(1->4)-beta-D-glucan multiple interactions EXP 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of HPRT1 mRNA CTD PMID:36331819 1,1,1-trichloroethane increases expression EXP 6480464 1 more ... CTD PMID:25270620 1,2-dimethylhydrazine multiple interactions EXP 6480464 [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of HPRT1 mRNA CTD PMID:22206623 1,2-dimethylhydrazine decreases expression EXP 6480464 1 and 2-Dimethylhydrazine results in decreased expression of HPRT1 mRNA CTD PMID:22206623 1-Methylpyrene multiple interactions ISO HPRT1 (Homo sapiens) 6480464 1-aminobenzotriazole inhibits the reaction [[[SULT1A1 protein co-treated with CYP2E1 protein] results in increased susceptibility to 1-methylpyrene] which results in increased mutagenesis of HPRT1 gene] more ... CTD PMID:25243916 1-nitropyrene multiple interactions ISO HPRT1 (Homo sapiens) 6480464 CYP1A2 affects the reaction [1-nitropyrene results in increased mutagenesis of HPRT1 gene] CTD PMID:10727902 17alpha-ethynylestradiol multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HPRT1 mRNA CTD PMID:17942748 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of HPRT1 mRNA CTD PMID:17555576 and PMID:17942748 17beta-estradiol increases expression EXP 6480464 Estradiol results in increased expression of HPRT1 mRNA CTD PMID:22467019 17beta-estradiol multiple interactions ISO Hprt1 (Rattus norvegicus) 6480464 [bisphenol A co-treated with Estradiol] results in decreased expression of HPRT1 mRNA CTD PMID:26496021 2,2',4,5-tetrachlorobiphenyl multiple interactions ISO HPRT1 (Homo sapiens) 6480464 [[SULT1A1 protein co-treated with CYP2E1 protein] results in increased susceptibility to 2 more ... CTD PMID:27913846 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO HPRT1 (Homo sapiens) 6480464 [[SULT1A1 protein co-treated with CYP2E1 protein] results in increased susceptibility to 2 more ... CTD PMID:27913846 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HPRT1 mRNA and Tetrachlorodibenzodioxin affects the reaction [AHR protein binds to HPRT1 promoter] CTD PMID:17942748 and PMID:19654925 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO Hprt1 (Rattus norvegicus) 6480464 Tetrachlorodibenzodioxin results in increased expression of HPRT1 mRNA CTD PMID:34747641 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO HPRT1 (Homo sapiens) 6480464 Tetrachlorodibenzodioxin affects the expression of HPRT1 mRNA CTD PMID:22574217 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of HPRT1 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO Hprt1 (Rattus norvegicus) 6480464 Tetrachlorodibenzodioxin results in decreased expression of HPRT1 mRNA CTD PMID:21215274 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of HPRT1 mRNA CTD PMID:17942748 2-Amino-9H-pyrido[2,3-b]indole multiple interactions ISO HPRT1 (Homo sapiens) 6480464 [CYP1A2 protein co-treated with NAT2 gene polymorphism] promotes the reaction [2-amino-9H-pyrido(2 and 3-b)indole binds to and results in increased mutagenesis of HPRT1 gene] CTD PMID:19243127 2-hydroxypropanoic acid decreases expression ISO HPRT1 (Homo sapiens) 6480464 Lactic Acid results in decreased expression of HPRT1 mRNA CTD PMID:30851411 2-naphthylamine multiple interactions ISO HPRT1 (Homo sapiens) 6480464 NAT2 polymorphism affects the reaction [2-Naphthylamine results in increased mutagenesis of HPRT1 gene] CTD PMID:36040704 3-Amino-1-methyl-5H-pyrido[4,3-b]indole increases mutagenesis ISO HPRT1 (Homo sapiens) 6480464 3-amino-1-methyl-5H-pyrido(4 and 3-b)indole results in increased mutagenesis of HPRT1 gene CTD PMID:2335011 3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone increases mutagenesis ISO Hprt1 (Rattus norvegicus) 6480464 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone results in increased mutagenesis of HPRT1 gene CTD PMID:17993254 3-chloropropane-1,2-diol affects expression ISO Hprt1 (Rattus norvegicus) 6480464 alpha-Chlorohydrin affects the expression of HPRT1 mRNA CTD PMID:28522335 3-chloropropane-1,2-diol increases expression ISO Hprt1 (Rattus norvegicus) 6480464 alpha-Chlorohydrin results in increased expression of HPRT1 protein CTD PMID:34915118 3-methyl-3H-imidazo[4,5-f]quinolin-2-amine increases mutagenesis ISO Hprt1 (Rattus norvegicus) 6480464 2-amino-3-methylimidazo(4 and 5-f)quinoline results in increased mutagenesis of HPRT1 gene CTD PMID:12467141 3-Nitrobenzanthrone multiple interactions ISO HPRT1 (Homo sapiens) 6480464 [NAT2 protein co-treated with 3-nitrobenzanthrone] results in increased mutagenesis of HPRT1 gene and [SULT1A1 protein co-treated with 3-nitrobenzanthrone] results in increased mutagenesis of HPRT1 gene CTD PMID:17483118 3-phenylprop-2-enal decreases mutagenesis ISO HPRT1 (Homo sapiens) 6480464 cinnamaldehyde results in decreased mutagenesis of HPRT1 