Eif3g (eukaryotic translation initiation factor 3, subunit G) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Eif3g (eukaryotic translation initiation factor 3, subunit G) Mus musculus
Analyze
Symbol: Eif3g
Name: eukaryotic translation initiation factor 3, subunit G
RGD ID: 1316235
MGI Page MGI
Description: Contributes to translation initiation factor activity. Involved in translational initiation. Part of eukaryotic translation initiation factor 3 complex. Is expressed in embryo. Orthologous to human EIF3G (eukaryotic translation initiation factor 3 subunit G).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 44kD; 44kDa; D0Jmb4; eIF-3 RNA-binding subunit; eIF-3-delta; Eif3; eiF3 delta; eIF3 p42; eIF3 p44; eIF3-p44; Eif3s4; eukaryotic translation initiation factor 3 RNA-binding subunit; eukaryotic translation initiation factor 3 subunit 4; eukaryotic translation initiation factor 3 subunit G; eukaryotic translation initiation factor 3 subunit p42; eukaryotic translation initiation factor 3, subunit 4 (delta); eukaryotic translation initiation factor 3, subunit 4 (delta, 44 kDa); eukaryotic translation initiation factor 3, subunit 4 (delta, 44kD); p4; p44; translation initiation factor eIF3-p44; TU-189B2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39920,805,645 - 20,809,886 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl920,805,645 - 20,809,919 (-)EnsemblGRCm39 Ensembl
GRCm38920,894,349 - 20,898,590 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl920,894,349 - 20,898,623 (-)EnsemblGRCm38mm10GRCm38
MGSCv37920,698,793 - 20,703,034 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36920,644,751 - 20,648,992 (-)NCBIMGSCv36mm8
Celera918,163,047 - 18,167,288 (-)NCBICelera
Cytogenetic Map9A3NCBI
cM Map97.66NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The scanning mechanism of eukaryotic translation initiation. Hinnebusch AG Annu Rev Biochem. 2014;83:779-812. doi: 10.1146/annurev-biochem-060713-035802. Epub 2014 Jan 29.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1602141   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12176995   PMID:12466851   PMID:12477932   PMID:12904583   PMID:14610273   PMID:15345747  
PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16602821   PMID:17581632   PMID:21677750   PMID:21873635   PMID:22354994   PMID:23665500   PMID:24396066   PMID:24457600  
PMID:26365490   PMID:30409884   PMID:31162944   PMID:32325033   PMID:34133714   PMID:34752747  


Genomics

Comparative Map Data
Eif3g
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39920,805,645 - 20,809,886 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl920,805,645 - 20,809,919 (-)EnsemblGRCm39 Ensembl
GRCm38920,894,349 - 20,898,590 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl920,894,349 - 20,898,623 (-)EnsemblGRCm38mm10GRCm38
MGSCv37920,698,793 - 20,703,034 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36920,644,751 - 20,648,992 (-)NCBIMGSCv36mm8
Celera918,163,047 - 18,167,288 (-)NCBICelera
Cytogenetic Map9A3NCBI
cM Map97.66NCBI
EIF3G
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381910,115,014 - 10,119,899 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1910,115,014 - 10,119,918 (-)EnsemblGRCh38hg38GRCh38
GRCh371910,225,690 - 10,230,575 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361910,086,690 - 10,091,599 (-)NCBINCBI36Build 36hg18NCBI36
Build 341910,086,690 - 10,091,585NCBI
Celera1910,121,181 - 10,126,038 (-)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef199,806,336 - 9,811,241 (-)NCBIHuRef
CHM1_11910,225,972 - 10,230,857 (-)NCBICHM1_1
T2T-CHM13v2.01910,241,223 - 10,246,106 (-)NCBIT2T-CHM13v2.0
Eif3g
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8827,705,914 - 27,709,946 (-)NCBIGRCr8
mRatBN7.2819,429,728 - 19,433,760 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl819,429,643 - 19,433,808 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx823,449,092 - 23,453,123 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0821,746,939 - 21,750,970 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0819,659,410 - 19,663,443 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0821,911,632 - 21,915,664 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl821,911,625 - 21,915,716 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0821,967,947 - 21,971,979 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4819,915,632 - 19,920,117 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1819,915,632 - 19,920,117 (-)NCBI
