Alox5 (arachidonate 5-lipoxygenase) - Rat Genome Database

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Gene: Alox5 (arachidonate 5-lipoxygenase) Mus musculus
Analyze
Symbol: Alox5
Name: arachidonate 5-lipoxygenase
RGD ID: 10147
MGI Page MGI
Description: Enables arachidonate 5-lipoxygenase activity. Involved in several processes, including leukocyte migration; negative regulation of angiogenesis; and regulation of cellular response to stress. Acts upstream of or within leukotriene biosynthetic process and leukotriene production involved in inflammatory response. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in artery disease (multiple); asthma (multiple); pancreatic cancer; and pulmonary tuberculosis. Orthologous to human ALOX5 (arachidonate 5-lipoxygenase); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; INTERACTS WITH (4Z,7Z,10Z,13Z,15E,19Z)-17-hydroxydocosahexaenoic acid; 1,2-dimethylhydrazine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 5-L; 5-lipoxygenase; 5-LO; 5-LOX; 5L; 5LO; 5LX; AI850497; F730011J02; polyunsaturated fatty acid 5-lipoxygenase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396116,387,030 - 116,438,139 (-)NCBIGRCm39mm39
GRCm39 Ensembl6116,387,038 - 116,438,139 (-)Ensembl
GRCm386116,410,071 - 116,461,178 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6116,410,077 - 116,461,178 (-)EnsemblGRCm38mm10GRCm38
MGSCv376116,360,089 - 116,411,196 (-)NCBIGRCm37mm9NCBIm37
MGSCv366116,375,696 - 116,426,797 (-)NCBImm8
Celera6118,247,670 - 118,299,116 (-)NCBICelera
Cytogenetic Map6E3NCBI
cM Map653.79NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(4Z,7Z,10Z,13Z,15E,19Z)-17-hydroxydocosahexaenoic acid  (EXP)
(5Z,8Z,11Z,13E)-15-HETE  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP)
1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (EXP,ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
4-hydroxycyclophosphamide  (ISO)
4-hydroxynon-2-enal  (EXP)
acetamide  (ISO)
acrolein  (EXP)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
ammonium chloride  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
arachidonic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
baicalin  (ISO)
benoxaprofen  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
beta-D-glucosamine 6-sulfate  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
Calcimycin  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
capsaicin  (ISO)
carbon nanotube  (EXP)
celecoxib  (EXP)
cetirizine  (ISO)
choline  (EXP)
chromium(6+)  (EXP)
cis-caffeic acid  (EXP,ISO)
cisplatin  (ISO)
coumarin  (ISO)
curcumin  (ISO)
D-glucitol  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
dextran sulfate  (EXP)
dimethyl sulfoxide  (EXP)
dioxygen  (ISO)
dithiol  (ISO)
docebenone  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ebselen  (ISO)
edaravone  (ISO)
elemental selenium  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
ethoxyquin  (ISO)
flavonoids  (ISO)
folic acid  (EXP)
fructose  (ISO)
furan  (ISO)
glucose  (ISO)
histamine  (ISO)
hydrogen peroxide  (ISO)
hydroxamic acid  (ISO)
hydroxyurea  (ISO)
indometacin  (ISO)
kaempferol  (ISO)
L-methionine  (EXP)
leukotriene A4  (ISO)
leukotriene B4  (EXP,ISO)
leukotriene C4  (EXP,ISO)
leukotriene D4  (EXP,ISO)
leukotriene E4  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
lipoxin A4  (ISO)
lonapalene  (ISO)
Loratadine  (ISO)
losartan  (ISO)
luteolin  (ISO)
masoprocol  (ISO)
meclofenamic acid  (ISO)
melittin  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
miquelianin  (ISO)
montelukast  (ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
niclosamide  (EXP,ISO)
nicotine  (ISO)
nitric oxide  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (ISO)
paracetamol  (EXP)
paraquat  (EXP,ISO)
pentanal  (ISO)
peroxynitrous acid  (ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
poly(propylene imine) macromolecule  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propanal  (ISO)
propranolol  (ISO)
quercetin  (ISO)
quercetin 3-sulfate  (ISO)