gene CTD PMID:17178418 3H-1,2-dithiole-3-thione decreases expression ISO Hprt1 (Rattus norvegicus) 6480464 1 and 2-dithiol-3-thione results in decreased expression of HPRT1 mRNA CTD PMID:19162173 4,4'-diaminodiphenylmethane decreases expression EXP 6480464 4 and 4'-diaminodiphenylmethane results in decreased expression of HPRT1 mRNA CTD PMID:18648102 4,4'-sulfonyldiphenol multiple interactions ISO Hprt1 (Rattus norvegicus) 6480464 [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of HPRT1 mRNA CTD PMID:36041667 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one multiple interactions EXP 6480464 [Ozone co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased mutagenesis of HPRT1 gene and Dibutyl Phthalate promotes the reaction [[Ozone co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased mutagenesis of HPRT1 gene] CTD PMID:15613823 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one increases mutagenesis EXP 6480464 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased mutagenesis of HPRT1 gene CTD PMID:15613823 4-hydroxynon-2-enal increases expression EXP 6480464 4-hydroxy-2-nonenal results in increased expression of HPRT1 mRNA CTD PMID:19191707 4-nitroquinoline N-oxide increases mutagenesis ISO HPRT1 (Homo sapiens) 6480464 4-Nitroquinoline-1-oxide results in increased mutagenesis of HPRT1 gene CTD PMID:26362870 and PMID:28454271 5-aza-2'-deoxycytidine increases expression EXP 6480464 Decitabine results in increased expression of HPRT1 mRNA CTD PMID:27915011 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole affects expression ISO Hprt1 (Rattus norvegicus) 6480464 Omeprazole affects the expression of HPRT1 mRNA CTD PMID:19483382 6-propyl-2-thiouracil affects expression ISO Hprt1 (Rattus norvegicus) 6480464 Propylthiouracil affects the expression of HPRT1 mRNA CTD PMID:19483382 6-propyl-2-thiouracil increases expression ISO Hprt1 (Rattus norvegicus) 6480464 Propylthiouracil results in increased expression of HPRT1 mRNA CTD PMID:30047161 acrylamide increases mutagenesis EXP 6480464 Acrylamide results in increased mutagenesis of HPRT1 gene CTD PMID:15957192 acrylamide increases expression ISO HPRT1 (Homo sapiens) 6480464 Acrylamide results in increased expression of HPRT1 mRNA CTD PMID:32763439 acrylamide increases mutagenesis ISO Hprt1 (Rattus norvegicus) 6480464 Acrylamide results in increased mutagenesis of HPRT1 gene CTD PMID:20200216 acrylamide increases mutagenesis ISO HPRT1 (Homo sapiens) 6480464 Acrylamide results in increased mutagenesis of HPRT1 gene CTD PMID:18407966 acrylonitrile increases mutagenesis EXP 6480464 Acrylonitrile results in increased mutagenesis of HPRT1 gene CTD PMID:32529832 acrylonitrile multiple interactions EXP 6480464 CYP2E1 gene mutant form inhibits the reaction [Acrylonitrile results in increased mutagenesis of HPRT1 gene] CTD PMID:32529832 acrylonitrile increases mutagenesis ISO Hprt1 (Rattus norvegicus) 6480464 Acrylonitrile results in increased mutagenesis of HPRT1 gene CTD PMID:32529823 aldehydo-D-glucose decreases expression ISO HPRT1 (Homo sapiens) 6480464 Glucose results in decreased expression of HPRT1 mRNA CTD PMID:31655124 all-trans-retinoic acid increases expression ISO Hprt1 (Rattus norvegicus) 6480464 Tretinoin results in increased expression of HPRT1 mRNA CTD PMID:24977338 all-trans-retinoic acid decreases expression ISO HPRT1 (Homo sapiens) 6480464 Tretinoin results in decreased expression of HPRT1 mRNA CTD PMID:21934132 more ... amiodarone affects expression ISO Hprt1 (Rattus norvegicus) 6480464 Amiodarone affects the expression of HPRT1 mRNA CTD PMID:19483382 amitrole increases expression ISO Hprt1 (Rattus norvegicus) 6480464 Amitrole results in increased expression of HPRT1 mRNA CTD PMID:30047161 ammonium chloride affects expression ISO Hprt1 (Rattus norvegicus) 6480464 Ammonium Chloride affects the expression of HPRT1 mRNA CTD PMID:16483693 amphetamine increases expression ISO Hprt1 (Rattus norvegicus) 6480464 Amphetamine results in increased expression of HPRT1 mRNA CTD PMID:30779732 aristolochic acid A increases expression ISO HPRT1 (Homo sapiens) 6480464 aristolochic acid I results in increased expression of HPRT1 protein CTD PMID:33212167 aristolochic acid A decreases expression ISO HPRT1 (Homo sapiens) 6480464 aristolochic acid I results in decreased expression of HPRT1 mRNA CTD PMID:33212167 Aroclor 1254 decreases expression EXP 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of HPRT1 mRNA CTD PMID:23650126 arsane decreases expression ISO HPRT1 (Homo sapiens) 6480464 Arsenic results in decreased expression of HPRT1 mRNA CTD PMID:36178927 arsenic atom decreases expression ISO HPRT1 (Homo sapiens) 6480464 Arsenic results in decreased expression of HPRT1 mRNA CTD PMID:36178927 arsenite(3-) multiple interactions