)NCBINCBI36hg18NCBI36
Build 342204,396,703 - 204,428,062NCBI
Celera2198,326,049 - 198,357,410 (+)NCBI
Cytogenetic Map2q33.2NCBI
HuRef2196,418,462 - 196,450,899 (+)NCBIHuRef
CHM1_12204,577,787 - 204,610,219 (+)NCBICHM1_1
Cd28
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0967,546,408 - 67,573,858 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl967,546,408 - 67,571,871 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0967,358,994 - 67,386,424 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4959,342,273 - 59,367,743 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1959,489,254 - 59,514,725 (+)NCBI
Celera959,589,124 - 59,614,592 (+)NCBICelera
Cytogenetic Map9q32NCBI
RH 3.4 Map9504.6RGD
Cd28
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545711,162,282 - 11,192,991 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545711,159,769 - 11,253,099 (-)NCBIChiLan1.0ChiLan1.0
CD28
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B209,076,388 - 209,111,213 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B209,076,388 - 209,111,213 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B90,938,795 - 90,971,438 (+)NCBIMhudiblu_PPA_v0panPan3
CD28
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl3712,503,811 - 12,532,854 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.13712,503,849 - 12,536,362 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Cd28
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936631335,411 - 363,407 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CD28
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15107,128,208 - 107,162,943 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115107,128,103 - 107,155,431 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215118,472,553 - 118,502,433 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CD28
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl1089,471,730 - 89,500,387 (+)Ensembl
ChlSab1.11089,471,710 - 89,505,152 (+)NCBI
Cd28
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476512,650,092 - 12,667,168 (-)NCBI

Position Markers
M34563  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38160,770,133 - 60,770,242UniSTSGRCm38
MGSCv37160,826,977 - 60,827,086UniSTSGRCm37
Celera161,285,413 - 61,285,522UniSTS
Cytogenetic Map1C1-C3UniSTS
Whitehead/MRC_RH1881.78UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13824984Twq5_mtestis weight QTL 5 (mouse)13000000185000000Mouse
1357475w3q13_mweight 3 weeks QTL 13 (mouse)Not determined12307051073937756Mouse
11100001Col4a1m1_mcollagen, type IV, alpha 1 modifier 1 (mouse)12551111062907723Mouse
1357822Lvrq3_mliver weight QTL 3 (mouse)Not determined13472105773937756Mouse
1357759W3q12_mweight 3 weeks QTL 12 (mouse)Not determined13472105773937756Mouse
1357651Lgq5_mlate growth QTL 5 (mouse)Not determined13472105773937756Mouse
1357506W10q6_mweight 10 weeks QTL 6 (mouse)Not determined13472105773937756Mouse
1357524W6q14_mweight 6 weeks QTL 14 (mouse)Not determined13472105773937756Mouse
1357824Estoq4_membryo survival total QTL 4 (mouse)Not determined13472105773937756Mouse
39128207Lwq16_mliver weight QTL 16 (mouse)13472105773937756Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134721057150318120Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134721057150318120Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134721057150318120Mouse
1301954Lrnx11_mlearning-contextual 11 (mouse)Not determined13909372774477206Mouse
1357721Sle17_msystematic lupus erythematosus susceptibility 17 (mouse)Not determined139093727126517573Mouse
12910780Pwgrq11_mpost-weaning growth rate QTL 11 (mouse)14082884867231097Mouse
12910786Pwgrq10_mpost-weaning growth rate QTL 10 (mouse)14082884867231097Mouse
12910788Pwgrq9_mpost-weaning growth rate QTL 9 (mouse)14082884867231097Mouse
1301166Thypr2_mthymocyte proliferative response 2 (mouse)Not determined14123396575234112Mouse
18182931Metl1_mmetabolite locus 1, pyridoxate (mouse)14123624075236240Mouse
4141032Wbcc1_mwhite blood cell count 1 (mouse)Not determined4222050876220508Mouse
1301714Vertcling_mvertical clinging (mouse)Not determined14289887276899008Mouse
12879917Shm3_msperm head morphology 3 (mouse)14414774462907723Mouse
1558855Eae30_mexperimental allergic encephalomyelitis susceptibility 30 (mouse)Not determined14537861372935898Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145744740189571420Mouse
1301670Ssta1_msusceptibility to Salmonella typhimurium antigens 1 (mouse)Not determined14590759679907723Mouse
1301225Sle7_msystematic lupus erythematosus susceptibility 7 (mouse)Not determined14681553180815680Mouse
