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Gene: Alox5 (arachidonate 5-lipoxygenase) Mus musculus
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Symbol: Alox5
Name: arachidonate 5-lipoxygenase
RGD ID: 10147
Description: Exhibits arachidonate 5-lipoxygenase activity. Involved in several processes, including leukocyte migration; negative regulation of angiogenesis; and regulation of inflammatory response. Localizes to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in arteriosclerosis; asthma; pancreatic cancer; pulmonary hypertension; and pulmonary tuberculosis. Orthologous to human ALOX5 (arachidonate 5-lipoxygenase); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; INTERACTS WITH (4Z,7Z,10Z,13Z,15E,19Z)-17-hydroxydocosahexaenoic acid; 1,2-dimethylhydrazine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 5-L; 5-lipoxygenase; 5-LO; 5-LOX; 5L; 5LO; 5LX; AI850497; F730011J02; polyunsaturated fatty acid 5-lipoxygenase
Orthologs:
Homo sapiens (human) : ALOX5 (arachidonate 5-lipoxygenase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Alox5 (arachidonate 5-lipoxygenase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Alox5 (arachidonate 5-lipoxygenase)
Pan paniscus (bonobo/pygmy chimpanzee) : ALOX5 (arachidonate 5-lipoxygenase)
Canis lupus familiaris (dog) : ALOX5 (arachidonate 5-lipoxygenase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Alox5 (arachidonate 5-lipoxygenase)
Sus scrofa (pig) : ALOX5 (arachidonate 5-lipoxygenase)
Chlorocebus sabaeus (African green monkey) : ALOX5 (arachidonate 5-lipoxygenase)
Heterocephalus glaber (naked mole-rat) : Alox5 (arachidonate 5-lipoxygenase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl6116,410,077 - 116,461,178 (-)EnsemblGRCm38mm10GRCm38
GRCm386116,410,071 - 116,461,178 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv376116,360,089 - 116,411,196 (-)NCBIGRCm37mm9NCBIm37
MGSCv366116,375,696 - 116,426,797 (-)NCBImm8
Celera6118,247,670 - 118,299,116 (-)NCBICelera
Cytogenetic Map6E3NCBI
cM Map653.79NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Alox5
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10147
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.