ISO HPRT1 (Homo sapiens) 6480464 arsenite inhibits the reaction [G3BP1 protein binds to HPRT1 protein] CTD PMID:32406909 atrazine decreases expression ISO HPRT1 (Homo sapiens) 6480464 Atrazine results in decreased expression of HPRT1 mRNA CTD PMID:22378314 atrazine decreases expression ISO Hprt1 (Rattus norvegicus) 6480464 Atrazine results in decreased expression of HPRT1 mRNA CTD PMID:36841081 azathioprine increases mutagenesis EXP 6480464 Azathioprine results in increased mutagenesis of HPRT1 gene CTD PMID:16107271 benzbromarone affects expression ISO Hprt1 (Rattus norvegicus) 6480464 Benzbromarone affects the expression of HPRT1 mRNA CTD PMID:19483382 benzene increases mutagenesis EXP 6480464 Benzene results in increased mutagenesis of HPRT1 gene CTD PMID:20035728 benzidine multiple interactions ISO HPRT1 (Homo sapiens) 6480464 [NAT1 polymorphism affects the susceptibility to benzidine] which affects the mutagenesis of HPRT1 CTD PMID:37097310 benzo[a]pyrene multiple interactions EXP 6480464 Benzo(a)pyrene affects the reaction [AHR protein binds to HPRT1 promoter] and POLB protein promotes the reaction [Benzo(a)pyrene results in increased mutagenesis of HPRT1 gene] CTD PMID:19654925 and PMID:23652152 benzo[a]pyrene affects methylation ISO HPRT1 (Homo sapiens) 6480464 Benzo(a)pyrene affects the methylation of HPRT1 promoter CTD PMID:27901495 benzo[a]pyrene increases methylation ISO HPRT1 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased methylation of HPRT1 5' UTR CTD PMID:27901495 benzo[a]pyrene increases expression ISO HPRT1 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased expression of HPRT1 mRNA CTD PMID:16269432 benzo[a]pyrene multiple interactions ISO HPRT1 (Homo sapiens) 6480464 [[POR protein co-treated with CYP3A4 protein] results in increased susceptibility to Benzo(a)pyrene] which results in increased mutagenesis of HPRT1 gene more ... CTD PMID:17525473 and PMID:27913846 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of HPRT1 mRNA CTD PMID:22228805 benzo[a]pyrene increases mutagenesis EXP 6480464 Benzo(a)pyrene results in increased mutagenesis of HPRT1 gene CTD PMID:23652152 benzo[a]pyrene diol epoxide I multiple interactions EXP 6480464 POLH mutant form inhibits the reaction [7 more ... CTD PMID:22745795 benzo[a]pyrene diol epoxide I multiple interactions ISO HPRT1 (Homo sapiens) 6480464 POLH mutant form inhibits the reaction [7 more ... CTD PMID:22745795 benzo[a]pyrene diol epoxide I increases mutagenesis EXP 6480464 7 more ... CTD PMID:22745795 benzo[a]pyrene diol epoxide I increases mutagenesis ISO HPRT1 (Homo sapiens) 6480464 7 more ... CTD PMID:22745795 Benzo[a]pyrene-7,8-diol multiple interactions ISO HPRT1 (Homo sapiens) 6480464 CYP1A1 protein promotes the reaction [benzo(a)pyrene 7 more ... CTD PMID:17525473 beta-carotene multiple interactions ISO Hprt1 (Rattus norvegicus) 6480464 beta Carotene inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4 and 5-b)pyridine results in increased mutagenesis of HPRT1 gene] CTD PMID:12467141 biphenyl-4-amine multiple interactions ISO HPRT1 (Homo sapiens) 6480464 [NAT1 polymorphism results in increased susceptibility to 4-biphenylamine] which results in increased mutagenesis of HPRT1 gene and NAT2 polymorphism affects the reaction [4-biphenylamine results in increased mutagenesis of HPRT1 gene] CTD PMID:22114069 and PMID:36040704 bis(2-chloroethyl) sulfide affects expression ISO Hprt1 (Rattus norvegicus) 6480464 Mustard Gas affects the expression of HPRT1 mRNA CTD PMID:15651846 bis(2-ethylhexyl) phthalate increases expression EXP 6480464 Diethylhexyl Phthalate results in increased expression of HPRT1 mRNA CTD PMID:19850644 bis(2-ethylhexyl) phthalate multiple interactions EXP 6480464 PPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of HPRT1 mRNA] CTD PMID:19850644 bisphenol A multiple interactions ISO Hprt1 (Rattus norvegicus) 6480464 [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of HPRT1 mRNA and [bisphenol A co-treated with Estradiol] results in decreased expression of HPRT1 mRNA CTD PMID:26496021 and PMID:36041667 bisphenol A decreases expression ISO Hprt1 (Rattus norvegicus) 6480464 bisphenol A results in decreased expression of HPRT1 mRNA CTD PMID:34947998 bisphenol A decreases expression ISO HPRT1 (Homo sapiens) 6480464 bisphenol A results in decreased expression of HPRT1 mRNA CTD PMID:29275510 and PMID:33670352 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of HPRT1 mRNA CTD PMID:25270620 bisphenol A increases expression ISO Hprt1 (Rattus norvegicus) 6480464 bisphenol A results in increased expression of HPRT1 protein CTD PMID:22649256 bisphenol A affects expression ISO Hprt1 (Rattus norvegicus) 6480464 bisphenol A affects the expression of HPRT1 mRNA CTD PMID:25181051 Bisphenol B increases