reactive oxygen species  (ISO)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium dichromate  (ISO)
steviol  (ISO)
stevioside  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tenidap  (ISO)
tepoxalin  (ISO)
tert-butanol  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (EXP)
thapsigargin  (ISO)
thimerosal  (ISO)
titanium dioxide  (EXP)
trans-caffeic acid  (EXP,ISO)
triamcinolone acetonide  (EXP)
triclosan  (ISO)
trimellitic anhydride  (EXP)
troglitazone  (ISO)
tyrphostin AG 1478  (EXP,ISO)
valproic acid  (ISO)
vitamin E  (ISO)
zileuton  (EXP,ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute inflammatory response  (ISO)
arachidonic acid metabolic process  (IBA)
dendritic cell migration  (IMP)
glucose homeostasis  (IMP)
hepoxilin biosynthetic process  (IBA)
humoral immune response  (IMP)
inflammatory response  (IMP)
leukocyte chemotaxis involved in inflammatory response  (ISO)
leukocyte migration involved in inflammatory response  (IMP)
leukotriene A4 biosynthetic process  (IMP,ISO)
leukotriene biosynthetic process  (IDA,IMP,ISO)
leukotriene metabolic process  (IMP)
leukotriene production involved in inflammatory response  (IMP)
linoleic acid metabolic process  (IBA)
lipid oxidation  (IBA)
lipoxin biosynthetic process  (ISO)
lipoxygenase pathway  (IBA)
negative regulation of angiogenesis  (IMP)
negative regulation of endothelial cell proliferation  (IMP)
negative regulation of inflammatory response  (ISO)
negative regulation of response to endoplasmic reticulum stress  (IMP)
negative regulation of sprouting angiogenesis  (IMP)
negative regulation of vascular wound healing  (IMP)
negative regulation of wound healing  (IMP)
positive regulation of bone mineralization  (IMP)
positive regulation of cytochrome-c oxidase activity  (ISO)
positive regulation of leukocyte adhesion to arterial endothelial cell  (IMP)
positive regulation of vasoconstriction  (ISO)
regulation of cellular response to oxidative stress  (IMP)
regulation of cytokine production involved in inflammatory response  (IMP)
regulation of fat cell differentiation  (IMP)
regulation of inflammatory response  (IMP,ISO)
regulation of inflammatory response to wounding  (IMP)
regulation of insulin secretion  (IMP)
regulation of reactive oxygen species biosynthetic process  (ISO)
response to hyperoxia  (ISO)
response to nutrient  (ISO)
sensory perception of pain  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
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35. MGD and Homologene mouse data transfer
36. MGD data from the GO Consortium
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41. Pipeline to import KEGG annotations from KEGG into RGD
42. Pipeline to import SMPDB annotations from SMPDB into RGD
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46. RGD automated import pipeline
47. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
48. RGD automated import pipeline for gene-chemical interactions
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Additional References at PubMed
PMID:7629107   PMID:7732821   PMID:8017775   PMID:8889548   PMID:8944751   PMID:8955165   PMID:9088981   PMID:9091580   PMID:9227503   PMID:10349636   PMID:10384136   PMID:11027682  
PMID:11042125   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11325876   PMID:11714834   PMID:11790660   PMID:11867678   PMID:11919084   PMID:12021253   PMID:12140292   PMID:12142344  
PMID:12237493   PMID:12466851   PMID:12477932   PMID:12730086   PMID:12923494   PMID:12941149   PMID:12943700   PMID:14530386   PMID:14572603   PMID:14681479   PMID:15033436   PMID:15197007  
PMID:15240672   PMID:15240726   PMID:15328042   PMID:15328337   PMID:15371096   PMID:15479450   PMID:15549416   PMID:15593193   PMID:15661924   PMID:15718414   PMID:15821759   PMID:15931391  
PMID:16006535   PMID:16019083   PMID:16046553   PMID:16081317   PMID:16141072   PMID:16141073   PMID:16148135   PMID:16200066   PMID:16339565   PMID:16444258   PMID:16565390   PMID:16567388  
PMID:16574771   PMID:16624897   PMID:16645143   PMID:16698924   PMID:16849505   PMID:16920959   PMID:17392829   PMID:17404289   PMID:17586489   PMID:17643886   PMID:17761955   PMID:17873277  
