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Gene: Alox5 (arachidonate 5-lipoxygenase) Mus musculus
Symbol: Alox5
Name: arachidonate 5-lipoxygenase
RGD ID: 10147
Description: Exhibits arachidonate 5-lipoxygenase activity. Involved in several processes, including leukocyte migration; negative regulation of angiogenesis; and regulation of inflammatory response. Localizes to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in arteriosclerosis; asthma; pancreatic cancer; pulmonary hypertension; and pulmonary tuberculosis. Orthologous to human ALOX5 (arachidonate 5-lipoxygenase); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; INTERACTS WITH (4Z,7Z,10Z,13Z,15E,19Z)-17-hydroxydocosahexaenoic acid; 1,2-dimethylhydrazine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 5-L; 5-lipoxygenase; 5-LO; 5-LOX; 5L; 5LO; 5LX; AI850497; F730011J02; polyunsaturated fatty acid 5-lipoxygenase
Homo sapiens (human) : ALOX5 (arachidonate 5-lipoxygenase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Alox5 (arachidonate 5-lipoxygenase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Alox5 (arachidonate 5-lipoxygenase)
Pan paniscus (bonobo/pygmy chimpanzee) : ALOX5 (arachidonate 5-lipoxygenase)
Canis lupus familiaris (dog) : ALOX5 (arachidonate 5-lipoxygenase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Alox5 (arachidonate 5-lipoxygenase)
Sus scrofa (pig) : ALOX5 (arachidonate 5-lipoxygenase)
Chlorocebus sabaeus (African green monkey) : ALOX5 (arachidonate 5-lipoxygenase)
Heterocephalus glaber (naked mole-rat) : Alox5 (arachidonate 5-lipoxygenase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl6116,410,077 - 116,461,178 (-)EnsemblGRCm38mm10GRCm38
GRCm386116,410,071 - 116,461,178 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv376116,360,089 - 116,411,196 (-)NCBIGRCm37mm9NCBIm37
MGSCv366116,375,696 - 116,426,797 (-)NCBImm8
Celera6118,247,670 - 118,299,116 (-)NCBICelera
Cytogenetic Map6E3NCBI
cM Map653.79NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Alox5
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10147
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.