1301616Yaa2_mY-linked autoimmune acceleration 2 (mouse)Not determined14681553180815680Mouse
1558905Gct7_mgranulosa cell tumorigenesis 7 (mouse)Not determined14731073581310854Mouse
1558822Vas1_mautoimmune vasitis resistance 1 (mouse)Not determined14884984782850051Mouse
1301211Bbaa11_mB.burgdorferi-associated arthritis 11 (mouse)Not determined14884984782850051Mouse
1301430Cdcs2_mcytokine deficiency colitis susceptibility 2 (mouse)Not determined14885318682853326Mouse
10043965Obq24_mobesity QTL 24 (mouse)Not determined15085105784851057Mouse
4141305Tgq9_mtriglyceride QTL 9 (mouse)Not determined5138244685382446Mouse
4142307Shali1_msurvival time to hyperoxic acute lung injury 1 (mouse)Not determined5192486670367430Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52418578182423027Mouse
1357741Nidd5k_mNidd5 on KK-A<y> (mouse)Not determined15593578989935898Mouse
1357505Vtbt1_mvertebral trabecular bone trait 1 (mouse)Not determined15622705590227201Mouse
4142467Wbcq1_mwhite blood cell quantitative locus 1 (mouse)Not determined15622705590227201Mouse
1301933Insq6_minsulin QTL 6 (mouse)Not determined15668776390687918Mouse
1558717Ses1a_msalmonella enteritidis susceptibility 1a (mouse)Not determined15668776390687918Mouse
4141724Idd5.1_minsulin dependent diabetes susceptibility 5.1 (mouse)Not determined5768911762907723Mouse
14746998Mancz1_mmandible centroid size 1 (mouse)15790219291902192Mouse
14747009Manh49_mmandible shape 49 (mouse)15790219291902192Mouse
1300746Skl1_mskeletal size (tail length) 1 (mouse)Not determined15795281891952921Mouse
1357679Egrm1_mearly growth rate, maternal effect 1 (mouse)Not determined15795281891952921Mouse
1301162Skull1_mskull morphology 1 (mouse)Not determined15795281891952921Mouse
1301444Alcw5_malcohol withdrawal 5 (mouse)Not determined15857254792572799Mouse
1301667Lxw5_mlupus BXSB x NZW 5 (mouse)Not determined15857254792572799Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1236
Count of miRNA genes:606
Interacting mature miRNAs:765
Transcripts:ENSMUST00000027165, ENSMUST00000132833, ENSMUST00000153207
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000027165   ⟹   ENSMUSP00000027165
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl160,746,358 - 60,773,359 (+)Ensembl
RefSeq Acc Id: ENSMUST00000132833
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl160,716,800 - 60,763,163 (+)Ensembl
RefSeq Acc Id: ENSMUST00000153207
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl160,746,402 - 60,764,626 (+)Ensembl
RefSeq Acc Id: NM_007642   ⟹   NP_031668
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39160,785,547 - 60,812,518 (+)NCBI
GRCm38160,746,388 - 60,773,359 (+)ENTREZGENE
MGSCv37160,803,232 - 60,830,203 (+)RGD
Celera161,261,669 - 61,288,639 (+)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036156388   ⟹   XP_036012281
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39160,789,155 - 60,812,521 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_031668   ⟸   NM_007642
- Peptide Label: precursor
- UniProtKB: P31041 (UniProtKB/Swiss-Prot),   Q8CDB3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000027165   ⟸   ENSMUST00000027165
RefSeq Acc Id: XP_036012281   ⟸   XM_036156388
- Peptide Label: isoform X1
Protein Domains
Ig-like V-type   IGv

Promoters
RGD ID:6873898
Promoter ID:EPDNEW_M393
Type:initiation region
Name:Cd28_1
Description:Mus musculus CD28 antigen , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38160,746,410 - 60,746,470EPDNEW
RGD ID:6817485
Promoter ID:MM_KWN:914
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung,   Spleen
Transcripts:OTTMUST00000004499,   OTTMUST00000004500
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36160,803,049 - 60,803,549 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88327 AgrOrtholog
Ensembl Genes ENSMUSG00000026012 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000027165 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000027165 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CD28 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTLA4/CD28 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12487 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:88327 ENTREZGENE
NCBI Gene 12487 ENTREZGENE
PANTHER PTHR11494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam V-set_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cd28 PhenoGen
PRINTS CD28ANTIGEN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.255003 ENTREZGENE
UniProt CD28_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q8CDB3 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q6GSH7 UniProtKB/Swiss-Prot