PMID:17894798   PMID:17913976   PMID:17979156   PMID:17982097   PMID:17998412   PMID:18025235   PMID:18048478   PMID:18276782   PMID:18305891   PMID:18344982   PMID:18346986   PMID:18403121  
PMID:18421434   PMID:18645210   PMID:18804760   PMID:18978352   PMID:19050273   PMID:19075240   PMID:19135147   PMID:19289819   PMID:19299700   PMID:19416808   PMID:19428550   PMID:19503090  
PMID:19509298   PMID:19561612   PMID:19734227   PMID:19778587   PMID:19965960   PMID:20008149   PMID:20031637   PMID:20052386   PMID:20173212   PMID:20219953   PMID:20227514   PMID:20370567  
PMID:20381637   PMID:20554538   PMID:20622882   PMID:20684827   PMID:20696828   PMID:20724598   PMID:20817008   PMID:20851170   PMID:20876351   PMID:21206089   PMID:21216893   PMID:21224059  
PMID:21253592   PMID:21267068   PMID:21270404   PMID:21307302   PMID:21435457   PMID:21536805   PMID:21555210   PMID:21558275   PMID:21596859   PMID:21677750   PMID:21873635   PMID:21951814  
PMID:22072302   PMID:22128029   PMID:22220211   PMID:22448213   PMID:22493243   PMID:22536403   PMID:22551156   PMID:22658486   PMID:22675576   PMID:22688342   PMID:22696442   PMID:22902502  
PMID:23034916   PMID:23079635   PMID:23109727   PMID:23112187   PMID:23246375   PMID:23325886   PMID:23381993   PMID:23408836   PMID:23478745   PMID:23485965   PMID:23613965   PMID:23634895  
PMID:23708969   PMID:23720274   PMID:23809162   PMID:23812248   PMID:23859654   PMID:23892084   PMID:23947598   PMID:23951061   PMID:23991239   PMID:24076233   PMID:24130502   PMID:24226420  
PMID:24288682   PMID:24332986   PMID:24338629   PMID:24348260   PMID:24743022   PMID:24747745   PMID:24889202   PMID:24906289   PMID:24990750   PMID:25025884   PMID:25082812   PMID:25122659  
PMID:25229347   PMID:25246560   PMID:25270168   PMID:25302946   PMID:25309905   PMID:25313597   PMID:25324573   PMID:25477712   PMID:25583526   PMID:25628460   PMID:25698732   PMID:25779634  
PMID:25802082   PMID:25870230   PMID:26076991   PMID:26432261   PMID:26649828   PMID:26663781   PMID:27060751   PMID:27313091   PMID:27630217   PMID:27784744   PMID:27887739   PMID:27896923  
PMID:28011865   PMID:28053185   PMID:28108297   PMID:28334897   PMID:28383037   PMID:28529998   PMID:28645655   PMID:28694473   PMID:28743859   PMID:28947611   PMID:28965882   PMID:29106033  
PMID:29128902   PMID:29167447   PMID:29174564   PMID:29247243   PMID:29311656   PMID:29339153   PMID:29610142   PMID:30185672   PMID:30242286   PMID:31057373   PMID:31300449   PMID:31642348  
PMID:31666208   PMID:32118582   PMID:32234475   PMID:32325033   PMID:32690653   PMID:32854115  


Genomics

Comparative Map Data
Alox5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396116,387,030 - 116,438,139 (-)NCBIGRCm39mm39
GRCm39 Ensembl6116,387,038 - 116,438,139 (-)Ensembl
GRCm386116,410,071 - 116,461,178 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6116,410,077 - 116,461,178 (-)EnsemblGRCm38mm10GRCm38
MGSCv376116,360,089 - 116,411,196 (-)NCBIGRCm37mm9NCBIm37
MGSCv366116,375,696 - 116,426,797 (-)NCBImm8
Celera6118,247,670 - 118,299,116 (-)NCBICelera
Cytogenetic Map6E3NCBI
cM Map653.79NCBI
ALOX5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1045,374,176 - 45,446,119 (+)EnsemblGRCh38hg38GRCh38
GRCh381045,374,209 - 45,446,121 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371045,869,664 - 45,941,565 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361045,189,635 - 45,261,571 (+)NCBINCBI36hg18NCBI36
Build 341045,189,691 - 45,261,567NCBI
Celera1041,889,257 - 41,939,521 (+)NCBI
Cytogenetic Map10q11.21NCBI
HuRef1042,394,884 - 42,467,216 (+)NCBIHuRef
CHM1_11045,908,843 - 45,980,778 (+)NCBICHM1_1
Alox5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24149,531,329 - 149,578,696 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl4149,531,515 - 149,578,743 (-)Ensembl