expression ISO HPRT1 (Homo sapiens) 6480464 bisphenol B results in increased expression of HPRT1 protein CTD PMID:34186270 bisphenol F increases expression ISO HPRT1 (Homo sapiens) 6480464 bisphenol F results in increased expression of HPRT1 protein CTD PMID:34186270 bisphenol F multiple interactions ISO Hprt1 (Rattus norvegicus) 6480464 [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of HPRT1 mRNA CTD PMID:36041667 Brodifacoum increases expression ISO Hprt1 (Rattus norvegicus) 6480464 bromfenacoum results in increased expression of HPRT1 protein CTD PMID:28903499 buspirone increases expression ISO Hprt1 (Rattus norvegicus) 6480464 Buspirone results in increased expression of HPRT1 mRNA CTD PMID:24136188 buta-1,3-diene increases mutagenesis ISO Hprt1 (Rattus norvegicus) 6480464 1 more ... CTD PMID:20017413 more ... buta-1,3-diene increases mutagenesis ISO HPRT1 (Homo sapiens) 6480464 1 and 3-butadiene metabolite results in increased mutagenesis of HPRT1 gene CTD PMID:20853577 buta-1,3-diene increases mutagenesis EXP 6480464 1 more ... CTD PMID:20017413 more ... cadmium dichloride multiple interactions EXP 6480464 [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of HPRT1 mRNA CTD PMID:19840844 caffeine increases expression ISO Hprt1 (Rattus norvegicus) 6480464 Caffeine results in increased expression of HPRT1 protein CTD PMID:6149265 calcitriol multiple interactions ISO HPRT1 (Homo sapiens) 6480464 [Testosterone co-treated with Calcitriol] results in decreased expression of HPRT1 mRNA CTD PMID:21592394 calcitriol decreases expression ISO HPRT1 (Homo sapiens) 6480464 Calcitriol results in decreased expression of HPRT1 mRNA CTD PMID:21592394 calyculin a increases expression EXP 6480464 calyculin A results in increased expression of HPRT1 mRNA CTD PMID:25270620 carbon nanotube increases expression EXP 6480464 Nanotubes more ... CTD PMID:25620056 carmustine increases mutagenesis EXP 6480464 Carmustine results in increased mutagenesis of HPRT1 gene CTD PMID:17116724 chromium(6+) increases mutagenesis ISO HPRT1 (Homo sapiens) 6480464 chromium hexavalent ion results in increased mutagenesis of HPRT1 gene CTD PMID:7508562 clofibrate multiple interactions EXP 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of HPRT1 mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of HPRT1 mRNA] CTD PMID:17585979 clofibrate increases expression EXP 6480464 Clofibrate results in increased expression of HPRT1 mRNA CTD PMID:17585979 clofibrate affects expression ISO Hprt1 (Rattus norvegicus) 6480464 Clofibrate affects the expression of HPRT1 mRNA CTD PMID:19483382 clofibric acid multiple interactions ISO Hprt1 (Rattus norvegicus) 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of HPRT1 mRNA CTD PMID:17602206 cobalt dichloride decreases expression ISO HPRT1 (Homo sapiens) 6480464 cobaltous chloride results in decreased expression of HPRT1 mRNA CTD PMID:19320972 coumarin decreases phosphorylation ISO HPRT1 (Homo sapiens) 6480464 coumarin results in decreased phosphorylation of HPRT1 protein CTD PMID:35688186 coumestrol increases expression ISO HPRT1 (Homo sapiens) 6480464 Coumestrol results in increased expression of HPRT1 mRNA CTD PMID:19167446 coumestrol multiple interactions ISO HPRT1 (Homo sapiens) 6480464 [Coumestrol co-treated with 2 more ... CTD PMID:19167446 curcumin increases expression ISO HPRT1 (Homo sapiens) 6480464 Curcumin results in increased expression of HPRT1 mRNA CTD PMID:16101141 cyclophosphamide increases mutagenesis EXP 6480464 Cyclophosphamide results in increased mutagenesis of HPRT1 gene CTD PMID:17116724 cyclophosphamide increases mutagenesis ISO Hprt1 (Rattus norvegicus) 6480464 Cyclophosphamide results in increased mutagenesis of HPRT1 gene CTD PMID:23677247 cyclosporin A increases expression ISO HPRT1 (Homo sapiens) 6480464 Cyclosporine results in increased expression of HPRT1 mRNA CTD PMID:27989131 cyhalothrin increases expression ISO Hprt1 (Rattus norvegicus) 6480464 cyhalothrin results in increased expression of HPRT1 mRNA CTD PMID:29727961 cyproconazole decreases expression EXP 6480464 cyproconazole results in decreased expression of HPRT1 mRNA CTD PMID:22045034 cyproconazole increases expression EXP 6480464 cyproconazole results in increased expression of HPRT1 mRNA CTD PMID:22334560 D-glucose decreases expression ISO HPRT1 (Homo sapiens) 6480464 Glucose results in decreased expression of HPRT1 mRNA CTD PMID:31655124 D-mannitol increases expression EXP 6480464 Mannitol results in increased expression of HPRT1 mRNA CTD PMID:25270620 deguelin increases expression ISO HPRT1 (Homo sapiens) 6480464 deguelin results in increased expression of HPRT1 mRNA CTD PMID:33512557 dibutyl phthalate multiple interactions EXP 6480464 [Ozone co-treated with Dibutyl Phthalate] results in increased