Myocardial Ischemia - Ontology Report - Rat Genome Database

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RGD DISEASE ONTOLOGY - ANNOTATIONS

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RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:	Myocardial Ischemia	go back to main search page
Accession:	DOID:9007102	browse the term
Definition:	A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
Synonyms:	exact_synonym:	Ischemic Heart Disease; Ischemic Heart Diseases; Myocardial Ischemias
	related_synonym:	Ischemic heart disease, susceptibility to; SUPEROXIDE DISMUTASE, ELEVATED EXTRACELLULAR
	primary_id:	MESH:D017202
	xref:	EFO:1001375

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Genes (854)

Myocardial Ischemia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acyl-CoA thioesterase 2

CTD Direct Evidence: marker/mechanism

NCBI chr14:54,128,445...54,135,067

G

actin beta

CTD Direct Evidence: marker/mechanism

G

activin A receptor type 1B

NCBI chr12:36,765,655...36,811,355
Ensembl chr12:37,541,867...37,566,660

G

adiponectin, C1Q and collagen domain containing

CTD Direct Evidence: therapeutic

NCBI chr 3:183,876,051...183,889,723
Ensembl chr 3:192,341,320...192,354,885

G

adrenomedullin

protein:increased expression:plasma

NCBI chr11:10,437,712...10,440,053
Ensembl chr11:10,165,418...10,167,842

G

adrenomedullin 2

CTD Direct Evidence: marker/mechanism

NCBI chr22:30,729,236...30,734,801
Ensembl chr22:49,715,342...49,719,989

G

adrenoceptor beta 1

CTD Direct Evidence: marker/mechanism

NCBI chr10:110,642,491...110,646,595

G

adrenoceptor beta 2

CTD Direct Evidence: marker/mechanism

NCBI chr 5:144,259,756...144,398,421
Ensembl chr 5:150,267,554...150,315,892

G

advanced glycosylation end-product specific receptor

associated with Diabetes Mellitus, Type 2;DNA:SNP:promoter:-374T>A (human)

NCBI chr 6:31,828,363...31,831,981
Ensembl chr 6:32,708,251...32,711,641

G

angiotensinogen

CTD Direct Evidence: marker/mechanism

NCBI chr 1:206,252,141...206,263,830
Ensembl chr 1:211,279,015...211,291,044

G

adenylate kinase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 9:98,987,348...98,997,252
Ensembl chr 9:127,657,338...127,678,245

G

aldo-keto reductase family 1 member B

protein:increased activity:heart

NCBI chr 7:126,400,861...126,417,756
Ensembl chr 7:138,912,953...138,924,095

G

aldehyde dehydrogenase 2 family member

NCBI chr12:109,343,020...109,385,060
Ensembl chr12:112,734,243...112,776,471

G

aldehyde dehydrogenase 6 family member A1

CTD Direct Evidence: marker/mechanism

NCBI chr14:54,616,531...54,643,346
Ensembl chr14:73,472,255...73,495,734

G

aldolase, fructose-bisphosphate A

CTD Direct Evidence: marker/mechanism

G

adenosine monophosphate deaminase 1

susceptibility

associated with congestive heart failure; DNA:SNP:exon 2:34C>T (human)

NCBI chr 1:87,858,602...87,881,348
Ensembl chr 1:122,912,417...122,934,476

G

annexin A5

NCBI chr 4:113,868,218...113,897,243
Ensembl chr 4:125,006,038...125,034,972

G

amyloid beta precursor like protein 2

CTD Direct Evidence: marker/mechanism

NCBI chr11:124,881,191...124,944,472
Ensembl chr11:128,775,329...128,847,482

G

apolipoprotein B

NCBI chr2A:20,986,464...21,029,004
Ensembl chr2A:21,100,356...21,145,129

G

apolipoprotein E

susceptibility

DNA:polymorphism:promoter:-219G>T (human)

NCBI chr19:41,853,669...41,857,252
Ensembl chr19:50,459,906...50,463,490

G

amphiregulin

CTD Direct Evidence: marker/mechanism

NCBI chr 4:49,737,191...49,747,013
Ensembl chr 4:55,570,299...55,580,142

G

ATPase Na+/K+ transporting subunit alpha 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:86,162,401...86,193,883
Ensembl chr 1:121,212,488...121,243,099

G

axin 2

CTD Direct Evidence: marker/mechanism

NCBI chr17:59,476,336...59,509,358
Ensembl chr17:64,688,416...64,720,086

G

BCL2 associated X, apoptosis regulator

treatment

NCBI chr19:45,955,926...45,962,870
Ensembl chr19:54,793,594...54,800,468

G

BCL2 apoptosis regulator

treatment

NCBI chr18:56,481,212...56,679,012
Ensembl chr18:59,802,443...59,992,100

G

basic helix-loop-helix family member e40

CTD Direct Evidence: marker/mechanism

NCBI chr 3:4,927,487...4,933,215
Ensembl chr 3:5,028,515...5,032,470

G

basic helix-loop-helix ARNT like 1

CTD Direct Evidence: marker/mechanism

NCBI chr11:13,436,580...13,547,135
Ensembl chr11:13,163,028...13,240,376

G

complement C1q B chain

CTD Direct Evidence: marker/mechanism

NCBI chr 1:21,838,514...21,846,855
Ensembl chr 1:22,786,685...22,797,581

G

calcium voltage-gated channel auxiliary subunit alpha2delta 2

protein:decreased expression:heart

NCBI chr 3:50,288,926...50,430,152
Ensembl chr 3:51,526,075...51,640,406

G

calreticulin

CTD Direct Evidence: marker/mechanism

NCBI chr19:12,501,013...12,506,909
Ensembl chr19:13,242,900...13,249,416

G

calcium/calmodulin dependent protein kinase II delta

CTD Direct Evidence: marker/mechanism

NCBI chr 4:105,957,773...106,271,887
Ensembl chr 4:116,523,850...116,835,387

G

calnexin

CTD Direct Evidence: marker/mechanism

NCBI chr 5:174,832,964...174,884,804
Ensembl chr 5:182,167,012...182,197,403

G

C-C motif chemokine ligand 2

CTD Direct Evidence: marker/mechanism
protein:increased expression:plasma, heart (rat)

PMID:10068207 PMID:16214533

NCBI chr17:22,528,154...22,530,091
Ensembl chr17:22,820,890...22,823,384

G

cyclin A2

NCBI chr 4:114,016,917...114,024,816
Ensembl chr 4:125,153,810...125,161,302

G

cyclin D1

CTD Direct Evidence: marker/mechanism

NCBI chr11:64,737,006...64,750,353

G

cyclin D2

CTD Direct Evidence: marker/mechanism

NCBI chr12:4,385,957...4,417,602
Ensembl chr12:4,309,272...4,335,551

G

CD36 molecule (CD36 blood group)

CTD Direct Evidence: marker/mechanism

NCBI chr 7:72,566,478...72,643,517
Ensembl chr 7:86,265,114...86,305,865

G

CD38 molecule

protein:increased activity:ventricle myocardium
CTD Direct Evidence: marker/mechanism

PMID:12111041 PMID:16214533

NCBI chr 4:10,228,803...10,295,129
Ensembl chr 4:15,525,835...15,587,677

G

CD40 molecule

treatment

NCBI chr20:42,455,711...42,467,139
Ensembl chr20:43,541,619...43,552,994

G

CD40 ligand

treatment

protein:increased expression:myocardium (rat)

PMID:19204010 PMID:19565716

RGD:11352677 RGD:11352684

NCBI chr X:125,776,138...125,788,820
Ensembl chr X:136,042,849...136,058,202

G

cadherin 2

CTD Direct Evidence: marker/mechanism

NCBI chr18:21,210,001...21,435,919
Ensembl chr18:24,812,019...25,008,325

G

CCAAT enhancer binding protein delta

CTD Direct Evidence: marker/mechanism

NCBI chr 8:44,167,256...44,168,545

G

carboxylesterase 3

CTD Direct Evidence: marker/mechanism

NCBI chr16:47,292,042...47,340,670

G

cold inducible RNA binding protein

CTD Direct Evidence: marker/mechanism

G

C-type lectin domain containing 10A

CTD Direct Evidence: marker/mechanism

NCBI chr17:7,104,887...7,111,883
Ensembl chr17:7,092,968...7,097,462

G

carnitine palmitoyltransferase 1B

CTD Direct Evidence: marker/mechanism

NCBI chr22:30,815,073...30,825,341
Ensembl chr22:49,926,893...49,935,420

G

CRK proto-oncogene, adaptor protein

CTD Direct Evidence: marker/mechanism

NCBI chr17:1,406,335...1,438,587
Ensembl chr17:1,306,509...1,336,569

G

C-reactive protein

protein:increased expression:serum
CTD Direct Evidence: marker/mechanism

PMID:11840375 PMID:21122204

NCBI chr 1:135,062,102...135,064,402

G

crystallin alpha B

NCBI chr11:106,795,406...106,800,019
Ensembl chr11:110,639,442...110,644,272

G

catenin beta 1

CTD Direct Evidence: marker/mechanism

NCBI chr 3:41,104,940...41,145,934
Ensembl chr 3:41,373,726...41,414,030

G

cathepsin C

CTD Direct Evidence: marker/mechanism

NCBI chr11:83,299,827...83,345,383
Ensembl chr11:86,890,010...86,933,847

G

cortactin binding protein 2

CTD Direct Evidence: marker/mechanism

NCBI chr 7:109,675,275...109,837,178
Ensembl chr 7:122,370,616...122,520,397

G

C-X3-C motif chemokine ligand 1

CTD Direct Evidence: marker/mechanism

NCBI chr16:37,646,447...37,659,078
Ensembl chr16:56,779,065...56,791,760

G

C-X-C motif chemokine ligand 10

CTD Direct Evidence: marker/mechanism

NCBI chr 4:48,182,355...48,184,733
Ensembl chr 4:54,020,204...54,022,606

G

decorin

CTD Direct Evidence: marker/mechanism

NCBI chr12:88,678,791...88,715,677
Ensembl chr12:91,994,129...92,031,413

G

dihydrolipoamide S-acetyltransferase

CTD Direct Evidence: marker/mechanism

NCBI chr11:106,910,857...106,950,851
Ensembl chr11:110,756,001...110,792,795

G

delta like canonical Notch ligand 4

treatment

NCBI chr15:19,871,584...19,881,817
Ensembl chr15:38,121,574...38,129,471

G

dynamin 1 like

CTD Direct Evidence: marker/mechanism

NCBI chr12:53,476,553...53,541,421
Ensembl chr12:56,077,504...56,142,376

G

dual specificity phosphatase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 5:168,121,536...168,124,671
Ensembl chr 5:175,032,803...175,035,960

G

dual specificity phosphatase 6

CTD Direct Evidence: marker/mechanism

NCBI chr12:86,875,289...86,879,731
Ensembl chr12:90,195,482...90,200,321

G

endothelin 1

CTD Direct Evidence: marker/mechanism

PMID:10462014 PMID:11707688 PMID:16306806

NCBI chr 6:12,076,312...12,142,861
Ensembl chr 6:12,462,718...12,503,545

G

endothelin receptor type A

NCBI chr 4:139,815,336...139,879,600
Ensembl chr 4:151,476,356...151,536,497

G

endothelin receptor type B

NCBI chr13:59,112,349...59,136,615
Ensembl chr13:78,153,020...78,177,286

G

early growth response 2

CTD Direct Evidence: marker/mechanism

NCBI chr10:59,320,073...59,326,869
Ensembl chr10:61,648,364...61,652,846

G

eukaryotic translation initiation factor 2A

CTD Direct Evidence: marker/mechanism

NCBI chr 3:147,564,293...147,601,939
Ensembl chr 3:155,137,410...155,175,492

G

eukaryotic translation initiation factor 2 alpha kinase 3

CTD Direct Evidence: marker/mechanism

NCBI chr2A:87,688,732...87,759,580
Ensembl chr2A:89,596,833...89,667,468

G

eukaryotic translation initiation factor 4E

NCBI chr 4:91,268,463...91,329,800
Ensembl chr 4:101,941,142...101,994,809

G

eukaryotic translation initiation factor 4E binding protein 1

NCBI chr 8:37,336,698...37,362,768
Ensembl chr 8:34,513,359...34,538,936

G

eukaryotic translation initiation factor 4 gamma 1

NCBI chr 3:181,351,938...181,372,776
Ensembl chr 3:189,833,490...189,855,060

G

elastin

CTD Direct Evidence: marker/mechanism

G

endosulfine alpha

CTD Direct Evidence: marker/mechanism

NCBI chr 1:125,973,344...125,980,839
Ensembl chr 1:129,599,495...129,629,779

G

epoxide hydrolase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:201,271,366...201,306,635
Ensembl chr 1:206,272,866...206,307,581

G

epoxide hydrolase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 8:26,761,090...26,818,436
Ensembl chr 8:23,964,094...24,017,749

G

erb-b2 receptor tyrosine kinase 2

NCBI chr17:17,560,337...17,600,808
Ensembl chr17:17,777,434...17,805,862

G

F2R like trypsin receptor 1

CTD Direct Evidence: marker/mechanism

Ensembl chr 5:39,006,331...39,024,265

G

coagulation factor III, tissue factor

CTD Direct Evidence: marker/mechanism

NCBI chr 1:97,190,381...97,203,076
Ensembl chr 1:95,918,502...95,931,050

G

coagulation factor V

DNA:mutation, haplotype: :1691G>A (human)

NCBI chr 1:144,996,757...145,070,046
Ensembl chr 1:148,718,897...148,790,915

G

fatty acid binding protein 5

CTD Direct Evidence: marker/mechanism

NCBI chr 8:77,803,369...77,807,630
Ensembl chr 8:79,426,684...79,430,879

G

FEV transcription factor, ETS family member

CTD Direct Evidence: marker/mechanism

NCBI chr2B:106,238,933...106,243,499

G

fasciculation and elongation protein zeta 2

CTD Direct Evidence: marker/mechanism

NCBI chr2A:36,581,436...36,628,054
Ensembl chr2A:37,344,973...37,390,525

G

fibroblast growth factor 1

CTD Direct Evidence: marker/mechanism

NCBI chr 5:137,949,100...138,054,553
Ensembl chr 5:144,056,387...144,078,001

G

fibroblast growth factor 2

CTD Direct Evidence: therapeutic

PMID:12173832 PMID:14583313

NCBI chr 4:115,005,136...115,076,369
Ensembl chr 4:126,149,813...126,214,942

G

FXYD domain containing ion transport regulator 1

NCBI chr19:32,080,180...32,089,141
Ensembl chr19:40,824,448...40,827,039

G

glycine amidinotransferase

CTD Direct Evidence: marker/mechanism

NCBI chr15:24,309,045...24,326,673
Ensembl chr15:42,639,597...42,657,209

G

guanylate binding protein 2

CTD Direct Evidence: marker/mechanism

NCBI chr 1:91,816,602...91,836,594
Ensembl chr 1:90,569,151...90,588,158

G

GTP cyclohydrolase 1

CTD Direct Evidence: marker/mechanism

NCBI chr14:35,428,676...35,489,359
Ensembl chr14:53,706,723...53,767,393

G

glutamate-cysteine ligase catalytic subunit

CTD Direct Evidence: marker/mechanism

NCBI chr 6:53,052,145...53,102,794
Ensembl chr 6:54,687,315...54,734,994

G

growth differentiation factor 1

protein:increased expression:Left ventricle (human)

NCBI chr19:18,306,513...18,334,328
Ensembl chr19:19,317,173...19,342,487

G

growth differentiation factor 15

CTD Direct Evidence: marker/mechanism

NCBI chr19:17,864,840...17,867,883
Ensembl chr19:18,835,216...18,838,470

G

growth hormone receptor

CTD Direct Evidence: marker/mechanism

NCBI chr 5:67,654,326...67,953,140
Ensembl chr 5:72,700,150...72,871,278

G

ghrelin and obestatin prepropeptide

treatment
disease_progression

mRNA,protein:increased expression:plasma,myocardia:

NCBI chr 3:10,221,829...10,229,229
Ensembl chr 3:10,573,537...10,580,723

G

growth hormone secretagogue receptor

mRNA,protein:increased expression,increased activity:myocardia:

NCBI chr 3:169,448,217...169,458,602
Ensembl chr 3:177,633,039...177,638,202

G

glycerol kinase

CTD Direct Evidence: marker/mechanism

NCBI chr X:23,250,290...23,327,373
Ensembl chr X:30,806,950...30,877,131

G

G protein subunit alpha 12

CTD Direct Evidence: marker/mechanism

NCBI chr 7:2,989,832...3,104,848

G

glutamic--pyruvic transaminase

Ensembl chr 8:144,259,991...144,263,737

G

glutathione S-transferase mu 2

CTD Direct Evidence: marker/mechanism

NCBI chr 1:112,043,201...112,050,810

G

glutathione S-transferase pi 1

CTD Direct Evidence: marker/mechanism

NCBI chr11:62,942,756...62,945,701
Ensembl chr11:66,253,421...66,256,472

G

glycogenin 1

CTD Direct Evidence: marker/mechanism

NCBI chr 3:146,015,629...146,055,412
Ensembl chr 3:153,595,624...153,632,740

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha

CTD Direct Evidence: marker/mechanism

NCBI chr2A:26,185,938...26,240,229
Ensembl chr2A:26,279,995...26,334,068

G

homeostatic iron regulator

susceptibility

NCBI chr 6:25,921,663...25,930,852
Ensembl chr 6:26,580,358...26,588,591

G

hepatocyte growth factor

CTD Direct Evidence: therapeutic

NCBI chr 7:73,667,618...73,738,960
Ensembl chr 7:87,327,798...87,397,811

G

hypoxia inducible factor 1 subunit alpha

mRNA, protein:increased expression:myocardium (rat)

NCBI chr14:42,295,691...42,348,478
Ensembl chr14:60,552,374...60,604,885

G

HIVEP zinc finger 2

CTD Direct Evidence: marker/mechanism

NCBI chr 6:140,518,954...140,712,849
Ensembl chr 6:145,240,914...145,328,850

G

hexokinase 1

CTD Direct Evidence: marker/mechanism

NCBI chr10:65,786,940...65,870,204
Ensembl chr10:68,289,288...68,401,045

G

hexokinase 2

CTD Direct Evidence: marker/mechanism

NCBI chr2A:74,897,914...74,957,234
Ensembl chr2A:76,400,240...76,460,874

G

high mobility group box 1

CTD Direct Evidence: marker/mechanism

NCBI chr13:11,737,942...11,894,923
Ensembl chr13:30,174,899...30,179,527

G

3-hydroxy-3-methylglutaryl-CoA synthase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 1:82,778,489...82,798,987
Ensembl chr 1:117,775,770...117,796,679

G

heme oxygenase 1

susceptibility

CTD Direct Evidence: marker/mechanism

PMID:15064108 PMID:15734859 PMID:16214533

RGD:1582713 RGD:1598399

NCBI chr22:16,388,368...16,401,289
Ensembl chr22:34,230,825...34,244,063

G

heat shock protein family A (Hsp70) member 1A

CTD Direct Evidence: marker/mechanism

NCBI chr 6:31,476,710...31,491,411

G

heat shock protein family A (Hsp70) member 2

CTD Direct Evidence: marker/mechanism

NCBI chr14:45,124,326...45,127,105
Ensembl chr14:63,373,840...63,375,762

G

heat shock protein family A (Hsp70) member 9

CTD Direct Evidence: marker/mechanism

NCBI chr 5:133,934,859...133,955,048
Ensembl chr 5:140,064,207...140,084,551

G

heat shock protein family D (Hsp60) member 1

protein:increased expression:heart

NCBI chr2B:84,729,615...84,743,352
Ensembl chr2B:202,623,497...202,636,959

G

intercellular adhesion molecule 1

CTD Direct Evidence: marker/mechanism

NCBI chr19:9,821,402...9,837,021
Ensembl chr19:10,484,414...10,500,605

G

inhibitor of DNA binding 1

CTD Direct Evidence: marker/mechanism

NCBI chr20:27,895,177...27,896,414
Ensembl chr20:28,535,582...28,536,311

G

inhibitor of DNA binding 3

CTD Direct Evidence: marker/mechanism

NCBI chr 1:22,748,714...22,750,582
Ensembl chr 1:23,734,263...23,736,175

G

interferon gamma receptor 1

CTD Direct Evidence: marker/mechanism

NCBI chr 6:134,958,270...134,980,560
Ensembl chr 6:139,045,821...139,068,053

G

insulin like growth factor 1

severity

CTD Direct Evidence: marker/mechanism

PMID:16214533 PMID:16698918 PMID:16793032

RGD:1598425 RGD:1598426

NCBI chr12:99,986,887...100,066,773
Ensembl chr12:103,385,911...103,462,177

G

insulin like growth factor binding protein 3

CTD Direct Evidence: marker/mechanism

NCBI chr 7:46,564,234...46,573,145

G

interleukin 1 alpha

CTD Direct Evidence: marker/mechanism

NCBI chr2A:89,273,482...89,284,421
Ensembl chr2A:113,784,854...113,795,801

G

interleukin 1 beta

CTD Direct Evidence: marker/mechanism

NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424

G

interleukin 6

CTD Direct Evidence: marker/mechanism

NCBI chr 7:23,415,922...23,420,767

G

interleukin 6 cytokine family signal transducer

CTD Direct Evidence: marker/mechanism

NCBI chr 5:58,023,704...58,081,895
Ensembl chr 5:59,669,606...59,708,817

G

interferon regulatory factor 1

CTD Direct Evidence: marker/mechanism

NCBI chr 5:127,903,887...127,913,843
Ensembl chr 5:134,067,441...134,075,035

G

integrin subunit alpha V

NCBI chr2B:73,880,962...73,972,486
Ensembl chr2B:191,680,655...191,773,028

G

Janus kinase 2

CTD Direct Evidence: marker/mechanism

PMID:15746188 PMID:16214533

NCBI chr 9:4,820,303...4,971,867
Ensembl chr 9:5,006,271...5,156,626

G

JunB proto-oncogene, AP-1 transcription factor subunit

CTD Direct Evidence: marker/mechanism

NCBI chr19:12,353,760...12,355,598
Ensembl chr19:13,097,931...13,098,974

G

potassium inwardly rectifying channel subfamily J member 11

NCBI chr11:17,440,522...17,444,075
Ensembl chr11:17,127,557...17,128,729

G

potassium inwardly rectifying channel subfamily J member 8

CTD Direct Evidence: marker/mechanism

PMID:9399952 PMID:16214533 PMID:26591689

RGD:12790977 RGD:1598652

NCBI chr12:64,522,172...64,532,848
Ensembl chr12:67,127,263...67,137,128

G

potassium two pore domain channel subfamily K member 2

mRNA:increased expression:heart left ventricle, epicardium, endocardium (rat)

NCBI chr 1:190,576,180...190,807,367
Ensembl chr 1:195,430,994...195,662,840

G

potassium calcium-activated channel subfamily M regulatory beta subunit 1

no_association

NCBI chr 5:165,712,588...165,747,948
Ensembl chr 5:172,495,762...172,507,318

G

kinase insert domain receptor

CTD Direct Evidence: marker/mechanism

NCBI chr 4:68,813,894...68,861,018
Ensembl chr 4:75,377,375...75,427,109

G

KIT ligand

CTD Direct Evidence: marker/mechanism

NCBI chr12:86,036,501...86,124,274
Ensembl chr12:89,341,921...89,436,758

G

KLF transcription factor 4

CTD Direct Evidence: marker/mechanism

NCBI chr 9:78,634,545...78,639,447
Ensembl chr 9:106,820,954...106,825,797

G

leptin receptor

susceptibility

DNA:missense mutation:CDS:p.Q223R (human)

NCBI chr 1:64,772,612...64,881,886
Ensembl chr 1:66,693,926...66,764,768

G

sulfotransferase 1A1

CTD Direct Evidence: marker/mechanism

G

thioredoxin-interacting protein

NCBI chr 1:90,007,878...90,012,055

G

cytochrome c oxidase subunit 5B, mitochondrial

CTD Direct Evidence: marker/mechanism

NCBI chr2A:101,675,232...101,677,417
Ensembl chr2A:98,544,980...98,547,502

G

uncharacterized LOC100974886

CTD Direct Evidence: marker/mechanism

NCBI chr 4:50,092,989...50,095,541
Ensembl chr 4:55,925,562...55,986,555

G

cytochrome b-c1 complex subunit Rieske, mitochondrial

CTD Direct Evidence: marker/mechanism

NCBI chr19:26,139,335...26,145,231
Ensembl chr19:34,905,765...34,911,712

G

patr class I histocompatibility antigen, alpha chain E

CTD Direct Evidence: marker/mechanism

NCBI chr 6:30,233,293...30,238,056
Ensembl chr 6:31,101,251...31,107,262

G

signal transducer and activator of transcription 5A

CTD Direct Evidence: marker/mechanism

NCBI chr17:15,005,025...15,029,110
Ensembl chr17:15,228,465...15,251,783

G

transducin-like enhancer protein 4

CTD Direct Evidence: marker/mechanism

NCBI chr 9:45,103,762...45,258,137
Ensembl chr 9:78,436,831...78,590,626

G

latent transforming growth factor beta binding protein 2

mRNA:increased expression:myocardium (human)

NCBI chr14:55,051,325...55,164,613
Ensembl chr14:73,901,851...74,011,914

G

microtubule associated protein 1 light chain 3 beta

NCBI chr16:68,063,869...68,076,772

G

mitogen-activated protein kinase kinase kinase 8

CTD Direct Evidence: marker/mechanism

NCBI chr10:30,579,220...30,607,249
Ensembl chr10:30,933,483...30,960,824

G

mitogen-activated protein kinase 14

CTD Direct Evidence: marker/mechanism

NCBI chr 6:35,586,847...35,683,041
Ensembl chr 6:36,788,233...36,871,114

G

microtubule associated protein RP/EB family member 1

CTD Direct Evidence: marker/mechanism

NCBI chr20:29,103,963...29,134,439
Ensembl chr20:30,222,155...30,252,440

G

myoglobin

susceptibility

PMID:12935692 PMID:15762290

RGD:1582393 RGD:1582426

NCBI chr22:16,612,519...16,645,333
Ensembl chr22:34,452,451...34,463,224

G

mesenchyme homeobox 2

CTD Direct Evidence: marker/mechanism

NCBI chr 7:16,268,225...16,343,914
Ensembl chr 7:15,598,466...15,673,935

G

mitofusin 1

treatment

NCBI chr 3:176,378,175...176,423,943
Ensembl chr 3:184,552,108...184,596,763

G

mitofusin 2

treatment

NCBI chr 1:10,729,933...10,764,865
Ensembl chr 1:11,945,880...11,981,077

G

myeloperoxidase

Acute Coronary Syndrome; protein:increased expression:plasma

NCBI chr17:52,333,882...52,357,838
Ensembl chr17:57,201,073...57,212,111

G

moesin

CTD Direct Evidence: marker/mechanism

NCBI chr X:54,785,309...54,859,364
Ensembl chr X:64,781,550...64,933,292

G

macrophage scavenger receptor 1

disease_progression

mRNA:increased expression:blood, mononuclear cell

NCBI chr 8:15,335,795...15,421,472
Ensembl chr 8:12,088,873...12,175,927

G

MX dynamin like GTPase 1

CTD Direct Evidence: marker/mechanism

NCBI chr21:27,756,768...27,795,307
Ensembl chr21:41,095,928...41,123,019

G

nucleolin

CTD Direct Evidence: marker/mechanism

NCBI chr2B:118,703,148...118,712,893
Ensembl chr2B:237,490,378...237,500,193

G

NEDD4 E3 ubiquitin protein ligase

CTD Direct Evidence: marker/mechanism

NCBI chr15:34,798,880...34,963,823
Ensembl chr15:53,118,411...53,283,076

G

NFKB inhibitor alpha

CTD Direct Evidence: marker/mechanism

NCBI chr14:16,155,331...16,158,588

G

nitric oxide synthase 3

susceptibility

DNA:duplication, snp:intron, cds:g.IVS4?-?+27, p.E298D (human)
ClinVar Annotator: match by term: Ischemic heart disease, susceptibility to

PMID:9737779 PMID:9894802 PMID:10475066 PMID:10510054 PMID:10514107 More...

NCBI chr 7:142,577,334...142,600,702
Ensembl chr 7:154,730,009...154,755,233

G

notch receptor 1

treatment

NCBI chr 9:107,568,670...107,621,032
Ensembl chr 9:136,544,639...136,598,740

G

natriuretic peptide A

CTD Direct Evidence: marker/mechanism

NCBI chr 1:10,608,025...10,610,287
Ensembl chr 1:11,825,072...11,827,373

G

neuroplastin

CTD Direct Evidence: marker/mechanism

NCBI chr15:52,470,545...52,544,046
Ensembl chr15:71,229,992...71,269,579

G

nuclear receptor subfamily 1 group H member 3

susceptibility

DNA:SNPs, haplotype:promoter:c.-115G>A, c.-840C>A (rs12221497, rs61896015) (human)

NCBI chr11:47,195,122...47,215,277
Ensembl chr11:47,748,353...47,768,672

G

nuclear receptor subfamily 4 group A member 1

CTD Direct Evidence: marker/mechanism

NCBI chr12:36,703,903...36,740,211
Ensembl chr12:37,480,300...37,501,188

G

OPA1 mitochondrial dynamin like GTPase

treatment

NCBI chr 3:190,890,242...190,995,133
Ensembl chr 3:201,207,607...201,312,358

G

prolyl 4-hydroxylase subunit beta

CTD Direct Evidence: marker/mechanism

NCBI chr17:76,248,252...76,266,152
Ensembl chr17:81,950,422...81,968,109

G

phosphodiesterase 4B

CTD Direct Evidence: marker/mechanism

NCBI chr 1:65,038,120...65,620,764
Ensembl chr 1:67,045,911...67,506,291

G

pyruvate dehydrogenase E1 subunit alpha 1

CTD Direct Evidence: marker/mechanism

NCBI chr X:11,967,944...11,985,837
Ensembl chr X:19,330,508...19,348,443

G

pyruvate dehydrogenase kinase 4

CTD Direct Evidence: marker/mechanism

NCBI chr 7:87,540,600...87,553,673
Ensembl chr 7:101,128,060...101,141,157

G

PDZ and LIM domain 5

CTD Direct Evidence: marker/mechanism

NCBI chr 4:86,814,136...87,030,605
Ensembl chr 4:97,486,566...97,702,060

G

phosphatidylethanolamine binding protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr12:115,716,953...115,726,412
Ensembl chr12:119,093,952...119,105,054

G

proenkephalin

treatment

NCBI chr 8:52,864,388...52,870,144
Ensembl chr 8:50,234,170...50,239,949

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3

CTD Direct Evidence: marker/mechanism

NCBI chr10:6,185,415...6,294,641
Ensembl chr10:6,167,841...6,275,940

G

phosphofructokinase, muscle

CTD Direct Evidence: marker/mechanism

NCBI chr12:40,584,321...40,625,245
Ensembl chr12:41,459,346...41,499,476

G

placental growth factor

NCBI chr14:55,494,152...55,508,066
Ensembl chr14:74,338,976...74,352,964

G

phosphoglucomutase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:62,849,451...62,916,359
Ensembl chr 1:64,658,599...64,725,496

G

phospholipase A2 group IIA

CTD Direct Evidence: marker/mechanism

NCBI chr 1:18,930,294...18,934,563
Ensembl chr 1:19,971,084...19,977,627

G

phospholipase C delta 1

protein:decreased expression:heart

NCBI chr 3:37,906,359...37,928,564
Ensembl chr 3:38,189,496...38,206,886

G

proopiomelanocortin

CTD Direct Evidence: marker/mechanism

NCBI chr2A:25,161,668...25,165,600
Ensembl chr2A:25,258,768...25,262,706

G

phosphoribosyl pyrophosphate amidotransferase

CTD Direct Evidence: marker/mechanism

NCBI chr 4:67,491,407...67,533,822
Ensembl chr 4:74,059,966...74,102,002

G

protein phosphatase, Mg2+/Mn2+ dependent 1B

CTD Direct Evidence: marker/mechanism

NCBI chr2A:44,254,168...44,325,132
Ensembl chr2A:45,230,001...45,262,587

G

protein phosphatase 2 catalytic subunit alpha

CTD Direct Evidence: marker/mechanism

NCBI chr 5:129,599,606...129,629,312
Ensembl chr 5:135,751,958...135,765,786

G

protein phosphatase 3 regulatory subunit B, alpha

CTD Direct Evidence: marker/mechanism

NCBI chr2A:68,227,282...68,300,482

G

peroxiredoxin 6

CTD Direct Evidence: marker/mechanism

NCBI chr 1:148,988,836...149,000,345

G

protein kinase C delta

mRNA, protein:increased expression, altered phosphorylation:heart

NCBI chr 3:53,104,137...53,135,588
Ensembl chr 3:54,330,328...54,357,910

G

protein kinase C epsilon

CTD Direct Evidence: marker/mechanism

NCBI chr2A:45,757,629...46,294,064
Ensembl chr2A:46,688,436...47,220,313

G

proteasome 20S subunit beta 5

CTD Direct Evidence: marker/mechanism

NCBI chr14:3,845,951...3,855,335
Ensembl chr14:21,943,432...21,952,169

G

protein tyrosine phosphatase receptor type A

CTD Direct Evidence: marker/mechanism

NCBI chr20:2,962,701...3,125,282
Ensembl chr20:2,801,905...2,888,195

G

glycogen phosphorylase B

CTD Direct Evidence: marker/mechanism

NCBI chr20:25,191,066...25,242,955
Ensembl chr20:25,593,589...25,648,066

G

glycogen phosphorylase, muscle associated

NCBI chr11:60,101,810...60,115,813
Ensembl chr11:63,443,609...63,457,430

G

RAB12, member RAS oncogene family

CTD Direct Evidence: marker/mechanism

NCBI chr18:5,646,023...5,675,920
Ensembl chr18:7,972,938...8,027,500

G

RAB1B, member RAS oncogene family

CTD Direct Evidence: marker/mechanism

NCBI chr11:61,634,017...61,642,945
Ensembl chr11:64,959,957...64,968,843

G

RAB5A, member RAS oncogene family

CTD Direct Evidence: marker/mechanism

NCBI chr 3:19,866,110...19,903,701
Ensembl chr 3:20,197,067...20,234,579

G

RAB7A, member RAS oncogene family

CTD Direct Evidence: marker/mechanism

NCBI chr 3:125,784,604...125,873,051

G

ralA binding protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr18:4,747,555...4,810,710
Ensembl chr18:7,028,188...7,090,934