Rnor_6.04148,398,004 - 148,446,308 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4148,398,892 - 148,446,303 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04214,345,956 - 214,393,337 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44152,610,283 - 152,657,891 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14152,855,123 - 152,902,732 (-)NCBI
Celera4138,415,564 - 138,454,485 (-)NCBICelera
Cytogenetic Map4q42NCBI
Alox5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555462,494,819 - 2,550,909 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555462,495,226 - 2,550,909 (+)NCBIChiLan1.0ChiLan1.0
ALOX5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11045,639,946 - 45,710,016 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1045,639,946 - 45,710,016 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01042,461,398 - 42,531,576 (+)NCBIMhudiblu_PPA_v0panPan3
ALOX5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1282,170,920 - 2,218,765 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl282,170,920 - 2,219,609 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha282,405,370 - 2,462,571 (-)NCBI
ROS_Cfam_1.0282,349,844 - 2,407,164 (-)NCBI
UMICH_Zoey_3.1282,147,070 - 2,204,281 (-)NCBI
UNSW_CanFamBas_1.0282,183,953 - 2,241,179 (-)NCBI
UU_Cfam_GSD_1.0282,315,780 - 2,373,040 (-)NCBI
Alox5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721381,798,191 - 81,858,352 (-)NCBI
SpeTri2.0NW_0049365547,807,914 - 7,848,691 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALOX5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1490,858,975 - 90,907,094 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11490,859,209 - 90,907,084 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21498,902,267 - 98,950,236 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ALOX5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1941,085,257 - 41,145,760 (+)NCBI
ChlSab1.1 Ensembl941,085,361 - 41,145,331 (+)Ensembl
Vero_WHO_p1.0NW_023666048764,154 - 824,908 (+)NCBI
Alox5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624966168,244 - 220,430 (+)NCBI

Position Markers
AI850497  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386116,410,251 - 116,410,392UniSTSGRCm38
MGSCv376116,360,269 - 116,360,410UniSTSGRCm37
Celera6118,247,850 - 118,247,991UniSTS
Cytogenetic Map6F1UniSTS
cM Map653.2UniSTS
Whitehead/MRC_RH61199.02UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645314059128835032Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46935985136423692Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648720000125360000Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648720000148450000Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648726556125356785Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673500000134700000Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678629504121115387Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683713869147052561Mouse
11251720Ewc4_methanol withdrawal and consumption 4 (mouse)684122513118122513Mouse
1301744Hdlq11_mHDL QTL 11 (mouse)Not determined687503360121503555Mouse
1301262Gasa3_mgastritis type A susceptibility locus 3 (mouse)Not determined689005405123005603Mouse
1301244Ichs_mimmediate cutaneous hypersensitivity QTL (mouse)Not determined690795610124795846Mouse
11353842Bmiq4_mbody mass index QTL 4 (mouse)692607306146429238Mouse
1301292Cfbw2_mcystic fibrosis body weight 2 (mouse)Not determined695004651129004738Mouse
1300704Cia3_mcollagen induced arthritis QTL 3 (mouse)Not determined696347325130347522Mouse
11040599Lmr4b_mleishmaniasis resistance 4b (mouse)696347325130347522Mouse
4141940W6q5_mweight 6 weeks QTL 5 (mouse)Not determined96655951146633626Mouse
4142416Egq11_mearly growth QTL 11 (mouse)Not determined96655951146633626Mouse
1357555Tesq2_mtestis weight QTL 2 (mouse)Not determined696655951146633626Mouse
10043923Bhr7_mbronchial hyperresponsiveness 7 (mouse)Not determined698242853132242977Mouse
1301518Bbaa5_mB.burgdorferi-associated arthritis 5 (mouse)Not determined698506837145935444Mouse
1301923Lith6_mlithogenic gene 6 (mouse)Not determined698717516132717715Mouse
