HTRA2 (HtrA serine peptidase 2) - Rat Genome Database

Name: HTRA2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: HTRA2 (HtrA serine peptidase 2) Pan paniscus

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Symbol:

HTRA2

Name:

HtrA serine peptidase 2

RGD ID:

12005662

Description:

ENCODES a protein that exhibits serine-type peptidase activity (ortholog); INVOLVED IN adult locomotory behavior (ortholog); adult walking behavior (ortholog); ceramide metabolic process (ortholog); PARTICIPATES IN intrinsic apoptotic pathway; ASSOCIATED WITH 3-methylglutaconic aciduria type 8 (ortholog); Alzheimer's disease (ortholog); asphyxia neonatorum (ortholog); FOUND IN CD40 receptor complex (inferred); chromatin (inferred); cytoplasmic side of plasma membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

serine protease HTRA2, mitochondrial

RGD Orthologs

Alliance Genes

More Info

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More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	HTRA2 (HtrA serine peptidase 2)	NCBI	Ortholog
Mus musculus (house mouse):	Htra2 (HtrA serine peptidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Htra2 (HtrA serine peptidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Htra2 (HtrA serine peptidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	HTRA2 (HtrA serine peptidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Htra2 (HtrA serine peptidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	HTRA2 (HtrA serine peptidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	HTRA2 (HtrA serine peptidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Htra2 (HtrA serine peptidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	51,856,074 - 51,859,242 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	51,858,033 - 51,861,996 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	74,596,020 - 74,599,790 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	76,102,240 - 76,106,169 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	76,102,240 - 76,106,152 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

3-methylglutaconic aciduria type 8 (ISO)

Alzheimer's disease (ISO)

asphyxia neonatorum (ISO)

breast ductal carcinoma (ISO)

cardiomyopathy (ISO)

colorectal cancer (ISO)

congenital disorder of glycosylation type IIb (ISO)

cryptorchidism (ISO)

dystonia (ISO)

endometrial cancer (ISO)

Female Infertility (ISO)

genetic disease (ISO)

Huntington's disease (ISO)

invasive ductal carcinoma (ISO)

Leigh disease (ISO)

Methylmalonyl-CoA Epimerase Deficiency (ISO)

middle cerebral artery infarction (ISO)

motor neuron disease (ISO)

Myocardial Reperfusion Injury (ISO)

ovarian cancer (ISO)

Parkinson's disease (ISO)

Parkinson's Disease 13 (ISO)

Parkinsonism (ISO)

Premature Aging (ISO)

prostate cancer (ISO)

Sepsis (ISO)

Splenomegaly (ISO)

status epilepticus (ISO)

stomach cancer (ISO)

transient cerebral ischemia (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adult locomotory behavior (IEA,ISO)

adult walking behavior (IEA,ISO)

cellular response to growth factor stimulus (IEA)

cellular response to heat (IEA)

cellular response to interferon-beta (IEA)

cellular response to oxidative stress (IEA)

cellular response to retinoic acid (IEA)

ceramide metabolic process (ISO)

forebrain development (IEA,ISO)

intrinsic apoptotic signaling pathway (IEA,ISO)

intrinsic apoptotic signaling pathway in response to DNA damage (IEA)

mitochondrion organization (IEA,ISO)

negative regulation of mitophagy in response to mitochondrial depolarization (IEA)

neuron apoptotic process (ISO)

neuron development (IEA,ISO)

obsolete positive regulation of mitochondrion organization (IEA)

pentacyclic triterpenoid metabolic process (ISO)

positive regulation of apoptotic process (IEA,ISO)

positive regulation of execution phase of apoptosis (IEA)

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (IEA)

positive regulation of protein targeting to mitochondrion (ISO)

programmed cell death (IEA)

protein catabolic process (IEA)

proteolysis (IEA)

regulation of multicellular organism growth (IEA,ISO)

response to herbicide (ISO)

Cellular Component

CD40 receptor complex (IEA)

chromatin (IEA)

cytoplasmic side of plasma membrane (IEA)

cytoskeleton (IEA)

cytosol (IEA)

membrane (IEA)

mitochondrial intermembrane space (IEA)

mitochondrion (IEA)

nucleus (IEA)

serine-type endopeptidase complex (IEA)

Molecular Function

hydrolase activity (IEA)

identical protein binding (IEA)

peptidase activity (IEA)

protein binding (ISO)

serine-type endopeptidase activity (IEA)

serine-type peptidase activity (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

intrinsic apoptotic pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

HTRA2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	51,856,074 - 51,859,242 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	51,858,033 - 51,861,996 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	74,596,020 - 74,599,790 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	76,102,240 - 76,106,169 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	76,102,240 - 76,106,152 (+)	Ensembl	panpan1.1		panPan2