G

receptor activity modifying protein 2

mRNA:increased expression:ventricle myocardium

NCBI chr17:14,554,888...14,557,175
Ensembl chr17:14,779,666...14,781,481

G

regulator of cell cycle

CTD Direct Evidence: marker/mechanism

NCBI chr13:22,639,289...22,652,594
Ensembl chr13:41,228,643...41,241,909

G

ras homolog family member C

CTD Direct Evidence: marker/mechanism

NCBI chr 1:115,353,868...115,360,036
Ensembl chr 1:124,993,063...125,001,708

G

relaxin 3

CTD Direct Evidence: therapeutic

Ensembl chr19:14,320,043...14,323,448

G

ribosomal protein L17

CTD Direct Evidence: marker/mechanism

NCBI chr18:42,870,133...42,874,162
Ensembl chr18:46,219,530...46,223,503

G

radical S-adenosyl methionine domain containing 2

CTD Direct Evidence: marker/mechanism

NCBI chr2A:6,873,821...6,906,087
Ensembl chr2A:7,021,937...7,042,961

G

reticulon 1

CTD Direct Evidence: marker/mechanism

NCBI chr14:40,198,279...40,472,255

G

retinoid X receptor gamma

CTD Direct Evidence: marker/mechanism

NCBI chr 1:140,832,717...140,877,046
Ensembl chr 1:144,623,133...144,723,494

G

ryanodine receptor 2

CTD Direct Evidence: marker/mechanism

NCBI chr 1:212,600,198...213,387,312
Ensembl chr 1:217,815,676...218,383,509

G

S100 calcium binding protein A1

protein:increased expression:serum (human)

NCBI chr 1:128,984,296...128,987,979

G

selectin E

CTD Direct Evidence: marker/mechanism

NCBI chr 1:145,205,684...145,217,143
Ensembl chr 1:148,930,437...148,938,313

G

selectin P

CTD Direct Evidence: marker/mechanism

NCBI chr 1:145,071,094...145,112,851
Ensembl chr 1:148,793,677...148,834,701

G

serpin family A member 1

associated with Aortic Aneurysm, Abdominal;DNA:polymorphism: :p.E342K (human)

NCBI chr14:75,001,714...75,014,214
Ensembl chr14:94,334,258...94,345,419

G

serpin family F member 1

associated with chronic kidney disease;protein:increased expression:blood (human)

NCBI chr17:1,745,597...1,761,399
Ensembl chr17:1,638,556...1,653,568

G

secreted frizzled related protein 4

NCBI chr 7:38,542,105...38,553,008
Ensembl chr 7:38,764,146...38,774,264

G

solute carrier family 6 member 6

CTD Direct Evidence: marker/mechanism

NCBI chr 3:14,323,251...14,411,949
Ensembl chr 3:14,663,955...14,752,326

G

solute carrier family 8 member A1

CTD Direct Evidence: marker/mechanism

NCBI chr2A:40,169,339...40,586,546
Ensembl chr2A:40,939,900...41,363,038

G

solute carrier family 9 member A1

NCBI chr 1:26,359,818...26,418,910
Ensembl chr 1:27,414,937...27,475,089

G

synaptosome associated protein 23

CTD Direct Evidence: marker/mechanism

NCBI chr15:21,456,247...21,494,340
Ensembl chr15:39,612,445...39,650,759

G

suppressor of cytokine signaling 3

CTD Direct Evidence: marker/mechanism

NCBI chr17:72,433,206...72,436,500
Ensembl chr17:77,983,389...77,984,066

G

superoxide dismutase 2

CTD Direct Evidence: marker/mechanism

PMID:15681709 PMID:16214533

NCBI chr 6:157,562,814...157,610,155
Ensembl chr 6:162,576,082...162,589,960

G

superoxide dismutase 3

ClinVar Annotator: match by term: Superoxide dismutase, elevated extracellular

PMID:7662997 PMID:8034674 PMID:14662715

NCBI chr 4:19,195,941...19,201,298
Ensembl chr 4:24,485,059...24,485,781

G

SRY-box transcription factor 2

NCBI chr 3:178,744,881...178,747,392
Ensembl chr 3:186,922,705...186,923,662

G

secreted protein acidic and cysteine rich

CTD Direct Evidence: marker/mechanism

NCBI chr 5:147,087,903...147,112,466
Ensembl chr 5:153,090,181...153,115,750

G

transporter 1, ATP binding cassette subfamily B member

CTD Direct Evidence: marker/mechanism

NCBI chr 6:32,414,665...32,423,488
Ensembl chr 6:33,530,171...33,538,978

G

transcription factor 7 like 2

CTD Direct Evidence: marker/mechanism

NCBI chr10:109,541,524...109,759,499
Ensembl chr10:112,978,167...113,192,281

G

transferrin receptor

CTD Direct Evidence: marker/mechanism

NCBI chr 3:193,384,817...193,417,532
Ensembl chr 3:203,333,953...203,373,998

G

trans-golgi network protein 2

CTD Direct Evidence: marker/mechanism

NCBI chr2A:85,370,686...85,381,607

G

TLE family member 5, transcriptional modulator

CTD Direct Evidence: marker/mechanism

NCBI chr19:2,078,933...2,089,117
Ensembl chr19:3,030,550...3,040,375

G

transmembrane p24 trafficking protein 2

CTD Direct Evidence: marker/mechanism

NCBI chr12:121,169,915...121,183,524
Ensembl chr12:125,397,391...125,410,794

G

thymopoietin

CTD Direct Evidence: marker/mechanism

NCBI chr12:96,100,509...96,135,364
Ensembl chr12:99,514,803...99,546,535

G

tumor necrosis factor

CTD Direct Evidence: marker/mechanism

PMID:16214533 PMID:16775501

NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381

G

troponin T2, cardiac type

CTD Direct Evidence: marker/mechanism

NCBI chr 1:176,957,298...176,976,033

G

titin

NCBI chr2B:65,783,512...66,064,618

G

thioredoxin reductase 1

CTD Direct Evidence: marker/mechanism

NCBI chr12:101,862,703...101,925,104
Ensembl chr12:105,187,128...105,321,112

G

UDP-glucose ceramide glucosyltransferase

CTD Direct Evidence: marker/mechanism

NCBI chr 9:83,024,602...83,065,017
Ensembl chr 9:111,184,478...111,222,613

G

vascular cell adhesion molecule 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:103,377,815...103,395,118
Ensembl chr 1:102,091,336...102,107,732

G

vascular endothelial growth factor A

CTD Direct Evidence: marker/mechanism|therapeutic

PMID:9860779 PMID:14503966 PMID:14583313 PMID:15347709 PMID:16214533

NCBI chr 6:43,361,053...43,377,366
Ensembl chr 6:44,650,365...44,666,353

G

zinc finger E-box binding homeobox 1

CTD Direct Evidence: marker/mechanism

NCBI chr10:31,449,202...31,659,534
Ensembl chr10:32,046,491...32,253,550

G

ZFP36 ring finger protein

CTD Direct Evidence: marker/mechanism

NCBI chr19:36,505,056...36,507,693
Ensembl chr19:45,052,801...45,055,390

Acute Coronary Syndrome

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

actin gamma 1

CTD Direct Evidence: marker/mechanism

NCBI chr17:75,965,911...75,968,822
Ensembl chr17:81,668,221...81,671,087

G

advanced glycosylation end-product specific receptor

protein:increased expression:serum (human)

NCBI chr 6:31,828,363...31,831,981
Ensembl chr 6:32,708,251...32,711,641

G

albumin

treatment

NCBI chr 4:50,773,244...50,790,474
Ensembl chr 4:56,605,322...56,622,418

G

Rho GDP dissociation inhibitor beta

CTD Direct Evidence: marker/mechanism

NCBI chr12:14,944,746...14,964,357
Ensembl chr12:15,341,491...15,361,160

G

capping actin protein of muscle Z-line subunit beta

CTD Direct Evidence: marker/mechanism

NCBI chr 1:18,297,434...18,444,011
Ensembl chr 1:19,344,154...19,488,133

G

cellular communication network factor 1

susceptibility

DNA:SNP,haplotypes:5'utr: (rs6576776) (human)

NCBI chr 1:118,138,739...118,141,681
Ensembl chr 1:86,994,296...86,997,147

G

CD40 molecule

DNA:SNP:5' utr:rs1883832 (human)

NCBI chr20:42,455,711...42,467,139
Ensembl chr20:43,541,619...43,552,994

G

CD40 ligand

treatment

associated with Anxiety Disorders;protein:increased expression:serum

PMID:20170788 PMID:31624788

RGD:21081509 RGD:5490548

NCBI chr X:125,776,138...125,788,820
Ensembl chr X:136,042,849...136,058,202

G

creatine kinase B

CTD Direct Evidence: marker/mechanism

NCBI chr14:84,145,931...84,149,093

G

creatine kinase, M-type

CTD Direct Evidence: marker/mechanism

NCBI chr19:42,255,158...42,271,467
Ensembl chr19:50,854,556...50,870,366

G

C-reactive protein

CTD Direct Evidence: marker/mechanism
protein:increased expression: :

PMID:15966572 PMID:18973750 PMID:21794939 PMID:23305094

RGD:6907401 RGD:9491837

NCBI chr 1:135,062,102...135,064,402

G

cytochrome P450 family 2 subfamily C member 19

treatment

DNA:SNPs::CYP2C19*2 (681G>A,rs4244285), CYP2C19*17 (-806C>T, rs12248560) (human)
ClinVar Annotator: match by term: Acute coronary syndrome

PMID:7969038 PMID:9093256 PMID:19444287 PMID:21270786 PMID:27441996 More...

NCBI chr10:91,375,255...91,465,215
Ensembl chr10:94,884,472...94,970,065

G

enolase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:7,619,490...7,637,558
Ensembl chr 1:8,855,074...8,873,215

G

coagulation factor XII

ClinVar Annotator: match by term: FACTOR XII POLYMORPHISM

PMID:9490684 PMID:11843842 PMID:20303064 PMID:24033266 PMID:25741868

NCBI chr 5:172,703,724...172,711,618
Ensembl chr 5:179,766,243...179,773,485

G

coagulation factor II, thrombin

NCBI chr11:46,669,925...46,690,391
Ensembl chr11:47,227,891...47,249,157

G

fatty acid synthase

CTD Direct Evidence: marker/mechanism

NCBI chr17:76,483,108...76,503,148
Ensembl chr17:82,187,516...82,205,647

G

FTO alpha-ketoglutarate dependent dioxygenase

susceptibility

DNA:SNP: :rs17817449 (human)

NCBI chr16:33,939,300...34,343,419
Ensembl chr16:53,023,425...53,490,231

G

glyceraldehyde-3-phosphate dehydrogenase

CTD Direct Evidence: marker/mechanism

NCBI chr12:6,665,218...6,669,170
Ensembl chr12:6,583,895...6,587,729

G

GTP cyclohydrolase 1

DNa:SNP: :rs3783637 (human)

NCBI chr14:35,428,676...35,489,359
Ensembl chr14:53,706,723...53,767,393

G

glycoprotein VI platelet

disease_progression

protein:increased expression:platelet (human)

PMID:17340467 PMID:20071043

RGD:401794408 RGD:401824680

NCBI chr19:52,051,138...52,071,673
Ensembl chr19:60,746,578...60,770,643

G

glutathione peroxidase 1

mRNA, protein:increased expression:blood, plasma

NCBI chr 3:49,280,038...49,281,455
Ensembl chr 3:50,360,947...50,361,826

G

glutathione peroxidase 3

mRNA, protein:increased expression:blood, plasma

NCBI chr 5:146,447,939...146,456,476

G

glutathione peroxidase 4

mRNA, protein:increased expression:blood, plasma

NCBI chr19:20,904...23,828

G

gelsolin

CTD Direct Evidence: marker/mechanism

NCBI chr 9:92,413,819...92,460,483
Ensembl chr 9:120,741,148...120,805,831

G

glutathione S-transferase pi 1

CTD Direct Evidence: marker/mechanism

NCBI chr11:62,942,756...62,945,701
Ensembl chr11:66,253,421...66,256,472

G

heat shock protein family A (Hsp70) member 1A

DNA:SNP: :190G>C(human)

NCBI chr 6:31,476,710...31,491,411

G

heat shock protein family A (Hsp70) member 8

CTD Direct Evidence: marker/mechanism

NCBI chr11:117,890,545...117,895,262
Ensembl chr11:121,809,800...121,815,773

G

heat shock protein family D (Hsp60) member 1

CTD Direct Evidence: marker/mechanism

NCBI chr2B:84,729,615...84,743,352
Ensembl chr2B:202,623,497...202,636,959

G

interleukin 6

treatment

CTD Direct Evidence: marker/mechanism
protein:increased expression:blood serum (human)

PMID:23305094 PMID:32178736

NCBI chr 7:23,415,922...23,420,767

G

integrin subunit beta 3

CTD Direct Evidence: marker/mechanism

NCBI chr17:10,134,450...10,194,596
Ensembl chr17:10,353,111...10,392,382

G

lactate dehydrogenase B

CTD Direct Evidence: marker/mechanism

NCBI chr12:64,640,994...64,663,418
Ensembl chr12:67,245,130...67,267,487

G

lipoprotein(a)

protein:increased expression:plasma:increased levels of β(2)-GPI-Lp(a) complex, Lp(a) and/or ox-Lp(a)

NCBI chr 6:158,434,394...158,628,028

G

matrix metallopeptidase 9

CTD Direct Evidence: marker/mechanism

NCBI chr20:42,346,305...42,354,018
Ensembl chr20:43,432,389...43,440,129

G

8-oxoguanine DNA glycosylase

susceptibility

DNA:SNP,haplotype: :p.S326C (rs1052133) (human)

NCBI chr 3:9,702,311...9,742,283
Ensembl chr 3:9,940,955...9,947,335

G

pappalysin 1

CTD Direct Evidence: marker/mechanism

NCBI chr 9:87,287,289...87,535,414
Ensembl chr 9:115,671,212...115,883,435

G

protein disulfide isomerase family A member 3

CTD Direct Evidence: marker/mechanism

NCBI chr15:22,706,520...22,731,672
Ensembl chr15:40,794,144...40,821,763

G

platelet and endothelial cell adhesion molecule 1

protein:increased expression:coronary artery, intima (human)

NCBI chr17:58,417,134...58,526,409
Ensembl chr17:63,511,784...63,579,067

G

phosphatase and actin regulator 1

exacerbates

protein:increased expression:monocyte (human)

NCBI chr 6:12,560,862...13,136,126
Ensembl chr 6:12,922,871...13,505,609

G

phospholipase A2 group VII

disease_progression

NCBI chr 6:46,264,262...46,318,487
Ensembl chr 6:47,558,861...47,590,212

G

paraoxonase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 7:87,253,476...87,279,650
Ensembl chr 7:100,841,286...100,867,493

G

proteasome 20S subunit beta 1

CTD Direct Evidence: marker/mechanism

NCBI chr 6:168,695,047...168,713,257
Ensembl chr 6:173,781,040...173,799,342

G

RAB7B, member RAS oncogene family

CTD Direct Evidence: marker/mechanism

NCBI chr 1:181,584,814...181,611,831
Ensembl chr 1:185,867,145...185,894,691

G

retinol binding protein 4

onset
severity

protein:increased expression:blood serum (human)
protein:increased expression:blood plasma (human)

PMID:25437889 PMID:32449048

RGD:329845573 RGD:329845576

NCBI chr10:90,337,879...90,347,530
Ensembl chr10:93,848,166...93,857,887

G

S100 calcium binding protein B

protein:increased expression:serum

NCBI chr21:33,063,845...33,070,073
Ensembl chr21:46,197,750...46,203,953

G

serpin family C member 1

CTD Direct Evidence: therapeutic

NCBI chr 1:149,421,737...149,435,301
Ensembl chr 1:153,126,031...153,139,369

G

superoxide dismutase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 6:157,562,814...157,610,155
Ensembl chr 6:162,576,082...162,589,960

G

toll like receptor 4

CTD Direct Evidence: marker/mechanism

NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711

G

tumor necrosis factor

treatment

CTD Direct Evidence: marker/mechanism
protein:increased expression:blood serum (human)

PMID:20981132 PMID:32178736

NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381

G

troponin I3, cardiac type

CTD Direct Evidence: marker/mechanism

NCBI chr19:52,193,061...52,198,782
Ensembl chr19:60,887,630...60,894,219

G

troponin T2, cardiac type

CTD Direct Evidence: marker/mechanism

NCBI chr 1:176,957,298...176,976,033

G

tropomyosin 4

CTD Direct Evidence: marker/mechanism

NCBI chr19:15,557,683...15,593,143
Ensembl chr19:16,540,805...16,575,312

G

tubulin alpha 1c

CTD Direct Evidence: marker/mechanism

NCBI chr12:39,476,809...39,524,473
Ensembl chr12:40,362,655...40,402,092

G

tubulin beta 1 class VI

CTD Direct Evidence: marker/mechanism

NCBI chr20:55,370,122...55,377,616
Ensembl chr20:56,730,882...56,738,741

G

vinculin

CTD Direct Evidence: marker/mechanism

NCBI chr10:70,521,259...70,641,917
Ensembl chr10:73,191,375...73,311,296

G

vimentin

CTD Direct Evidence: marker/mechanism

NCBI chr10:17,546,389...17,554,702
Ensembl chr10:17,818,285...17,826,642

acute myocardial infarction

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

Rho GTPase activating protein 17

ameliorates

Ensembl chr16:25,161,229...25,220,151

G

BCL2 associated X, apoptosis regulator

ameliorates

NCBI chr19:45,955,926...45,962,870
Ensembl chr19:54,793,594...54,800,468

G

complement C3

NCBI chr19:5,708,211...5,753,178
Ensembl chr19:6,629,287...6,674,699

G

calcium voltage-gated channel auxiliary subunit gamma 4

mRNA:decreased expression:blood:

NCBI chr17:60,900,645...60,969,659

G

caspase 3

treatment

NCBI chr 4:176,793,190...176,815,023
Ensembl chr 4:189,018,422...189,040,185

G

caspase 7

treatment

NCBI chr10:110,273,318...110,324,800
Ensembl chr10:113,707,780...113,758,626

G

cellular communication network factor 1

ameliorates

NCBI chr 1:118,138,739...118,141,681
Ensembl chr 1:86,994,296...86,997,147

G

DNA damage regulated autophagy modulator 1

ameliorates

mRNA,protein:decreased expression:heart

NCBI chr12:99,464,540...99,509,793
Ensembl chr12:102,862,707...102,907,385

G

desmocollin 2

ameliorates

NCBI chr18:24,296,505...24,332,997
Ensembl chr18:27,894,603...27,930,843

G

Fos proto-oncogene, AP-1 transcription factor subunit

treatment

NCBI chr14:55,832,570...55,835,984
Ensembl chr14:74,676,316...74,679,766

G

FTO alpha-ketoglutarate dependent dioxygenase

mRNA:increased expression:blood

NCBI chr16:33,939,300...34,343,419
Ensembl chr16:53,023,425...53,490,231

G

GATA binding protein 5

susceptibility

DNA:SNPs:promoter:rs80197101, rs77067995 (human)

Ensembl chr20:60,148,359...60,158,886

G

glycoprotein VI platelet

sexual_dimorphism
ameliorates

DNA:missense mutation:intron 1, intron 5: (rs1671207, rs11084382) (human)
DNA:missense mutation:CDS:p.S219P (rs1613662) (human)

NCBI chr19:52,051,138...52,071,673
Ensembl chr19:60,746,578...60,770,643

G

glutathione peroxidase 3

protein:increased expression:plasma

NCBI chr 5:146,447,939...146,456,476

G

glycogen synthase kinase 3 beta

treatment
ameliorates

PMID:26591365 PMID:32068187

RGD:13792778 RGD:267358468

NCBI chr 3:116,943,205...117,215,001
Ensembl chr 3:123,861,379...124,126,771

G

isocitrate dehydrogenase (NADP(+)) 2

ClinVar Annotator: match by term: Acute myocardial infarction

PMID:20946881 PMID:21250968 PMID:21596855 PMID:21997850 PMID:22160010 More...

NCBI chr15:68,771,050...68,790,523
Ensembl chr15:87,972,889...87,991,276

G

interferon gamma

ameliorates

NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829

G

inhibitor of nuclear factor kappa B kinase regulatory subunit gamma

ameliorates

NCBI chr X:143,988,720...144,010,078
Ensembl chr X:153,854,493...153,876,092

G

interleukin 10

ameliorates

NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371

G

interleukin 17A

ameliorates

NCBI chr 6:51,736,269...51,740,538
Ensembl chr 6:53,004,820...53,009,074

G

interleukin 1 beta

ameliorates

NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424

G

interleukin 1 receptor like 1

G

interleukin 33

NCBI chr 9:6,027,014...6,069,540
Ensembl chr 9:6,234,178...6,248,624

G

interleukin 4

ameliorates

NCBI chr 5:128,091,342...128,099,886
Ensembl chr 5:134,253,039...134,261,581

G

interleukin 6

ameliorates

NCBI chr 7:23,415,922...23,420,767

G

integrin subunit alpha M

treatment

NCBI chr16:23,634,476...23,707,147
Ensembl chr16:31,630,146...31,702,406

G

kinesin family member 6

DNA:SNP: :p.W719R (rs20455) (human)

NCBI chr 6:38,917,083...39,306,190
Ensembl chr 6:40,234,426...40,616,738

G

microtubule associated protein 1 light chain 3 alpha

treatment

NCBI chr20:30,887,345...30,888,986
Ensembl chr20:32,010,284...32,020,411

G

NADH:ubiquinone oxidoreductase subunit B5

ameliorates

associated with obesity

NCBI chr 3:176,636,937...176,659,813
Ensembl chr 3:184,807,246...184,827,011

G

platelet factor 4

treatment

NCBI chr 4:50,208,806...50,210,570
Ensembl chr 4:56,041,833...56,043,750

G

phospholipase C gamma 1

ameliorates

NCBI chr20:37,477,077...37,515,854
Ensembl chr20:38,572,709...38,615,145

G

pro-platelet basic protein

treatment

NCBI chr 4:50,203,168...50,204,303
Ensembl chr 4:56,035,060...56,037,702

G

phosphatase and tensin homolog

ameliorates

mRNA:decreased expression:heart left ventricle (rat)
RNA:increased expression:serum

PMID:26973267 PMID:29990866 PMID:32595526

RGD:11526378 RGD:155882565 RGD:401851053

NCBI chr10:84,587,841...84,689,043
Ensembl chr10:88,093,539...88,194,605

G

ras homolog family member A

ameliorates

NCBI chr 3:49,282,009...49,339,887

G

Ras like without CAAX 2

ameliorates

NCBI chr18:36,008,302...36,381,259
Ensembl chr18:39,557,814...39,930,393

G

succinate dehydrogenase complex iron sulfur subunit B

ameliorates

associated with obesity

NCBI chr 1:15,962,383...15,998,056
Ensembl chr 1:17,018,542...17,054,509

G

serpin family G member 1

mRNA:increased expression:heart

NCBI chr11:52,838,502...52,855,781
Ensembl chr11:56,309,686...56,326,639

G

sequestosome 1

treatment

NCBI chr 5:174,960,727...174,989,946
Ensembl chr 5:182,284,436...182,299,093

G

T-box transcription factor 1

treatment

NCBI chr22:2,521,080...2,541,267

G

tumor necrosis factor

ameliorates

NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381

G

zinc finger E-box binding homeobox 1

ameliorates

NCBI chr10:31,449,202...31,659,534
Ensembl chr10:32,046,491...32,253,550

Angina Pectoris

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adrenoceptor beta 1

NCBI chr10:110,642,491...110,646,595

G

adrenoceptor beta 2

NCBI chr 5:144,259,756...144,398,421
Ensembl chr 5:150,267,554...150,315,892

G

arginine vasopressin

CTD Direct Evidence: marker/mechanism

PMID:11128043 PMID:11791009

NCBI chr20:3,169,094...3,172,900

G

carboxypeptidase B2

NCBI chr13:26,926,788...26,979,767

G

plasminogen activator, urokinase

CTD Direct Evidence: therapeutic

NCBI chr10:70,433,340...70,441,569
Ensembl chr10:73,105,895...73,113,136

G

pro-platelet basic protein

protein:increased expression:plasma

NCBI chr 4:50,203,168...50,204,303
Ensembl chr 4:56,035,060...56,037,702

G

secreted phosphoprotein 1

NCBI chr 4:80,263,711...80,271,466
Ensembl chr 4:90,988,200...90,995,935

anterolateral myocardial infarction

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

endothelin 1

protein:increased expression:aortic root, coronary sinus, plasma (human)

NCBI chr 6:12,076,312...12,142,861
Ensembl chr 6:12,462,718...12,503,545

G

serpin family E member 1

disease_progression

protein:decreased expression, decreased activity:heart:

NCBI chr 7:93,267,517...93,279,728
Ensembl chr 7:106,510,130...106,518,450

Cardiac Allograft Vasculopathy

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

coagulation factor III, tissue factor

NCBI chr 1:97,190,381...97,203,076
Ensembl chr 1:95,918,502...95,931,050

G

heterogeneous nuclear ribonucleoprotein K

NCBI chr 9:40,898,593...40,911,159
Ensembl chr 9:83,324,238...83,336,756

G

platelet derived growth factor D

NCBI chr11:98,852,652...99,110,147
Ensembl chr11:102,357,079...102,593,273

Cardiogenic Shock

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

erythropoietin

CTD Direct Evidence: marker/mechanism

NCBI chr 7:92,747,671...92,750,886
Ensembl chr 7:106,148,062...106,150,974

G

plasminogen activator, tissue type

CTD Direct Evidence: therapeutic

NCBI chr 8:41,419,415...41,451,951
Ensembl chr 8:38,864,918...38,897,779

G

superoxide dismutase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 6:157,562,814...157,610,155
Ensembl chr 6:162,576,082...162,589,960

coronary aneurysm

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adiponectin, C1Q and collagen domain containing

associated with Mucocutaneous Lymph Node Syndrome;protein:increased expression:serum

NCBI chr 3:183,876,051...183,889,723
Ensembl chr 3:192,341,320...192,354,885

G

gap junction protein alpha 1

CTD Direct Evidence: marker/mechanism

NCBI chr 6:119,213,513...119,227,617

G

inositol-trisphosphate 3-kinase C

CTD Direct Evidence: marker/mechanism

NCBI chr19:37,761,221...37,785,118
Ensembl chr19:46,267,754...46,290,935

G

matrix metallopeptidase 12

susceptibility

NCBI chr11:97,809,644...97,822,063
Ensembl chr11:101,294,475...101,306,762

coronary artery disease

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 1

NCBI chr 9:75,948,831...76,096,136
Ensembl chr 9:104,076,516...104,224,188

G

ATP binding cassette subfamily G member 5

CTD Direct Evidence: marker/mechanism

PMID:11099417 PMID:11138003

NCBI chr2A:43,896,188...43,922,756
Ensembl chr2A:44,745,183...44,771,012

G

ATP binding cassette subfamily G member 8

ClinVar Annotator: match by term: Premature coronary artery atherosclerosis

NCBI chr2A:43,922,787...43,966,678
Ensembl chr2A:44,771,247...44,904,830

G

ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase

CTD Direct Evidence: marker/mechanism

NCBI chr 9:104,354,115...104,399,057
Ensembl chr 9:132,989,574...133,010,324

G

acetyl-CoA acetyltransferase 2

susceptibility

DNA:polymorphisms: :41A>G, 734C>T, IVS4-57_58ins48bp

NCBI chr 6:157,644,894...157,661,965
Ensembl chr 6:162,656,497...162,673,606

G

angiotensin I converting enzyme

susceptibility

CTD Direct Evidence: marker/mechanism
DNA:deletion:intron:IVS16+1464-1751del (human)

PMID:12975417 PMID:14989558

NCBI chr17:57,556,294...57,577,294
Ensembl chr17:62,702,341...62,733,853

G

acid phosphatase 1

NCBI chr2A:257,892...271,320
Ensembl chr2A:253,656...267,086

G

ADAM metallopeptidase with thrombospondin type 1 motif 7

CTD Direct Evidence: marker/mechanism

NCBI chr15:61,291,451...61,295,148

G

adiponectin, C1Q and collagen domain containing

susceptibility

protein:decreased expression:adipose tissue
associated with type 2 diabetes mellitus; DNA:SNP: (rs2241766) +45T>G(human)

PMID:17878891 PMID:27218147

RGD:329956419 RGD:5686802

NCBI chr 3:183,876,051...183,889,723
Ensembl chr 3:192,341,320...192,354,885

G

adrenoceptor beta 3

no_association

DNA:missense mutation:cds:p.W64R rs4994 (human)
DNA:missense mutation:cds:p.W64R (human)

PMID:9126344 PMID:11229427

RGD:1559325 RGD:5684412

NCBI chr 8:37,263,730...37,267,475
Ensembl chr 8:34,441,311...34,443,949

G

androgen dependent TFPI regulating protein

CTD Direct Evidence: marker/mechanism

NCBI chr 6:11,550,584...11,648,755
Ensembl chr 6:11,829,782...11,895,656

G

advanced glycosylation end-product specific receptor

susceptibility

DNA:polymorphism:cds:p.G82S (human)
associated with Mucocutaneous Lymph Node Syndrome

PMID:20668462 PMID:22337222

RGD:6767569 RGD:8695960

NCBI chr 6:31,828,363...31,831,981
Ensembl chr 6:32,708,251...32,711,641

G

angiotensin II receptor type 1

NCBI chr 3:145,722,475...145,767,550
Ensembl chr 3:153,341,947...153,345,380

G

alanine--glyoxylate aminotransferase 2

DNA:missense mutation:cds:rs37369, rs16899974 (human)

NCBI chr 5:75,322,351...75,373,261
Ensembl chr 5:80,601,554...80,652,575

G

alpha 2-HS glycoprotein

susceptibility

associated with Diabetes Mellitus, Type 2;DNA:SNPs

NCBI chr 3:183,644,223...183,652,620
Ensembl chr 3:192,110,770...192,119,915

G

AKT serine/threonine kinase 1

NCBI chr14:85,417,229...85,444,722
Ensembl chr14:105,208,128...105,236,756

G

arachidonate 5-lipoxygenase activating protein

DNA:snps:multiple (human)

NCBI chr13:12,012,399...12,041,557
Ensembl chr13:30,425,510...30,476,607

G

adenosine monophosphate deaminase 1

susceptibility

DNA:SNP:exon:34C>T (human)
DNA:SNP:exon 2:34C>T (human)

PMID:11028479 PMID:24508110

RGD:329349360 RGD:329412480

NCBI chr 1:87,858,602...87,881,348
Ensembl chr 1:122,912,417...122,934,476

G

angiopoietin like 4

CTD Direct Evidence: marker/mechanism

NCBI chr19:7,649,429...7,660,154
Ensembl chr19:8,499,858...8,510,148

G

ankyrin repeat and sterile alpha motif domain containing 1A

CTD Direct Evidence: marker/mechanism

NCBI chr 6:34,450,695...34,653,881
Ensembl chr 6:35,548,124...35,776,185

G

amyloid P component, serum

CTD Direct Evidence: marker/mechanism

NCBI chr 1:134,937,472...134,938,512
Ensembl chr 1:138,734,046...138,735,093

G

aph-1 homolog B, gamma-secretase subunit

DNA:SNP:CDS:p.F217L (rs1047552) (human)

NCBI chr15:42,224,593...42,256,202
Ensembl chr15:60,520,031...60,551,599

G

apolipoprotein A1

CTD Direct Evidence: marker/mechanism

PMID:2128269 PMID:27135400

NCBI chr11:111,673,539...111,675,428
Ensembl chr11:115,606,136...115,608,122

G

apolipoprotein A2

protein:decreased expression:serum

NCBI chr 1:136,634,754...136,636,122
Ensembl chr 1:140,546,591...140,547,959

G

apolipoprotein A5

no_association

DNA:polymorphism:promoter:-1131T>C (human)
CTD Direct Evidence: marker/mechanism
DNA:polymorphism:promoter:-1131T>C, c.56C>G (human)

PMID:15177130 PMID:15306190 PMID:24097064

RGD:1578412 RGD:2313322

NCBI chr11:111,625,403...111,627,932
Ensembl chr11:115,559,231...115,562,286

G

apolipoprotein B

no_association

DNA:SNP:CDS:rs1042031 (human)

PMID:1732399 PMID:9585673 PMID:28167353

RGD:1578417 RGD:1578418 RGD:329901772

NCBI chr2A:20,986,464...21,029,004
Ensembl chr2A:21,100,356...21,145,129

G

apolipoprotein C3

CTD Direct Evidence: marker/mechanism
DNA:SNP:promoter:-482C>T, in women without Diabetes Mellitus, Type 2 (MeSH:D003924)

PMID:14709372 PMID:15059615 PMID:24097064

RGD:1578443 RGD:1626412

NCBI chr11:111,667,816...111,670,861
Ensembl chr11:115,600,416...115,603,460

G

apolipoprotein E

susceptibility

DNA:missense mutation:cds:p.C112R (human)
associated with Diabetes Mellitus, Non-Insulin Dependent;DNA:SNP:promoter:-219G>T (human)
DNA:snp, missense mutation:promoter, cds:g.-219G>T, p.C112R (human)

PMID:12860263 PMID:14563588 PMID:15059615 PMID:28808185

RGD:13703132 RGD:1578449 RGD:1580039 RGD:1626412

NCBI chr19:41,853,669...41,857,252
Ensembl chr19:50,459,906...50,463,490

G

apolipoprotein M

susceptibility

DNA:SNP:promoter:g.-778T>C(rs805296)(human)

NCBI chr 6:31,313,543...31,319,374
Ensembl chr 6:32,206,514...32,209,249

G

Rho GTPase activating protein 31

susceptibility

associated with nicotine dependence;DNA:SNP: (rs10934490) (human)

NCBI chr 3:116,412,238...116,536,900
Ensembl chr 3:123,324,166...123,450,236

G

ATPase plasma membrane Ca2+ transporting 1

CTD Direct Evidence: marker/mechanism

NCBI chr12:87,107,900...87,229,514
Ensembl chr12:90,427,560...90,495,320

G

butyrylcholinesterase

susceptibility

DNA:polymorphism: :p.A539T (human)

NCBI chr 3:162,794,184...162,858,574
Ensembl chr 3:170,845,494...170,911,481

G

BMP/retinoic acid inducible neural specific 3

DNA:SNP: :rs12732361(human), associated with male.