1301915Chab3_mcholesterol absorption 3 (mouse)Not determined698931748132940036Mouse
1302131Bmd8_mbone mineral density 8 (mouse)Not determined699155128133155267Mouse
1300887Pabr1_mplasma apolipoprotein B (human) regulator 1 (mouse)Not determined6103777444136423692Mouse
1301509Sluc3_msusceptibility to lung cancer 3 (mouse)Not determined6104503360127042975Mouse
1357806Aaj3_manxiety in A/J 3 (mouse)Not determined6104503360136423692Mouse
4141699Ibdq2_minflammatory bowel disease QTL 2 (mouse)Not determined106005405120917141Mouse
10412207Cypr5_mcytokine production 5 (mouse)Not determined6110838217144838360Mouse
13463481Mcvq14_mmean corpuscular volume QTL 14 (mouse)6111165485145165578Mouse
10043891Tilss4_mTNF-induced lethal shock susceptibility 3 (mouse)Not determined6112269957125356785Mouse
11252138Clas1_mcarcinogen-induced lung adenoma susceptibility 1 (mouse)6112269957147052561Mouse
8552704Cia43_mcollagen induced arthritis QTL 43 (mouse)Not determined6114182280119760571Mouse
4140980Mvwf2_mmodifier of von Willebrand factor 2 (mouse)Not determined114368732145656013Mouse
1301658Radpf3_mradiation pulmonary fibrosis 3 (mouse)Not determined6115242853146429238Mouse
4141194Cyx_mcycloheximide tasting (mouse)Not determined115569842149572401Mouse
4141889Qui_mquinine sensitivity, taste (mouse)Not determined115569842149572401Mouse
4141295Rua_mraffinose acetate tasting (mouse)Not determined115569842149572401Mouse
1301927Etohcta6_methanol conditioned taste aversion 6 (mouse)Not determined6115601042149601187Mouse
1301083Bhr5_mbronchial hyperresponsiveness 5 (mouse)Not determined6115717516132601187Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1375
Count of miRNA genes:522
Interacting mature miRNAs:612
Transcripts:ENSMUST00000026795, ENSMUST00000164547, ENSMUST00000167174, ENSMUST00000167447, ENSMUST00000167585, ENSMUST00000169625, ENSMUST00000170186
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_009662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036165760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA388919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC123548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF393814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK089344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK136868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK137481 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK169938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC049768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC139102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC141213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY205433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY555055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CAAA01059195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L42198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000026795   ⟹   ENSMUSP00000026795
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6116,387,038 - 116,438,139 (-)Ensembl
GRCm38.p6 Ensembl6116,410,077 - 116,461,178 (-)Ensembl
RefSeq Acc Id: ENSMUST00000164547   ⟹   ENSMUSP00000130780
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6116,387,680 - 116,437,985 (-)Ensembl
GRCm38.p6 Ensembl6116,410,719 - 116,461,024 (-)Ensembl
RefSeq Acc Id: ENSMUST00000167174
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6116,392,431 - 116,401,924 (-)Ensembl
GRCm38.p6 Ensembl6116,415,470 - 116,424,963 (-)Ensembl
RefSeq Acc Id: ENSMUST00000167447
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6116,387,235 - 116,438,092 (-)Ensembl
GRCm38.p6 Ensembl6116,410,274 - 116,461,131 (-)Ensembl
RefSeq Acc Id: ENSMUST00000167585
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6116,389,552 - 116,390,981 (-)Ensembl
GRCm38.p6 Ensembl6116,412,591 - 116,414,020 (-)Ensembl
RefSeq Acc Id: ENSMUST00000169625
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6116,387,237 - 116,389,753 (-)Ensembl
GRCm38.p6 Ensembl6116,410,276 - 116,412,792 (-)Ensembl
RefSeq Acc Id: ENSMUST00000170186   ⟹   ENSMUSP00000130424