mutagenesis of HPRT1 gene and Dibutyl Phthalate promotes the reaction [[Ozone co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased mutagenesis of HPRT1 gene] CTD PMID:15613823 dibutyl phthalate increases mutagenesis EXP 6480464 Dibutyl Phthalate results in increased mutagenesis of HPRT1 gene CTD PMID:15613823 dichlorine increases expression ISO Hprt1 (Rattus norvegicus) 6480464 Chlorine results in increased expression of HPRT1 mRNA CTD PMID:18636392 dichlorine multiple interactions ISO Hprt1 (Rattus norvegicus) 6480464 [Ozone co-treated with Chlorine] affects the expression of HPRT1 mRNA CTD PMID:18636392 diepoxybutane increases mutagenesis ISO HPRT1 (Homo sapiens) 6480464 diepoxybutane results in increased mutagenesis of HPRT1 gene CTD PMID:20853577 Diisodecyl phthalate increases expression EXP 6480464 diisodecyl phthalate results in increased expression of HPRT1 mRNA CTD PMID:25270620 dimethyl sulfoxide decreases expression ISO Hprt1 (Rattus norvegicus) 6480464 Dimethyl Sulfoxide results in decreased expression of HPRT1 mRNA CTD PMID:12883083 dioxygen decreases expression ISO HPRT1 (Homo sapiens) 6480464 Oxygen deficiency results in decreased expression of HPRT1 mRNA CTD PMID:35883890 dorsomorphin multiple interactions ISO HPRT1 (Homo sapiens) 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HPRT1 mRNA CTD PMID:27188386 endosulfan decreases expression ISO Hprt1 (Rattus norvegicus) 6480464 Endosulfan results in decreased expression of HPRT1 mRNA CTD PMID:29391264 Enterolactone multiple interactions ISO HPRT1 (Homo sapiens) 6480464 [Coumestrol co-treated with 2 and 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of HPRT1 mRNA CTD PMID:19167446 enzyme inhibitor multiple interactions ISO HPRT1 (Homo sapiens) 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of HPRT1 protein CTD PMID:23301498 epoxiconazole increases expression EXP 6480464 epoxiconazole results in increased expression of HPRT1 mRNA CTD PMID:22334560 ethanol increases expression EXP 6480464 Ethanol results in increased expression of HPRT1 mRNA CTD PMID:30319688 ethyl methanesulfonate increases mutagenesis ISO Hprt1 (Rattus norvegicus) 6480464 Ethyl Methanesulfonate results in increased mutagenesis of HPRT1 gene CTD PMID:7728755 fenthion increases expression EXP 6480464 Fenthion results in increased expression of HPRT1 mRNA CTD PMID:34813904 fipronil increases expression ISO Hprt1 (Rattus norvegicus) 6480464 fipronil results in increased expression of HPRT1 mRNA CTD PMID:23962444 folic acid multiple interactions EXP 6480464 [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of HPRT1 mRNA CTD PMID:22206623 fructose decreases expression ISO HPRT1 (Homo sapiens) 6480464 Fructose results in decreased expression of HPRT1 mRNA CTD PMID:31655124 fumonisin B1 increases expression EXP 6480464 fumonisin B1 results in increased expression of HPRT1 mRNA CTD PMID:16221962 gamma-hexachlorocyclohexane decreases expression ISO Hprt1 (Rattus norvegicus) 6480464 Hexachlorocyclohexane results in decreased expression of HPRT1 mRNA CTD PMID:17785943 genistein decreases expression ISO HPRT1 (Homo sapiens) 6480464 Genistein results in decreased expression of HPRT1 mRNA CTD PMID:22228119 gentamycin increases expression ISO Hprt1 (Rattus norvegicus) 6480464 Gentamicins results in increased expression of HPRT1 mRNA CTD PMID:33387578 glucose decreases expression ISO HPRT1 (Homo sapiens) 6480464 Glucose results in decreased expression of HPRT1 mRNA CTD PMID:31655124 gold atom decreases expression ISO HPRT1 (Homo sapiens) 6480464 Gold results in decreased expression of HPRT1 mRNA CTD PMID:25523186 gold(0) decreases expression ISO HPRT1 (Homo sapiens) 6480464 Gold results in decreased expression of HPRT1 mRNA CTD PMID:25523186 hexaconazole decreases expression EXP 6480464 hexaconazole results in decreased expression of HPRT1 mRNA CTD PMID:22045034 hydrogen peroxide increases mutagenesis ISO HPRT1 (Homo sapiens) 6480464 Hydrogen Peroxide results in increased mutagenesis of HPRT1 gene CTD PMID:22539617 and PMID:7508562 hypochlorous acid increases mutagenesis ISO HPRT1 (Homo sapiens) 6480464 Hypochlorous Acid results in increased mutagenesis of HPRT1 gene CTD PMID:19892774 inulin multiple interactions EXP 6480464 [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of HPRT1 mRNA CTD PMID:36331819 isoniazide increases expression ISO Hprt1 (Rattus norvegicus) 6480464 Isoniazid results in increased expression of HPRT1 mRNA CTD PMID:12883083 ivermectin decreases expression ISO HPRT1 (Homo sapiens) 6480464 Ivermectin results in decreased expression of HPRT1 protein CTD PMID:32959892 L-ascorbic acid multiple interactions ISO Hprt1 (Rattus norvegicus) 6480464 Ascorbic Acid inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4 and 5-b)pyridine results in