Celera820,824,729 - 20,828,761 (-)NCBICelera
Cytogenetic Map8q13NCBI
Eif3g
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554951,451,454 - 1,457,216 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554951,452,806 - 1,456,834 (-)NCBIChiLan1.0ChiLan1.0
EIF3G
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22015,030,048 - 15,035,003 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11914,030,358 - 14,035,308 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0199,663,525 - 9,668,475 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11910,324,063 - 10,328,960 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1910,324,063 - 10,328,960 (-)Ensemblpanpan1.1panPan2
EIF3G
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12050,941,413 - 50,946,042 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2050,941,503 - 50,946,041 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2050,810,980 - 50,815,575 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02051,463,242 - 51,467,835 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2051,463,297 - 51,467,829 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12050,670,901 - 50,675,493 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02051,098,150 - 51,102,741 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02051,339,040 - 51,343,631 (+)NCBIUU_Cfam_GSD_1.0
Eif3g
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118209,843,936 - 209,848,244 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936659506,359 - 510,776 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936659506,460 - 510,752 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EIF3G
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl268,966,222 - 68,970,614 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1268,966,221 - 68,970,648 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2269,294,401 - 69,298,556 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EIF3G
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.169,183,740 - 9,188,896 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607410,872,836 - 10,877,556 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eif3g
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248282,308,178 - 2,312,247 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248282,308,086 - 2,311,986 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Eif3g
162 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:191
Count of miRNA genes:181
Interacting mature miRNAs:189
Transcripts:ENSMUST00000004206
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142326Tgq19_mtriglyceride QTL 19 (mouse)Not determined121060750Mouse
1300899Chol6_mcholesterol 6 (mouse)Not determined9129902913Mouse
13434920Dcollq1_mdifferential colonization level QTL 1 (mouse)9130341840Mouse
35673312Ari7_mantibody response to influenza 7, day 45, IgG3 (mouse)9780000122211296Mouse
1300849Sles4_msystemic lupus erythmatosus suppressor 4 (mouse)Not determined9910756237306370Mouse
13504833Bglu19_mblood glucose level 19 (mouse)9991076843910768Mouse
1300532Tbs2_mtuberculosis severity 2 (mouse)Not determined91236997046370114Mouse
10043917Obq37_mobesity QTL 37 (mouse)Not determined91339117547391175Mouse
1357637Si5lq2_mserum IGFBP-5 level QTL 2 (mouse)Not determined91541175149411890Mouse
4141591Cq4_mcholesterol QTL 4 (mouse)Not determined91541175149411890Mouse
1301421Lgth4_mbody length 4 (mouse)Not determined91541175149411890Mouse
4141447Cfmq2_mcystic fibrosis modifier QTL 2 (mouse)Not determined91541175149411890Mouse
12790993Adq1_maortic diameter QTL 1 (mouse)91574962749749627Mouse
11354951Pdcc3_mplasmacytoid dentritic cell compartment 3 (mouse)91574962749749627Mouse
12790997Adq2_maortic diameter QTL 2 (mouse)91574962749749627Mouse
12880415V125Dq7_mvitamin D active form serum level QTL 7 (mouse)91601129650011296Mouse
12880416V125Dq8_mvitamin D active form serum level QTL 8 (mouse)91601129650011296Mouse
13504834Hdlq109_mHDL QTL 109 (mouse)91670964150709641Mouse
1357465Vtbt6_mvertebral trabecular bone trait 6 (mouse)Not determined91697884050978943Mouse
1300643Pvcan2_mprotection against vaginal candidiasis 2 (mouse)Not determined91994340653943525Mouse