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6116,387,680 - 116,437,985 (-)Ensembl
GRCm38.p6 Ensembl6116,410,719 - 116,461,024 (-)Ensembl
RefSeq Acc Id: ENSMUST00000203722   ⟹   ENSMUSP00000145367
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6116,387,568 - 116,437,985 (-)Ensembl
GRCm38.p6 Ensembl6116,410,607 - 116,461,024 (-)Ensembl
RefSeq Acc Id: NM_009662   ⟹   NP_033792
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396116,387,032 - 116,438,139 (-)NCBI
GRCm386116,410,071 - 116,461,178 (-)NCBI
MGSCv376116,360,089 - 116,411,196 (-)RGD
Celera6118,247,670 - 118,299,116 (-)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036165760   ⟹   XP_036021653
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396116,387,030 - 116,402,080 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_033792   ⟸   NM_009662
- UniProtKB: P48999 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000130424   ⟸   ENSMUST00000170186
RefSeq Acc Id: ENSMUSP00000145367   ⟸   ENSMUST00000203722
RefSeq Acc Id: ENSMUSP00000130780   ⟸   ENSMUST00000164547
RefSeq Acc Id: ENSMUSP00000026795   ⟸   ENSMUST00000026795
RefSeq Acc Id: XP_036021653   ⟸   XM_036165760
- Peptide Label: isoform X1
Protein Domains
Lipoxygenase   PLAT

Promoters
RGD ID:6838928
Promoter ID:MM_KWN:47294
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   Brain,   Kidney,   Lung
Transcripts:UC009DKC.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv366116,362,406 - 116,363,347 (-)MPROMDB
RGD ID:6838927
Promoter ID:MM_KWN:47295
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   ES_Cell,   Lung
Transcripts:NM_009662
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv366116,410,896 - 116,411,396 (-)MPROMDB
RGD ID:6890762
Promoter ID:EPDNEW_M8832
Type:initiation region
Name:Alox5_1
Description:Mus musculus arachidonate 5-lipoxygenase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm386116,461,134 - 116,461,194EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:87999 AgrOrtholog
Ensembl Genes ENSMUSG00000025701 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000026795 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000130424 UniProtKB/TrEMBL
  ENSMUSP00000130780 UniProtKB/TrEMBL
  ENSMUSP00000145367 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000026795 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000164547 UniProtKB/TrEMBL
  ENSMUST00000170186 UniProtKB/TrEMBL
  ENSMUST00000203722 UniProtKB/TrEMBL
InterPro LipOase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LipOase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LipOase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LipOase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LipOase_Fe_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LipOase_mml UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT/LH2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT/LH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT_LOX_verte UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:11689 UniProtKB/Swiss-Prot
MGD MGI:87999 ENTREZGENE
NCBI Gene 11689 ENTREZGENE
PANTHER PTHR11771 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Lipoxygenase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ALOX5 RGD
PhenoGen Alox5 PhenoGen
PRINTS LIPOXYGENASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAMLPOXGNASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE LIPOXYGENASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIPOXYGENASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIPOXYGENASE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART LH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48484 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49723 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0N4SW45_MOUSE UniProtKB/TrEMBL
  E9Q6H6_MOUSE UniProtKB/TrEMBL
  E9QA93_MOUSE UniProtKB/TrEMBL
  LOX5_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3TBK8_MOUSE UniProtKB/TrEMBL
  Q3TC68_MOUSE UniProtKB/TrEMBL
  Q810M3_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q3TB75 UniProtKB/Swiss-Prot