increased mutagenesis of HPRT1 gene] CTD PMID:12467141 L-ethionine affects expression ISO Hprt1 (Rattus norvegicus) 6480464 Ethionine affects the expression of HPRT1 mRNA CTD PMID:19483382 lead diacetate decreases activity ISO HPRT1 (Homo sapiens) 6480464 lead acetate results in decreased activity of HPRT1 protein CTD PMID:19428946 lead diacetate decreases expression EXP 6480464 lead acetate results in decreased expression of HPRT1 mRNA CTD PMID:21829687 lead diacetate decreases activity ISO Hprt1 (Rattus norvegicus) 6480464 lead acetate results in decreased activity of HPRT1 protein CTD PMID:19428946 lithium atom increases expression ISO Hprt1 (Rattus norvegicus) 6480464 Lithium results in increased expression of HPRT1 protein CTD PMID:18296634 lithium hydride increases expression ISO Hprt1 (Rattus norvegicus) 6480464 Lithium results in increased expression of HPRT1 protein CTD PMID:18296634 MeIQ increases mutagenesis ISO Hprt1 (Rattus norvegicus) 6480464 2-amino-3 more ... CTD PMID:12467141 MeIQx increases mutagenesis ISO Hprt1 (Rattus norvegicus) 6480464 2-amino-3 more ... CTD PMID:12467141 methapyrilene increases expression ISO Hprt1 (Rattus norvegicus) 6480464 Methapyrilene results in increased expression of HPRT1 mRNA CTD PMID:28935588 methidathion increases expression EXP 6480464 methidathion results in increased expression of HPRT1 mRNA CTD PMID:34813904 methimazole increases expression ISO Hprt1 (Rattus norvegicus) 6480464 Methimazole results in increased expression of HPRT1 mRNA CTD PMID:30047161 methotrexate decreases expression ISO HPRT1 (Homo sapiens) 6480464 Methotrexate results in decreased expression of HPRT1 mRNA CTD PMID:17400583 methoxychlor increases methylation ISO Hprt1 (Rattus norvegicus) 6480464 Methoxychlor results in increased methylation of HPRT1 gene CTD PMID:23303685 microcystin-LR multiple interactions ISO HPRT1 (Homo sapiens) 6480464 BLK protein inhibits the reaction [cyanoginosin LR results in increased mutagenesis of HPRT1 gene] CTD PMID:36435412 microcystin-LR increases mutagenesis ISO HPRT1 (Homo sapiens) 6480464 cyanoginosin LR results in increased mutagenesis of HPRT1 gene CTD PMID:36435412 N-ethyl-N-nitrosourea increases mutagenesis ISO Hprt1 (Rattus norvegicus) 6480464 Ethylnitrosourea results in increased mutagenesis of HPRT1 gene CTD PMID:22167886 N-ethyl-N-nitrosourea increases mutagenesis EXP 6480464 Ethylnitrosourea results in increased mutagenesis of HPRT1 gene CTD PMID:32529823 N-methyl-N'-nitro-N-nitrosoguanidine multiple interactions EXP 6480464 [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of HPRT1 mRNA more ... CTD PMID:19840844 N-methyl-N-nitrosourea increases mutagenesis ISO Hprt1 (Rattus norvegicus) 6480464 Methylnitrosourea results in increased mutagenesis of HPRT1 gene CTD PMID:18249417 N-methyl-N-nitrosourea increases expression EXP 6480464 Methylnitrosourea results in increased expression of HPRT1 mRNA CTD PMID:25270620 N-nitrosodiethylamine multiple interactions ISO Hprt1 (Rattus norvegicus) 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of HPRT1 mRNA CTD PMID:17602206 N-nitrosodimethylamine multiple interactions ISO HPRT1 (Homo sapiens) 6480464 [[SULT1A1 protein co-treated with CYP2E1 protein] results in increased susceptibility to Dimethylnitrosamine] which results in increased mutagenesis of HPRT1 gene CTD PMID:27913846 nefazodone increases expression ISO Hprt1 (Rattus norvegicus) 6480464 nefazodone results in increased expression of HPRT1 mRNA CTD PMID:24136188 neoglucobrassicin increases mutagenesis ISO HPRT1 (Homo sapiens) 6480464 1-methoxy-3-indolylmethylglucosinolate metabolite results in increased mutagenesis of HPRT1 gene CTD PMID:20846518 nickel sulfate affects expression ISO HPRT1 (Homo sapiens) 6480464 nickel sulfate affects the expression of HPRT1 mRNA CTD PMID:18202158 nimesulide increases expression ISO Hprt1 (Rattus norvegicus) 6480464 nimesulide results in increased expression of HPRT1 mRNA CTD PMID:24136188 nitric oxide increases mutagenesis ISO HPRT1 (Homo sapiens) 6480464 Nitric Oxide results in increased mutagenesis of HPRT1 gene CTD PMID:22303861 and PMID:28454271 okadaic acid multiple interactions EXP 6480464 [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of HPRT1 mRNA CTD PMID:19840844 okadaic acid increases expression EXP 6480464 Okadaic Acid results in increased expression of HPRT1 mRNA CTD PMID:25270620 omeprazole affects expression ISO Hprt1 (Rattus norvegicus) 6480464 Omeprazole affects the expression of HPRT1 mRNA CTD PMID:19483382 oxirane increases mutagenesis EXP 6480464 Ethylene Oxide results in increased mutagenesis of HPRT1 gene CTD PMID:10636004 ozone multiple interactions EXP 6480464 [Ozone co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased mutagenesis of HPRT1 gene more ... CTD