NCBI chr 1:165,586,510...165,972,173
Ensembl chr 1:169,873,541...170,258,015

G

butyrophilin like 2

susceptibility

associated with Mucocutaneous Lymph Node Syndrome; DNA:SNP: :rs 2395158(human)

NCBI chr 6:32,067,223...32,126,032

G

chromosome 1 C1orf167 homolog

DNA:SNP: :rs56001051(human)

NCBI chr 1:10,524,980...10,551,759
Ensembl chr 1:11,741,083...11,769,155

G

calcium responsive transcription factor

CTD Direct Evidence: marker/mechanism

NCBI chr2B:90,145,504...90,224,042
Ensembl chr2B:208,291,742...208,367,028

G

cystathionine beta-synthase

CBS variant c.844ins68

NCBI chr21:29,361,519...29,385,610
Ensembl chr21:42,670,530...42,690,932

G

C-C motif chemokine ligand 2

ClinVar Annotator: match by term: Coronary artery disease, modifier of

PMID:11500196 PMID:15466648 PMID:16352737 PMID:16596675 PMID:18940815

NCBI chr17:22,528,154...22,530,091
Ensembl chr17:22,820,890...22,823,384

G

C-C motif chemokine ligand 26

susceptibility

protein:decreased expression:plasma (human)

NCBI chr 7:68,230,804...68,251,369
Ensembl chr 7:82,221,846...82,242,874

G

C-C motif chemokine receptor 1

NCBI chr 3:46,107,526...46,114,229
Ensembl chr 3:47,214,688...47,215,755

G

C-C motif chemokine receptor 2

NCBI chr 3:46,255,725...46,263,285
Ensembl chr 3:47,361,124...47,368,312

G

C-C motif chemokine receptor 5

mRNA:increased expression:heart (rat)

NCBI chr 3:46,273,096...46,278,471
Ensembl chr 3:47,380,321...47,381,379

G

CD14 molecule

no_association

DNA:SNP:promoter

NCBI chr 5:135,996,265...135,997,909
Ensembl chr 5:142,113,082...142,118,966

G

CD36 molecule (CD36 blood group)

ClinVar Annotator: match by term: Premature coronary artery atherosclerosis

NCBI chr 7:72,566,478...72,643,517
Ensembl chr 7:86,265,114...86,305,865

G

CD40 ligand

associated with Mucocutaneous Lymph Node Syndrome;DNA:SNP: :rs4810485 (human)
CTD Direct Evidence: marker/mechanism
protein:increased expression:serum
protein:increased expression:coronary artery, serum
associated with Kidney Failure, Chronic

PMID:16368305 PMID:16494885 PMID:17635572 PMID:22645426 PMID:23819214

RGD:2314209 RGD:7248436 RGD:7248750 RGD:8547776

NCBI chr X:125,776,138...125,788,820
Ensembl chr X:136,042,849...136,058,202

G

cadherin 5

NCBI chr16:46,684,545...46,722,740
Ensembl chr16:65,787,370...65,825,360

G

cyclin dependent kinase inhibitor 2B

CTD Direct Evidence: marker/mechanism

PMID:23104008 PMID:34961328

NCBI chr 9:21,838,902...21,845,355
Ensembl chr 9:22,455,662...22,462,156

G

cadherin EGF LAG seven-pass G-type receptor 2

CTD Direct Evidence: marker/mechanism

NCBI chr 1:111,627,551...111,653,775
Ensembl chr 1:110,791,682...110,815,421

G

cholesteryl ester transfer protein

ClinVar Annotator: match by term: Coronary artery disease

PMID:14559957 PMID:17190939 PMID:20068209 PMID:25741868 PMID:28492532

NCBI chr16:37,239,756...37,261,859
Ensembl chr16:56,374,363...56,396,103

G

chitinase 3 like 1

protein:increased secretion:serum (human)

NCBI chr 1:178,778,081...178,789,704
Ensembl chr 1:183,075,312...183,083,229

G

chloride voltage-gated channel 6

susceptibility

DNA:SNP: :rs3737964(human)

NCBI chr 1:10,568,222...10,605,459
Ensembl chr 1:11,785,643...11,822,505

G

clusterin

associated with Mucocutaneous Lymph Node Syndrome;protein:decreased expression:plasma

NCBI chr 8:26,867,973...26,884,838
Ensembl chr 8:24,070,053...24,083,523

G

carboxypeptidase E

severity

DNA:SNPs:CDS:intron 4, exon 4 (A2925G, G2855A) (human)

NCBI chr 4:157,575,157...157,705,173
Ensembl chr 4:169,659,007...169,780,739

G

C-reactive protein

associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:serum
CTD Direct Evidence: marker/mechanism

PMID:19615354 PMID:24868163

NCBI chr 1:135,062,102...135,064,402

G

cystatin C

protein:increased expression:serum (human)

NCBI chr20:23,583,043...23,587,399
Ensembl chr20:23,935,942...23,940,425

G

cubilin

susceptibility

DNA:SNP,haplotypes:intron: (rs2291521)G>A (human)

NCBI chr10:17,141,464...17,446,867
Ensembl chr10:17,415,551...17,719,129

G

C-X-C motif chemokine ligand 12

CTD Direct Evidence: marker/mechanism

NCBI chr10:41,296,975...41,384,864
Ensembl chr10:44,552,480...44,564,231

G

cytochrome P450 family 27 subfamily A member 1

ClinVar Annotator: match by term: Premature coronary artery atherosclerosis

PMID:25741868 PMID:28492532

NCBI chr2B:106,042,235...106,076,840
Ensembl chr2B:224,637,238...224,671,474

G

cytochrome P450 family 2 subfamily R member 1

DNA:SNP:CDS:rs10741657 (human)

NCBI chr11:14,960,651...14,989,083
Ensembl chr11:14,656,939...14,671,584

G

DAB2 interacting protein

onset

DNA:SNP:CDS:rs7025486 (human)

NCBI chr 9:92,696,798...92,912,425
Ensembl chr 9:121,143,457...121,254,336

G

dimethylarginine dimethylaminohydrolase 1

DNA:missense mutation:cds:rs997251 (human)

NCBI chr 1:117,875,875...118,136,304

G

DDAH family member 2, ADMA-independent

CTD Direct Evidence: marker/mechanism

NCBI chr 6:31,388,401...31,391,637
Ensembl chr 6:32,277,102...32,280,338

G

endothelin converting enzyme 1

protein:increased expression:smooth muscle cell,macrophage

PMID:8994440 PMID:10973835

RGD:1580909 RGD:7244168

NCBI chr 1:20,166,019...20,290,803
Ensembl chr 1:21,206,199...21,278,909

G

endothelin 1

treatment
severity

protein:increased expression:atherosclerotic lesions (human)
associated with Hypertension;DNA:missense mutation:cds:p.L198N (human)

PMID:7968078 PMID:11927217 PMID:18923236

RGD:4144886 RGD:8661705 RGD:8662294

NCBI chr 6:12,076,312...12,142,861
Ensembl chr 6:12,462,718...12,503,545

G

endoglin

severity

protein:increased expression:plasma (human)

NCBI chr 9:98,934,080...98,973,862
Ensembl chr 9:127,605,608...127,644,641

G

epoxide hydrolase 2

NCBI chr 8:26,761,090...26,818,436
Ensembl chr 8:23,964,094...24,017,749

G

erythropoietin

CTD Direct Evidence: therapeutic

NCBI chr 7:92,747,671...92,750,886
Ensembl chr 7:106,148,062...106,150,974

G

ERCC excision repair 2, TFIIH core complex helicase subunit

susceptibility

DNA:SNP: :rs13181(human)

NCBI chr19:42,298,927...42,319,816
Ensembl chr19:50,897,004...50,915,819

G

estrogen receptor 1

CTD Direct Evidence: marker/mechanism

PMID:9396482 PMID:16159931 PMID:20559769

NCBI chr 6:149,507,599...149,918,523
Ensembl chr 6:154,317,002...154,631,551

G

estrogen receptor 2

CTD Direct Evidence: marker/mechanism

PMID:16099331 PMID:20559769

NCBI chr14:44,807,875...44,919,780
Ensembl chr14:63,064,402...63,131,303

G

coagulation factor II, thrombin

treatment

NCBI chr11:46,669,925...46,690,391
Ensembl chr11:47,227,891...47,249,157

G

coagulation factor VII

associated with Diabetes Mellitus, Non-Insulin-Dependent; protein:increased activity:plasma (human)
DNA:polymorphisms:cds:R353Q (human)

PMID:8522401 PMID:10599031 PMID:11334615

RGD:2312397 RGD:2312400 RGD:2312408

NCBI chr13:94,246,694...94,261,133
Ensembl chr13:113,315,868...113,329,995

G

fatty acid binding protein 2

DNA:SNP:CDS:2445G>A, amino acid A54T, associated with Diabetes Mellitus, Type 2 (MeSH:D003924) in women

NCBI chr 4:111,505,269...111,510,197
Ensembl chr 4:122,055,544...122,060,461

G

Fc gamma receptor IIIa

susceptibility

DNA:SNP:exon:p.F158V (rs396991)(human)

NCBI chr 1:137,027,943...137,036,738

G

FES proto-oncogene, tyrosine kinase

CTD Direct Evidence: marker/mechanism

NCBI chr15:69,576,936...69,588,834
Ensembl chr15:88,774,965...88,786,965

G

fibrinogen beta chain

NCBI chr 4:146,929,561...146,937,665
Ensembl chr 4:158,747,659...158,755,766

G

fibroblast growth factor 2

associated with Diabetes Mellitus

NCBI chr 4:115,005,136...115,076,369
Ensembl chr 4:126,149,813...126,214,942

G

FTO alpha-ketoglutarate dependent dioxygenase

DNA:SNP: :rs9939609 (human)
DNA:SNP:intron:rs9939609 (human)

PMID:24622111 PMID:28167353

RGD:329812039 RGD:329901772

NCBI chr16:33,939,300...34,343,419
Ensembl chr16:53,023,425...53,490,231

G

furin, paired basic amino acid cleaving enzyme

CTD Direct Evidence: marker/mechanism

NCBI chr15:69,560,774...69,576,007
Ensembl chr15:88,763,269...88,774,023

G

glucokinase

susceptibility

DNA:SNP:promoter:-30G>A (human)

NCBI chr 7:44,857,604...44,903,683
Ensembl chr 7:44,926,848...44,937,751

G

growth differentiation factor 15

CTD Direct Evidence: marker/mechanism

NCBI chr19:17,864,840...17,867,883
Ensembl chr19:18,835,216...18,838,470

G

Gfo/Idh/MocA-like oxidoreductase domain containing 1

CTD Direct Evidence: marker/mechanism

NCBI chr 6:13,203,295...13,332,651
Ensembl chr 6:13,582,487...13,704,047

G

gamma-glutamyl carboxylase

CTD Direct Evidence: marker/mechanism

NCBI chr2A:85,599,227...85,612,274
Ensembl chr2A:87,152,111...87,164,567

G

gap junction protein alpha 4

DNA:SNP:CDS:C allele of 1019C>T, amino acid P319S in men only (p = 0.0047) in a Swiss population
DNA:SNP:CDS:1019C>T, amino acid P319S, in men both with and without Diabetes Mellitus, Type 2 (MeSH:D003924)

PMID:15059615 PMID:16677656

RGD:1626412 RGD:1626615

NCBI chr 1:34,059,901...34,063,181

G

G protein subunit beta 3

CTD Direct Evidence: marker/mechanism

NCBI chr12:6,971,854...6,979,214
Ensembl chr12:6,883,280...6,890,692

G

glycoprotein VI platelet

treatment

protein:increased expression:platelet (human)

NCBI chr19:52,051,138...52,071,673
Ensembl chr19:60,746,578...60,770,643

G

glutathione peroxidase 1

DNA:repeat:exon
cardiovascular complications in type 2 diabetics; protein:reduced_activity:blood

PMID:12655278 PMID:16338763

RGD:1600677 RGD:1600708

NCBI chr 3:49,280,038...49,281,455
Ensembl chr 3:50,360,947...50,361,826

G

glutathione peroxidase 3

mRNA:increased expression:epicardial fat

NCBI chr 5:146,447,939...146,456,476

G

glutathione-disulfide reductase

cardiovascular complications in type 2 diabetics; protein:reduced_activity:blood

NCBI chr 8:29,990,543...30,040,157
Ensembl chr 8:27,180,300...27,229,557

G

glutathione S-transferase mu 1

susceptibility

associated with Diabetes Mellitus, Non-Insulin-Dependent
DNA:deletion

PMID:16620396 PMID:19102712

RGD:2306625 RGD:2306633

Ensembl chr 1:127,979,238...128,010,411

G

guanylate cyclase 1 soluble subunit alpha 1

CTD Direct Evidence: marker/mechanism

NCBI chr 4:148,032,167...148,102,757
Ensembl chr 4:159,850,107...159,913,338

G

HECT domain E3 ubiquitin protein ligase 4

CTD Direct Evidence: marker/mechanism

NCBI chr12:109,756,303...109,978,510
Ensembl chr12:113,151,017...113,311,809

G

homeostatic iron regulator

no_association

NCBI chr 6:25,921,663...25,930,852
Ensembl chr 6:26,580,358...26,588,591

G

hepatocyte growth factor

NCBI chr 7:73,667,618...73,738,960
Ensembl chr 7:87,327,798...87,397,811

G

HHIP like 1

CTD Direct Evidence: marker/mechanism

NCBI chr14:80,229,854...80,304,418

G

3-hydroxy-3-methylglutaryl-CoA reductase

NCBI chr 5:39,936,630...39,961,519
Ensembl chr 5:40,548,919...40,573,785

G

heme oxygenase 1

no_association
susceptibility

DNA:repeat:promoter
CTD Direct Evidence: marker/mechanism

PMID:12136229 PMID:12377749 PMID:14691581

RGD:1580454 RGD:1580470 RGD:1598401

NCBI chr22:16,388,368...16,401,289
Ensembl chr22:34,230,825...34,244,063

G

HNF1 homeobox A

susceptibility

DNA:SNP,haplotypes:intron: (rs55783344) C>T(human)
DNA:SNP:intron 1: (rs7310409) G>A (human)
DNA:SNPs,haplotypes:multiple

PMID:25202455 PMID:28035729 PMID:33004870

RGD:329901832 RGD:329901837 RGD:329901841

NCBI chr12:118,562,308...118,584,596
Ensembl chr12:121,932,671...121,955,911

G

heparan sulfate-glucosamine 3-sulfotransferase 1

ClinVar Annotator: match by term: Coronary artery disease

PMID:15266341 PMID:15965027 PMID:16024819 PMID:16410828 PMID:17179217 More...

NCBI chr 4:5,797,803...5,829,976
Ensembl chr 4:11,108,374...11,109,297

G

hydroxysteroid 11-beta dehydrogenase 1

sexual_dimorphism

associated with obesity;mRNA,protein:increased expression:multiple (human)

NCBI chr 1:185,262,599...185,311,417
Ensembl chr 1:190,086,449...190,116,765

G

heat shock protein family D (Hsp60) member 1

severity

NCBI chr2B:84,729,615...84,743,352
Ensembl chr2B:202,623,497...202,636,959

G

islet cell autoantigen 1 like

CTD Direct Evidence: marker/mechanism

NCBI chr2B:90,034,205...90,105,600
Ensembl chr2B:208,184,023...208,251,254

G

interleukin 10

no_association
susceptibility

DNA:SNPs:promoter:-592C>A (rs1800872), -819C>T (rs1800871) (human)
DNA:SNP:promoter:-1082A>G (rs1800896) (human)

PMID:16460885 PMID:29525679

RGD:14975129 RGD:1598621

NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371

G

interleukin 15

associated with Hypertension;protein:increased expression:serum

NCBI chr 4:133,693,995...134,115,470
Ensembl chr 4:145,402,111...145,416,622

G

interleukin 1 beta

mRNA:increased expression:peripheral blood (human)

NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424

G

interleukin 1 receptor like 1

severity

DNA:polymorphisms: :-27307T>A, -27614C>A (human)

G

interleukin 6

associated with Diabetes Mellitus, Non-Insulin-Dependent; protein:increased expression:extracellular space (human)

NCBI chr 7:23,415,922...23,420,767

G

interleukin 1 receptor associated kinase 1

CTD Direct Evidence: marker/mechanism

NCBI chr X:143,560,802...143,570,185
Ensembl chr X:153,446,827...153,460,602

G

insulin receptor substrate 1

CTD Direct Evidence: marker/mechanism
DNA:polymorphism:exon:G972R

NCBI chr2B:113,973,191...114,041,127
Ensembl chr2B:232,849,239...232,852,967

G

integrin subunit alpha 2

no_association

NCBI chr 5:60,935,452...61,040,726
Ensembl chr 5:62,555,370...62,659,720

G

junctional cadherin 5 associated

CTD Direct Evidence: marker/mechanism

NCBI chr10:30,163,932...30,266,266
Ensembl chr10:30,528,772...30,553,865

G

kalirin RhoGEF kinase

severity
onset
susceptibility

DNA:SNP:intron: (rs9289231) (human)
associated with nicotine dependence; DNA:SNPs:multiple
associated with type 2 diabetes mellitus;DNA:SNP:intron: (rs9289231) T>G (human)

PMID:19706030 PMID:25316661 PMID:27218147 PMID:30483314

RGD:11076452 RGD:329955537 RGD:329956419 RGD:329970276

NCBI chr 3:121,138,136...121,828,723
Ensembl chr 3:128,225,413...128,720,441

G

potassium voltage-gated channel subfamily E regulatory subunit 2

CTD Direct Evidence: marker/mechanism

G

potassium inwardly rectifying channel subfamily J member 8

OMIM:300464 | OMIM:607339 | OMIM:608316 | OMIM:608318 | OMIM:608320 | OMIM:608901 | OMIM:610938 | OMIM:610947 | OMIM:611139 | OMIM:612030 | OMIM:614293 | OMIM:614466

NCBI chr12:64,522,172...64,532,848
Ensembl chr12:67,127,263...67,137,128

G

kinesin family member 6

no_association
sexual_dimorphism
treatment

DNA:SNP: :p.W719R (rs20455) (human)
associated with type 2 diabetes mellitus;DNA:SNP: :p.W719R (rs20455) (human)
DNA:SNP: :rs20455 (human)

PMID:18222354 PMID:19371834 PMID:21458191 PMID:25629058 PMID:26443250 More...

RGD:11527801 RGD:243048446 RGD:243048447 RGD:243048449 RGD:243048451 RGD:243048454

NCBI chr 6:38,917,083...39,306,190
Ensembl chr 6:40,234,426...40,616,738

G

klotho

DNA:SNP:promoter: -G395>A (human)
CTD Direct Evidence: marker/mechanism

PMID:12669274 PMID:16579981 PMID:16979405

RGD:1581721 RGD:1581723

NCBI chr13:14,272,463...14,321,122
Ensembl chr13:32,702,336...32,751,458

G

low density lipoprotein receptor

no_association

CTD Direct Evidence: marker/mechanism

PMID:16459141 PMID:21378990 PMID:27135400

NCBI chr19:10,640,225...10,683,728
Ensembl chr19:11,357,311...11,396,791

G

leptin receptor

susceptibility

DNA:missense mutation:CDS:p.Q223R (human)

NCBI chr 1:64,772,612...64,881,886
Ensembl chr 1:66,693,926...66,764,768

G

lipase A, lysosomal acid type

CTD Direct Evidence: marker/mechanism

PMID:21378988 PMID:34961328 PMID:35590109

NCBI chr10:85,938,240...85,976,610
Ensembl chr10:89,477,082...89,516,874

G

lipase C, hepatic type

susceptibility
no_association

250G/A
DNA:SNP,haplotypes: (rs17269397)A>G (human)
C514T
associated with Diabetes Mellitus, Insulin-Dependent; DNA:transition:promoter:-480C>T (human)

PMID:11916946 PMID:12689525 PMID:15099346 PMID:33004870

RGD:1600663 RGD:1600664 RGD:2308839 RGD:329901841

NCBI chr15:37,363,507...37,537,723
Ensembl chr15:55,814,017...55,847,005

G

lipase G, endothelial type

NCBI chr18:42,942,132...42,972,112
Ensembl chr18:46,292,154...46,320,652

G

leiomodin 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:177,493,627...177,543,853
Ensembl chr 1:181,798,304...181,845,295

G

cytochrome b-245 light chain

NCBI chr16:69,356,396...69,364,225
Ensembl chr16:89,016,349...89,024,719

G

low affinity immunoglobulin gamma Fc region receptor II-a

DNA:polymorphism: :p.H131R (human)

NCBI chr 1:136,892,311...136,906,450

G

chymotrypsin-like elastase family member 2A

ClinVar Annotator: match by term: Coronary artery disease

PMID:25741868 PMID:31358993

NCBI chr 1:14,595,218...14,606,322
Ensembl chr 1:15,589,878...15,604,926

G

lysyl oxidase

NCBI chr 5:117,450,833...117,464,957
Ensembl chr 5:123,234,662...123,248,717

G

lipoprotein(a)

ClinVar Annotator: match by term: Coronary artery disease
ClinVar Annotator: match by term: LIPOPROTEIN(a) POLYMORPHISM

NCBI chr 6:158,434,394...158,628,028

G

lipoprotein lipase

NCBI chr 8:19,164,541...19,193,100
Ensembl chr 8:16,113,415...16,142,966

G

LDL receptor related protein 6

ClinVar Annotator: match by term: Coronary artery disease

NCBI chr12:12,121,411...12,288,590
Ensembl chr12:12,508,108...12,657,973

G

LDL receptor related protein 8

no_association
onset

DNA:missense mutation:cds:p.R952Q (human)

PMID:17847002 PMID:18592168

RGD:2306124 RGD:2306125

NCBI chr 1:52,515,534...52,600,390
Ensembl chr 1:54,114,909...54,199,452

G

lymphotoxin alpha

CTD Direct Evidence: marker/mechanism

PMID:15266304 PMID:15973460

NCBI chr 6:31,233,411...31,235,409
Ensembl chr 6:32,123,353...32,125,375

G

lumican

NCBI chr12:88,636,825...88,644,665
Ensembl chr12:91,952,277...91,960,388

G

mitogen-activated protein kinase kinase kinase 7

associated with hypothyroidism;mRNA:decreased expression:venous blood (human)

NCBI chr 6:88,398,329...88,470,926
Ensembl chr 6:91,664,263...91,737,468

G

methionine adenosyltransferase 2A

CTD Direct Evidence: marker/mechanism

NCBI chr2A:85,589,301...85,595,437
Ensembl chr2A:87,141,857...87,148,322

G

MIA SH3 domain ER export factor 3

ClinVar Annotator: match by term: Coronary artery disease

NCBI chr 1:198,291,200...198,339,502
Ensembl chr 1:203,304,237...203,354,919

G

MLX interacting protein like

susceptibility

DNA:SNP:cds: G771C, Q241H (rs381231)
DNA:SNPs,haplotypes: (rs3812316) (human)
DNA:SNP:cds: C771G, H241Q

PMID:19571538 PMID:21726544 PMID:25179879

RGD:401794579 RGD:401794581 RGD:401794582

Ensembl chr 7:80,745,765...80,776,153

G

matrix metallopeptidase 1

severity

DNA:insertion, haplotype:promoter:g.-1607insG rs799750 (human)

PMID:15619398 PMID:17893005

RGD:1582527 RGD:7207049

NCBI chr11:97,730,545...97,739,190
Ensembl chr11:101,221,393...101,230,104

G

matrix metallopeptidase 12

susceptibility

NCBI chr11:97,809,644...97,822,063
Ensembl chr11:101,294,475...101,306,762

G

matrix metallopeptidase 3

associated with Mucocutaneous Lymph Node Syndrome
DNA:insertion, haplotype:promoter:g.-1613insA rs3025058 (human)
CTD Direct Evidence: marker/mechanism

PMID:8662692 PMID:16100452 PMID:17893005

RGD:7207049 RGD:8693322

NCBI chr11:97,776,729...97,784,549
Ensembl chr11:101,267,566...101,275,354

G

matrix metallopeptidase 9

treatment
susceptibility

PMID:15191941 PMID:26261622

RGD:11344965 RGD:1582644

NCBI chr20:42,346,305...42,354,018
Ensembl chr20:43,432,389...43,440,129

G

muscle RAS oncogene homolog

CTD Direct Evidence: marker/mechanism

PMID:21378990 PMID:35590109

NCBI chr 3:135,377,488...135,435,338
Ensembl chr 3:142,827,020...142,884,582

G

mitochondrial ribosomal protein S6

CTD Direct Evidence: marker/mechanism

PMID:21378990 PMID:34961328

NCBI chr21:20,441,365...20,510,800
Ensembl chr21:33,862,033...33,879,670

G

methylenetetrahydrofolate reductase

susceptibility
no_association

DNA:transition:cds:g.677C>T (human)
DNA:SNPs: (rs1801133, rs4846049) (Human)

PMID:12387655 PMID:15648053 PMID:24315498

RGD:1580579 RGD:401850782 RGD:6893453

NCBI chr 1:10,548,196...10,568,174
Ensembl chr 1:11,766,334...11,785,419

G

myosin regulatory light chain interacting protein

ClinVar Annotator: match by term: Coronary atherosclerosis

NCBI chr 6:15,985,844...16,005,043
Ensembl chr 6:16,350,852...16,370,253

G

myosin light chain kinase

susceptibility

associated with nicotine dependence; DNA:SNP: (rs16834817)

NCBI chr 3:120,711,705...120,983,432
Ensembl chr 3:127,614,173...127,793,261

G

nicotinamide phosphoribosyltransferase

NCBI chr 7:98,227,071...98,262,254
Ensembl chr 7:110,952,876...110,981,967

G

N-acetyltransferase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 8:17,606,445...17,623,397
Ensembl chr 8:14,575,455...14,576,327

G

neurobeachin like 1

CTD Direct Evidence: marker/mechanism

NCBI chr2B:90,250,567...90,459,507
Ensembl chr2B:208,395,950...208,594,273

G

nerve growth factor

NCBI chr 1:87,223,597...87,276,759

G

nerve growth factor receptor

NCBI chr17:8,089,600...8,109,361
Ensembl chr17:8,075,316...8,094,966

G

nicotinamide N-methyltransferase

severity

protein:increased expression:blood serum (human)

NCBI chr11:109,174,490...109,186,758
Ensembl chr11:113,016,613...113,029,581

G

nucleotide binding oligomerization domain containing 2

DNA:polymorphisms: :p.G908R, 3020_3021insC (human)

NCBI chr16:30,955,976...30,995,451
Ensembl chr16:49,837,891...49,873,773

G

nitric oxide synthase 2

associated with Mucocutaneous Lymph Node Syndrome; protein:increased expression:neutrophil, monocyte

NCBI chr17:28,984,295...29,021,516
Ensembl chr17:29,471,510...29,617,093

G

nitric oxide synthase 3

susceptibility

CTD Direct Evidence: marker/mechanism
DNA:snp:cds:c.894G>T (human)
DNA:snp:promoter:g.-786T>C (human)
DNA:duplication:intron:IVS4?-?+27 (human)

PMID:8564837 PMID:10510054 PMID:14989558 PMID:16284093 PMID:17267746 More...

RGD:7421529 RGD:7771567 RGD:7771578

NCBI chr 7:142,577,334...142,600,702
Ensembl chr 7:154,730,009...154,755,233

G

natriuretic peptide A

DNA:snp:cds:c.2238T>C (human)
associated with Diabetes Mellitus, Type 2;DNA:SNP:exon: 2238T>C,rs5065 (human)

PMID:12514664 PMID:22170009

RGD:1579982 RGD:7247716

NCBI chr 1:10,608,025...10,610,287
Ensembl chr 1:11,825,072...11,827,373

G

natriuretic peptide B

CTD Direct Evidence: marker/mechanism

NCBI chr 1:10,621,416...10,622,960
Ensembl chr 1:11,838,518...11,839,995

G

nuclear receptor subfamily 1 group H member 3

associated with type 2 diabetes mellitus;mRNA:increased expression:peripheral blood mononuclear cell (human)

NCBI chr11:47,195,122...47,215,277
Ensembl chr11:47,748,353...47,768,672

G

nuclear receptor subfamily 3 group C member 1

DNA:missense mutation:cds:p.N363S (human)

NCBI chr 5:138,634,278...139,089,171
Ensembl chr 5:144,741,452...144,865,269

G

8-oxoguanine DNA glycosylase

susceptibility

DNA:SNP,haplotype: :p.S326C (rs1052133) (human)

NCBI chr 3:9,702,311...9,742,283
Ensembl chr 3:9,940,955...9,947,335

G

oxidized low density lipoprotein receptor 1

severity

DNA:snp:3' utr:T>C (human)
DNA:missense mutation:cds:p.K167N (human)

PMID:12810610 PMID:15562935

RGD:1580994 RGD:1580995

NCBI chr12:10,196,712...10,210,432
Ensembl chr12:10,445,202...10,461,071

G

pappalysin 1

severity

CTD Direct Evidence: marker/mechanism

PMID:11586954 PMID:16055491

NCBI chr 9:87,287,289...87,535,414
Ensembl chr 9:115,671,212...115,883,435

G

presenilin associated rhomboid like

susceptibility

DNA:missense mutation:cds:p.L262V (human)

NCBI chr 3:180,862,434...180,921,197
Ensembl chr 3:189,032,816...189,088,036

G

proprotein convertase subtilisin/kexin type 9

CTD Direct Evidence: marker/mechanism

PMID:21378990 PMID:27135400

NCBI chr 1:54,323,036...54,355,397
Ensembl chr 1:55,911,016...55,936,456

G

platelet derived growth factor D

CTD Direct Evidence: marker/mechanism

PMID:21378988 PMID:34961328

NCBI chr11:98,852,652...99,110,147
Ensembl chr11:102,357,079...102,593,273

G

platelet and endothelial cell adhesion molecule 1

no_association

DNA:missense mutation:cds:p.L125V (human)
DNA:polymorphism:5' utr:g.53G>A (human)
DNA:missense mutations:cds:p.N536S, p.G670R (human)
CTD Direct Evidence: marker/mechanism

PMID:10780329 PMID:11795274 PMID:12732396 PMID:28530674

RGD:1581010 RGD:2311656 RGD:6771225

NCBI chr17:58,417,134...58,526,409
Ensembl chr17:63,511,784...63,579,067

G

platelet factor 4 variant 1

protein:increased expression:plasma

NCBI chr 4:50,341,931...50,343,220
Ensembl chr 4:56,173,293...56,175,607

G

phosphatase and actin regulator 1

susceptibility
sexual_dimorphism

CTD Direct Evidence: marker/mechanism
DNA:SNP:exon: (rs4714955) (human)
DNA:hypermethylation, hypomethylation:promoter, exon: (human)
DNA:SNPs:intron: (rs9381439, rs9349379) (human)
associated with familial hypercholesterolemia;DNA:SNP:intron: (rs12526453) (human)
DNA:SNP:intron:g.12903957A>G (rs9349379) (human)
DNA:SNP:intron:g.12903725A>G (rs9349379) (human)

PMID:21378990 PMID:22751097 PMID:26098115 PMID:27066539 PMID:27517945 More...

RGD:401851919 RGD:401900135 RGD:401900687 RGD:401900688 RGD:401901243 RGD:401901251

NCBI chr 6:12,560,862...13,136,126
Ensembl chr 6:12,922,871...13,505,609

G

phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma

ClinVar Annotator: match by term: Premature coronary artery atherosclerosis

NCBI chr12:18,258,487...18,644,464
Ensembl chr12:18,664,631...19,030,493

G

phospholipase A2 group VII

disease_progression
susceptibility

DNA:polymorphism: :p.A379V (human)

PMID:15115767 PMID:17070179

RGD:6482777 RGD:6482781

NCBI chr 6:46,264,262...46,318,487
Ensembl chr 6:47,558,861...47,590,212

G

phospholipid phosphatase 3

CTD Direct Evidence: marker/mechanism

NCBI chr 1:55,779,343...55,862,717
Ensembl chr 1:57,489,178...57,573,398

G

patatin like phospholipase domain containing 3

associated with type 2 diabetes mellitus;DNA:SNP: :rs738409 (p.I148M) (human)

NCBI chr22:24,812,831...24,836,161
Ensembl chr22:43,004,499...43,027,003

G

paraoxonase 1

susceptibility

DNA:missense mutation:cds:p.Q192R (human)
ClinVar Annotator: match by term: Coronary artery spasm 2, susceptibility to

PMID:7916578 PMID:8098250 PMID:8675673 PMID:8770857 PMID:9215303 More...