1301439Morph2_mmorphine antinociception 2 (mouse)Not determined92015336254153492Mouse
1301883Skull12_mskull morphology 12 (mouse)Not determined92030619754306370Mouse
1301045Sluc10_msusceptibility to lung cancer 10 (mouse)Not determined92030619754306370Mouse
10043950Pbft5_mpercent body fat 5 (mouse)Not determined92030619754306370Mouse
4142352Lmr17_mleishmaniasis resistance 17 (mouse)Not determined92030619754306370Mouse

Markers in Region
RH141339  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38920,894,406 - 20,894,883UniSTSGRCm38
MGSCv37920,698,850 - 20,699,327UniSTSGRCm37
Celera918,163,104 - 18,163,581UniSTS
Cytogenetic Map9A3UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000004206   ⟹   ENSMUSP00000004206
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl920,805,645 - 20,809,919 (-)Ensembl
GRCm38.p6 Ensembl920,894,349 - 20,898,623 (-)Ensembl
RefSeq Acc Id: ENSMUST00000213454
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl920,806,484 - 20,809,902 (-)Ensembl
GRCm38.p6 Ensembl920,895,188 - 20,898,606 (-)Ensembl
RefSeq Acc Id: ENSMUST00000213882
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl920,807,171 - 20,808,070 (-)Ensembl
GRCm38.p6 Ensembl920,895,875 - 20,896,774 (-)Ensembl
RefSeq Acc Id: ENSMUST00000216133
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl920,807,436 - 20,809,878 (-)Ensembl
GRCm38.p6 Ensembl920,896,140 - 20,898,582 (-)Ensembl
RefSeq Acc Id: NM_016876   ⟹   NP_058572
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39920,805,645 - 20,809,886 (-)NCBI
GRCm38920,894,349 - 20,898,590 (-)ENTREZGENE
MGSCv37920,698,793 - 20,703,034 (-)RGD
Celera918,163,047 - 18,167,288 (-)RGD
cM Map9 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_058572   ⟸   NM_016876
- UniProtKB: Q9R079 (UniProtKB/Swiss-Prot),   Q9Z1D1 (UniProtKB/Swiss-Prot),   Q544H0 (UniProtKB/TrEMBL),   Q3THA0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000004206   ⟸   ENSMUST00000004206
Protein Domains
RRM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z1D1-F1-model_v2 AlphaFold Q9Z1D1 1-320 view protein structure

Promoters
RGD ID:6848410
Promoter ID:MM_ACW:49727
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   Brain,   Spleen
Transcripts:EIF3G.CSEP07,   EIF3G.ESEP07,   EIF3G.FSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36920,699,186 - 20,699,686 (-)MPROMDB
RGD ID:6844462
Promoter ID:MM_KWN:56533
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000004206
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36920,702,921 - 20,703,697 (-)MPROMDB
RGD ID:8668900
Promoter ID:EPDNEW_M12481
Type:initiation region
Name:Eif3g_1
Description:Mus musculus eukaryotic translation initiation factor 3, subunitG , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38920,898,600 - 20,898,660EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1858258 AgrOrtholog
Ensembl Genes ENSMUSG00000070319 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000004206 ENTREZGENE
  ENSMUST00000004206.10 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.70.330 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro eIF3_g UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  eIF3g_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  eIF3G_RRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleotide-bd_a/b_plait_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RRM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:53356 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1858258 ENTREZGENE
NCBI Gene 53356 ENTREZGENE
PANTHER EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G UniProtKB/Swiss-Prot
  EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G UniProtKB/Swiss-Prot
  EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G UniProtKB/TrEMBL
  EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G UniProtKB/TrEMBL
Pfam eIF3g UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RRM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Eif3g PhenoGen
PIRSF Transl_init_eIF-3_RNA-bind UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE RRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54928 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt EIF3G_MOUSE UniProtKB/Swiss-Prot
  Q3THA0 ENTREZGENE, UniProtKB/TrEMBL
  Q544H0 ENTREZGENE, UniProtKB/TrEMBL
  Q9R079 ENTREZGENE
  Q9Z1D1 ENTREZGENE
UniProt Secondary Q9R079 UniProtKB/Swiss-Prot