PMID:15613823 ozone multiple interactions ISO Hprt1 (Rattus norvegicus) 6480464 [Ozone co-treated with Chlorine] affects the expression of HPRT1 mRNA CTD PMID:18636392 ozone increases mutagenesis EXP 6480464 Ozone results in increased mutagenesis of HPRT1 gene CTD PMID:15613823 p-toluidine increases expression ISO Hprt1 (Rattus norvegicus) 6480464 4-toluidine results in increased expression of HPRT1 mRNA CTD PMID:27638505 paracetamol increases expression ISO Hprt1 (Rattus norvegicus) 6480464 Acetaminophen results in increased expression of HPRT1 mRNA CTD PMID:12883083 paracetamol multiple interactions EXP 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of HPRT1 mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of HPRT1 mRNA] CTD PMID:17585979 paraquat increases expression EXP 6480464 Paraquat results in increased expression of HPRT1 mRNA CTD PMID:21371552 pent-4-enoic acid increases expression ISO Hprt1 (Rattus norvegicus) 6480464 4-pentenoic acid results in increased expression of HPRT1 mRNA CTD PMID:12883083 pentachlorophenol multiple interactions ISO HPRT1 (Homo sapiens) 6480464 Pentachlorophenol inhibits the reaction [[[SULT1A1 protein co-treated with CYP2E1 protein] results in increased susceptibility to 1-hydroxymethylpyrene] which results in increased mutagenesis of HPRT1 gene] and Pentachlorophenol inhibits the reaction [[[SULT1A1 protein co-treated with CYP2E1 protein] results in increased susceptibility to 1-methylpyrene] which results in increased mutagenesis of HPRT1 gene] CTD PMID:25243916 perfluorooctane-1-sulfonic acid multiple interactions EXP 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of HPRT1 mRNA more ... CTD PMID:36331819 perfluorooctanoic acid multiple interactions EXP 6480464 Dietary Fats and Unsaturated inhibits the reaction [perfluorooctanoic acid results in increased expression of HPRT1 mRNA] CTD PMID:23626681 perfluorooctanoic acid increases expression EXP 6480464 perfluorooctanoic acid results in increased expression of HPRT1 mRNA CTD PMID:23626681 phenobarbital decreases expression ISO Hprt1 (Rattus norvegicus) 6480464 Phenobarbital results in decreased expression of HPRT1 mRNA CTD PMID:16940010 phenobarbital increases expression ISO Hprt1 (Rattus norvegicus) 6480464 Phenobarbital results in increased expression of HPRT1 mRNA CTD PMID:30047161 PhIP multiple interactions ISO HPRT1 (Homo sapiens) 6480464 [2-amino-1-methyl-6-phenylimidazo(4 more ... CTD PMID:7728948 and PMID:8625468 PhIP increases mutagenesis ISO HPRT1 (Homo sapiens) 6480464 2-amino-1-methyl-6-phenylimidazo(4 more ... CTD PMID:10728688 more ... PhIP multiple interactions ISO Hprt1 (Rattus norvegicus) 6480464 Ascorbic Acid inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4 more ... CTD PMID:12467141 PhIP increases mutagenesis ISO Hprt1 (Rattus norvegicus) 6480464 2-amino-1-methyl-6-phenylimidazo(4 and 5-b)pyridine results in increased mutagenesis of HPRT1 gene CTD PMID:11289141 and PMID:12467141 phorbol 13-acetate 12-myristate multiple interactions EXP 6480464 [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of HPRT1 mRNA CTD PMID:19840844 picoxystrobin increases expression ISO HPRT1 (Homo sapiens) 6480464 picoxystrobin results in increased expression of HPRT1 mRNA CTD PMID:33512557 pirinixic acid increases expression EXP 6480464 pirinixic acid results in increased expression of HPRT1 mRNA CTD PMID:16221962 more ... pirinixic acid multiple interactions EXP 6480464 PPARA protein promotes the reaction [pirinixic acid results in increased expression of HPRT1 mRNA] CTD PMID:20059764 pirinixic acid affects expression ISO Hprt1 (Rattus norvegicus) 6480464 pirinixic acid affects the expression of HPRT1 mRNA CTD PMID:19483382 potassium bromate increases mutagenesis ISO HPRT1 (Homo sapiens) 6480464 potassium bromate results in increased mutagenesis of HPRT1 gene CTD PMID:22539617 potassium bromate increases mutagenesis EXP 6480464 potassium bromate results in increased mutagenesis of HPRT1 gene CTD PMID:19853637 potassium dichromate increases mutagenesis ISO HPRT1 (Homo sapiens) 6480464 Potassium Dichromate results in increased mutagenesis of HPRT1 gene CTD PMID:7508562 propiconazole increases expression EXP 6480464 propiconazole results in increased expression of HPRT1 mRNA CTD PMID:21278054 and PMID:22334560 pyrogallol increases expression EXP 6480464 Pyrogallol results in increased expression of HPRT1 mRNA CTD PMID:20362636 rac-lactic acid decreases expression ISO HPRT1 (Homo sapiens) 6480464 Lactic Acid results in decreased expression of HPRT1 mRNA CTD PMID:30851411 resveratrol multiple interactions ISO HPRT1 (Homo sapiens) 6480464 [Coumestrol co-treated with resveratrol] results in increased expression of HPRT1 mRNA CTD PMID:19167446 resveratrol decreases expression ISO HPRT1 (Homo sapiens) 