NCBI chr 7:87,253,476...87,279,650
Ensembl chr 7:100,841,286...100,867,493

G

paraoxonase 2

severity

DNA:missense mutation:cds:p.C311S (human)

NCBI chr 7:87,362,447...87,392,795
Ensembl chr 7:100,950,074...100,980,433

G

peroxisome proliferator activated receptor alpha

susceptibility

DNA:snp:intron: (human)

Ensembl chr22:45,218,364...45,302,970

G

peroxisome proliferator activated receptor gamma

protein:decreased expression:carotid artery, macrophage, smooth muscle cell (human)

NCBI chr 3:12,215,322...12,361,669
Ensembl chr 3:12,622,397...12,705,060

G

protein phosphatase 4 catalytic subunit

mRNA:decreased expression:blood (human)

Ensembl chr16:30,450,467...30,464,446

G

PR/SET domain 16

CTD Direct Evidence: marker/mechanism

NCBI chr 1:1,730,122...2,100,636
Ensembl chr 1:2,981,667...3,234,251

G

protein kinase AMP-activated non-catalytic subunit gamma 2

ClinVar Annotator: match by term: Coronary artery disease

PMID:25741868 PMID:28492532

NCBI chr 7:143,143,556...143,463,492
Ensembl chr 7:155,293,748...155,610,078

G

protein C receptor

CTD Direct Evidence: marker/mechanism

NCBI chr20:31,500,838...31,543,928
Ensembl chr20:32,622,876...32,628,320

G

proline and serine rich coiled-coil 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:111,657,568...111,661,225
Ensembl chr 1:110,820,918...110,824,522

G

prostaglandin-endoperoxide synthase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 1:162,205,534...162,214,130
Ensembl chr 1:166,355,845...166,364,519

G

parathyroid hormone

protein:increased expression:serum (human)

NCBI chr11:13,653,777...13,657,901
Ensembl chr11:13,347,838...13,351,802

G

protein tyrosine phosphatase non-receptor type 1

DNA:SNP:exon 8:g.981C>T (human)

NCBI chr20:46,854,918...46,929,509
Ensembl chr20:47,983,098...48,057,421

G

protein tyrosine phosphatase non-receptor type 22

DNA: snp: cds: rs2476601

NCBI chr 1:88,685,736...88,743,164
Ensembl chr 1:123,734,511...123,790,830

G

protein tyrosine phosphatase receptor type D

DNA:SNP:intron: (rs10115782) (human)

NCBI chr 9:8,113,171...10,420,732
Ensembl chr 9:8,288,569...8,831,227

G

retinol binding protein 4

severity
susceptibility
sexual_dimorphism
disease_progression

associated with hypothyroidism;protein:increased expression:blood serum (human)
DNA:SNP:intron: (rs7094671) (human)
protein:increased expression:blood plasma (human)
protein:increased expression:epicardial fat (human)

PMID:18854400 PMID:21645024 PMID:25437889 PMID:25479076 PMID:31278889

RGD:329845573 RGD:329845584 RGD:329845843 RGD:329845849 RGD:329845882

NCBI chr10:90,337,879...90,347,530
Ensembl chr10:93,848,166...93,857,887

G

ryanodine receptor 2

ClinVar Annotator: match by term: Premature coronary artery atherosclerosis

NCBI chr 1:212,600,198...213,387,312
Ensembl chr 1:217,815,676...218,383,509

G

seryl-tRNA synthetase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:111,590,850...111,615,068
Ensembl chr 1:110,755,054...110,779,704

G

selectin E

susceptibility

associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:mutation: :p.S128R (human)
ClinVar Annotator: match by term: Coronary artery disease

PMID:17578587 PMID:25741868

NCBI chr 1:145,205,684...145,217,143
Ensembl chr 1:148,930,437...148,938,313

G

selectin P

ClinVar Annotator: match by term: Premature coronary artery atherosclerosis

NCBI chr 1:145,071,094...145,112,851
Ensembl chr 1:148,793,677...148,834,701

G

serpin family A member 1

protein:increased expression:serum

NCBI chr14:75,001,714...75,014,214
Ensembl chr14:94,334,258...94,345,419

G

serpin family E member 1

susceptibility

DNA:insertion:promoter: (human)

NCBI chr 7:93,267,517...93,279,728
Ensembl chr 7:106,510,130...106,518,450

G

serpin family F member 2

NCBI chr17:1,725,469...1,738,887
Ensembl chr17:1,618,549...1,631,570

G

SH2B adaptor protein 3

CTD Direct Evidence: marker/mechanism

NCBI chr12:108,977,344...109,024,029

G

solute carrier family 2 member 4

mRNA:decreased expression:epicardial fat, subcutaneous adipose tissue (human)

NCBI chr17:7,312,605...7,319,430
Ensembl chr17:7,299,966...7,306,344

G

solute carrier family 5 member 3

CTD Direct Evidence: marker/mechanism

NCBI chr21:20,441,434...20,474,101
Ensembl chr21:33,831,917...33,834,073

G

SMAD family member 3

ClinVar Annotator: match by term: Coronary artery disease

NCBI chr15:46,013,764...46,143,126
Ensembl chr15:64,284,949...64,414,185

G

sterol O-acyltransferase 2

susceptibility

DNA:polymorphisms: :p.E41G, p.T734I, IVS4-57_-58ins48bp (human)

NCBI chr12:35,632,018...35,653,227
Ensembl chr12:36,413,954...36,434,074

G

superoxide dismutase 1

associated with Diabetes Mellitus, Non-Insulin-Dependent

NCBI chr21:18,029,831...18,037,526

G

superoxide dismutase 3

NCBI chr 4:19,195,941...19,201,298
Ensembl chr 4:24,485,059...24,485,781

G

sortilin 1

CTD Direct Evidence: marker/mechanism

PMID:21378990 PMID:34961328

NCBI chr 1:111,687,119...111,775,339

G

secreted phosphoprotein 1

In type 2 diabetic patients

NCBI chr 4:80,263,711...80,271,466
Ensembl chr 4:90,988,200...90,995,935

G

sterol regulatory element binding transcription factor 1

susceptibility
disease_progression
severity

DNA:SNP, haplotype:: -36delG (human)
associated with type 2 diabetes mellitus; mRNA:increased expression:epicardial fat (human)
mRNA:decreased expression:blood serum (human)

PMID:12752570 PMID:28367087 PMID:31610782

RGD:401827912 RGD:401842364 RGD:401842368

NCBI chr17:33,458,196...33,484,643
Ensembl chr17:38,405,794...38,432,045

G

sterol regulatory element binding transcription factor 2

disease_progression

associated with type 2 diabetes mellitus;mRNA:increased expression:epicardial fat (human)

NCBI chr22:22,725,790...22,799,749
Ensembl chr22:40,811,459...40,884,947

G

T-box transcription factor 2

CTD Direct Evidence: marker/mechanism

NCBI chr17:55,501,932...55,511,537
Ensembl chr17:60,622,098...60,630,189

G

transcription factor 21

susceptibility

CTD Direct Evidence: marker/mechanism
DNA:SNP: (rs12190287) (human)

PMID:21378990 PMID:22751097 PMID:26909569

NCBI chr 6:131,656,582...131,662,983
Ensembl chr 6:135,754,896...135,761,294

G

TEK receptor tyrosine kinase

protein:increased expression:plasma

NCBI chr 9:26,955,339...27,077,809
Ensembl chr 9:27,561,421...27,683,572

G

telomerase reverse transcriptase

CTD Direct Evidence: marker/mechanism

Ensembl chr 5:1,300,960...1,338,872

G

thrombomodulin

severity

NCBI chr20:22,992,341...22,996,415
Ensembl chr20:23,345,917...23,347,812

G

tolloid like 1

severity

associated with type 2 diabetes:DNA:SNP:CDS:rs1503298 (human)

NCBI chr 4:158,068,424...158,300,856
Ensembl chr 4:170,157,417...170,384,260

G

toll like receptor 4

CTD Direct Evidence: marker/mechanism

PMID:15632890 PMID:20524934

NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711

G

tumor necrosis factor

DNA:SNP:promoter:-863C>A, in men without Diabetes Mellitus, Type 2 (MeSH:D003924)

NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381

G

TNF receptor superfamily member 11b

protein:increased expression:serum

NCBI chr 8:115,614,778...115,643,387
Ensembl chr 8:118,134,305...118,162,422

G

TNF receptor superfamily member 1A

severity

NCBI chr12:6,457,617...6,470,969
Ensembl chr12:6,374,257...6,387,613

G

troponin I3, cardiac type

NCBI chr19:52,193,061...52,198,782
Ensembl chr19:60,887,630...60,894,219

G

tumor protein p53

DNA:misssense mutation: :p.R72P (rs1042522) (human)

NCBI chr17:7,699,449...7,717,812
Ensembl chr17:7,684,922...7,706,120

G

TNF receptor associated factor 6

CTD Direct Evidence: marker/mechanism

NCBI chr11:36,457,633...36,483,616
Ensembl chr11:36,335,609...36,356,334

G

tribbles pseudokinase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 8:122,115,194...122,123,319
Ensembl chr 8:124,867,359...124,872,924

G

titin

NCBI chr2B:65,783,512...66,064,618

G

twist family bHLH transcription factor 1

CTD Direct Evidence: marker/mechanism

NCBI chr 7:19,761,041...19,765,665

G

vesicle associated membrane protein 5

CTD Direct Evidence: marker/mechanism

NCBI chr2A:85,634,555...85,646,120
Ensembl chr2A:87,187,569...87,196,532

G

vesicle associated membrane protein 8

CTD Direct Evidence: marker/mechanism

NCBI chr2A:85,627,678...85,632,205
Ensembl chr2A:87,180,681...87,185,195

G

vitamin D receptor

severity

DNA:SNP (human)

NCBI chr12:40,828,413...40,891,700
Ensembl chr12:41,702,742...41,766,192

G

vascular endothelial growth factor A

CTD Direct Evidence: marker/mechanism|therapeutic

PMID:14668888 PMID:15754021 PMID:15937083

NCBI chr 6:43,361,053...43,377,366
Ensembl chr 6:44,650,365...44,666,353

G

vimentin

protein:increased expression:monocyte

NCBI chr10:17,546,389...17,554,702
Ensembl chr10:17,818,285...17,826,642

G

vitronectin

NCBI chr17:28,403,813...28,407,202
Ensembl chr17:28,906,508...28,909,583

G

WD repeat domain 12

CTD Direct Evidence: marker/mechanism

NCBI chr2B:90,112,037...90,145,520
Ensembl chr2B:208,260,696...208,291,783

G

WRN RecQ like helicase

NCBI chr 8:30,353,643...30,492,978
Ensembl chr 8:27,541,145...27,679,855

G

X-ray repair cross complementing 1

onset

DNA:polymorphism:: (rs1799782) (human)

NCBI chr19:40,485,052...40,522,188
Ensembl chr19:49,094,014...49,125,520

G

X-ray repair cross complementing 3

susceptibility

DNA:SNP,haplotypes:exon 7: p.T241M (rs861539) (Human)

NCBI chr14:84,323,644...84,341,763
Ensembl chr14:104,131,903...104,149,037

G

zinc finger C3HC-type containing 1

CTD Direct Evidence: marker/mechanism

NCBI chr 7:121,983,549...122,018,106
Ensembl chr 7:134,502,334...134,536,401

G

zinc finger FYVE-type containing 21

ClinVar Annotator: match by term: Premature coronary artery atherosclerosis

NCBI chr14:84,341,941...84,359,831
Ensembl chr14:104,161,904...104,168,787

G

zinc fingers and homeoboxes 3

ClinVar Annotator: match by term: Coronary atherosclerosis

PMID:25741868 PMID:28492532

NCBI chr20:37,518,569...37,659,417
Ensembl chr20:38,621,651...38,755,797

Coronary Artery Disease, Autosomal Dominant 1

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

myocyte enhancer factor 2A

ClinVar Annotator: match by term: Coronary artery disease, autosomal dominant, 1 | ClinVar Annotator: match by term: Coronary artery disease/myocardial infarction

PMID:14645853 PMID:15496429 PMID:15841183 PMID:25741868

NCBI chr15:78,246,439...78,396,720
Ensembl chr15:97,428,744...97,579,092

Coronary Artery Disease, Autosomal Dominant 2

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

ClinVar Annotator: match by term: Coronary artery disease, autosomal dominant 2

PMID:25741868 PMID:28492532

NCBI chr2A:27,218,699...27,245,156
Ensembl chr2A:27,306,527...27,332,804

G

LDL receptor related protein 6

ClinVar Annotator: match by term: Coronary artery disease, autosomal dominant 2

PMID:17332414 PMID:23703864 PMID:25741868 PMID:28492532

NCBI chr12:12,121,411...12,288,590
Ensembl chr12:12,508,108...12,657,973

Coronary Artery Disease, Development of, in HIV

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

C-C motif chemokine ligand 2

ClinVar Annotator: match by term: Coronary artery disease, development of, in HIV

PMID:11500196 PMID:15466648 PMID:16352737 PMID:16596675 PMID:18940815

NCBI chr17:22,528,154...22,530,091
Ensembl chr17:22,820,890...22,823,384

coronary artery vasospasm

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

Rho GTPase activating protein 9

ClinVar Annotator: match by term: Coronary artery spasm 3, susceptibility to

NCBI chr12:31,445,732...31,453,763
Ensembl chr12:31,693,309...31,710,064

G

nitric oxide synthase 3

ClinVar Annotator: match by term: Coronary artery spasm 1, susceptibility to

PMID:9737779 PMID:9894802 PMID:10359729 PMID:10475066 PMID:10510054 More...

NCBI chr 7:142,577,334...142,600,702
Ensembl chr 7:154,730,009...154,755,233

G

paraoxonase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 7:87,253,476...87,279,650
Ensembl chr 7:100,841,286...100,867,493

Coronary Disease

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 1

ClinVar Annotator: match by term: Early-onset coronary artery disease

NCBI chr 9:75,948,831...76,096,136
Ensembl chr 9:104,076,516...104,224,188

G

ATP binding cassette subfamily G member 5

ClinVar Annotator: match by term: Early-onset coronary artery disease

NCBI chr2A:43,896,188...43,922,756
Ensembl chr2A:44,745,183...44,771,012

G

ATP binding cassette subfamily G member 8

ClinVar Annotator: match by term: Early-onset coronary artery disease

PMID:11452359 PMID:15375183 PMID:16029460 PMID:16199547 PMID:28492532

NCBI chr2A:43,922,787...43,966,678
Ensembl chr2A:44,771,247...44,904,830

G

ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase

ClinVar Annotator: match by term: Three Vessel Coronary Disease

NCBI chr 9:104,354,115...104,399,057
Ensembl chr 9:132,989,574...133,010,324

G

angiotensin I converting enzyme

susceptibility

CTD Direct Evidence: marker/mechanism
DNA:deletion:intron:IVS16+1464-1751del (human)

PMID:8170965 PMID:9488209

NCBI chr17:57,556,294...57,577,294
Ensembl chr17:62,702,341...62,733,853

G

angiotensin converting enzyme 2

susceptibility

associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism: :8790G>A (human)

NCBI chr X:8,189,267...8,229,415
Ensembl chr X:15,470,896...15,510,891

G

adenosine deaminase

protein:increased expression:leukocyte

NCBI chr20:40,950,238...40,982,481
Ensembl chr20:42,044,613...42,076,868

G

ADAM metallopeptidase with thrombospondin type 1 motif 13

ClinVar Annotator: match by term: Three Vessel Coronary Disease

PMID:25741868 PMID:28492532

NCBI chr 9:104,541,051...104,582,574
Ensembl chr 9:133,156,761...133,193,707

G

ADAM metallopeptidase with thrombospondin type 1 motif 7

ClinVar Annotator: match by term: Three Vessel Coronary Disease

NCBI chr15:61,291,451...61,295,148

G

adiponectin, C1Q and collagen domain containing

disease_progression

associated with Diabetes mellitus, Type2;

PMID:22019747 PMID:22207678

RGD:5686379 RGD:5686406

NCBI chr 3:183,876,051...183,889,723
Ensembl chr 3:192,341,320...192,354,885

G

adrenoceptor beta 2

susceptibility

DNA:polymorphism: :p.Q27E

NCBI chr 5:144,259,756...144,398,421
Ensembl chr 5:150,267,554...150,315,892

G

adrenoceptor beta 3

susceptibility

associated with Diabetes Mellitus, Type 2; DNA:missense mutation:cds:p.W64R rs4994(human)

PMID:10421225 PMID:20536507

RGD:1559326 RGD:5684776

NCBI chr 8:37,263,730...37,267,475
Ensembl chr 8:34,441,311...34,443,949

G

advanced glycosylation end-product specific receptor

susceptibility

associated with Heart Failure; protein:increased expression:plasma (human)
protein:decreased expression:plasma (human)

PMID:20685687 PMID:23396398

RGD:7243186 RGD:7244134

NCBI chr 6:31,828,363...31,831,981
Ensembl chr 6:32,708,251...32,711,641

G

angiotensin II receptor type 1

no_association
susceptibility

DNA:polymorphism:3' utr:1166A>C (human)

PMID:9456365 PMID:9857918

RGD:1566499 RGD:1601152

NCBI chr 3:145,722,475...145,767,550
Ensembl chr 3:153,341,947...153,345,380

G

alanine--glyoxylate aminotransferase 2

DNA:missense mutation:cds:V140I (rs37369)(human)

NCBI chr 5:75,322,351...75,373,261
Ensembl chr 5:80,601,554...80,652,575

G

apolipoprotein A4

susceptibility
no_association

DNA:missense mutation:cds:p.T347S (human)

PMID:9013087 PMID:12676816

RGD:1578411 RGD:5685683

NCBI chr11:111,659,186...111,661,790
Ensembl chr11:115,591,788...115,594,382

G

apolipoprotein B

ClinVar Annotator: match by term: Early-onset coronary artery disease

NCBI chr2A:20,986,464...21,029,004
Ensembl chr2A:21,100,356...21,145,129

G

apolipoprotein C2

susceptibility

NCBI chr19:41,892,954...41,896,461

G

apolipoprotein C3

no_association
susceptibility

DNA:polymorphism:promoter:-482C>T
ClinVar Annotator: match by term: Coronary heart disease
associated with Diabetes Mellitus, Non-Insulin-Dependent

PMID:11060345 PMID:16321685 PMID:17654446 PMID:19074352 PMID:20097930 More...

RGD:1601224 RGD:2306754

NCBI chr11:111,667,816...111,670,861
Ensembl chr11:115,600,416...115,603,460

G

apolipoprotein E

onset

CTD Direct Evidence: marker/mechanism
DNA:polymorphisms, haplotype:promoter, cds:g.-219G>T, p.C112R, p.R158C (human)

PMID:10736278 PMID:11862316

NCBI chr19:41,853,669...41,857,252
Ensembl chr19:50,459,906...50,463,490

G

coiled-coil domain containing 92

CTD Direct Evidence: marker/mechanism

NCBI chr12:121,522,378...121,558,864
Ensembl chr12:125,745,846...125,756,265

G

C-C motif chemokine receptor 5

resistance

DNA:polymorphisms:multiple (human)

NCBI chr 3:46,273,096...46,278,471
Ensembl chr 3:47,380,321...47,381,379

G

CD14 molecule

protein:increased expression:monocyte

NCBI chr 5:135,996,265...135,997,909
Ensembl chr 5:142,113,082...142,118,966

G

CD36 molecule (CD36 blood group)

ClinVar Annotator: match by term: CORONARY HEART DISEASE, SUSCEPTIBILITY TO, 7

PMID:25741868 PMID:28960434 PMID:33116287

NCBI chr 7:72,566,478...72,643,517
Ensembl chr 7:86,265,114...86,305,865

G

CD40 ligand

treatment

NCBI chr X:125,776,138...125,788,820
Ensembl chr X:136,042,849...136,058,202

G

cyclin dependent kinase inhibitor 2B

ClinVar Annotator: match by term: Three Vessel Coronary Disease

NCBI chr 9:21,838,902...21,845,355
Ensembl chr 9:22,455,662...22,462,156

G

cholesteryl ester transfer protein

susceptibility

DNA:SNP: G>A (rs4783961) in younger than 55 years of age

NCBI chr16:37,239,756...37,261,859
Ensembl chr16:56,374,363...56,396,103

G

C-X3-C motif chemokine receptor 1

ClinVar Annotator: match by term: Coronary heart disease, susceptibility to, 1

NCBI chr 3:39,158,346...39,176,604
Ensembl chr 3:39,440,955...39,457,219

G

cytochrome P450 family 2 subfamily J member 2

resistance

DNA:polymorphism:promoter:-50G>T (human)

NCBI chr 1:59,151,079...59,184,625
Ensembl chr 1:60,856,269...60,889,810

G

DAB2 interacting protein

DNA:SNP:CDS:rs7025486 (human)

NCBI chr 9:92,696,798...92,912,425
Ensembl chr 9:121,143,457...121,254,336

G

dynein axonemal heavy chain 11

CTD Direct Evidence: marker/mechanism

NCBI chr 7:22,228,345...22,585,681
Ensembl chr 7:21,540,932...21,897,485

G

epoxide hydrolase 2

NCBI chr 8:26,761,090...26,818,436
Ensembl chr 8:23,964,094...24,017,749

G

estrogen receptor 2

CTD Direct Evidence: marker/mechanism

NCBI chr14:44,807,875...44,919,780
Ensembl chr14:63,064,402...63,131,303

G

coagulation factor XII

protein:decreased activity::

NCBI chr 5:172,703,724...172,711,618
Ensembl chr 5:179,766,243...179,773,485

G

coagulation factor XIII A chain

NCBI chr 6:5,978,505...6,156,705
Ensembl chr 6:6,157,926...6,513,961

G

fibroblast growth factor 2

associated with Diabetes Mellitus

NCBI chr 4:115,005,136...115,076,369
Ensembl chr 4:126,149,813...126,214,942

G

fms related receptor tyrosine kinase 1

mRNA, protein:increased expression:ventricle myocardium

NCBI chr13:9,584,850...9,779,542

G

FTO alpha-ketoglutarate dependent dioxygenase

DNA:SNP: :rs9939609 (human)

NCBI chr16:33,939,300...34,343,419
Ensembl chr16:53,023,425...53,490,231

G

glucose-6-phosphate dehydrogenase

ClinVar Annotator: match by term: Early-onset coronary artery disease

PMID:1945893 PMID:3198117 PMID:6805883 PMID:7803800 PMID:8244337 More...

NCBI chr X:143,972,798...143,988,960
Ensembl chr X:153,843,092...153,860,674

G

gamma-glutamyltransferase 1

associated with Diabetes Mellitus, Non-Insulin-Dependent; protein:increased activity:serum

NCBI chr22:5,424,334...5,469,705

G

glutamate-ammonia ligase

associated with type 2 diabetes mellitus;DNA:SNP: :rs10911021 (human)

NCBI chr 1:157,882,258...157,891,562
Ensembl chr 1:161,534,106...161,543,411

G

glycoprotein Ib platelet subunit alpha

NCBI chr17:4,980,083...4,983,219

G

glycoprotein VI platelet

treatment
exacerbates

DNA:hypomethylation:promoter
protein:increased expression:venous blood, platelet (human)

PMID:17105818 PMID:20049463 PMID:31783053

RGD:401794440 RGD:401824645 RGD:401824649

NCBI chr19:52,051,138...52,071,673
Ensembl chr19:60,746,578...60,770,643

G

3-hydroxy-3-methylglutaryl-CoA reductase

disease_progression

NCBI chr 5:39,936,630...39,961,519
Ensembl chr 5:40,548,919...40,573,785

G

heme oxygenase 1

NCBI chr22:16,388,368...16,401,289
Ensembl chr22:34,230,825...34,244,063

G

HNF1 homeobox A

CTD Direct Evidence: marker/mechanism

NCBI chr12:118,562,308...118,584,596
Ensembl chr12:121,932,671...121,955,911

G

heat shock protein family A (Hsp70) member 1A

DNA:SNPs: : -110A>C (rs1008438), 190G>C (rs1043618) (human)

NCBI chr 6:31,476,710...31,491,411

G

heat shock protein family D (Hsp60) member 1

NCBI chr2B:84,729,615...84,743,352
Ensembl chr2B:202,623,497...202,636,959

G

insulin like growth factor 1

NCBI chr12:99,986,887...100,066,773
Ensembl chr12:103,385,911...103,462,177

G

insulin like growth factor binding protein acid labile subunit

NCBI chr16:412,671...418,351
Ensembl chr16:1,843,979...1,848,442

G

insulin like growth factor binding protein 3

NCBI chr 7:46,564,234...46,573,145

G

insulin like growth factor binding protein 5

NCBI chr2B:103,932,983...103,956,475
Ensembl chr2B:222,534,967...222,558,432

G

inhibitor of nuclear factor kappa B kinase regulatory subunit gamma

ClinVar Annotator: match by term: Early-onset coronary artery disease

PMID:1945893 PMID:3198117 PMID:6805883 PMID:7803800 PMID:8244337 More...

NCBI chr X:143,988,720...144,010,078
Ensembl chr X:153,854,493...153,876,092

G

interleukin 18

ClinVar Annotator: match by term: Three Vessel Coronary Disease

NCBI chr11:107,024,376...107,045,194
Ensembl chr11:110,867,586...110,888,371

G

interleukin 1 beta

DNA:polymorphism

NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424

G

interferon regulatory factor 8

susceptibility

DNA:SNPs:intron 4, intron 2: (rs925994,rs10514610) (human)

NCBI chr16:66,568,370...66,591,949
Ensembl chr16:85,905,334...85,929,073

G

insulin receptor substrate 1

CTD Direct Evidence: marker/mechanism

NCBI chr2B:113,973,191...114,041,127
Ensembl chr2B:232,849,239...232,852,967

G

integrin subunit alpha 2

no_association

NCBI chr 5:60,935,452...61,040,726
Ensembl chr 5:62,555,370...62,659,720

G

integrin subunit alpha M

exacerbates

protein:increased expression:monocyte (human)

NCBI chr16:23,634,476...23,707,147
Ensembl chr16:31,630,146...31,702,406

G

integrin subunit beta 3

DNA:polymorphism:exon

NCBI chr17:10,134,450...10,194,596
Ensembl chr17:10,353,111...10,392,382

G

kalirin RhoGEF kinase

ClinVar Annotator: match by term: Coronary heart disease, susceptibility to, 5

PMID:17357071 PMID:25741868

NCBI chr 3:121,138,136...121,828,723
Ensembl chr 3:128,225,413...128,720,441

G

lysine acetyltransferase 2B

severity

DNA:snp:promoter:g.-2481G>C (human)

NCBI chr 3:19,956,067...20,070,637
Ensembl chr 3:20,286,865...20,400,770

G

potassium inwardly rectifying channel subfamily J member 8

no_association

NCBI chr12:64,522,172...64,532,848
Ensembl chr12:67,127,263...67,137,128

G

kinase insert domain receptor

mRNA, protein:increased expression:ventricle myocardium

NCBI chr 4:68,813,894...68,861,018
Ensembl chr 4:75,377,375...75,427,109

G

low density lipoprotein receptor

ClinVar Annotator: match by term: Early-onset coronary artery disease

PMID:9712531 PMID:10422804 PMID:11810272 PMID:11845603 PMID:17765246 More...

NCBI chr19:10,640,225...10,683,728
Ensembl chr19:11,357,311...11,396,791

G

leptin receptor

onset

DNA:SNP: C>T (rs6656451) (human)

NCBI chr 1:64,772,612...64,881,886
Ensembl chr 1:66,693,926...66,764,768

G

galectin 2

susceptibility

NCBI chr22:18,488,257...18,498,401
Ensembl chr22:36,320,775...36,330,281

G

lipase C, hepatic type

susceptibility

associated with Obesity and Diabetes; DNA:transition:promoter:-514C>T (human)

NCBI chr15:37,363,507...37,537,723
Ensembl chr15:55,814,017...55,847,005

G

cytochrome b-245 light chain

NCBI chr16:69,356,396...69,364,225
Ensembl chr16:89,016,349...89,024,719

G

lipoprotein(a)

CTD Direct Evidence: marker/mechanism

NCBI chr 6:158,434,394...158,628,028

G

lipoprotein lipase

ClinVar Annotator: match by term: Coronary heart disease

PMID:8199176 PMID:8541837 PMID:8872057 PMID:10364086 PMID:10517255 More...

NCBI chr 8:19,164,541...19,193,100
Ensembl chr 8:16,113,415...16,142,966

G

LDL receptor related protein 1

susceptibility

NCBI chr12:31,713,938...31,799,287
Ensembl chr12:31,966,149...32,051,979

G

macoilin 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:24,701,352...24,771,038
Ensembl chr 1:25,771,175...25,839,635

G

myoglobin

severity

NCBI chr22:16,612,519...16,645,333
Ensembl chr22:34,452,451...34,463,224

G

matrix Gla protein

susceptibility

NCBI chr12:14,887,806...14,891,796
Ensembl chr12:15,284,883...15,288,523

G

macrophage migration inhibitory factor

coronary occlusion; mRNA:increased expression:myocardium

NCBI chr22:4,646,986...4,647,831
Ensembl chr22:22,730,807...22,732,009

G

MLX interacting protein

susceptibility

DNA:SNP:3'utr: (rs4758685) (human)

NCBI chr12:119,679,514...119,747,932
Ensembl chr12:123,048,304...123,112,241

G

MLX interacting protein like

susceptibility

DNA:SNP: (rs35493868); in younger than 55 years of age

Ensembl chr 7:80,745,765...80,776,153

G

matrix metallopeptidase 1

susceptibility

DNA:insertion:promoter:g.-1607insG (human)

NCBI chr11:97,730,545...97,739,190
Ensembl chr11:101,221,393...101,230,104

G

matrix metallopeptidase 3

susceptibility

ClinVar Annotator: match by term: Coronary heart disease, susceptibility to, 6

PMID:7727178 PMID:8662692 PMID:9699891 PMID:10190398 PMID:10351963 More...

NCBI chr11:97,776,729...97,784,549
Ensembl chr11:101,267,566...101,275,354

G

muscle RAS oncogene homolog

CTD Direct Evidence: marker/mechanism

NCBI chr 3:135,377,488...135,435,338
Ensembl chr 3:142,827,020...142,884,582

G

methylenetetrahydrofolate reductase

CTD Direct Evidence: marker/mechanism

NCBI chr 1:10,548,196...10,568,174
Ensembl chr 1:11,766,334...11,785,419

G

microsomal triglyceride transfer protein

susceptibility

DNA:polymorphism:promoter:-493G>T

NCBI chr 4:91,987,756...92,047,127
Ensembl chr 4:102,648,793...102,708,107

G

myosin heavy chain 15

DNA:snp:exon:EX28T>C rs3900940 (human)

NCBI chr 3:105,498,196...105,635,979
Ensembl chr 3:112,432,417...112,586,559

G

nuclear receptor subfamily 1 group H member 3

exacerbates

mRNA:decreased expression:peripheral blood mononuclear cell (human)
mRNA:increased expression:peripheral blood mononuclear cell (human)

PMID:16252156 PMID:19211025

RGD:401827902 RGD:401850788

NCBI chr11:47,195,122...47,215,277
Ensembl chr11:47,748,353...47,768,672

G

ornithine decarboxylase antizyme 1

susceptibility

DNA:SNP:intron:c.2222A>G (rs2074458) (human)

NCBI chr19:1,279,139...1,283,079
Ensembl chr19:2,250,678...2,254,179

G

proprotein convertase subtilisin/kexin type 9

susceptibility

DNA:missense mutation, nonsense mutations:cds:p.R46L, p.Y142X, p.C679X (human)

NCBI chr 1:54,323,036...54,355,397
Ensembl chr 1:55,911,016...55,936,456

G

platelet and endothelial cell adhesion molecule 1

ClinVar Annotator: match by term: Three Vessel Coronary Disease

NCBI chr17:58,417,134...58,526,409
Ensembl chr17:63,511,784...63,579,067

G

phosphatase and actin regulator 1

no_association
susceptibility

DNA:SNP:intron 3: (rs12526453) (human)
associated with type 2 diabetes mellitus;DNA:SNP:intron: (rs12526453) (human)

PMID:22152955 PMID:28287809

RGD:11055500 RGD:401901081

NCBI chr 6:12,560,862...13,136,126
Ensembl chr 6:12,922,871...13,505,609

G

phospholipase A2 group VII

CTD Direct Evidence: marker/mechanism

PMID:15699277 PMID:21356620

NCBI chr 6:46,264,262...46,318,487
Ensembl chr 6:47,558,861...47,590,212

G

plasminogen activator, urokinase

CTD Direct Evidence: therapeutic

PMID:1730212 PMID:9181759

NCBI chr10:70,433,340...70,441,569
Ensembl chr10:73,105,895...73,113,136

G

phospholipid transfer protein

susceptibility

protein:increased expression:serum (human)

NCBI chr20:42,237,434...42,251,189
Ensembl chr20:43,324,609...43,337,999

G

paraoxonase 1

severity
no_association

protein:decreased expression:serum
ClinVar Annotator: match by term: Coronary artery disease, susceptibility to
DNA:missense mutation:cds:p.Q192R (human)

PMID:7916578 PMID:8098250 PMID:8675673 PMID:8770857 PMID:9011577 More...