6480464 resveratrol results in decreased expression of HPRT1 protein CTD PMID:23724044 retinyl acetate increases expression EXP 6480464 retinol acetate results in increased expression of HPRT1 mRNA CTD PMID:16772331 rotenone increases expression ISO HPRT1 (Homo sapiens) 6480464 Rotenone results in increased expression of HPRT1 mRNA CTD PMID:33512557 SB 431542 multiple interactions ISO HPRT1 (Homo sapiens) 6480464 [LDN 193189 co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 and PMID:37664457 sodium arsenite multiple interactions ISO HPRT1 (Homo sapiens) 6480464 [ATF4 mutant form results in increased susceptibility to sodium arsenite] which results in increased mutagenesis of HPRT1 gene and APEX1 inhibits the reaction [[ATF4 mutant form results in increased susceptibility to sodium arsenite] which results in increased mutagenesis of HPRT1 gene] CTD PMID:17938202 sodium arsenite increases expression ISO HPRT1 (Homo sapiens) 6480464 sodium arsenite results in increased expression of HPRT1 mRNA CTD PMID:34032870 sodium arsenite increases expression EXP 6480464 sodium arsenite results in increased expression of HPRT1 protein CTD PMID:29044176 sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of HPRT1 mRNA CTD PMID:36209798 styrene multiple interactions ISO HPRT1 (Homo sapiens) 6480464 GSTP1 gene polymorphism promotes the reaction [Styrene results in increased mutagenesis of HPRT1 gene] CTD PMID:12893075 styrene increases mutagenesis ISO HPRT1 (Homo sapiens) 6480464 Styrene results in increased mutagenesis of HPRT1 gene CTD PMID:11535253 and PMID:12893075 sulfadimethoxine increases expression ISO Hprt1 (Rattus norvegicus) 6480464 Sulfadimethoxine results in increased expression of HPRT1 mRNA CTD PMID:30047161 tamoxifen affects expression EXP 6480464 Tamoxifen affects the expression of HPRT1 mRNA CTD PMID:17555576 temozolomide increases mutagenesis EXP 6480464 temozolomide results in increased mutagenesis of HPRT1 gene CTD PMID:17116724 temozolomide multiple interactions EXP 6480464 MGMT protein inhibits the reaction [temozolomide results in increased mutagenesis of HPRT1 gene] CTD PMID:17116724 testosterone multiple interactions ISO HPRT1 (Homo sapiens) 6480464 [Testosterone co-treated with Calcitriol] results in decreased expression of HPRT1 mRNA CTD PMID:21592394 testosterone decreases expression ISO HPRT1 (Homo sapiens) 6480464 Testosterone results in decreased expression of HPRT1 mRNA CTD PMID:21592394 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of HPRT1 mRNA CTD PMID:31919559 thapsigargin decreases expression ISO HPRT1 (Homo sapiens) 6480464 Thapsigargin results in decreased expression of HPRT1 mRNA CTD PMID:22378314 thioacetamide affects expression ISO Hprt1 (Rattus norvegicus) 6480464 Thioacetamide affects the expression of HPRT1 mRNA CTD PMID:19483382 Thiotepa increases mutagenesis ISO Hprt1 (Rattus norvegicus) 6480464 Thiotepa results in increased mutagenesis of HPRT1 gene CTD PMID:10069464 tioguanine decreases response to substance ISO HPRT1 (Homo sapiens) 6480464 HPRT1 gene mutant form results in decreased susceptibility to Thioguanine CTD PMID:28446605 trichloroethene decreases expression ISO Hprt1 (Rattus norvegicus) 6480464 Trichloroethylene results in decreased expression of HPRT1 mRNA CTD PMID:33387578 trimellitic anhydride increases expression EXP 6480464 trimellitic anhydride results in increased expression of HPRT1 mRNA CTD PMID:19042947 triphenyl phosphate increases expression ISO Hprt1 (Rattus norvegicus) 6480464 triphenyl phosphate results in increased expression of HPRT1 mRNA CTD PMID:30589522 troglitazone decreases expression ISO HPRT1 (Homo sapiens) 6480464 troglitazone results in decreased expression of HPRT1 mRNA CTD PMID:19631733 tungsten increases expression EXP 6480464 Tungsten results in increased expression of HPRT1 mRNA CTD PMID:30912803 tunicamycin decreases expression ISO HPRT1 (Homo sapiens) 6480464 Tunicamycin results in decreased expression of HPRT1 mRNA CTD PMID:22378314 valproic acid increases expression ISO HPRT1 (Homo sapiens) 6480464 Valproic Acid results in increased expression of HPRT1 mRNA CTD PMID:23179753 more ... valproic acid multiple interactions ISO HPRT1 (Homo sapiens) 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HPRT1 mRNA CTD PMID:27188386 vanillin decreases mutagenesis ISO HPRT1 (Homo sapiens) 6480464 vanillin results in decreased mutagenesis of HPRT1 gene CTD PMID:17178418 vitamin E multiple interactions ISO Hprt1 (Rattus norvegicus) 6480464 Vitamin E inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4 and 5-b)pyridine results in increased mutagenesis of HPRT1 gene] CTD PMID:12467141 zidovudine increases mutagenesis ISO HPRT1 (Homo sapiens) 6480464 Zidovudine results in increased mutagenesis of HPRT1 exon CTD PMID:10526209