RGD:2313267 RGD:8547675

NCBI chr 7:87,253,476...87,279,650
Ensembl chr 7:100,841,286...100,867,493

G

paraoxonase 2

susceptibility

DNA:missense mutation:cds:p.C311S (human)

NCBI chr 7:87,362,447...87,392,795
Ensembl chr 7:100,950,074...100,980,433

G

pro-platelet basic protein

associated with menopause; mRNA,protein:increased expression:peripheral blood mononuclear cell ,plasma

NCBI chr 4:50,203,168...50,204,303
Ensembl chr 4:56,035,060...56,037,702

G

retinol binding protein 4

protein:increased expression:blood plasma (human)

NCBI chr10:90,337,879...90,347,530
Ensembl chr10:93,848,166...93,857,887

G

resistin

protein:increased expression:blood

NCBI chr19:6,958,536...6,960,032
Ensembl chr19:7,812,942...7,814,909

G

regulator of telomere elongation helicase 1

ameliorates

DNA:SNP:cds:rs6010620|rs4809324 (human)

Ensembl chr20:61,581,331...61,618,718

G

scavenger receptor class B member 1

NCBI chr12:122,293,803...122,455,314
Ensembl chr12:126,659,532...126,694,767

G

selectin P

protein:altered expression:serum

NCBI chr 1:145,071,094...145,112,851
Ensembl chr 1:148,793,677...148,834,701

G

serpin family F member 2

protein:increased expression:blood

NCBI chr17:1,725,469...1,738,887
Ensembl chr17:1,618,549...1,631,570

G

transcription factor 7 like 2

CTD Direct Evidence: marker/mechanism

NCBI chr10:109,541,524...109,759,499
Ensembl chr10:112,978,167...113,192,281

G

telomerase reverse transcriptase

ClinVar Annotator: match by term: Coronary artery disease, susceptibility to

Ensembl chr 5:1,300,960...1,338,872

G

thrombomodulin

associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:plasma

NCBI chr20:22,992,341...22,996,415
Ensembl chr20:23,345,917...23,347,812

G

vascular endothelial growth factor A

mRNA, protein:increased expression:ventricle myocardium

NCBI chr 6:43,361,053...43,377,366
Ensembl chr 6:44,650,365...44,666,353

G

vitamin K epoxide reductase complex subunit 1

CTD Direct Evidence: marker/mechanism

NCBI chr16:23,871,756...23,876,599
Ensembl chr16:31,459,560...31,464,897

G

von Willebrand factor

NCBI chr12:6,073,836...6,249,806
Ensembl chr12:5,990,612...6,165,153

G

zinc finger C3HC-type containing 1

CTD Direct Evidence: marker/mechanism

NCBI chr 7:121,983,549...122,018,106
Ensembl chr 7:134,502,334...134,536,401

Coronary Occlusion

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aldehyde dehydrogenase 1 family member A2

disease_progression

NCBI chr15:36,925,443...37,038,288
Ensembl chr15:55,237,101...55,557,168

G

heat shock protein family A (Hsp70) member 1A

mRNA:increased expression:heart:

NCBI chr 6:31,476,710...31,491,411

coronary restenosis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin I converting enzyme

CTD Direct Evidence: marker/mechanism

NCBI chr17:57,556,294...57,577,294
Ensembl chr17:62,702,341...62,733,853

G

adiponectin, C1Q and collagen domain containing

CTD Direct Evidence: therapeutic

NCBI chr 3:183,876,051...183,889,723
Ensembl chr 3:192,341,320...192,354,885

G

alpha hemoglobin stabilizing protein

mRNA:decreased expression:blood (human)

NCBI chr16:23,436,746...23,438,184
Ensembl chr16:31,897,868...31,899,143

G

butyrylcholinesterase

susceptibility

DNA:polymorphism: :p.A539T (human)

NCBI chr 3:162,794,184...162,858,574
Ensembl chr 3:170,845,494...170,911,481

G

cadherin 13

protein:increased expression:artery, smooth muscle cell

NCBI chr16:63,255,482...64,418,053
Ensembl chr16:82,883,184...83,808,996

G

C-X-C motif chemokine ligand 10

protein:increased expression:plasma

NCBI chr 4:48,182,355...48,184,733
Ensembl chr 4:54,020,204...54,022,606

G

C-X-C motif chemokine receptor 3

NCBI chr X:60,880,759...60,883,355
Ensembl chr X:70,933,160...70,935,756

G

heme oxygenase 1

susceptibility

NCBI chr22:16,388,368...16,401,289
Ensembl chr22:34,230,825...34,244,063

G

integrin subunit beta 2

NCBI chr21:31,181,228...31,216,033
Ensembl chr21:44,470,999...44,505,963

G

lysyl oxidase

NCBI chr 5:117,450,833...117,464,957
Ensembl chr 5:123,234,662...123,248,717

G

mitogen-activated protein kinase 1

NCBI chr22:3,883,119...3,990,368
Ensembl chr22:20,365,487...20,450,335

G

mannose binding lectin 2

susceptibility

DNA:polymorphisms:5' utr, exon:multiple (human)

NCBI chr10:49,401,364...49,409,328
Ensembl chr10:51,527,758...51,543,432

G

matrix metallopeptidase 3

CTD Direct Evidence: marker/mechanism

NCBI chr11:97,776,729...97,784,549
Ensembl chr11:101,267,566...101,275,354

G

matrix metallopeptidase 7

treatment

NCBI chr11:97,467,037...97,477,305
Ensembl chr11:100,960,032...100,971,099

G

methylenetetrahydrofolate reductase

CTD Direct Evidence: marker/mechanism

NCBI chr 1:10,548,196...10,568,174
Ensembl chr 1:11,766,334...11,785,419

G

MYC proto-oncogene, bHLH transcription factor

treatment

NCBI chr 8:124,387,561...124,393,551
Ensembl chr 8:127,131,512...127,136,863

G

neuropeptide Y receptor Y5

mRNA, protein:increased expression:carotid artery

NCBI chr 4:155,603,739...155,612,302

G

ornithine decarboxylase antizyme 1

susceptibility

DNA:SNP:intron:c.2222A>G (rs2074458) (human)

NCBI chr19:1,279,139...1,283,079
Ensembl chr19:2,250,678...2,254,179

G

secreted phosphoprotein 1

PMID:12114325 PMID:16373617

RGD:1581358 RGD:1581366

NCBI chr 4:80,263,711...80,271,466
Ensembl chr 4:90,988,200...90,995,935

G

tumor necrosis factor

CTD Direct Evidence: marker/mechanism

NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381

G

tumor protein p53

NCBI chr17:7,699,449...7,717,812
Ensembl chr17:7,684,922...7,706,120

G

uncoupling protein 3

susceptibility

DNA:polymorphism:promoter:-55C>T (human)

NCBI chr11:69,072,143...69,085,424
Ensembl chr11:72,380,180...72,389,274

coronary stenosis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

apelin

protein:decreased expression:plasma

NCBI chr X:118,775,509...118,785,224

G

cytochrome P450 family 2 subfamily R member 1

DNA:SNP:CDS: (Rs6486205|rs10741657|rs2060793)

NCBI chr11:14,960,651...14,989,083
Ensembl chr11:14,656,939...14,671,584

G

endothelin 1

treatment

NCBI chr 6:12,076,312...12,142,861
Ensembl chr 6:12,462,718...12,503,545

G

histamine receptor H2

CTD Direct Evidence: marker/mechanism

NCBI chr 5:171,004,893...171,057,539
Ensembl chr 5:177,928,039...177,931,566

G

insulin like growth factor 1

mRNA:increased expression:myocyte:

NCBI chr12:99,986,887...100,066,773
Ensembl chr12:103,385,911...103,462,177

G

insulin like growth factor 1 receptor

mRNA:increased expression:myocyte:

NCBI chr15:77,332,926...77,648,474
Ensembl chr15:96,535,164...96,832,974

G

integrin subunit alpha V

NCBI chr2B:73,880,962...73,972,486
Ensembl chr2B:191,680,655...191,773,028

G

LIM and cysteine rich domains 1

protein:increased expression:coronary artery

NCBI chr 3:8,448,143...8,521,214

G

myosin-7

CTD Direct Evidence: marker/mechanism

NCBI chr14:4,231,344...4,254,295
Ensembl chr14:22,325,812...22,348,763

G

midkine

NCBI chr11:46,339,365...46,342,388
Ensembl chr11:46,891,540...46,893,254

G

natriuretic peptide A

CTD Direct Evidence: marker/mechanism

NCBI chr 1:10,608,025...10,610,287
Ensembl chr 1:11,825,072...11,827,373

G

platelet and endothelial cell adhesion molecule 1

DNA:missense mutations:cds:p.L125V, p.S563N (human)

NCBI chr17:58,417,134...58,526,409
Ensembl chr17:63,511,784...63,579,067

G

phosphatase and actin regulator 1

susceptibility

DNA:SNP::g.13011943A>G (rs9349379) (human)

NCBI chr 6:12,560,862...13,136,126
Ensembl chr 6:12,922,871...13,505,609

G

protein kinase C epsilon

CTD Direct Evidence: marker/mechanism

NCBI chr2A:45,757,629...46,294,064
Ensembl chr2A:46,688,436...47,220,313

G

TNF receptor superfamily member 11b

protein:increased expression:serum

NCBI chr 8:115,614,778...115,643,387
Ensembl chr 8:118,134,305...118,162,422

coronary thrombosis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

glycoprotein VI platelet

DNA:missense mutation:CDS:c.13254T>C (human)

NCBI chr19:52,051,138...52,071,673
Ensembl chr19:60,746,578...60,770,643

G

integrin subunit beta 3

CTD Direct Evidence: marker/mechanism

NCBI chr17:10,134,450...10,194,596
Ensembl chr17:10,353,111...10,392,382

G

plasminogen activator, tissue type

CTD Direct Evidence: therapeutic

PMID:1452937 PMID:8172379 PMID:15301905

NCBI chr 8:41,419,415...41,451,951
Ensembl chr 8:38,864,918...38,897,779

Hypertension Resistant to Conventional Therapy

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

glutathione S-transferase mu 1

susceptibility

DNA:deletion:cds: (human)

Ensembl chr 1:127,979,238...128,010,411

G

nitric oxide synthase 3

ClinVar Annotator: match by term: Hypertension resistant to conventional therapy

PMID:9737779 PMID:9894802 PMID:10475066 PMID:10510054 PMID:10514107 More...

NCBI chr 7:142,577,334...142,600,702
Ensembl chr 7:154,730,009...154,755,233

G

protein tyrosine phosphatase receptor type D

susceptibility

associated with coronary artery disease;DNA:SNP:intron: (rs324498) (human)

NCBI chr 9:8,113,171...10,420,732
Ensembl chr 9:8,288,569...8,831,227

intermediate coronary syndrome

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin I converting enzyme

mRNA:increased expression:ventricular myocardium (human)
mRNA:increased expression:myocardium

PMID:11451295 PMID:15131005

RGD:8142363 RGD:8548894

NCBI chr17:57,556,294...57,577,294
Ensembl chr17:62,702,341...62,733,853

G

angiotensinogen

mRNA:increased expression:myocardium

NCBI chr 1:206,252,141...206,263,830
Ensembl chr 1:211,279,015...211,291,044

G

angiotensin II receptor type 1

mRNA:increased expression:myocardium

NCBI chr 3:145,722,475...145,767,550
Ensembl chr 3:153,341,947...153,345,380

G

AKT serine/threonine kinase 1

protein:increased serine phosphorylation:platelet

NCBI chr14:85,417,229...85,444,722
Ensembl chr14:105,208,128...105,236,756

G

apolipoprotein A4

protein:decreased expression:blood plasma (human)

NCBI chr11:111,659,186...111,661,790
Ensembl chr11:115,591,788...115,594,382

G

brain derived neurotrophic factor

NCBI chr11:27,618,322...27,687,661
Ensembl chr11:27,520,312...27,589,239

G

C-reactive protein

disease_progression

NCBI chr 1:135,062,102...135,064,402

G

C-X-C motif chemokine ligand 8

CTD Direct Evidence: marker/mechanism

NCBI chr 4:50,452,857...50,456,015
Ensembl chr 4:56,286,708...56,288,083

G

endothelin 1

associated with Coronary Artery Disease;protein:increased expression:coronary sinus, plasma (human)

NCBI chr 6:12,076,312...12,142,861
Ensembl chr 6:12,462,718...12,503,545

G

coagulation factor VII

protein:increased expression:plasma (human)

NCBI chr13:94,246,694...94,261,133
Ensembl chr13:113,315,868...113,329,995

G

3-hydroxy-3-methylglutaryl-CoA reductase

NCBI chr 5:39,936,630...39,961,519
Ensembl chr 5:40,548,919...40,573,785

G

integrin subunit alpha 2

susceptibility

NCBI chr 5:60,935,452...61,040,726
Ensembl chr 5:62,555,370...62,659,720

G

integrin subunit alpha M

ameliorates

protein:decreased expression:neutrophil (human)

NCBI chr16:23,634,476...23,707,147
Ensembl chr16:31,630,146...31,702,406

G

inter-alpha-trypsin inhibitor heavy chain 4

NCBI chr 3:52,754,664...52,774,867
Ensembl chr 3:53,980,668...53,998,038

G

matrix metallopeptidase 1

NCBI chr11:97,730,545...97,739,190
Ensembl chr11:101,221,393...101,230,104

G

pappalysin 1

CTD Direct Evidence: marker/mechanism

NCBI chr 9:87,287,289...87,535,414
Ensembl chr 9:115,671,212...115,883,435

G

plasminogen activator, urokinase

CTD Direct Evidence: therapeutic

NCBI chr10:70,433,340...70,441,569
Ensembl chr10:73,105,895...73,113,136

G

phosphatase and tensin homolog

RNA:increased expression:serum

NCBI chr10:84,587,841...84,689,043
Ensembl chr10:88,093,539...88,194,605

G

selectin P

protein:increased expression:serum

NCBI chr 1:145,071,094...145,112,851
Ensembl chr 1:148,793,677...148,834,701

G

serpin family C member 1

treatment

NCBI chr 1:149,421,737...149,435,301
Ensembl chr 1:153,126,031...153,139,369

G

superoxide dismutase 3

NCBI chr 4:19,195,941...19,201,298
Ensembl chr 4:24,485,059...24,485,781

G

thioredoxin

NCBI chr 9:81,399,056...81,411,607
Ensembl chr 9:109,565,557...109,578,311

Medial Coronary Sclerosis of Infancy

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ectonucleotide pyrophosphatase/phosphodiesterase 1

ClinVar Annotator: match by term: Coronary sclerosis, medial, of infancy

PMID:9536098 PMID:15940697 PMID:17576681 PMID:25741868 PMID:28492532

NCBI chr 6:129,591,858...129,673,000
Ensembl chr 6:133,698,640...133,783,644

Microvascular Angina

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

bradykinin receptor B1

mRNA:increased expression:blood, mononuclear cell

NCBI chr14:76,885,923...76,894,456

G

bradykinin receptor B2

mRNA:increased expression:blood, mononuclear cell

NCBI chr14:76,832,833...76,873,860
Ensembl chr14:96,156,494...96,196,253

G

methylenetetrahydrofolate reductase

CTD Direct Evidence: marker/mechanism
DNA:transition:cds:g.677C>T (human)

NCBI chr 1:10,548,196...10,568,174
Ensembl chr 1:11,766,334...11,785,419

G

TNF receptor superfamily member 11b

protein:decreased expression:serum

NCBI chr 8:115,614,778...115,643,387
Ensembl chr 8:118,134,305...118,162,422

myocardial infarction

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 9

ClinVar Annotator: match by term: Myocardial infarction

PMID:16563363 PMID:18239147 PMID:20474083 PMID:21846889 PMID:23739550 More...

NCBI chr12:64,357,176...64,500,358
Ensembl chr12:66,960,888...67,102,496

G

angiotensin I converting enzyme

treatment
susceptibility

ClinVar Annotator: match by term: Myocardial infarction, susceptibility to
associated with Diabetes Mellitus, Type 1;DNA:deletion:intron:IVS16+1464-1751del (human)

PMID:1313972 PMID:1319114 PMID:1328889 PMID:1386652 PMID:1976655 More...

RGD:1558664 RGD:7829785 RGD:9685449

NCBI chr17:57,556,294...57,577,294
Ensembl chr17:62,702,341...62,733,853

G

angiotensin converting enzyme 2

treatment

mRNA:increased expression:myocardium

PMID:15671045 PMID:23959549

RGD:1558664 RGD:9685449

NCBI chr X:8,189,267...8,229,415
Ensembl chr X:15,470,896...15,510,891

G

actin alpha 2, smooth muscle

CTD Direct Evidence: marker/mechanism

NCBI chr10:85,660,983...85,678,729
Ensembl chr10:89,164,344...89,182,080

G

activin A receptor type 2A

mRNA:decreased expression:myocardium (mouse)

NCBI chr2B:11,933,683...12,020,287
Ensembl chr2B:152,253,826...152,288,385

G

activin A receptor type 2B

mRNA:decreased expression:myocardium (mouse)

NCBI chr 3:38,350,838...38,389,839
Ensembl chr 3:38,633,093...38,662,063

G

ADAM metallopeptidase with thrombospondin type 1 motif 1

NCBI chr21:13,270,668...13,279,217
Ensembl chr21:26,656,370...26,665,485

G

adducin 1

no_association

DNA:missense mutation:cds:p.G460W (human)

PMID:16420563 PMID:17082469

RGD:5147995 RGD:5148001

NCBI chr 4:2,986,301...3,072,590
Ensembl chr 4:2,920,781...2,975,012

G

adiponectin, C1Q and collagen domain containing

disease_progression

NCBI chr 3:183,876,051...183,889,723
Ensembl chr 3:192,341,320...192,354,885

G

adiponectin receptor 1

mRNA, protein:decreased expression:heart left ventricle

NCBI chr 1:178,542,496...178,560,055
Ensembl chr 1:182,837,589...182,854,782

G

adiponectin receptor 2

mRNA, protein:decreased expression:heart left ventricle

NCBI chr12:1,772,426...1,902,070
Ensembl chr12:1,817,620...1,852,251

G

adenosine A1 receptor

CTD Direct Evidence: therapeutic

NCBI chr 1:178,728,751...178,769,066
Ensembl chr 1:183,023,466...183,063,760

G

adrenoceptor alpha 2B

NCBI chr2A:103,198,432...103,202,506
Ensembl chr2A:97,040,126...97,041,472

G

adrenoceptor beta 1

NCBI chr10:110,642,491...110,646,595

G

adrenoceptor beta 2

susceptibility

mRNA:decreased expression:heart
DNA:polymorphisms: :p.G16R, p.Q27E, p.T164I

PMID:12400771 PMID:15520258

RGD:1601126 RGD:8548519

NCBI chr 5:144,259,756...144,398,421
Ensembl chr 5:150,267,554...150,315,892

G

advanced glycosylation end-product specific receptor

susceptibility

mRNA:increased expression:left ventricle myocardium (rat)
DNA:polymorphism:promoter:-429T>C (human)

PMID:16728681 PMID:19910580

RGD:1625333 RGD:2325647

NCBI chr 6:31,828,363...31,831,981
Ensembl chr 6:32,708,251...32,711,641

G

angiotensinogen

susceptibility

associated with hypertension;DNA:polymorphism: :p.M235T
CTD Direct Evidence: marker/mechanism
associated with Coronary Artery Disease;DNA:polymorphism: :p.M235T (human)

PMID:1668233 PMID:11393670 PMID:16413583 PMID:17299437 PMID:21167013

RGD:1566452 RGD:1601132 RGD:5129191

NCBI chr 1:206,252,141...206,263,830
Ensembl chr 1:211,279,015...211,291,044

G

angiotensin II receptor type 1

no_association
susceptibility

DNA:polymorphism:3' utr:1166A>C (human)

PMID:9652322 PMID:9857918 PMID:16061119

RGD:10047101 RGD:1566499 RGD:1601150

NCBI chr 3:145,722,475...145,767,550
Ensembl chr 3:153,341,947...153,345,380

G

alpha 2-HS glycoprotein

protein:increased expression:plasma

NCBI chr 3:183,644,223...183,652,620
Ensembl chr 3:192,110,770...192,119,915

G

aminoacyl tRNA synthetase complex interacting multifunctional protein 1

NCBI chr 4:98,796,320...98,830,095
Ensembl chr 4:109,404,352...109,436,566

G

adenylate kinase 1

treatment

NCBI chr 9:98,987,348...98,997,252
Ensembl chr 9:127,657,338...127,678,245

G

AKT serine/threonine kinase 1

protein:increased serine phosphorylation:platelet
protein:decreased serine phosphorylation:heart

PMID:20352476 PMID:20467748

RGD:10041035 RGD:5509094

NCBI chr14:85,417,229...85,444,722
Ensembl chr14:105,208,128...105,236,756

G

aldehyde dehydrogenase 2 family member

DNA:missense mutation: :p.E487K (human)

NCBI chr12:109,343,020...109,385,060
Ensembl chr12:112,734,243...112,776,471

G

arachidonate 5-lipoxygenase activating protein

no_association

DNA:snps:multiple (human)

PMID:14770184 PMID:19046748

RGD:1578317 RGD:2313891

NCBI chr13:12,012,399...12,041,557
Ensembl chr13:30,425,510...30,476,607

G

angiogenin

NCBI chr14:1,548,693...1,558,528
Ensembl chr14:19,614,950...19,615,393

G

angiopoietin 1

mRNA, protein:decreased expression:myocardium

NCBI chr 8:103,893,234...104,137,661
Ensembl chr 8:106,042,041...106,286,783

G

angiopoietin 2

protein:increased expression:left ventricular wall, heart septum (rat)

NCBI chr 8:718,367...782,534
Ensembl chr 8:6,506,014...6,566,915

G

annexin A5

no_association
susceptibility

DNA:polymorphism: :-1C>T (human)
protein:altered localization:cardiac muscle cell, sarcolemma
protein:increased expression:plasma

PMID:8814351 PMID:12200370 PMID:16025836 PMID:16501019

RGD:1578384 RGD:2317541 RGD:2317542 RGD:2317543

NCBI chr 4:113,868,218...113,897,243
Ensembl chr 4:125,006,038...125,034,972

G

apurinic/apyrimidinic endodeoxyribonuclease 1

susceptibility

DNA:polymorphism:exon 5: G>A (human)

NCBI chr14:1,329,745...1,332,315
Ensembl chr14:19,381,911...19,384,542

G

apolipoprotein A1

treatment
no_association

DNA:polymorphisms

PMID:10428310 PMID:20176799 PMID:31734577

RGD:1578442 RGD:2325759 RGD:408418726

NCBI chr11:111,673,539...111,675,428
Ensembl chr11:115,606,136...115,608,122

G

apolipoprotein A4

no_association
susceptibility

DNA:mutation:intron:IVS2 (human)
associated with Diabetes Mellitus, Type 2; DNA:missense mutation:cds:p.Q360H (human)

PMID:7958503 PMID:10428310

RGD:1578442 RGD:5685678

NCBI chr11:111,659,186...111,661,790
Ensembl chr11:115,591,788...115,594,382

G

apolipoprotein C3

no_association

ClinVar Annotator: match by term: Myocardial infarction, susceptibility to

PMID:10428310 PMID:25741868

NCBI chr11:111,667,816...111,670,861
Ensembl chr11:115,600,416...115,603,460

G

apolipoprotein E

susceptibility

DNA:missense mutations, haplotype:cds:p.C112R, p.C158R (human)
DNA:missense mutations, haplotypes:cds:p.C112R, p.R158C (human)
CTD Direct Evidence: marker/mechanism

PMID:10090925 PMID:10587578 PMID:17217375

RGD:10449412 RGD:1601229

NCBI chr19:41,853,669...41,857,252
Ensembl chr19:50,459,906...50,463,490

G

apolipoprotein H

PMID:12826288 PMID:15322656

RGD:10054111 RGD:2313985

NCBI chr17:60,154,389...60,171,762
Ensembl chr17:65,365,250...65,382,483

G

autophagy related 7

mRNA:increased expression:plantaris

NCBI chr 3:11,208,600...11,488,757
Ensembl chr 3:11,554,100...11,833,398

G

ATM serine/threonine kinase

CTD Direct Evidence: marker/mechanism

NCBI chr11:103,109,979...103,256,405
Ensembl chr11:106,584,228...106,727,041

G

ATPase Na+/K+ transporting subunit alpha 1

CTD Direct Evidence: therapeutic

NCBI chr 1:86,162,401...86,193,883
Ensembl chr 1:121,212,488...121,243,099

G

ATP synthase F1 subunit delta

treatment

protein:decreased expression:myocardium (rat)

PMID:23809007 PMID:29300489

RGD:13792656 RGD:13792681

G

ATP synthase peripheral stalk subunit OSCP

treatment

NCBI chr21:20,270,442...20,282,865

G

arginine vasopressin receptor 1A

NCBI chr12:25,793,633...25,803,026
Ensembl chr12:26,065,882...26,075,972

G

BCL2 antagonist/killer 1

CTD Direct Evidence: marker/mechanism

NCBI chr 6:33,146,998...33,154,755
Ensembl chr 6:34,255,769...34,263,211

G

BCL2 associated X, apoptosis regulator

CTD Direct Evidence: marker/mechanism

PMID:20079142 PMID:25450231

NCBI chr19:45,955,926...45,962,870
Ensembl chr19:54,793,594...54,800,468

G

BCL2 apoptosis regulator

CTD Direct Evidence: marker/mechanism

NCBI chr18:56,481,212...56,679,012
Ensembl chr18:59,802,443...59,992,100

G

BCL2 like 1

CTD Direct Evidence: marker/mechanism

PMID:17467744 PMID:20079142

NCBI chr20:27,955,688...28,015,950
Ensembl chr20:29,088,055...29,146,585

G

bradykinin receptor B1

mRNA:increased expression:heart

NCBI chr14:76,885,923...76,894,456

G

bradykinin receptor B2

mRNA:increased expression:heart

NCBI chr14:76,832,833...76,873,860
Ensembl chr14:96,156,494...96,196,253

G

beclin 1

treatment

CTD Direct Evidence: marker/mechanism

NCBI chr17:14,493,619...14,507,809
Ensembl chr17:14,719,781...14,733,286

G

baculoviral IAP repeat containing 5

NCBI chr17:72,292,332...72,303,493
Ensembl chr17:77,842,724...77,854,159

G

BCL2 interacting protein 3

mRNA:increased expression:plantaris

NCBI chr10:128,671,663...128,685,952
Ensembl chr10:132,858,211...132,871,634

G

BRCA1 associated protein

CTD Direct Evidence: marker/mechanism

NCBI chr12:109,216,171...109,263,160
Ensembl chr12:112,610,179...112,654,017

G

BMP/retinoic acid inducible neural specific 3

susceptibility

DNA:SNPs:3' end:

NCBI chr 1:165,586,510...165,972,173
Ensembl chr 1:169,873,541...170,258,015

G

complement C3

treatment

mRNA, protein:increased expression:myocardium

PMID:16996480 PMID:31734577

RGD:1600605 RGD:408418726

NCBI chr19:5,708,211...5,753,178
Ensembl chr19:6,629,287...6,674,699

G

complement C7

Protein:increased activity:serum, myocardium

NCBI chr 5:69,405,041...69,478,445
Ensembl chr 5:74,447,559...74,520,649

G

complement C8 alpha chain

NCBI chr 1:56,137,596...56,201,975
Ensembl chr 1:57,847,726...57,912,392

G

complement C8 beta chain

NCBI chr 1:56,213,618...56,250,488
Ensembl chr 1:57,923,720...57,960,674

G

calcyclin binding protein

mRNA:increased expression:heart

NCBI chr 1:150,511,021...150,522,369
Ensembl chr 1:154,210,001...154,220,583

G

calcium/calmodulin dependent protein kinase II delta

treatment

mRNA, protein:splice variants, increased expression:heart left ventricle (rat)

NCBI chr 4:105,957,773...106,271,887
Ensembl chr 4:116,523,850...116,835,387

G

caspase 1

severity
ameliorates

PMID:17303764 PMID:33389498

RGD:2315913 RGD:242905187

NCBI chr11:99,965,964...99,975,640
Ensembl chr11:103,448,497...103,458,149
Ensembl chr11:103,448,497...103,458,149

G

caspase 3

ameliorates
treatment

CTD Direct Evidence: marker/mechanism

PMID:25450231 PMID:27904666 PMID:28622474

RGD:13782309 RGD:329333030

NCBI chr 4:176,793,190...176,815,023
Ensembl chr 4:189,018,422...189,040,185

G

calcium sensing receptor

protein:increased expression:myocardium (rat)

NCBI chr 3:119,278,071...119,383,901
Ensembl chr 3:126,252,765...126,285,268

G

catalase

CTD Direct Evidence: therapeutic

PMID:14575298 PMID:21600015

NCBI chr11:34,413,253...34,446,831
Ensembl chr11:34,289,603...34,323,160

G

caveolin 3

Protein:increased expression:cytosol
mRNA, protein; increased expression; myocardium (rat)

PMID:12566108 PMID:29438664

RGD:126925221 RGD:1599542

NCBI chr 3:8,684,829...8,697,731
Ensembl chr 3:8,928,069...8,940,942

G

C-C motif chemokine ligand 2

treatment

protein:increased expression:serum
DNA:snp:promoter:g.-2518A>G (human)

PMID:16116069 PMID:18459941 PMID:18753699

RGD:1581161 RGD:2307033 RGD:8549616

NCBI chr17:22,528,154...22,530,091
Ensembl chr17:22,820,890...22,823,384

G

C-C motif chemokine ligand 5

mRNA:increased expression:heart (rat)

NCBI chr17:20,915,198...20,923,530
Ensembl chr17:21,210,798...21,219,172

G

cellular communication network factor 1

mRNA,protein:increased expression:myocardium (mouse)

NCBI chr 1:118,138,739...118,141,681
Ensembl chr 1:86,994,296...86,997,147

G

cellular communication network factor 2

treatment

mRNA:increased expression:left ventricle (rat)

PMID:18167060 PMID:29849775

RGD:2314623 RGD:35673318

NCBI chr 6:129,729,572...129,733,113
Ensembl chr 6:133,836,319...133,842,077

G

cyclin A2

protein:increased expression:cardiomyocyte:

NCBI chr 4:114,016,917...114,024,816
Ensembl chr 4:125,153,810...125,161,302

G

C-C motif chemokine receptor 2

PMID:12719858 PMID:12853162

RGD:1581174 RGD:1581177

NCBI chr 3:46,255,725...46,263,285
Ensembl chr 3:47,361,124...47,368,312

G

C-C motif chemokine receptor 3

NCBI chr 3:46,147,928...46,172,947
Ensembl chr 3:47,253,878...47,278,630

G

chaperonin containing TCP1 subunit 7

ClinVar Annotator: match by term: Myocardial infarction, susceptibility to, 1

NCBI chr2A:73,287,026...73,305,792
Ensembl chr2A:74,775,781...74,794,515

G

CD14 molecule

no_association

associated with Coronary Artery Disease;DNA:SNP:promoter

PMID:10195920 PMID:14587643 PMID:17436151

RGD:1580252 RGD:1580255 RGD:2314155

NCBI chr 5:135,996,265...135,997,909
Ensembl chr 5:142,113,082...142,118,966

G

CD36 molecule (CD36 blood group)

severity

NCBI chr 7:72,566,478...72,643,517
Ensembl chr 7:86,265,114...86,305,865

G

CD40 ligand

protein:increased expression:serum

NCBI chr X:125,776,138...125,788,820
Ensembl chr X:136,042,849...136,058,202

G

CD59 molecule (CD59 blood group)

protein:decreased expression:myocardium

NCBI chr11:33,680,580...33,708,479
Ensembl chr11:33,552,164...33,590,157

G

cyclin dependent kinase inhibitor 1B

treatment

NCBI chr12:12,742,258...12,747,404
Ensembl chr12:13,120,306...13,125,541

G

cofilin 1

treatment

NCBI chr11:61,215,092...61,218,628
Ensembl chr11:64,544,275...64,550,806

G

CF transmembrane conductance regulator

associated with Myocardial Reperfusion Injury

NCBI chr 7:109,449,847...109,633,023
Ensembl chr 7:122,129,798...122,327,864

G

chitinase 3 like 1

protein:increased secretion:serum (human)

NCBI chr 1:178,778,081...178,789,704
Ensembl chr 1:183,075,312...183,083,229

G

class II major histocompatibility complex transactivator

susceptibility
no_association

DNA:polymorphism:promoter:-168A>G

PMID:15821736 PMID:17183695

RGD:1358146 RGD:5491201

NCBI chr16:9,819,440...9,885,379
Ensembl chr16:11,041,434...11,090,485

G

creatine kinase B

CTD Direct Evidence: marker/mechanism

NCBI chr14:84,145,931...84,149,093

G

creatine kinase, M-type

CTD Direct Evidence: marker/mechanism

PMID:3279722 PMID:12359538

NCBI chr19:42,255,158...42,271,467
Ensembl chr19:50,854,556...50,870,366

G

clusterin

treatment

NCBI chr 8:26,867,973...26,884,838
Ensembl chr 8:24,070,053...24,083,523

G

collagen type I alpha 1 chain

treatment

NCBI chr17:44,274,349...44,291,764
Ensembl chr17:49,150,677...49,166,677

G

collagen type III alpha 1 chain

treatment

NCBI chr2B:76,285,115...76,322,703
Ensembl chr2B:194,204,613...194,242,956

G

collagen type IV alpha 1 chain

susceptibility

DNA:polymorphism: :p.Q1334H (human)

NCBI chr13:91,282,617...91,440,187
Ensembl chr13:110,407,009...110,562,529

G

collagen type VI alpha 3 chain

DNA:SNP:CDS:E1386K (rs146092501) (human)

NCBI chr2B:124,554,478...124,644,482

G

cAMP responsive element binding protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr2B:94,762,796...94,836,304
Ensembl chr2B:212,891,261...212,958,130

G

cAMP responsive element modulator

CTD Direct Evidence: marker/mechanism

NCBI chr10:35,247,426...35,335,545
Ensembl chr10:35,825,218...35,912,432

G

C-reactive protein

protein:increased expression:serum
associated with Angina, Unstable;

PMID:9761079 PMID:21046814 PMID:22446866

RGD:5131456 RGD:6482304 RGD:9491780

NCBI chr 1:135,062,102...135,064,402

G

citrate synthase

severity

protein:decreased expression:diaphragm, mitochondrion

PMID:1877670 PMID:34416105

RGD:243048469 RGD:243048471

NCBI chr12:32,614,982...32,643,719
Ensembl chr12:32,867,225...32,895,854

G

colony stimulating factor 2

NCBI chr 5:127,496,951...127,499,325
Ensembl chr 5:133,660,775...133,663,146

G

colony stimulating factor 3

treatment

NCBI chr17:17,271,074...17,273,493
Ensembl chr17:17,491,276...17,493,729

G

casein kinase 2 alpha 1

NCBI chr20:689,494...752,092
Ensembl chr20:456,629...521,126

G

casein kinase 2 beta

NCBI chr 6:31,327,250...31,331,250

G

cytotoxic T-lymphocyte associated protein 4

DNA:SNP:CDS:49A>G (human)

NCBI chr2B:91,054,917...91,106,234
Ensembl chr2B:209,239,417...209,244,498

G

cathepsin B

protein:increased activity:serum, heart (rat)

NCBI chr 8:7,333,498...7,359,264

G

C-X-C motif chemokine ligand 12

mRNA:increased expression:heart left ventricle

PMID:11820456 PMID:19187644

RGD:2306567 RGD:632503

NCBI chr10:41,296,975...41,384,864
Ensembl chr10:44,552,480...44,564,231

G

cytochrome P450 family 11 subfamily B member 1

NCBI chr 8:139,584,976...139,592,466
Ensembl chr 8:142,629,127...142,634,654

G

cytochrome P450 family 1 subfamily B member 1

ameliorates

NCBI chr2A:38,087,863...38,096,529
Ensembl chr2A:38,851,000...38,859,824

G

cytochrome P450 family 2 subfamily J member 2

susceptibility

DNA:polymorphism

NCBI chr 1:59,151,079...59,184,625
Ensembl chr 1:60,856,269...60,889,810

G

cytochrome P450 family 2 subfamily R member 1

DNA:SNP:CDS:rs2060793, rs1993116, rs10766197 (human)

NCBI chr11:14,960,651...14,989,083
Ensembl chr11:14,656,939...14,671,584

G

DAB adaptor protein 2

protein:increased expression:cardiomyocyte

PMID:20666606 PMID:21762377

RGD:7243156 RGD:7243158

NCBI chr 5:70,951,198...71,004,836
Ensembl chr 5:76,022,143...76,041,443

G

DAB2 interacting protein

onset

CTD Direct Evidence: marker/mechanism
DNA:SNP:CDS:intron 1 (rs7025486) (human)

NCBI chr 9:92,696,798...92,912,425
Ensembl chr 9:121,143,457...121,254,336

G

dystroglycan 1

treatment

NCBI chr 3:49,396,180...49,464,689
Ensembl chr 3:50,640,615...50,703,852

G

decorin

NCBI chr12:88,678,791...88,715,677
Ensembl chr12:91,994,129...92,031,413

G

DNA damage inducible transcript 3

CTD Direct Evidence: marker/mechanism

NCBI chr12:31,406,332...31,410,293
Ensembl chr12:31,664,743...31,668,701

G

diacylglycerol kinase zeta

CTD Direct Evidence: therapeutic

NCBI chr11:46,291,592...46,339,127
Ensembl chr11:46,841,605...46,889,763

G

dishevelled segment polarity protein 1

NCBI chr 1:92,469...106,748
Ensembl chr 1:1,292,052...1,301,008

G

dual specificity tyrosine phosphorylation regulated kinase 1A

treatment

associated with heart failure; protein:increased expression, increased activity:heart left ventricle (rat)

NCBI chr21:23,729,204...23,878,820
Ensembl chr21:37,137,253...37,231,987

G

endothelin converting enzyme 1

NCBI chr 1:20,166,019...20,290,803
Ensembl chr 1:21,206,199...21,278,909

G

endothelin 1

severity

mRNA:increased expression:heart left ventricle (rat)
protein:increased secretion:plasma (human)

PMID:10573185 PMID:17893002

RGD:1580921 RGD:4144880

NCBI chr 6:12,076,312...12,142,861
Ensembl chr 6:12,462,718...12,503,545

G

endothelin 2

NCBI chr 1:40,777,582...40,783,410
Ensembl chr 1:42,092,811...42,098,721

G

endothelin receptor type A

NCBI chr 4:139,815,336...139,879,600
Ensembl chr 4:151,476,356...151,536,497

G

endothelin receptor type B

NCBI chr13:59,112,349...59,136,615
Ensembl chr13:78,153,020...78,177,286

G

egl-9 family hypoxia inducible factor 1

NCBI chr 1:206,915,541...206,976,656

G

egl-9 family hypoxia inducible factor 3

NCBI chr14:14,689,398...14,716,301
Ensembl chr14:32,880,324...32,907,241

G

endothelial PAS domain protein 1

PMID:15247145 PMID:18484163

RGD:1580977 RGD:5147886

NCBI chr2A:46,403,411...46,492,734
Ensembl chr2A:47,332,308...47,421,560

G

EPH receptor B1

ameliorates

NCBI chr 3:131,841,459...132,309,082
Ensembl chr 3:139,313,387...139,776,802

G

epoxide hydrolase 2

NCBI chr 8:26,761,090...26,818,436
Ensembl chr 8:23,964,094...24,017,749

G

erythropoietin

treatment

CTD Direct Evidence: marker/mechanism

PMID:19337937 PMID:21415704

NCBI chr 7:92,747,671...92,750,886
Ensembl chr 7:106,148,062...106,150,974

G

erythropoietin receptor

NCBI chr19:10,925,148...10,931,955
Ensembl chr19:11,635,248...11,642,383

G

erb-b2 receptor tyrosine kinase 2

treatment

NCBI chr17:17,560,337...17,600,808
Ensembl chr17:17,777,434...17,805,862

G

erb-b2 receptor tyrosine kinase 4

treatment

NCBI chr2B:98,625,630...99,795,371
Ensembl chr2B:217,069,644...218,272,006

G

estrogen receptor 1

susceptibility

ClinVar Annotator: match by term: Myocardial infarction, susceptibility to

PMID:11894143 PMID:11919305 PMID:14600184 PMID:15133719 PMID:25741868

NCBI chr 6:149,507,599...149,918,523
Ensembl chr 6:154,317,002...154,631,551

G

coagulation factor X

ClinVar Annotator: match by term: Myocardial infarction, decreased susceptibility to

PMID:10984565 PMID:12181036 PMID:25741868

NCBI chr13:94,263,202...94,289,612
Ensembl chr13:113,332,124...113,358,660

G

coagulation factor XII

susceptibility

DNA:polymorphism:promoter:-46C>T(human)

NCBI chr 5:172,703,724...172,711,618
Ensembl chr 5:179,766,243...179,773,485

G

coagulation factor XIII A chain

ClinVar Annotator: match by term: Myocardial infarction, protection against | ClinVar Annotator: match by term: Myocardial infarction, susceptibility to

PMID:8025280 PMID:9459313 PMID:9550516 PMID:10365735 PMID:10910914 More...

NCBI chr 6:5,978,505...6,156,705
Ensembl chr 6:6,157,926...6,513,961

G

coagulation factor II, thrombin

susceptibility

CTD Direct Evidence: marker/mechanism
DNA:polymorphism::20210G>A(human)

PMID:9292507 PMID:9531249 PMID:10027711 PMID:12480694

NCBI chr11:46,669,925...46,690,391
Ensembl chr11:47,227,891...47,249,157

G

coagulation factor III, tissue factor

treatment

NCBI chr 1:97,190,381...97,203,076
Ensembl chr 1:95,918,502...95,931,050

G

coagulation factor V

no_association
susceptibility

DNA:mutation:cds:1691G>A (human)
CTD Direct Evidence: marker/mechanism

PMID:9531249 PMID:10590188 PMID:15131548

RGD:11564335 RGD:11564337

NCBI chr 1:144,996,757...145,070,046
Ensembl chr 1:148,718,897...148,790,915

G

coagulation factor VII

susceptibility

ClinVar Annotator: match by term: F7-related condition | ClinVar Annotator: match by term: Myocardial infarction, decreased susceptibility to | ClinVar Annotator: match by term: Myocardial infarction, susceptibility to
DNA:missense mutation, repeat:cds, intron:p.R353Q, (human)

ClinVar
RGD
OMIM

PMID:1634227 PMID:2070047 PMID:6812354 PMID:7919338 PMID:7974346 More...

NCBI chr13:94,246,694...94,261,133
Ensembl chr13:113,315,868...113,329,995

G

fatty acid binding protein 3

NCBI chr 1:30,640,595...30,653,450
Ensembl chr 1:31,665,270...31,673,689

G

fibrinogen alpha chain

treatment

NCBI chr 4:146,949,680...146,957,291

G

fibrinogen beta chain

NCBI chr 4:146,929,561...146,937,665
Ensembl chr 4:158,747,659...158,755,766

G

fibroblast growth factor 1

treatment

NCBI chr 5:137,949,100...138,054,553
Ensembl chr 5:144,056,387...144,078,001

G

fibroblast growth factor receptor 1

NCBI chr 8:37,713,133...37,773,098
Ensembl chr 8:34,890,147...34,948,904

G

fibroblast growth factor receptor 2

ameliorates

NCBI chr10:118,055,854...118,175,440
Ensembl chr10:121,469,735...121,588,815

G

fibrinogen gamma chain

treatment

NCBI chr 4:146,970,671...146,979,348
Ensembl chr 4:158,788,966...158,797,237

G

fission, mitochondrial 1

protein:increased expression:plantaris (rat)

NCBI chr 7:93,381,058...93,386,483
Ensembl chr 7:106,621,211...106,626,683

G

fms related receptor tyrosine kinase 1

NCBI chr13:9,584,850...9,779,542

G

fms related receptor tyrosine kinase 3 ligand

treatment

NCBI chr19:46,486,169...46,499,008

G

fibronectin 1

protein:decreased expression:heart

NCBI chr2B:102,623,568...102,698,747
Ensembl chr2B:221,208,431...221,284,003

G

Fos proto-oncogene, AP-1 transcription factor subunit

protein:increased expression:paraventricular nucleus hypothalamus, paraventricular nucleus thalamus

NCBI chr14:55,832,570...55,835,984
Ensembl chr14:74,676,316...74,679,766

G

FTO alpha-ketoglutarate dependent dioxygenase

treatment

DNA:SNP: :rs17817449 (human)
associated with type 2 diabetes mellitus;DNA:SNP:intron:rs9939609 (human)
mRNA, protein:decreased expression:heart

PMID:20031593 PMID:26772723 PMID:29997116

RGD:11555187 RGD:329812009 RGD:329901766

NCBI chr16:33,939,300...34,343,419
Ensembl chr16:53,023,425...53,490,231

G

frizzled class receptor 2

mRNA:increased expression:heart left ventricle

NCBI chr17:12,839,362...12,843,803

G

glucose-6-phosphate dehydrogenase

treatment

NCBI chr X:143,972,798...143,988,960
Ensembl chr X:153,843,092...153,860,674

G

GATA binding protein 4

treatment

CTD Direct Evidence: therapeutic

PMID:20200331 PMID:23948075

NCBI chr 8:7,442,921...7,526,731

G

glycine amidinotransferase

NCBI chr15:24,309,045...24,326,673
Ensembl chr15:42,639,597...42,657,209

G

GTP cyclohydrolase 1

treatment

PMID:26192027 PMID:32782412

RGD:329961570 RGD:329970290

NCBI chr14:35,428,676...35,489,359
Ensembl chr14:53,706,723...53,767,393

G

glutamate-cysteine ligase catalytic subunit

susceptibility

ClinVar Annotator: match by term: Myocardial infarction, susceptibility to

NCBI chr 6:53,052,145...53,102,794
Ensembl chr 6:54,687,315...54,734,994

G

glutamate-cysteine ligase modifier subunit

susceptibility

ClinVar Annotator: match by term: Myocardial infarction, susceptibility to

PMID:12081989 PMID:12975258

NCBI chr 1:96,548,850...96,573,273
Ensembl chr 1:95,278,665...95,297,893

G

gamma-glutamyltransferase 1

CTD Direct Evidence: marker/mechanism

NCBI chr22:5,424,334...5,469,705

G

growth hormone releasing hormone

treatment

NCBI chr20:33,573,001...33,583,699
Ensembl chr20:34,687,587...34,693,240

G

gap junction protein alpha 1

treatment

protein:decreased phosphorylation

PMID:22841862 PMID:22969867 PMID:29428663

RGD:13592597 RGD:7207261 RGD:7207262

NCBI chr 6:119,213,513...119,227,617

G

gap junction protein alpha 4

DNA:SNP:CDS:T allele of 1019C>T in Japanese men (p<0.001)
associated with coronary artery disease; DNA:SNP:CDS:C allele of 1019C>T, amino acid P319S (p = 0.0026) in a Swiss population

PMID:12477941 PMID:15982495 PMID:16677656

RGD:1580400 RGD:1626615 RGD:1626626

NCBI chr 1:34,059,901...34,063,181

G

gap junction protein alpha 5

treatment

NCBI chr 1:123,200,111...123,224,626
Ensembl chr 1:112,328,337...112,329,413

G

glycoprotein Ib platelet subunit alpha

NCBI chr17:4,980,083...4,983,219

G

glycoprotein VI platelet

susceptibility
treatment
sexual_dimorphism
no_association
onset

DNA:SNP, missense mutation:promoter, CDS:c.-148C>T, c.13254T>C (p.S219P) (human)
human protein in a mouse model
DNA:missense mutation:CDS:c.13254T>C (p.S219P) (human)
DNA:missense mutation:CDS:c.13254T>C (p.S219P) (rs1613662) (human)
DNA:missense mutation:exon 7:c.645213C>T (p.T249A) (human)

PMID:11571236 PMID:12417295 PMID:20723028 PMID:22814400

RGD:401793749 RGD:401793754 RGD:401794407 RGD:401824647

NCBI chr19:52,051,138...52,071,673
Ensembl chr19:60,746,578...60,770,643

G

glutamic--pyruvic transaminase

treatment

Ensembl chr 8:144,259,991...144,263,737

G

glutathione peroxidase 1

susceptibility

NCBI chr 3:49,280,038...49,281,455
Ensembl chr 3:50,360,947...50,361,826

G

glycogen synthase kinase 3 beta

treatment

CTD Direct Evidence: marker/mechanism

PMID:16565311 PMID:16716347

NCBI chr 3:116,943,205...117,215,001
Ensembl chr 3:123,861,379...124,126,771

G

gelsolin

ameliorates

protein:decreased expression:blood serum (human)

PMID:9142022 PMID:28622474

RGD:329333022 RGD:329333030

NCBI chr 9:92,413,819...92,460,483
Ensembl chr 9:120,741,148...120,805,831

G

glutathione-disulfide reductase

treatment

NCBI chr 8:29,990,543...30,040,157
Ensembl chr 8:27,180,300...27,229,557

G

guanylate cyclase 1 soluble subunit alpha 1

ClinVar Annotator: match by term: Myocardial infarction, susceptibility to, 1

NCBI chr 4:148,032,167...148,102,757
Ensembl chr 4:159,850,107...159,913,338

G

hydroxyacyl-CoA dehydrogenase

NCBI chr 4:100,495,205...100,540,589
Ensembl chr 4:111,067,336...111,113,868

G

hepcidin antimicrobial peptide

mRNA:increased expression:heart

NCBI chr19:32,228,701...32,231,494
Ensembl chr19:40,964,445...40,968,861

G

homeostatic iron regulator

no_association
susceptibility

PMID:10491370 PMID:12850485

RGD:1582672 RGD:1582697

NCBI chr 6:25,921,663...25,930,852
Ensembl chr 6:26,580,358...26,588,591

G

hepatocyte growth factor

treatment

protein:increased expression:serum:

PMID:12419930 PMID:16570015

RGD:8548609 RGD:8548632

NCBI chr 7:73,667,618...73,738,960
Ensembl chr 7:87,327,798...87,397,811

G

hypoxia inducible factor 1 subunit alpha

ameliorates
treatment

mRNA:increased expression:heart left ventricle
human gene in a rat model

PMID:15247145 PMID:15999059 PMID:18484163 PMID:28622474

RGD:1580977 RGD:329333030 RGD:5147886 RGD:9068466

NCBI chr14:42,295,691...42,348,478
Ensembl chr14:60,552,374...60,604,885

G

high mobility group box 1

treatment

CTD Direct Evidence: marker/mechanism

PMID:21113057 PMID:23188125

NCBI chr13:11,737,942...11,894,923
Ensembl chr13:30,174,899...30,179,527

G

heme oxygenase 1

PMID:12392996 PMID:20925964

RGD:1598393 RGD:4145134

NCBI chr22:16,388,368...16,401,289
Ensembl chr22:34,230,825...34,244,063

G

hydroxysteroid 11-beta dehydrogenase 1

ameliorates

PMID:26465199 PMID:28522730

RGD:11087531 RGD:329902054

NCBI chr 1:185,262,599...185,311,417
Ensembl chr 1:190,086,449...190,116,765

G

hydroxysteroid 11-beta dehydrogenase 2

mRNA:increased expression:heart
CTD Direct Evidence: marker/mechanism

NCBI chr16:47,776,118...47,782,861
Ensembl chr16:67,165,215...67,171,417

G

heat shock protein family A (Hsp70) member 5

CTD Direct Evidence: marker/mechanism

NCBI chr 9:96,351,645...96,356,761
Ensembl chr 9:124,865,211...124,870,458

G

heat shock protein family D (Hsp60) member 1

NCBI chr2B:84,729,615...84,743,352
Ensembl chr2B:202,623,497...202,636,959

G

intercellular adhesion molecule 1

treatment

CTD Direct Evidence: marker/mechanism

PMID:10070497 PMID:23139358

NCBI chr19:9,821,402...9,837,021
Ensembl chr19:10,484,414...10,500,605

G

insulin like growth factor 1

severity

mRNA, protein:increased expression:myocardium

PMID:16635594 PMID:19295919

RGD:1598421 RGD:2306696

NCBI chr12:99,986,887...100,066,773
Ensembl chr12:103,385,911...103,462,177

G

insulin like growth factor 1 receptor

mRNA,protein:increased expression:myocyte:

NCBI chr15:77,332,926...77,648,474
Ensembl chr15:96,535,164...96,832,974

G

interleukin 10

susceptibility

CTD Direct Evidence: marker/mechanism

PMID:15466015 PMID:15883752 PMID:16310260

NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371

G

interleukin 17A

mRNA, protein:increased expression:heart left ventricle (rat)

NCBI chr 6:51,736,269...51,740,538
Ensembl chr 6:53,004,820...53,009,074

G

interleukin 18

ameliorates

NCBI chr11:107,024,376...107,045,194
Ensembl chr11:110,867,586...110,888,371

G

interleukin 18 binding protein

NCBI chr11:67,078,251...67,083,043
Ensembl chr11:70,302,923...70,307,511

G

interleukin 1 beta

ameliorates

CTD Direct Evidence: marker/mechanism
protein:increased expression:serum (rat)

PMID:11743230 PMID:15883752 PMID:16310260 PMID:23143013 PMID:23237935 More...

RGD:242905187 RGD:7175553 RGD:7204425

NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424

G

interleukin 1 receptor antagonist

CTD Direct Evidence: therapeutic

PMID:18474815 PMID:19005744

NCBI chr2A:88,991,646...89,008,013
Ensembl chr2A:114,061,182...114,078,839

G

interleukin 4 receptor

mRNA:increased expression:heart

Ensembl chr16:27,642,702...27,737,445

G

interleukin 6

treatment

CTD Direct Evidence: marker/mechanism

PMID:15883752 PMID:16310260 PMID:31734577

NCBI chr 7:23,415,922...23,420,767

G

interleukin 6 receptor

NCBI chr 1:129,761,914...129,824,386
Ensembl chr 1:133,374,078...133,433,089

G

inhibin subunit beta A

mRNA:increased expression:heart (rat)
mRNA:increased expression:myocardium (mouse)

PMID:14993131 PMID:32427381

RGD:1580888 RGD:329849118

NCBI chr 7:42,538,591...42,556,578
Ensembl chr 7:42,580,730...42,595,097

G

inhibin subunit beta B

mRNA:increased expression:myocardium (mouse)

NCBI chr2B:7,278,944...7,284,632

G

ISL LIM homeobox 1

ameliorates

PMID:22727192 PMID:29482621

RGD:243048463 RGD:243048464

NCBI chr 5:62,635,095...62,650,141
Ensembl chr 5:64,252,715...64,264,674

G

integrin subunit alpha 2

no_association
susceptibility

PMID:10194421 PMID:15227729 PMID:16697311

RGD:1581029 RGD:1582294 RGD:1582296

NCBI chr 5:60,935,452...61,040,726
Ensembl chr 5:62,555,370...62,659,720

G

integrin subunit alpha 3

protein:increased expression:myocardium (rat)

NCBI chr17:44,145,974...44,181,343
Ensembl chr17:49,019,892...49,055,245

G

integrin subunit alpha M

treatment

NCBI chr16:23,634,476...23,707,147
Ensembl chr16:31,630,146...31,702,406

G

integrin subunit beta 1

treatment

NCBI chr10:33,023,573...33,081,384
Ensembl chr10:33,608,978...33,644,031

G

integrin subunit beta 3

no_association
susceptibility

DNA:polymorphism:exon:
ClinVar Annotator: match by term: Myocardial infarction, susceptibility to

RGD
OMIM
ClinVar

PMID:2014236 PMID:7570918 PMID:8598867 PMID:8667943 PMID:8838346 More...

RGD:5128481 RGD:5128498

NCBI chr17:10,134,450...10,194,596
Ensembl chr17:10,353,111...10,392,382

G

inter-alpha-trypsin inhibitor heavy chain 4

NCBI chr 3:52,754,664...52,774,867
Ensembl chr 3:53,980,668...53,998,038

G

Janus kinase 2

susceptibility

associated with Myocardial Reperfusion Injury

NCBI chr 9:4,820,303...4,971,867
Ensembl chr 9:5,006,271...5,156,626

G

potassium inwardly rectifying channel subfamily J member 2

treatment

NCBI chr17:64,097,908...64,112,914
Ensembl chr17:69,487,846...69,489,129

G

potassium two pore domain channel subfamily K member 2

mRNA:decreased expression:heart left ventricle, epicardium, endocardium (rat)

NCBI chr 1:190,576,180...190,807,367
Ensembl chr 1:195,430,994...195,662,840

G

potassium calcium-activated channel subfamily N member 4

susceptibility

DNA:SNPs,haplotypes:introns:multiple

NCBI chr19:40,715,621...40,735,025
Ensembl chr19:49,321,403...49,335,900

G

lysine demethylase 5B

ameliorates

NCBI chr 1:178,323,073...178,406,608
Ensembl chr 1:182,622,425...182,702,994

G

lysine demethylase 6A

mRNA:increased expression:myocardium (rat)

NCBI chr X:37,313,000...37,548,630
Ensembl chr X:45,127,382...45,362,029

G

kinase insert domain receptor

treatment

PMID:16698275 PMID:25936512

RGD:126925214 RGD:1581717

NCBI chr 4:68,813,894...68,861,018
Ensembl chr 4:75,377,375...75,427,109

G

kinesin family member 6

no_association
treatment

DNA:SNP: :p.W719R (rs20455) (human)
CTD Direct Evidence: marker/mechanism
DNA:SNP: :rs20455 (human)

PMID:18222354 PMID:19371834 PMID:20403483 PMID:20927332 PMID:21943003 More...

RGD:11097528 RGD:243048446 RGD:243048447 RGD:243048449 RGD:243048450

NCBI chr 6:38,917,083...39,306,190
Ensembl chr 6:40,234,426...40,616,738

G

KLF transcription factor 13

CTD Direct Evidence: marker/mechanism

NCBI chr15:9,818,294...9,964,912

G

kallikrein 1

CTD Direct Evidence: therapeutic

PMID:12411458 PMID:17022964

NCBI chr19:47,784,368...47,789,004
Ensembl chr19:56,677,579...56,682,216

G

lysosomal associated membrane protein 2

mRNA:increased expression:plantaris

NCBI chr X:109,700,185...109,743,579
Ensembl chr X:119,886,982...119,929,896

G

lecithin-cholesterol acyltransferase

NCBI chr16:48,278,137...48,285,305
Ensembl chr16:67,668,646...67,673,127

G

lipocalin 2

ameliorates

NCBI chr 9:99,259,278...99,274,494
Ensembl chr 9:127,940,799...127,944,798

G

lactate dehydrogenase A

CTD Direct Evidence: marker/mechanism

NCBI chr11:18,432,347...18,445,694
Ensembl chr11:18,115,250...18,128,400

G

galectin 2

susceptibility

ClinVar Annotator: match by term: Myocardial infarction, susceptibility to

NCBI chr22:18,488,257...18,498,401
Ensembl chr22:36,320,775...36,330,281

G

galectin 3

CTD Direct Evidence: marker/mechanism

NCBI chr14:35,715,850...35,732,263
Ensembl chr14:53,990,023...54,006,412

G

lipase G, endothelial type

susceptibility

DNA:polymorphism: :584C>T (human)

NCBI chr18:42,942,132...42,972,112
Ensembl chr18:46,292,154...46,320,652

G

left-right determination factor 1

ameliorates

NCBI chr 1:201,347,411...201,351,295
Ensembl chr 1:206,348,419...206,350,787

G

somatotropin

treatment

NCBI chr17:58,010,848...58,013,421
Ensembl chr17:63,103,332...63,105,067

G

interferon alpha-2

CTD Direct Evidence: marker/mechanism

NCBI chr 9:21,245,017...21,246,210
Ensembl chr 9:21,863,062...21,863,736

G

myosin-7

CTD Direct Evidence: marker/mechanism

PMID:11743230 PMID:15090263

NCBI chr14:4,231,344...4,254,295
Ensembl chr14:22,325,812...22,348,763

G

adenosine receptor A3

CTD Direct Evidence: therapeutic

PMID:12160945 PMID:20132822

NCBI chr 1:114,144,642...114,225,407
Ensembl chr 1:126,122,352...126,202,396

G

cytochrome b-245 heavy chain

mRNA:increase expression:ventricle myocardium

NCBI chr X:30,230,394...30,267,379
Ensembl chr X:37,939,704...37,973,183

G

cytochrome b-245 light chain

mRNA:increased expression:myocardium
mRNA:increase expression:ventricle myocardium:

PMID:11243862 PMID:18762777

RGD:1599690 RGD:2317860

NCBI chr16:69,356,396...69,364,225
Ensembl chr16:89,016,349...89,024,719

G

lysyl oxidase

NCBI chr 5:117,450,833...117,464,957
Ensembl chr 5:123,234,662...123,248,717

G

lipoprotein(a)

DNA:SNP:CDS:rs3798220, g.160961137T>C, p.Ile1891Met

NCBI chr 6:158,434,394...158,628,028

G

lipoprotein lipase

susceptibility

associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:SNP: :p.D9N (rs1801177) (human)

NCBI chr 8:19,164,541...19,193,100
Ensembl chr 8:16,113,415...16,142,966

G

LDL receptor related protein 1

susceptibility

NCBI chr12:31,713,938...31,799,287
Ensembl chr12:31,966,149...32,051,979

G

LDL receptor related protein 8

susceptibility
onset
no_association

ClinVar Annotator: match by term: Myocardial infarction, susceptibility to, 1
DNA:missense mutation:cds:p.R952Q (human)

OMIM
ClinVar
RGD

PMID:17847002 PMID:18592168

RGD:2306124 RGD:2306125

NCBI chr 1:52,515,534...52,600,390
Ensembl chr 1:54,114,909...54,199,452

G

LDL receptor related protein associated protein 1

susceptibility

NCBI chr 4:3,663,649...3,683,450
Ensembl chr 4:3,646,179...3,666,098

G

lymphotoxin alpha

susceptibility
severity
no_association

ClinVar Annotator: match by term: Myocardial infarction, susceptibility to
DNA:SNP:exon:804C>A (p.T26N) (human)

OMIM
ClinVar
RGD

PMID:12426569 PMID:12746914 PMID:14681301 PMID:15175864 PMID:15266304 More...

RGD:1581940 RGD:8548841

NCBI chr 6:31,233,411...31,235,409
Ensembl chr 6:32,123,353...32,125,375

G

microtubule associated protein 1 light chain 3 alpha

treatment

NCBI chr20:30,887,345...30,888,986
Ensembl chr20:32,010,284...32,020,411

G

mitogen-activated protein kinase kinase kinase 5

treatment

NCBI chr 6:134,316,841...134,582,843
Ensembl chr 6:138,406,398...138,641,727

G

mitogen-activated protein kinase kinase kinase 7

treatment

mRNA, protein:increased expression:myocardium (rat)

PMID:16183734 PMID:27121011

RGD:11073666 RGD:2298758

NCBI chr 6:88,398,329...88,470,926
Ensembl chr 6:91,664,263...91,737,468

G

mitogen-activated protein kinase 1

NCBI chr22:3,883,119...3,990,368
Ensembl chr22:20,365,487...20,450,335

G

mitogen-activated protein kinase 14

ameliorates

NCBI chr 6:35,586,847...35,683,041
Ensembl chr 6:36,788,233...36,871,114

G

mitogen-activated protein kinase 8

ameliorates

NCBI chr10:45,806,748...45,936,362

G

malate dehydrogenase 2

NCBI chr 7:67,953,759...67,973,270
Ensembl chr 7:82,497,800...82,516,526

G

midkine

NCBI chr11:46,339,365...46,342,388
Ensembl chr11:46,891,540...46,893,254

G

myocyte enhancer factor 2C

treatment

NCBI chr 5:26,480,489...26,650,813
Ensembl chr 5:26,681,700...26,786,426

G

mesenchyme homeobox 2

protein:decreased expression:heart (rat)

NCBI chr 7:16,268,225...16,343,914
Ensembl chr 7:15,598,466...15,673,935

G

mesoderm posterior bHLH transcription factor 1

treatment

human gene and cell line in a rat model

NCBI chr15:68,440,626...68,441,935
Ensembl chr15:87,645,768...87,647,210

G

mitochondrial fission factor

treatment

CTD Direct Evidence: marker/mechanism

NCBI chr2B:114,569,893...114,602,158
Ensembl chr2B:233,381,466...233,413,778

G

mitofusin 2

treatment

NCBI chr 1:10,729,933...10,764,865
Ensembl chr 1:11,945,880...11,981,077

G

matrix Gla protein

susceptibility

NCBI chr12:14,887,806...14,891,796
Ensembl chr12:15,284,883...15,288,523

G

MIA SH3 domain ER export factor 3

CTD Direct Evidence: marker/mechanism

NCBI chr 1:198,291,200...198,339,502
Ensembl chr 1:203,304,237...203,354,919

G

macrophage migration inhibitory factor

protein:increased expression:plasma
mRNA, protein:increased expression:myocardium

PMID:11589847 PMID:12704210

RGD:1642003 RGD:1642008

NCBI chr22:4,646,986...4,647,831
Ensembl chr22:22,730,807...22,732,009

G

MLX interacting protein like

susceptibility

DNA:SNP:cd: C771G, p.Q241H (rs3812316) (human)

Ensembl chr 7:80,745,765...80,776,153

G

matrix metallopeptidase 1

susceptibility

protein:increased expression, increased activity:heart left ventricle (rat)
associated with Coronary Artery Disease; DNA:snps, haplotype:promoter:g.-519A>G, g.-340T>C (human)
human gene in rat model

PMID:8531210 PMID:11179039 PMID:15009768 PMID:16210545 PMID:19797822

RGD:1582520 RGD:1582535 RGD:7207135 RGD:7207136 RGD:7207198

NCBI chr11:97,730,545...97,739,190
Ensembl chr11:101,221,393...101,230,104

G

matrix metallopeptidase 13

NCBI chr11:97,890,811...97,902,778
Ensembl chr11:101,377,001...101,387,679

G

matrix metallopeptidase 14

PMID:10773235 PMID:16461815

RGD:1582569 RGD:1582587

NCBI chr14:3,654,125...3,665,158
Ensembl chr14:21,753,305...21,764,058

G

matrix metallopeptidase 2

CTD Direct Evidence: marker/mechanism

PMID:10773235 PMID:11179039 PMID:16310260 PMID:24358288

RGD:1582587 RGD:7207136

NCBI chr16:35,711,866...35,738,881
Ensembl chr16:54,812,694...54,844,279

G

matrix metallopeptidase 3

NCBI chr11:97,776,729...97,784,549
Ensembl chr11:101,267,566...101,275,354

G

matrix metallopeptidase 7

NCBI chr11:97,467,037...97,477,305
Ensembl chr11:100,960,032...100,971,099

G

matrix metallopeptidase 9

susceptibility

protein:increased expression:heart left ventricle
CTD Direct Evidence: marker/mechanism
protein:increased expression, increased activity:heart left ventricle (rat)
DNA:snps:promoter, exon:g.-1562C>T, p.R279Q (rs3918242, rs2664538) (human)
protein:increased expression:coronary artery, plasma (human)

PMID:8531210 PMID:14729404 PMID:15118287 PMID:16310260 PMID:16845718 More...

RGD:13204799 RGD:1582639 RGD:1582645 RGD:1582653 RGD:7207049 RGD:7207198

NCBI chr20:42,346,305...42,354,018
Ensembl chr20:43,432,389...43,440,129

G

myostatin

mRNA:decreased expression:myocardium (mouse)

NCBI chr2B:77,364,927...77,452,426
Ensembl chr2B:195,283,903...195,290,922

G

methylenetetrahydrofolate reductase

susceptibility

DNA:SNP: :677C>T (human)
associated with Kidney Failure, Chronic; DNA:transition:cds:g.677C>T rs1801133 (human)

PMID:10090925 PMID:19272686

RGD:10449412 RGD:6893548

NCBI chr 1:10,548,196...10,568,174
Ensembl chr 1:11,766,334...11,785,419

G

mechanistic target of rapamycin kinase

treatment

protein:decreased serine phosphorylation:heart
associated with Diabetes Mellitus, Experimental

PMID:20352476 PMID:23773982

RGD:10041035 RGD:10041040

NCBI chr 1:9,871,700...10,028,704
Ensembl chr 1:11,093,765...11,249,841

G

myosin heavy chain 6

NCBI chr14:4,200,616...4,226,193
Ensembl chr14:22,294,965...22,321,331

G

neural cell adhesion molecule 1

mRNA, protein:increased expression:heart
protein:alternative form, increased expression:myocardium

PMID:19853610 PMID:23462508

RGD:2325979 RGD:40924663

NCBI chr11:107,845,507...108,160,441
Ensembl chr11:111,925,677...112,000,401

G

NADH:ubiquinone oxidoreductase subunit B5

treatment

NCBI chr 3:176,636,937...176,659,813
Ensembl chr 3:184,807,246...184,827,011

G

NFE2 like bZIP transcription factor 2

treatment

PMID:23290949 PMID:24915518

RGD:10412734 RGD:10412738

NCBI chr2B:64,509,446...64,544,600
Ensembl chr2B:182,214,116...182,248,085

G

NFKB inhibitor alpha

treatment

NCBI chr14:16,155,331...16,158,588

G

nerve growth factor

treatment

protein:increased expression:myocardium

NCBI chr 1:87,223,597...87,276,759

G

nemo like kinase

mRNA, protein:decreased expression:heart

NCBI chr17:28,586,894...28,740,252

G

NLR family pyrin domain containing 3

ameliorates

NCBI chr 1:223,052,307...223,084,736
Ensembl chr 1:228,505,147...228,537,216

G

non-POU domain containing octamer binding

ameliorates

NCBI chr X:60,547,277...60,564,845
Ensembl chr X:70,602,456...70,619,956

G

nitric oxide synthase 2

treatment

CTD Direct Evidence: marker/mechanism

PMID:10090345 PMID:11489778 PMID:26192027

NCBI chr17:28,984,295...29,021,516
Ensembl chr17:29,471,510...29,617,093

G

nitric oxide synthase 3

susceptibility
treatment

protein:decreased expression:aorta (rat)
DNA:repeats:intron
human gene in rat model
DNA:duplication:intron:IVS4?-?+27 (human)
CTD Direct Evidence: marker/mechanism

PMID:10510054 PMID:10531147 PMID:11903359 PMID:12362496 PMID:16337503 More...

RGD:13450930 RGD:13503346 RGD:1580283 RGD:1580284 RGD:5128481 RGD:7771561 RGD:7771563

NCBI chr 7:142,577,334...142,600,702
Ensembl chr 7:154,730,009...154,755,233

G

nucleophosmin 1

protein:increased expression:cardiomyocyte:

NCBI chr 5:166,735,904...166,756,321
Ensembl chr 5:173,490,197...173,510,656

G

natriuretic peptide A

CTD Direct Evidence: marker/mechanism|therapeutic
DNA:snp:cds:c.2238T>C (human)

PMID:9527094 PMID:11743230 PMID:12514664 PMID:16087130

RGD:1579982 RGD:1580000

NCBI chr 1:10,608,025...10,610,287
Ensembl chr 1:11,825,072...11,827,373

G

natriuretic peptide B

PMID:17256064 PMID:17639095 PMID:19858735

RGD:1642266 RGD:2324680 RGD:7247724

NCBI chr 1:10,621,416...10,622,960
Ensembl chr 1:11,838,518...11,839,995

G

natriuretic peptide receptor 1

susceptibility

DNA:missense mutation:cds:p.M341I (human)

NCBI chr 1:129,034,972...129,050,439
Ensembl chr 1:132,664,948...132,679,327

G

nuclear receptor subfamily 1 group H member 3

susceptibility

DNA:SNPs, haplotype:promoter:c.-115G>A, c.-840C>A (rs12221497, rs61896015) (human)

NCBI chr11:47,195,122...47,215,277
Ensembl chr11:47,748,353...47,768,672

G

nuclear receptor subfamily 3 group C member 2

CTD Direct Evidence: marker/mechanism

PMID:16413583 PMID:17587755

NCBI chr 4:140,418,624...140,785,180
Ensembl chr 4:152,108,508...152,430,298

G

neuregulin 1

treatment

PMID:24200746 PMID:26892146 PMID:27993643

RGD:10449026 RGD:11522702 RGD:405145704

NCBI chr 8:30,954,852...32,084,411
Ensembl chr 8:29,050,222...29,263,977

G

nuclear receptor interacting protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr21:1,565,149...1,801,358
Ensembl chr21:15,065,197...15,068,673

G

oxidized low density lipoprotein receptor 1

susceptibility

ClinVar Annotator: match by term: Myocardial infarction, susceptibility to

PMID:12646194 PMID:12810610 PMID:14684693

NCBI chr12:10,196,712...10,210,432
Ensembl chr12:10,445,202...10,461,071

G

OPA1 mitochondrial dynamin like GTPase

treatment

NCBI chr 3:190,890,242...190,995,133
Ensembl chr 3:201,207,607...201,312,358

G

opioid receptor delta 1

PMID:12798419 PMID:15076225

RGD:2316587 RGD:9831425

NCBI chr 1:28,068,053...28,143,053
Ensembl chr 1:29,112,152...29,163,464

G

opioid receptor kappa 1

NCBI chr 8:49,650,844...49,677,494
Ensembl chr 8:47,029,313...47,056,577

G

purinergic receptor P2Y12

CTD Direct Evidence: marker/mechanism

NCBI chr 3:148,364,151...148,412,231

G

pappalysin 1

susceptibility

DNA:polymorphism:intron
CTD Direct Evidence: marker/mechanism

PMID:11586954 PMID:17700210

NCBI chr 9:87,287,289...87,535,414
Ensembl chr 9:115,671,212...115,883,435

G

poly(ADP-ribose) polymerase 1

protein:altered processing:left ventricle (mouse)

NCBI chr 1:201,820,355...201,867,673
Ensembl chr 1:206,812,981...206,860,356

G

proprotein convertase subtilisin/kexin type 2

DNA:SNP:intron: (rs6080699) (human)

NCBI chr20:17,184,878...17,443,355
Ensembl chr20:17,163,675...17,421,157

G

phosphodiesterase 3A

CTD Direct Evidence: marker/mechanism

NCBI chr12:20,380,213...20,690,540
Ensembl chr12:20,763,999...21,064,391

G

phosphodiesterase 5A

NCBI chr 4:111,682,772...111,817,234
Ensembl chr 4:122,832,175...122,966,636

G

platelet derived growth factor D

mRNA,protein:altered expression:myocardium:

NCBI chr11:98,852,652...99,110,147
Ensembl chr11:102,357,079...102,593,273

G

phosphatidylethanolamine binding protein 1

protein:decreased expression:right heart ventricle, ventricular septum

NCBI chr12:115,716,953...115,726,412
Ensembl chr12:119,093,952...119,105,054

G

platelet and endothelial cell adhesion molecule 1

onset
no_association

DNA:missense mutation:cds:p.R643G (human)
DNA:polymorphisms: :p.N563S, p.G670R (human)
DNA:missense mutations:cds:p.L125V, p.S563N (human)

PMID:11795274 PMID:15265022 PMID:15488875

RGD:1581009 RGD:2311656 RGD:6771224

NCBI chr17:58,417,134...58,526,409
Ensembl chr17:63,511,784...63,579,067

G

placental growth factor

PMID:20649603 PMID:21329947 PMID:22114497

RGD:6483584 RGD:6483773 RGD:6483777

NCBI chr14:55,494,152...55,508,066
Ensembl chr14:74,338,976...74,352,964

G

phosphatase and actin regulator 1

susceptibility
severity
no_association

CTD Direct Evidence: marker/mechanism
DNA:SNP:intron: (rs9369640) (human)
DNA:SNPs:multiple (human)
DNA:SNP:intron:(rs12526453) (human)
mRNA:increased expression:peripheral blood mononuclear cells (human)
DNA:SNPs:intron 3: (rs9349379, rs2026458, rs2876300) (human)
DNA:SNP:intron:g.13035530G>C (rs12526453) (human)
mRNA, protein:decreased expression:heart left ventricle (rat)

PMID:19198609 PMID:25738804 PMID:25838425 PMID:26086777 PMID:26098115 More...

RGD:11052493 RGD:11052994 RGD:11053274 RGD:11056926 RGD:401851907 RGD:401900171

NCBI chr 6:12,560,862...13,136,126
Ensembl chr 6:12,922,871...13,505,609

G

pleckstrin homology like domain family A member 3

CTD Direct Evidence: marker/mechanism

NCBI chr 1:177,063,775...177,067,714
Ensembl chr 1:181,367,976...181,368,359

G

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma

NCBI chr 7:98,841,974...98,885,446
Ensembl chr 7:111,570,148...111,611,614

G

phospholipase A2 group VII

protein:decreased expression:serum

NCBI chr 6:46,264,262...46,318,487
Ensembl chr 6:47,558,861...47,590,212

G

plasminogen activator, tissue type

treatment

CTD Direct Evidence: therapeutic
DNA:snp:enhancer:g.-7351C>T (human)

PMID:1430592 PMID:1492007 PMID:1898952 PMID:1899364 PMID:1900011 More...

RGD:11541077 RGD:1580881

NCBI chr 8:41,419,415...41,451,951
Ensembl chr 8:38,864,918...38,897,779

G

plasminogen activator, urokinase

mRNA, protein:increased expression:myocardium
DNA:SNP:3' utr:c.*141C>T (rs4065) (human)
CTD Direct Evidence: marker/mechanism|therapeutic

PMID:1908371 PMID:2174952 PMID:2382605 PMID:3068399 PMID:3984876 More...

RGD:6484126 RGD:6484133 RGD:6484145

NCBI chr10:70,433,340...70,441,569
Ensembl chr10:73,105,895...73,113,136

G

plasminogen activator, urokinase receptor

NCBI chr19:40,588,100...40,616,479
Ensembl chr19:49,197,341...49,222,561
Ensembl chr19:49,197,341...49,222,561

G

phospholipase C beta 1

protein:increased expression:heart

NCBI chr20:8,106,665...8,858,572
Ensembl chr20:7,887,960...8,636,019

G

phospholipase C beta 3

protein:increased expression:heart

NCBI chr11:59,608,651...59,626,289
Ensembl chr11:62,953,587...62,971,393

G

phospholamban

treatment

CTD Direct Evidence: marker/mechanism
protein:decreased expression:heart left ventricle (rat)

PMID:16026515 PMID:16162791 PMID:23781262 PMID:26067684

RGD:11097969 RGD:7327176

NCBI chr 6:116,357,335...116,370,382
Ensembl chr 6:120,509,510...120,509,668

G

paraoxonase 1

PMID:10610741 PMID:10978258

RGD:1580198 RGD:1580202

NCBI chr 7:87,253,476...87,279,650
Ensembl chr 7:100,841,286...100,867,493

G

periostin

protein:increased expression:heart:

NCBI chr13:18,779,297...18,815,207
Ensembl chr13:37,368,030...37,407,212

G

peroxisome proliferator activated receptor alpha

DNA:SNP:intron:rs4253623, minor allele associated with increased risk

Ensembl chr22:45,218,364...45,302,970

G

PPARG coactivator 1 alpha

protein:decreased expression:heart (rat)
CTD Direct Evidence: marker/mechanism

PMID:22087236 PMID:22503866

RGD:6484266 RGD:7242181

NCBI chr 4:18,196,431...18,876,889
Ensembl chr 4:23,483,377...23,581,212

G

protein kinase C epsilon

CTD Direct Evidence: therapeutic
RNA:decreased expression:myocardium:

PMID:16782078 PMID:28887629

NCBI chr2A:45,757,629...46,294,064
Ensembl chr2A:46,688,436...47,220,313

G

protein kinase D1

treatment

NCBI chr14:10,353,284...10,707,841
Ensembl chr14:28,496,282...28,650,030

G

protein C, inactivator of coagulation factors Va and VIIIa

NCBI chr2B:32,846,899...32,859,060
Ensembl chr2B:128,083,794...128,094,625

G

proteasome 20S subunit alpha 6

susceptibility

ClinVar Annotator: match by term: Myocardial infarction, susceptibility to

PMID:16845397 PMID:19282875

NCBI chr14:16,044,300...16,069,521
Ensembl chr14:34,214,271...34,252,347

G

prostaglandin I2 synthase

susceptibility

DNA:SNP::1117C>A (human)
DNA:silent mutation:exon 8:1117C>A (human)
DNA:SNP:CDS: (rs5629) (human)

PMID:12040339 PMID:19040046 PMID:19046748 PMID:19327107

RGD:2313891 RGD:401901147 RGD:401901155 RGD:401901268

NCBI chr20:45,841,238...45,905,641
Ensembl chr20:46,905,665...46,971,612

G

prostaglandin-endoperoxide synthase 2

NCBI chr 1:162,205,534...162,214,130
Ensembl chr 1:166,355,845...166,364,519

G

pleiotrophin

protein:increased expression:myocardium (rat)

NCBI chr 7:129,184,786...129,300,815
Ensembl chr 7:141,701,430...141,705,623

G

RAD50 double strand break repair protein

treatment

NCBI chr 5:127,972,630...128,059,911
Ensembl chr 5:134,134,495...134,222,261

G

RAN binding protein 1

protein:decreased expression:heart ventricle, cytoplasm (rat)

NCBI chr22:2,877,954...2,888,035
Ensembl chr22:18,549,055...18,560,573

G

retinol binding protein 4

protein:increased expression:blood serum (human)

NCBI chr10:90,337,879...90,347,530
Ensembl chr10:93,848,166...93,857,887

G

renin

susceptibility

CTD Direct Evidence: marker/mechanism
associated with Hypertension; protein:increased activity:plasma (human)

PMID:1668233 PMID:1759997

NCBI chr 1:179,757,653...179,769,530
Ensembl chr 1:184,046,117...184,057,393

G

resistin

protein:increased expression:plasma

NCBI chr19:6,958,536...6,960,032
Ensembl chr19:7,812,942...7,814,909

G

ribosomal protein S6 kinase B1

protein:increased threonine phosphorylation:heart left ventricle

NCBI chr17:53,958,807...54,014,752
Ensembl chr17:58,799,069...58,853,653

G

ryanodine receptor 1

protein:hyperphosphorylation:extensor digitorum longus:

NCBI chr19:35,527,466...35,685,446
Ensembl chr19:44,106,036...44,256,327

G

S100 calcium binding protein B

CTD Direct Evidence: marker/mechanism
mRNA, protein:increased expression:left ventricle myocardium, plasma

PMID:9788975 PMID:19910580

NCBI chr21:33,063,845...33,070,073
Ensembl chr21:46,197,750...46,203,953

G

syndecan 1

mRNA:increased expression:myocardium

NCBI chr2A:20,187,249...20,211,567
Ensembl chr2A:20,302,589...20,309,848

G

syndecan 4

protein:increased expression:plasma

NCBI chr20:41,656,406...41,679,549
Ensembl chr20:42,746,281...42,769,737

G

selectin L

CTD Direct Evidence: marker/mechanism

NCBI chr 1:145,173,700...145,194,927
Ensembl chr 1:148,895,373...148,916,393

G

selectin P

susceptibility

protein:increased expression:serum
DNA:polymorphisms, haplotypes:cds:p.S290N, p.N562D, p.T715P (human)
associated with Hypertension;protein:increased expression:plasma

PMID:12165563 PMID:17391113 PMID:21162967 PMID:21567088

RGD:1580075 RGD:2312304 RGD:6218991 RGD:6219003

NCBI chr 1:145,071,094...145,112,851
Ensembl chr 1:148,793,677...148,834,701

G

serpin family E member 1

susceptibility

DNA:deletion:promoter:g.-676_-674delG (human)

PMID:12477941 PMID:16053971

RGD:1626626 RGD:8547882

NCBI chr 7:93,267,517...93,279,728
Ensembl chr 7:106,510,130...106,518,450

G

secreted frizzled related protein 2

PMID:19079247 PMID:19109969

RGD:155883169 RGD:4107088

NCBI chr 4:146,123,075...146,131,543
Ensembl chr 4:157,944,733...157,953,258

G

SH2B adaptor protein 3

CTD Direct Evidence: marker/mechanism

NCBI chr12:108,977,344...109,024,029

G

sonic hedgehog signaling molecule

treatment

NCBI chr 7:147,400,112...147,414,036
Ensembl chr 7:159,114,666...159,126,651

G

sirtuin 1

protein:altered localization:nucleus

NCBI chr10:64,368,878...64,401,684
Ensembl chr10:66,681,598...66,715,069

G

sirtuin 3

treatment

NCBI chr11:210,052...233,969
Ensembl chr11:255,191...278,732

G

solute carrier family 27 member 1

protein:decreased expression:infarcted heart

NCBI chr19:16,956,000...16,993,429
Ensembl chr19:17,929,785...17,966,171

G

solute carrier family 27 member 6

protein:decreased expression:heart

NCBI chr 5:124,378,721...124,447,729
Ensembl chr 5:130,140,967...130,212,940

G

secretory leukocyte peptidase inhibitor

treatment

NCBI chr20:41,583,429...41,585,773
Ensembl chr20:42,673,417...42,675,773

G

SMAD family member 2

treatment
ameliorates

PMID:11087260 PMID:33409963

RGD:12903276 RGD:401794430

NCBI chr18:41,213,001...41,309,902
Ensembl chr18:44,580,905...44,668,530

G

SMAD family member 3

ameliorates

NCBI chr15:46,013,764...46,143,126
Ensembl chr15:64,284,949...64,414,185

G

SMAD family member 4

treatment

NCBI chr18:44,402,112...44,456,779
Ensembl chr18:47,764,568...47,797,359

G

suppressor of cytokine signaling 1

protein:increased expression:heart

NCBI chr16:10,196,432...10,198,205

G

superoxide dismutase 1

treatment

CTD Direct Evidence: therapeutic
human gene in a rat model

PMID:11864929 PMID:21600015 PMID:22006090

RGD:1581222 RGD:8655953

NCBI chr21:18,029,831...18,037,526

G

superoxide dismutase 2

CTD Direct Evidence: therapeutic

PMID:2313102 PMID:9250167 PMID:12160945 PMID:14575298

RGD:1580839 RGD:1580840 RGD:1581148

NCBI chr 6:157,562,814...157,610,155
Ensembl chr 6:162,576,082...162,589,960

G

superoxide dismutase 3

NCBI chr 4:19,195,941...19,201,298
Ensembl chr 4:24,485,059...24,485,781

G

secreted protein acidic and cysteine rich

mRNA:increased expression:heart

NCBI chr 5:147,087,903...147,112,466
Ensembl chr 5:153,090,181...153,115,750

G

secreted phosphoprotein 1

PMID:12939547 PMID:14500723

RGD:1581325 RGD:1581386

NCBI chr 4:80,263,711...80,271,466
Ensembl chr 4:90,988,200...90,995,935

G

serine and arginine rich splicing factor 1

treatment

protein:increased phosphorylation:heart left ventricle(rat)

NCBI chr17:52,083,676...52,087,454
Ensembl chr17:56,937,295...56,944,425

G

T-box transcription factor 3

NCBI chr12:112,240,050...112,254,299
Ensembl chr12:115,620,002...115,631,316

G

T-box transcription factor 5

treatment

NCBI chr12:111,954,222...112,009,261
Ensembl chr12:115,333,609...115,389,739

G

TEK receptor tyrosine kinase

protein:increased expression:ventricle myocardium

NCBI chr 9:26,955,339...27,077,809
Ensembl chr 9:27,561,421...27,683,572

G

tissue factor pathway inhibitor

treatment

mRNA,protein:increased expression:heart:

PMID:14656922 PMID:15630488 PMID:21229253

RGD:11060131 RGD:11060139 RGD:11062083

NCBI chr2B:74,744,154...74,834,338
Ensembl chr2B:192,541,881...192,581,384

G

transforming growth factor beta 1

susceptibility

mRNA,protein:increased expression:heart:
associated with Coronary Disease;DNA:polymorphism:promoter:-509C>T (human)
CTD Direct Evidence: marker/mechanism

PMID:16310260 PMID:16543493 PMID:27121011

RGD:11073666 RGD:1601560

NCBI chr19:38,324,009...38,347,003
Ensembl chr19:46,831,659...46,852,973

G

transforming growth factor beta 2

NCBI chr 1:193,907,398...194,005,800
Ensembl chr 1:198,758,751...198,859,041

G

transforming growth factor beta receptor 1

NCBI chr 9:70,195,007...70,243,514
Ensembl chr 9:98,332,739...98,362,748

G

transforming growth factor beta receptor 2

protein:increased expression:myocardium

NCBI chr 3:30,536,187...30,623,653
Ensembl chr 3:30,854,460...30,938,856

G

tyrosine hydroxylase

no_association

DNA:polymorphism:intron:g.1170_1173dupTCAT (human)

NCBI chr11:2,204,820...2,212,750
Ensembl chr11:2,231,248...2,242,433

G

thrombomodulin

CTD Direct Evidence: marker/mechanism

PMID:9843165 PMID:10627464

NCBI chr20:22,992,341...22,996,415
Ensembl chr20:23,345,917...23,347,812

G

thrombospondin 1

mRNA, protein:increased expression:myocardium

NCBI chr15:18,521,802...18,538,172
Ensembl chr15:36,776,756...36,793,170

G

TIMP metallopeptidase inhibitor 2

CTD Direct Evidence: marker/mechanism

NCBI chr17:72,928,692...73,001,892
Ensembl chr17:78,476,807...78,495,649

G

toll like receptor 4

DNA:SNP:intron:rs1927911, minor allele associated with decreased risk

PMID:15864121 PMID:18549840

RGD:1580734 RGD:5562819

NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711

G

transmembrane 6 superfamily member 2

CTD Direct Evidence: marker/mechanism

NCBI chr19:18,703,075...18,712,056
Ensembl chr19:19,706,235...19,715,096

G

tenascin C

protein:increased expression:heart, fibroblast

NCBI chr 9:86,125,672...86,222,804
Ensembl chr 9:114,486,778...114,584,299

G

tumor necrosis factor

CTD Direct Evidence: marker/mechanism
mRNA, protein:increased expression:left ventricle myocardium, plasma

PMID:15883752 PMID:16310260 PMID:21362018

NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381

G

TNF receptor superfamily member 11b

NCBI chr 8:115,614,778...115,643,387
Ensembl chr 8:118,134,305...118,162,422

G

TNF receptor superfamily member 12A

CTD Direct Evidence: marker/mechanism

NCBI chr16:1,962,179...1,964,223
Ensembl chr16:3,134,577...3,136,581

G

TNF receptor superfamily member 14

protein:increased expression:heart, cardiomyocyte, endothelial cell (rat)

NCBI chr 1:1,288,493...1,296,532
Ensembl chr 1:2,427,631...2,435,615

G

TNF receptor superfamily member 1A

mRNA, protein:increased expression:left ventricle myocardium (rat)

PMID:15117889 PMID:20651834 PMID:21362018

RGD:1624194 RGD:5130892 RGD:5130975

NCBI chr12:6,457,617...6,470,969
Ensembl chr12:6,374,257...6,387,613

G

TNF receptor superfamily member 1B

mRNA, protein:decreased expression:left ventricle myocardium (rat)

NCBI chr 1:10,915,743...10,957,765
Ensembl chr 1:12,130,663...12,172,646

G

TNF superfamily member 11

protein:increased expression:serum

NCBI chr13:23,750,835...23,784,740

G

TNF superfamily member 4

susceptibility

CTD Direct Evidence: marker/mechanism

NCBI chr 1:148,684,689...148,989,775
Ensembl chr 1:152,391,450...152,415,845
Ensembl chr 1:152,391,450...152,415,845

G

troponin I3, cardiac type

CTD Direct Evidence: marker/mechanism

NCBI chr19:52,193,061...52,198,782
Ensembl chr19:60,887,630...60,894,219

G

troponin T2, cardiac type

NCBI chr 1:176,957,298...176,976,033

G

tumor protein p53

CTD Direct Evidence: marker/mechanism

NCBI chr17:7,699,449...7,717,812
Ensembl chr17:7,684,922...7,706,120

G

triggering receptor expressed on myeloid cells 1

disease_progression
ameliorates

NCBI chr 6:40,861,283...40,874,446
Ensembl chr 6:42,163,337...42,183,091

G

transient receptor potential cation channel subfamily V member 1

NCBI chr17:3,612,781...3,658,608
Ensembl chr17:3,609,952...3,637,579

G

titin

NCBI chr2B:65,783,512...66,064,618

G

thioredoxin

NCBI chr 9:81,399,056...81,411,607
Ensembl chr 9:109,565,557...109,578,311

G

thioredoxin reductase 1

mRNA:decreased expression:heart left ventricle (rat)

NCBI chr12:101,862,703...101,925,104
Ensembl chr12:105,187,128...105,321,112

G

ubiquitin D

mRNA, protein; increased expression; myocardium (rat)

NCBI chr 6:29,359,680...29,364,014
Ensembl chr 6:30,018,444...30,022,814

G

urotensin 2

associated with Heart Failure, Congestive;mRNA:increased expression:heart ventricle

NCBI chr 1:6,609,104...6,616,966
Ensembl chr 1:7,854,687...7,864,688

G

urotensin 2 receptor

associated with Heart Failure, Congestive;mRNA:increased expression:heart ventricle

NCBI chr17:76,783,432...76,788,639
Ensembl chr17:82,592,312...82,593,702

G

versican

NCBI chr 5:31,699,278...31,810,169
Ensembl chr 5:32,019,709...32,130,351

G

voltage dependent anion channel 1

CTD Direct Evidence: marker/mechanism

NCBI chr 5:129,375,267...129,408,230
Ensembl chr 5:135,529,173...135,560,005

G

voltage dependent anion channel 2

treatment

NCBI chr10:71,739,395...71,763,835

G

vascular endothelial growth factor A

treatment

protein:increased expression:serum,platelet:

PMID:10652191 PMID:25936512

RGD:126925214 RGD:7483604

NCBI chr 6:43,361,053...43,377,366
Ensembl chr 6:44,650,365...44,666,353

G

vascular endothelial growth factor B

NCBI chr11:59,591,750...59,595,926

G

von Willebrand factor

protein:increased expression:heart:

NCBI chr12:6,073,836...6,249,806
Ensembl chr12:5,990,612...6,165,153

G

WD repeat domain 12

CTD Direct Evidence: marker/mechanism

PMID:19198609 PMID:25915632

NCBI chr2B:90,112,037...90,145,520
Ensembl chr2B:208,260,696...208,291,783

G

WRN RecQ like helicase

NCBI chr 8:30,353,643...30,492,978
Ensembl chr 8:27,541,145...27,679,855

G

X-ray repair cross complementing 3

susceptibility

DNA:polymorphism:: (human)

NCBI chr14:84,323,644...84,341,763
Ensembl chr14:104,131,903...104,149,037

G

zinc finger E-box binding homeobox 2

protein:increased expression:heart (rat)

NCBI chr2B:15,325,094...15,460,908
Ensembl chr2B:148,460,904...148,596,500

Myocardial Reperfusion Injury

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 8

NCBI chr11:17,447,564...17,531,513
Ensembl chr11:17,133,063...17,216,870

G

activin A receptor type 2B

treatment

mRNA, protein:decreased expression:heart (mouse)
human construct in mouse model

NCBI chr 3:38,350,838...38,389,839
Ensembl chr 3:38,633,093...38,662,063

G

adenosine deaminase

protein:increased expression

NCBI chr20:40,950,238...40,982,481
Ensembl chr20:42,044,613...42,076,868

G

adiponectin, C1Q and collagen domain containing

CTD Direct Evidence: therapeutic

NCBI chr 3:183,876,051...183,889,723
Ensembl chr 3:192,341,320...192,354,885

G

adrenoceptor beta 1

CTD Direct Evidence: marker/mechanism

PMID:10900253 PMID:17201736

NCBI chr10:110,642,491...110,646,595

G

adrenoceptor beta 2

NCBI chr 5:144,259,756...144,398,421
Ensembl chr 5:150,267,554...150,315,892

G

advanced glycosylation end-product specific receptor

protein:increased expression:heart (rat)

NCBI chr 6:31,828,363...31,831,981
Ensembl chr 6:32,708,251...32,711,641

G

amylo-alpha-1,6-glucosidase and 4-alpha-glucanotransferase

NCBI chr 1:102,506,234...102,580,183
Ensembl chr 1:101,226,120...101,299,511

G

angiotensinogen

CTD Direct Evidence: marker/mechanism|therapeutic

PMID:2535056 PMID:19166939

NCBI chr 1:206,252,141...206,263,830
Ensembl chr 1:211,279,015...211,291,044

G

angiotensin II receptor type 1

protein:increased expression:myocardium

NCBI chr 3:145,722,475...145,767,550
Ensembl chr 3:153,341,947...153,345,380

G

aryl hydrocarbon receptor

treatment

NCBI chr 7:17,949,254...17,998,737
Ensembl chr 7:17,278,637...17,326,171

G

apoptosis inducing factor mitochondria associated 1

protein:decreased expression:mitochondrion:

NCBI chr X:119,256,425...119,292,612
Ensembl chr X:129,550,287...129,586,271

G

AKT serine/threonine kinase 1

protein:increased phosphorylation:heart left ventricle

NCBI chr14:85,417,229...85,444,722
Ensembl chr14:105,208,128...105,236,756

G

AKT serine/threonine kinase 2

NCBI chr19:37,275,799...37,331,971
Ensembl chr19:45,791,800...45,840,271

G

albumin

CTD Direct Evidence: marker/mechanism

NCBI chr 4:50,773,244...50,790,474
Ensembl chr 4:56,605,322...56,622,418

G

aldehyde dehydrogenase 2 family member

NCBI chr12:109,343,020...109,385,060
Ensembl chr12:112,734,243...112,776,471

G

arachidonate 5-lipoxygenase

NCBI chr10:42,461,398...42,531,576
Ensembl chr10:45,639,946...45,710,016

G

angiopoietin 2

mRNA, protein:increased expression:myocardium (rat)

NCBI chr 8:718,367...782,534
Ensembl chr 8:6,506,014...6,566,915

G

ankyrin 1

NCBI chr 8:40,897,879...41,140,290
Ensembl chr 8:38,346,503...38,588,549

G

ankyrin 2

NCBI chr 4:105,315,776...105,882,506
Ensembl chr 4:115,967,106...116,443,905

G

ankyrin repeat domain 1

protein:decreased expression:myocardium

NCBI chr10:87,652,254...87,661,173
Ensembl chr10:91,180,034...91,188,165

G

annexin A1

treatment

protein:increased expression:heart, leukocyte

PMID:11641252 PMID:22924634

RGD:2306910 RGD:7421655

NCBI chr 9:51,647,404...51,665,990
Ensembl chr 9:71,929,728...71,948,779

G

apurinic/apyrimidinic endodeoxyribonuclease 1

protein:altered localization:cytoplasm

NCBI chr14:1,329,745...1,332,315
Ensembl chr14:19,381,911...19,384,542

G

arrestin beta 2

NCBI chr17:4,766,616...4,777,253
Ensembl chr17:4,757,048...4,767,517

G

activating transcription factor 3

NCBI chr 1:188,176,728...188,188,842
Ensembl chr 1:193,036,793...193,049,150

G

ATPase Na+/K+ transporting subunit alpha 1

CTD Direct Evidence: therapeutic

NCBI chr 1:86,162,401...86,193,883
Ensembl chr 1:121,212,488...121,243,099

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1

Ensembl chr16:29,265,516...29,290,807
Ensembl chr16:29,265,516...29,290,807

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

treatment

CTD Direct Evidence: marker/mechanism

PMID:10734148 PMID:28637456

NCBI chr12:107,857,009...107,924,938
Ensembl chr12:111,246,508...111,311,923

G

ATP synthase F1 subunit delta

treatment

protein:decreased expression:myocardium (rat)

PMID:25305180 PMID:26109848

RGD:13792666 RGD:13792676

G

BCL2 associated agonist of cell death

treatment

protein:increased expression, decreased serine phosphorylation:heart

PMID:15339931 PMID:23364609

RGD:10053674 RGD:2292700

NCBI chr11:59,626,981...59,641,824
Ensembl chr11:62,971,808...62,986,257

G

BCL2 associated X, apoptosis regulator

treatment

CTD Direct Evidence: marker/mechanism

PMID:20026869 PMID:21223820 PMID:25547710 PMID:31583047

RGD:10054103 RGD:13782178 RGD:155230831

NCBI chr19:45,955,926...45,962,870
Ensembl chr19:54,793,594...54,800,468

G

BCL2 apoptosis regulator

treatment

PMID:16289365 PMID:20821058 PMID:23364609 PMID:31583047

RGD:10053674 RGD:11561911 RGD:155230831 RGD:1599484

NCBI chr18:56,481,212...56,679,012
Ensembl chr18:59,802,443...59,992,100

G

BCL2 like 1

treatment

NCBI chr20:27,955,688...28,015,950
Ensembl chr20:29,088,055...29,146,585

G

beclin 1

treatment

PMID:20812860 PMID:20821058

RGD:11561911 RGD:11561944

NCBI chr17:14,493,619...14,507,809
Ensembl chr17:14,719,781...14,733,286

G

BH3 interacting domain death agonist

protein:increased cleavage:heart:

PMID:11934844 PMID:19940077

RGD:13782263 RGD:2317561

NCBI chr22:1,164,787...1,205,051
Ensembl chr22:16,594,186...16,632,844

G

BLK proto-oncogene, Src family tyrosine kinase

mRNA:increased expression:left ventricle (rat)

NCBI chr 8:7,637,680...7,708,914

G

BCL2 interacting protein 3

treatment

protein:decreased expression:myocardium (human)

PMID:16645637 PMID:28661226

RGD:11561983 RGD:155260328

NCBI chr10:128,671,663...128,685,952
Ensembl chr10:132,858,211...132,871,634

G

bromodomain containing 4

mRNA,protein:increased expression:heart

NCBI chr19:14,768,239...14,805,770
Ensembl chr19:15,754,930...15,789,600

G

BTG anti-proliferation factor 2

mRNA:increased expression:heart

NCBI chr 1:178,907,317...178,911,410
Ensembl chr 1:183,201,297...183,205,404

G

complement C3

protein:increased expression:myocardium

NCBI chr19:5,708,211...5,753,178
Ensembl chr19:6,629,287...6,674,699

G

complement C5

treatment

PMID:9631876 PMID:23067403

RGD:1600666 RGD:7411626

NCBI chr 9:92,069,574...92,202,513
Ensembl chr 9:120,426,354...120,523,856

G

caspase 1

CTD Direct Evidence: marker/mechanism

NCBI chr11:99,965,964...99,975,640
Ensembl chr11:103,448,497...103,458,149
Ensembl chr11:103,448,497...103,458,149

G

caspase 3

ameliorates
treatment

CTD Direct Evidence: marker/mechanism

PMID:14998631 PMID:18470603 PMID:29538428 PMID:30259997

RGD:13782276 RGD:2293314 RGD:329337366

NCBI chr 4:176,793,190...176,815,023
Ensembl chr 4:189,018,422...189,040,185

G

caspase 7

treatment

CTD Direct Evidence: marker/mechanism

PMID:14998631 PMID:29538428

NCBI chr10:110,273,318...110,324,800
Ensembl chr10:113,707,780...113,758,626

G

caspase 8

CTD Direct Evidence: marker/mechanism
protein:increased activity:cardiomyocyte

PMID:11934844 PMID:14998631

NCBI chr2B:88,490,611...88,542,132
Ensembl chr2B:206,669,544...206,696,468

G

caspase 9

treatment
ameliorates

CTD Direct Evidence: marker/mechanism
protein:increased activity:cardiomyocyte,endothelial cell

PMID:11934844 PMID:14998631 PMID:29538428 PMID:30259997

RGD:13782263 RGD:13782276 RGD:329337366

NCBI chr 1:14,630,659...14,662,865
Ensembl chr 1:15,624,666...15,656,266

G

calcium sensing receptor

protein:increased expression:ventricular myocardium (rat)

NCBI chr 3:119,278,071...119,383,901
Ensembl chr 3:126,252,765...126,285,268

G

calpastatin

ameliorates

human transcript overexpression in rat model

PMID:12482022 PMID:14519437

RGD:405101692 RGD:5683872

NCBI chr 5:91,972,572...92,084,657
Ensembl chr 5:97,527,071...97,636,650

G

catalase

CTD Direct Evidence: therapeutic

PMID:11510883 PMID:21600015

NCBI chr11:34,413,253...34,446,831
Ensembl chr11:34,289,603...34,323,160

G

Cbl proto-oncogene

severity

NCBI chr11:114,044,996...114,149,204
Ensembl chr11:117,973,187...118,074,671

G

C-C motif chemokine ligand 2

mRNA:increased expression:heart (rat)
CTD Direct Evidence: marker/mechanism

PMID:10908159 PMID:12087064

NCBI chr17:22,528,154...22,530,091
Ensembl chr17:22,820,890...22,823,384

G

C-C motif chemokine receptor 2

protein:decreased expression:monocyte:

NCBI chr 3:46,255,725...46,263,285
Ensembl chr 3:47,361,124...47,368,312

G

C-C motif chemokine receptor 5

treatment

protein:decreased expression:blood, monocyte (human)

PMID:15786508 PMID:23456481

RGD:4892017 RGD:8552227

NCBI chr 3:46,273,096...46,278,471
Ensembl chr 3:47,380,321...47,381,379

G

CASP8 and FADD like apoptosis regulator

treatment

NCBI chr2B:88,373,057...88,429,959
Ensembl chr2B:206,528,943...206,577,045

G

cannabinoid receptor 1

NCBI chr 6:86,017,141...86,044,889

G

cannabinoid receptor 2

NCBI chr 1:23,066,153...23,108,065
Ensembl chr 1:24,050,008...24,051,090

G

cordon-bleu WH2 repeat protein like 1

CTD Direct Evidence: marker/mechanism

NCBI chr2B:51,932,252...52,117,506
Ensembl chr2B:169,322,029...169,477,690

G

CREB binding protein

treatment

NCBI chr16:2,645,445...2,800,975
Ensembl chr16:3,820,519...3,974,206

G

C-reactive protein

protein:increased expression:serum

NCBI chr 1:135,062,102...135,064,402

G

C-X3-C motif chemokine receptor 1

protein:decreased expression:blood, monocyte

NCBI chr 3:39,158,346...39,176,604
Ensembl chr 3:39,440,955...39,457,219

G

C-X-C motif chemokine ligand 6

NCBI chr 4:50,357,643...50,359,822
Ensembl chr 4:56,189,961...56,192,402

G

diablo IAP-binding mitochondrial protein

CTD Direct Evidence: marker/mechanism

NCBI chr12:119,808,718...119,829,378
Ensembl chr12:123,176,405...123,196,359

G

dynamin 1 like

ameliorates

NCBI chr12:53,476,553...53,541,421
Ensembl chr12:56,077,504...56,142,376

G

endothelin converting enzyme 1

PMID:12193087 PMID:18586023

RGD:4892580 RGD:7244160

NCBI chr 1:20,166,019...20,290,803
Ensembl chr 1:21,206,199...21,278,909

G

endothelin 1

CTD Direct Evidence: marker/mechanism

PMID:15642760 PMID:16700825 PMID:18586023

NCBI chr 6:12,076,312...12,142,861
Ensembl chr 6:12,462,718...12,503,545

G

endothelin receptor type A

NCBI chr 4:139,815,336...139,879,600
Ensembl chr 4:151,476,356...151,536,497

G

endothelin receptor type B

NCBI chr13:59,112,349...59,136,615
Ensembl chr13:78,153,020...78,177,286

G

egl-9 family hypoxia inducible factor 1

susceptibility

NCBI chr 1:206,915,541...206,976,656

G

epoxide hydrolase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 8:26,761,090...26,818,436
Ensembl chr 8:23,964,094...24,017,749

G

estrogen receptor 1

NCBI chr 6:149,507,599...149,918,523
Ensembl chr 6:154,317,002...154,631,551

G

estrogen receptor 2

NCBI chr14:44,807,875...44,919,780
Ensembl chr14:63,064,402...63,131,303

G

Fas associated via death domain

treatment

PMID:26038570 PMID:26948086

RGD:11341801 RGD:13792504

NCBI chr11:65,300,889...65,305,020

G

Fas cell surface death receptor

treatment

NCBI chr10:85,707,457...85,741,539
Ensembl chr10:89,217,949...89,243,612

G

fission, mitochondrial 1

ameliorates

NCBI chr 7:93,381,058...93,386,483
Ensembl chr 7:106,621,211...106,626,683

G

glyceraldehyde-3-phosphate dehydrogenase

treatment

NCBI chr12:6,665,218...6,669,170
Ensembl chr12:6,583,895...6,587,729

G

glucagon

treatment

NCBI chr2B:49,436,379...49,446,559
Ensembl chr2B:166,806,016...166,811,155

G

growth differentiation factor 11

mRNA, protein:decreased expression:heart (mouse)

NCBI chr12:33,154,530...33,168,427
Ensembl chr12:33,879,180...33,893,252

G

gap junction protein alpha 1

CTD Direct Evidence: marker/mechanism

NCBI chr 6:119,213,513...119,227,617

G

glutaredoxin

mRNA:decreased expression:heart:

NCBI chr 5:19,526,210...19,535,237
Ensembl chr 5:19,671,965...19,680,685

G

glutathione peroxidase 3

NCBI chr 5:146,447,939...146,456,476

G

G protein-coupled receptor kinase 2

severity
treatment
susceptibility

associated with Diabetes Mellitus, Experimental
protein:increased expression:heart, mitochondrion (mouse)
associated with Hypertension

PMID:23467820 PMID:24170934 PMID:27296507 PMID:27601479 PMID:27865836

RGD:13513990 RGD:13513993 RGD:13513995 RGD:13792704 RGD:13792779

NCBI chr11:62,624,647...62,644,846
Ensembl chr11:65,939,164...65,959,066

G

glycogen synthase kinase 3 beta

treatment

PMID:20217242 PMID:26918336 PMID:29978610

RGD:13792725 RGD:13792772 RGD:5509104

NCBI chr 3:116,943,205...117,215,001
Ensembl chr 3:123,861,379...124,126,771

G

glutathione-disulfide reductase

treatment

NCBI chr 8:29,990,543...30,040,157
Ensembl chr 8:27,180,300...27,229,557

G

histone deacetylase 3

ameliorates

NCBI chr 5:136,981,790...136,997,786
Ensembl chr 5:143,094,406...143,110,322

G

hypoxia inducible factor 1 subunit alpha

treatment

mRNA:increased expression:heart
CTD Direct Evidence: marker/mechanism
protein:increased expression:myocardium

PMID:12189448 PMID:18549825 PMID:19727523 PMID:20170615 PMID:22050707

RGD:1626327 RGD:5147885 RGD:9068872

NCBI chr14:42,295,691...42,348,478
Ensembl chr14:60,552,374...60,604,885

G

high mobility group box 1

treatment

CTD Direct Evidence: marker/mechanism

PMID:19540007 PMID:21113057 PMID:23531454

RGD:10402066 RGD:10402170

NCBI chr13:11,737,942...11,894,923
Ensembl chr13:30,174,899...30,179,527

G

heme oxygenase 1

treatment

PMID:12709584 PMID:22179023 PMID:23921302

RGD:10755573 RGD:10755585 RGD:1598392

NCBI chr22:16,388,368...16,401,289
Ensembl chr22:34,230,825...34,244,063

G

histamine receptor H2

susceptibility

NCBI chr 5:171,004,893...171,057,539
Ensembl chr 5:177,928,039...177,931,566

G

histamine receptor H3

NCBI chr20:58,581,228...58,586,585
Ensembl chr20:59,901,327...59,909,901

G

heat shock transcription factor 1

NCBI chr 8:141,055,310...141,078,360
Ensembl chr 8:144,062,137...144,067,866

G

heat shock protein family A (Hsp70) member 1A

treatment

NCBI chr 6:31,476,710...31,491,411

G

heat shock protein family A (Hsp70) member 5

treatment

PMID:24129401 PMID:25547710

RGD:11354962 RGD:13782178

NCBI chr 9:96,351,645...96,356,761
Ensembl chr 9:124,865,211...124,870,458

G

HtrA serine peptidase 2

protein:increased expression:myocardium, cytosol (mouse)

NCBI chr2A:74,596,020...74,599,790
Ensembl chr2A:76,102,240...76,106,152

G

intercellular adhesion molecule 1

protein:increased expression:heart (rat)
CTD Direct Evidence: marker/mechanism

PMID:12087064 PMID:20851484

NCBI chr19:9,821,402...9,837,021
Ensembl chr19:10,484,414...10,500,605

G

interleukin 10

treatment

protein:increased expression:plasma

PMID:19275881 PMID:23840272

RGD:2311056 RGD:7365001

NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371

G

interleukin 17A

treatment

NCBI chr 6:51,736,269...51,740,538
Ensembl chr 6:53,004,820...53,009,074

G

interleukin 18

PMID:19164288 PMID:19805173

RGD:4889400 RGD:4889578

NCBI chr11:107,024,376...107,045,194
Ensembl chr11:110,867,586...110,888,371

G

interleukin 18 binding protein

mRNA:increased expression:heart

PMID:19164288 PMID:19805173

RGD:4889400 RGD:4889578

NCBI chr11:67,078,251...67,083,043
Ensembl chr11:70,302,923...70,307,511

G

interleukin 18 receptor accessory protein

NCBI chr2A:99,363,823...99,393,346
Ensembl chr2A:103,510,109...103,544,916

G

interleukin 1 alpha

treatment

PMID:7622355 PMID:8576926

RGD:7794741 RGD:7794764

NCBI chr2A:89,273,482...89,284,421
Ensembl chr2A:113,784,854...113,795,801

G

interleukin 1 beta

treatment

mRNA:increased expression:heart

PMID:17134725 PMID:31583047

RGD:155230831 RGD:1626628

NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424

G

interleukin 1 receptor like 2

compared to Wild Type in cardiopulmonary bypass model

Ensembl chr2A:103,237,996...103,289,414

G

interleukin 1 receptor antagonist

rat model treated with human protein

NCBI chr2A:88,991,646...89,008,013
Ensembl chr2A:114,061,182...114,078,839

G

interleukin 36 receptor antagonist

NCBI chr2A:89,059,526...89,065,695
Ensembl chr2A:114,004,209...114,009,865

G

interleukin 6

treatment

PMID:27087891 PMID:31583047

RGD:11062149 RGD:155230831

NCBI chr 7:23,415,922...23,420,767

G

interleukin 6 receptor

NCBI chr 1:129,761,914...129,824,386
Ensembl chr 1:133,374,078...133,433,089

G

inhibin subunit beta A

mRNA, protein:increased expression:heart (mouse)

NCBI chr 7:42,538,591...42,556,578
Ensembl chr 7:42,580,730...42,595,097

G

interleukin 1 receptor associated kinase 1

protein:increased activity:ventricle myocardium (rat)

NCBI chr X:143,560,802...143,570,185
Ensembl chr X:153,446,827...153,460,602

G

interferon regulatory factor 9

ameliorates
exacerbates

protein:increased expression:left ventricular free wall

NCBI chr14:4,937,068...4,942,870
Ensembl chr14:23,061,990...23,067,824

G

Janus kinase 2

treatment

associated with Diabetes Mellitus, Experimental

PMID:23747931 PMID:23796350

RGD:10403071 RGD:8694332

NCBI chr 9:4,820,303...4,971,867
Ensembl chr 9:5,006,271...5,156,626

G

potassium inwardly rectifying channel subfamily J member 11

NCBI chr11:17,440,522...17,444,075
Ensembl chr11:17,127,557...17,128,729

G

potassium inwardly rectifying channel subfamily J member 8

NCBI chr12:64,522,172...64,532,848
Ensembl chr12:67,127,263...67,137,128

G

kininogen 1

CTD Direct Evidence: therapeutic

PMID:2535056 PMID:7856280

NCBI chr 3:183,751,598...183,778,655
Ensembl chr 3:192,219,462...192,245,149

G

leptin

NCBI chr 7:120,230,896...120,248,602
Ensembl chr 7:132,885,011...132,901,519

G

leptin receptor

mRNA:decreased expression:heart
mRNA:altered expression:heart

PMID:15284063 PMID:17134725

RGD:1626628 RGD:5129123

NCBI chr 1:64,772,612...64,881,886
Ensembl chr 1:66,693,926...66,764,768

G

uncharacterized LOC100974886

NCBI chr 4:50,092,989...50,095,541
Ensembl chr 4:55,925,562...55,986,555

G

growth-regulated alpha protein

NCBI chr 4:50,325,248...50,327,165
Ensembl chr 4:56,153,899...56,159,474

G

cytochrome b-245 heavy chain

CTD Direct Evidence: marker/mechanism

NCBI chr X:30,230,394...30,267,379
Ensembl chr X:37,939,704...37,973,183

G

histone H2AX

treatment

NCBI chr11:113,932,078...113,933,679

G

lumican

NCBI chr12:88,636,825...88,644,665
Ensembl chr12:91,952,277...91,960,388

G

microtubule associated protein 1 light chain 3 alpha

treatment

protein:increased expression:heart

PMID:20812860 PMID:20821058

RGD:11561911 RGD:11561944

NCBI chr20:30,887,345...30,888,986
Ensembl chr20:32,010,284...32,020,411

G

mitogen-activated protein kinase kinase 6

PMID:14749328 PMID:15492008

RGD:1582277 RGD:7495840

NCBI chr17:63,342,720...63,483,926
Ensembl chr17:68,730,011...68,870,454

G

mitogen-activated protein kinase kinase kinase 5

treatment

NCBI chr 6:134,316,841...134,582,843
Ensembl chr 6:138,406,398...138,641,727

G

mitogen-activated protein kinase 1

treatment

PMID:15653762 PMID:25345742

RGD:13800900 RGD:1582282

NCBI chr22:3,883,119...3,990,368
Ensembl chr22:20,365,487...20,450,335

G

mitogen-activated protein kinase 14

NCBI chr 6:35,586,847...35,683,041
Ensembl chr 6:36,788,233...36,871,114

G

mitogen-activated protein kinase 3

treatment

PMID:25345742 PMID:28814571 PMID:29741915

RGD:13800564 RGD:13800874 RGD:13800900

Ensembl chr16:30,489,362...30,498,017

G

mitogen-activated protein kinase 8

treatment

PMID:12883833 PMID:15309413 PMID:31583047

RGD:155230831 RGD:1582311 RGD:1582312

NCBI chr10:45,806,748...45,936,362

G

myoglobin

PMID:11972171 PMID:15132981

RGD:1582385 RGD:1582431

NCBI chr22:16,612,519...16,645,333
Ensembl chr22:34,452,451...34,463,224

G

mannose binding lectin 2

treatment

NCBI chr10:49,401,364...49,409,328
Ensembl chr10:51,527,758...51,543,432

G

MDM2 proto-oncogene

protein:increased serine phosphorylation:heart ventricle (rat)

NCBI chr12:66,322,340...66,357,010
Ensembl chr12:69,102,084...69,133,278

G

mitofusin 2

treatment

NCBI chr 1:10,729,933...10,764,865
Ensembl chr 1:11,945,880...11,981,077

G

marker of proliferation Ki-67

NCBI chr10:124,684,336...124,714,143
Ensembl chr10:128,936,037...128,962,555

G

matrix metallopeptidase 1

PMID:12892382 PMID:17996137

RGD:1582539 RGD:7207397

NCBI chr11:97,730,545...97,739,190
Ensembl chr11:101,221,393...101,230,104

G

matrix metallopeptidase 2

treatment

PMID:16699069 PMID:23889688

RGD:1582614 RGD:8657084

NCBI chr16:35,711,866...35,738,881
Ensembl chr16:54,812,694...54,844,279

G

myostatin

mRNA, protein:increased expression:heart (mouse)

NCBI chr2B:77,364,927...77,452,426
Ensembl chr2B:195,283,903...195,290,922

G

MYD88 innate immune signal transduction adaptor

NCBI chr 3:38,036,565...38,041,014
Ensembl chr 3:38,319,024...38,323,572

G

nucleolin

protein:decreased expression:heart

NCBI chr2B:118,703,148...118,712,893
Ensembl chr2B:237,490,378...237,500,193

G

NADH:ubiquinone oxidoreductase core subunit S1

treatment

NCBI chr2B:93,363,092...93,399,326
Ensembl chr2B:211,493,021...211,528,496

G

NFE2 like bZIP transcription factor 1

treatment

NCBI chr17:9,476,482...9,489,661
Ensembl chr17:9,657,847...9,671,040

G

NFE2 like bZIP transcription factor 2

NCBI chr2B:64,509,446...64,544,600
Ensembl chr2B:182,214,116...182,248,085

G

NFKB inhibitor alpha

treatment

NCBI chr14:16,155,331...16,158,588

G

nitric oxide synthase 2

CTD Direct Evidence: marker/mechanism|therapeutic
mRNA:decreased expression:heart (rat)

PMID:12003803 PMID:12087064 PMID:14990356 PMID:19207477 PMID:20828608 More...

NCBI chr17:28,984,295...29,021,516
Ensembl chr17:29,471,510...29,617,093

G

nitric oxide synthase 3

treatment

CTD Direct Evidence: therapeutic

PMID:12354446 PMID:18390819 PMID:20828747 PMID:29274587 PMID:29299201

RGD:13503347 RGD:13504684 RGD:2292091 RGD:4891991

NCBI chr 7:142,577,334...142,600,702
Ensembl chr 7:154,730,009...154,755,233

G

NADPH oxidase 1

mRNA:increased expression:heart

NCBI chr X:90,046,023...90,076,968
Ensembl chr X:100,182,398...100,215,192

G

natriuretic peptide B

NCBI chr 1:10,621,416...10,622,960
Ensembl chr 1:11,838,518...11,839,995

G

natriuretic peptide C

NCBI chr2B:119,148,774...119,153,381
Ensembl chr2B:237,936,939...237,941,244

G

natriuretic peptide receptor 3

NCBI chr 5:77,542,200...77,621,983
Ensembl chr 5:82,926,409...83,004,964

G

neuropeptide Y receptor Y1

mRNA:decreased expression:heart left ventricle

NCBI chr 4:155,583,870...155,604,336
Ensembl chr 4:167,372,310...167,381,597

G

oxidized low density lipoprotein receptor 1

treatment

NCBI chr12:10,196,712...10,210,432
Ensembl chr12:10,445,202...10,461,071

G

opioid receptor delta 1

NCBI chr 1:28,068,053...28,143,053
Ensembl chr 1:29,112,152...29,163,464

G

oxytocin/neurophysin I prepropeptide

NCBI chr20:3,157,246...3,159,013

G

purinergic receptor P2Y12

NCBI chr 3:148,364,151...148,412,231

G

poly(ADP-ribose) polymerase 1

PMID:9670921 PMID:23598272

RGD:11073735 RGD:5683917

NCBI chr 1:201,820,355...201,867,673
Ensembl chr 1:206,812,981...206,860,356

G

pro-apoptotic WT1 regulator

treatment

NCBI chr12:77,114,282...77,224,116
Ensembl chr12:79,969,517...80,070,796

G

protein disulfide isomerase family A member 3

NCBI chr15:22,706,520...22,731,672
Ensembl chr15:40,794,144...40,821,763

G

platelet and endothelial cell adhesion molecule 1

NCBI chr17:58,417,134...58,526,409
Ensembl chr17:63,511,784...63,579,067

G

pleckstrin homology like domain family A member 3

CTD Direct Evidence: marker/mechanism

NCBI chr 1:177,063,775...177,067,714
Ensembl chr 1:181,367,976...181,368,359

G

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma

NCBI chr 7:98,841,974...98,885,446
Ensembl chr 7:111,570,148...111,611,614

G

phospholipase C delta 1

protein:altered activity

NCBI chr 3:37,906,359...37,928,564
Ensembl chr 3:38,189,496...38,206,886

G

phospholipase D2

protein:altered activity:sarcolemma, sarcoplasmic reticulum, heart left ventricle

NCBI chr17:4,853,919...4,870,254
Ensembl chr17:4,843,217...4,858,425

G

phospholamban

treatment

CTD Direct Evidence: marker/mechanism

PMID:10734148 PMID:21934351

NCBI chr 6:116,357,335...116,370,382
Ensembl chr 6:120,509,510...120,509,668

G

peroxisome proliferator activated receptor alpha

CTD Direct Evidence: therapeutic

Ensembl chr22:45,218,364...45,302,970

G

peroxisome proliferator activated receptor delta

NCBI chr 6:34,903,798...34,987,208
Ensembl chr 6:36,003,988...36,081,132

G

peroxisome proliferator activated receptor gamma

NCBI chr 3:12,215,322...12,361,669
Ensembl chr 3:12,622,397...12,705,060

G

PPARG coactivator 1 alpha

treatment

NCBI chr 4:18,196,431...18,876,889
Ensembl chr 4:23,483,377...23,581,212

G

protein kinase AMP-activated catalytic subunit alpha 2

treatment

NCBI chr 1:55,928,577...55,998,628
Ensembl chr 1:57,664,237...57,702,227

G

protein kinase C beta

NCBI chr16:13,888,936...14,268,759
Ensembl chr16:24,091,289...24,466,203

G

protein kinase C delta

protein:decreased expression:heart

NCBI chr 3:53,104,137...53,135,588
Ensembl chr 3:54,330,328...54,357,910

G

protein kinase D1

ameliorates

NCBI chr14:10,353,284...10,707,841
Ensembl chr14:28,496,282...28,650,030

G

protein kinase cGMP-dependent 1

treatment

PMID:18332860 PMID:19845676

RGD:7777120 RGD:7777130

NCBI chr10:47,642,312...48,935,188
Ensembl chr10:49,779,211...51,064,882

G

protein C receptor

treatment

NCBI chr20:31,500,838...31,543,928
Ensembl chr20:32,622,876...32,628,320

G

phosphatase and tensin homolog

treatment

CTD Direct Evidence: marker/mechanism

PMID:19038262 PMID:20951693

NCBI chr10:84,587,841...84,689,043
Ensembl chr10:88,093,539...88,194,605

G

prostaglandin E receptor 3

treatment

NCBI chr 1:70,076,610...70,271,475
Ensembl chr 1:72,059,441...72,254,063

G

prostaglandin-endoperoxide synthase 2

NCBI chr 1:162,205,534...162,214,130
Ensembl chr 1:166,355,845...166,364,519

G

RAP1A, member of RAS oncogene family

treatment

NCBI chr 1:114,279,255...114,376,977
Ensembl chr 1:125,971,598...125,994,813

G

RELA proto-oncogene, NF-kB subunit

treatment

protein:altered localization:nucleus

PMID:18636044 PMID:31583047

RGD:155230831 RGD:2298773

NCBI chr11:61,012,839...61,022,225
Ensembl chr11:64,347,859...64,356,868

G

ras homolog family member A

protein:altered localization:heart

NCBI chr 3:49,282,009...49,339,887

G

ring finger protein 41

severity

NCBI chr12:32,693,349...32,710,866
Ensembl chr12:32,944,814...32,962,584

G

renalase, FAD dependent amine oxidase

NCBI chr10:84,996,999...85,304,240
Ensembl chr10:88,503,683...88,808,990

G

S100 calcium binding protein B

mRNA, protein:increased expression:myocardium

NCBI chr21:33,063,845...33,070,073
Ensembl chr21:46,197,750...46,203,953

G

selectin P

CTD Direct Evidence: marker/mechanism

PMID:12087064 PMID:21146547

NCBI chr 1:145,071,094...145,112,851
Ensembl chr 1:148,793,677...148,834,701

G

serpin family A member 3

NCBI chr14:75,220,252...75,247,996
Ensembl chr14:94,551,934...94,579,515

G

serpin family E member 1

treatment

NCBI chr 7:93,267,517...93,279,728
Ensembl chr 7:106,510,130...106,518,450

G

serpin family G member 1

treatment

NCBI chr11:52,838,502...52,855,781
Ensembl chr11:56,309,686...56,326,639

G

secreted frizzled related protein 2

NCBI chr 4:146,123,075...146,131,543
Ensembl chr 4:157,944,733...157,953,258

G

SH2B adaptor protein 3

NCBI chr12:108,977,344...109,024,029

G

sonic hedgehog signaling molecule

protein:increased expression:heart

NCBI chr 7:147,400,112...147,414,036
Ensembl chr 7:159,114,666...159,126,651

G

sirtuin 1

CTD Direct Evidence: therapeutic

NCBI chr10:64,368,878...64,401,684
Ensembl chr10:66,681,598...66,715,069

G

solute carrier family 25 member 4

treatment

NCBI chr 4:177,310,982...177,315,016
Ensembl chr 4:189,531,914...189,534,549

G

solute carrier family 2 member 1

NCBI chr 1:42,224,273...42,257,184
Ensembl chr 1:43,600,733...43,634,143

G

solute carrier family 2 member 4

NCBI chr17:7,312,605...7,319,430
Ensembl chr17:7,299,966...7,306,344

G

solute carrier family 8 member A1

CTD Direct Evidence: marker/mechanism
protein:increased activity:cardiac muscle cell

PMID:15215644 PMID:17267548 PMID:17822695

RGD:1642716 RGD:1642729

NCBI chr2A:40,169,339...40,586,546
Ensembl chr2A:40,939,900...41,363,038

G

solute carrier family 9 member A1

NCBI chr 1:26,359,818...26,418,910
Ensembl chr 1:27,414,937...27,475,089

G

SMAD family member 1

NCBI chr 4:137,822,269...137,899,700
Ensembl chr 4:149,481,836...149,558,135

G

SMAD family member 3

treatment

NCBI chr15:46,013,764...46,143,126
Ensembl chr15:64,284,949...64,414,185

G

SMAD family member 4

treatment

NCBI chr18:44,402,112...44,456,779
Ensembl chr18:47,764,568...47,797,359

G

superoxide dismutase 1

treatment

human protein in a rat model

PMID:12668130 PMID:19277497 PMID:23629152

RGD:11035287 RGD:8655884 RGD:8655965

NCBI chr21:18,029,831...18,037,526

G

superoxide dismutase 2

treatment

PMID:11864929 PMID:12668130

RGD:11035287 RGD:1581222

NCBI chr 6:157,562,814...157,610,155
Ensembl chr 6:162,576,082...162,589,960

G

sorbitol dehydrogenase

protein:increased activity:heart
CTD Direct Evidence: marker/mechanism

PMID:14525943 PMID:18549825

NCBI chr15:23,971,017...24,025,043

G

secreted phosphoprotein 1

NCBI chr 4:80,263,711...80,271,466
Ensembl chr 4:90,988,200...90,995,935

G

signal transducer and activator of transcription 1

protein:increased phosphorylation:heart

NCBI chr2B:78,270,642...78,316,074
Ensembl chr2B:196,186,906...196,232,280

G

signal transducer and activator of transcription 3

treatment

NCBI chr17:14,928,689...15,003,644
Ensembl chr17:15,152,358...15,227,067

G

TEK receptor tyrosine kinase

mRNA, protein:increased expression:ventricle myocardium

NCBI chr 9:26,955,339...27,077,809
Ensembl chr 9:27,561,421...27,683,572

G

transferrin receptor

CTD Direct Evidence: marker/mechanism

NCBI chr 3:193,384,817...193,417,532
Ensembl chr 3:203,333,953...203,373,998

G

transforming growth factor beta 1

treatment

NCBI chr19:38,324,009...38,347,003
Ensembl chr19:46,831,659...46,852,973

G

thrombospondin 1

mRNA:increased expression:heart

NCBI chr15:18,521,802...18,538,172
Ensembl chr15:36,776,756...36,793,170

G

TIMP metallopeptidase inhibitor 4

protein:increased expression:blood

NCBI chr 3:12,079,195...12,087,485
Ensembl chr 3:12,425,429...12,433,192

G

toll like receptor 2

NCBI chr 4:146,024,653...146,091,388
Ensembl chr 4:157,866,977...157,869,331

G

toll like receptor 4

NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711

G

tenascin C

NCBI chr 9:86,125,672...86,222,804
Ensembl chr 9:114,486,778...114,584,299

G

tumor necrosis factor

treatment

protein:increased expression:serum, heart:

PMID:24157164 PMID:31583047

RGD:155230831 RGD:7387274

NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381

G

troponin I3, cardiac type

ameliorates

NCBI chr19:52,193,061...52,198,782
Ensembl chr19:60,887,630...60,894,219

G

tumor protein p53

protein:increased expression:heart

NCBI chr17:7,699,449...7,717,812
Ensembl chr17:7,684,922...7,706,120

G

thioredoxin

mRNA:decreased expression:heart

NCBI chr 9:81,399,056...81,411,607
Ensembl chr 9:109,565,557...109,578,311

G

thioredoxin 2

mRNA, protein:decreased expression:heart

NCBI chr22:17,384,017...17,398,965
Ensembl chr22:35,220,721...35,235,877

G

urocortin

NCBI chr2A:27,309,458...27,311,268
Ensembl chr2A:27,397,295...27,397,669

G

uncoupling protein 2

mRNA:increased expression:myocardium

NCBI chr11:69,047,397...69,056,056
Ensembl chr11:72,354,529...72,363,185

G

uncoupling protein 3

mRNA:increased expression:myocardium

NCBI chr11:69,072,143...69,085,424
Ensembl chr11:72,380,180...72,389,274

G

urotensin 2

NCBI chr 1:6,609,104...6,616,966
Ensembl chr 1:7,854,687...7,864,688

G

urotensin 2 receptor

NCBI chr17:76,783,432...76,788,639
Ensembl chr17:82,592,312...82,593,702

G

vascular cell adhesion molecule 1

protein:increased expression:heart

NCBI chr 1:103,377,815...103,395,118
Ensembl chr 1:102,091,336...102,107,732

G

versican

mRNA:increased expression:heart

NCBI chr 5:31,699,278...31,810,169
Ensembl chr 5:32,019,709...32,130,351

G

voltage dependent anion channel 1

CTD Direct Evidence: marker/mechanism

NCBI chr 5:129,375,267...129,408,230
Ensembl chr 5:135,529,173...135,560,005

G

vitamin D receptor

mRNA,protein:increased expression, activity:heart:

NCBI chr12:40,828,413...40,891,700
Ensembl chr12:41,702,742...41,766,192

G

vascular endothelial growth factor A

CTD Direct Evidence: marker/mechanism

NCBI chr 6:43,361,053...43,377,366
Ensembl chr 6:44,650,365...44,666,353

G

xanthine dehydrogenase

NCBI chr2A:31,356,011...31,435,111
Ensembl chr2A:31,425,183...31,504,455

G

X-linked inhibitor of apoptosis

treatment

CTD Direct Evidence: marker/mechanism

PMID:14998631 PMID:20501665

NCBI chr X:113,052,164...113,105,160
Ensembl chr X:123,232,643...123,278,606

G

YES proto-oncogene 1, Src family tyrosine kinase

mRNA,protein:increased expression:myocardium (mouse)

NCBI chr18:13,513,124...13,605,379
Ensembl chr18:15,848,765...17,245,246

myocardial stunning

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

CTD Direct Evidence: marker/mechanism

NCBI chr12:107,857,009...107,924,938
Ensembl chr12:111,246,508...111,311,923

G

nitric oxide synthase 2

CTD Direct Evidence: marker/mechanism

NCBI chr17:28,984,295...29,021,516
Ensembl chr17:29,471,510...29,617,093

G

phospholamban

CTD Direct Evidence: marker/mechanism

NCBI chr 6:116,357,335...116,370,382
Ensembl chr 6:120,509,510...120,509,668

G

tumor necrosis factor

CTD Direct Evidence: marker/mechanism

NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381

No-Reflow Phenomenon

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cadherin 5

CTD Direct Evidence: therapeutic

NCBI chr16:46,684,545...46,722,740
Ensembl chr16:65,787,370...65,825,360

G

catenin beta 1

CTD Direct Evidence: therapeutic

NCBI chr 3:41,104,940...41,145,934
Ensembl chr 3:41,373,726...41,414,030

G

junction plakoglobin

CTD Direct Evidence: therapeutic

NCBI chr17:15,527,115...15,559,251
Ensembl chr17:15,747,163...15,777,479

Prinzmetal angina

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

intercellular adhesion molecule 1

protein:increased expression:plasma

NCBI chr19:9,821,402...9,837,021
Ensembl chr19:10,484,414...10,500,605

G

potassium inwardly rectifying channel subfamily J member 8

NCBI chr12:64,522,172...64,532,848
Ensembl chr12:67,127,263...67,137,128

ST Elevation Myocardial Infarction

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1

treatment

DNA:SNPs: :rs1045642,rs7779562(human)

NCBI chr 7:79,497,536...79,706,277
Ensembl chr 7:93,147,950...93,243,238

G

ATP synthase membrane subunit c locus 2

severity

NCBI chr12:35,078,290...35,089,480

G

cellular communication network factor 1

sexual_dimorphism

protein:increased expression:blood serum (human)

NCBI chr 1:118,138,739...118,141,681
Ensembl chr 1:86,994,296...86,997,147

G

galectin 3

CTD Direct Evidence: marker/mechanism

NCBI chr14:35,715,850...35,732,263
Ensembl chr14:53,990,023...54,006,412

Stable Angina

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

coagulation factor VII

protein:increased activity:plasma (human)

NCBI chr13:94,246,694...94,261,133
Ensembl chr13:113,315,868...113,329,995

G

matrix metallopeptidase 9

CTD Direct Evidence: marker/mechanism

NCBI chr20:42,346,305...42,354,018
Ensembl chr20:43,432,389...43,440,129

G

retinol binding protein 4

protein:increased expression:blood serum (human)

NCBI chr10:90,337,879...90,347,530
Ensembl chr10:93,848,166...93,857,887

G

toll like receptor 4

CTD Direct Evidence: marker/mechanism

NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711

G

tumor necrosis factor

CTD Direct Evidence: marker/mechanism

NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381

Term paths to the root

Path 1
Term	Annotations
disease	15805
disease of anatomical entity	15483
cardiovascular system disease	4468
heart disease	3181
Myocardial Ischemia	854
Acute Coronary Syndrome	55
Angina Pectoris +	38
Coronary Disease +	594
Myocardial Reperfusion Injury	228
myocardial infarction +	416
Path 2
Term	Annotations
disease	15805
disease of anatomical entity	15483
cardiovascular system disease	4468
vascular disease	3056
ischemia	1371
Myocardial Ischemia	854
Acute Coronary Syndrome	55
Angina Pectoris +	38
Coronary Disease +	594
Myocardial Reperfusion Injury	228
myocardial infarction +	416

paths to the root