HTRA2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	74,529,405 - 74,533,556 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	74,529,596 - 74,533,350 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	74,756,532 - 74,760,683 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	74,610,040 - 74,614,191 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	74,668,186 - 74,672,098	NCBI
Celera	2	74,587,640 - 74,591,791 (+)	NCBI		Celera
Cytogenetic Map	2	p13.1	NCBI
HuRef	2	74,492,793 - 74,496,944 (+)	NCBI		HuRef
CHM1_1	2	74,685,928 - 74,690,079 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	74,537,971 - 74,542,122 (+)	NCBI		T2T-CHM13v2.0

Htra2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	83,028,247 - 83,031,552 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	83,028,247 - 83,032,254 (-)	Ensembl		GRCm39 Ensembl
GRCm38	6	83,051,266 - 83,054,571 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	83,051,266 - 83,055,273 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	83,001,260 - 83,004,565 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	83,016,940 - 83,020,229 (-)	NCBI		MGSCv36	mm8
Celera	6	85,033,853 - 85,037,160 (-)	NCBI		Celera
Cytogenetic Map	6	C3	NCBI
cM Map	6	35.94	NCBI

Htra2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	117,114,631 - 117,117,793 (-)	NCBI		GRCr8
mRatBN7.2	4	115,556,914 - 115,560,202 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	115,556,916 - 115,560,095 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	121,033,497 - 121,036,659 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	116,808,694 - 116,811,856 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	115,423,257 - 115,426,420 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	113,883,671 - 113,886,833 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	113,883,670 - 113,886,994 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	178,568,771 - 178,571,933 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	117,262,206 - 117,265,368 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	117,506,685 - 117,509,829 (-)	NCBI
Celera	4	104,551,592 - 104,554,754 (-)	NCBI		Celera
Cytogenetic Map	4	q34	NCBI

Htra2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955424	11,255,756 - 11,259,170 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955424	11,255,756 - 11,259,170 (-)	NCBI	ChiLan1.0	ChiLan1.0

HTRA2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	48,610,408 - 48,613,399 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	48,610,408 - 48,613,399 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	48,252,304 - 48,255,295 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	49,469,859 - 49,472,851 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	49,467,050 - 49,472,864 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	48,487,009 - 48,490,000 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	48,553,751 - 48,556,744 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	49,111,429 - 49,114,422 (-)	NCBI		UU_Cfam_GSD_1.0

Htra2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	9,992,054 - 9,996,178 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936556	741,718 - 749,090 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936556	741,718 - 746,016 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HTRA2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	68,516,500 - 68,519,886 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	68,516,666 - 68,520,025 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	71,688,452 - 71,690,709 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HTRA2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	32,745,436 - 32,749,176 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	32,743,708 - 32,748,577 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	79,422,108 - 79,425,985 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Htra2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624749	28,980,362 - 28,983,869 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624749	28,980,375 - 28,983,719 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003810328	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008962679	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000058967 ⟹ ENSPPAP00000036077

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	2A	76,102,240 - 76,106,152 (+)	Ensembl

RefSeq Acc Id:

XM_003810328 ⟹ XP_003810376

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	12	51,856,074 - 51,859,242 (-)	NCBI
NHGRI_mPanPan1	2A	51,858,448 - 51,861,996 (-)	NCBI
Mhudiblu_PPA_v0	2A	74,596,020 - 74,599,790 (+)	NCBI
PanPan1.1	2A	76,102,240 - 76,106,152 (+)	NCBI

Sequence:

show sequence

CGTGGATCCCGAGAAAGAGGCGCAGGACGAGGAGGCAGAACCCGACTGGCGCGTAGAGCAGCAG
CGCGAGCAGGAGGAAGCAGTCACCCGGGAGCCTGGGGGCGAGAGGCGAAGTGGTCAGGCGCCGA
AGGCCGAGAGGACGCGGGGATCGGTCTCTTCCCGCCGGGTCTCTTACCGGTGCGAGTCAAAGAG
CCGCTCCGGCCCCGGCCCTGAGGGAAGCTCCATAACTGCTGCTTCAGGAGCGCCCGGCCGTCGC
CGCCGCCGCCATCTTCGCGCCCGGCCGCAGGGGCTCTTGGGAAGGCGGAGTCTTTGGGCATCCG
CCCGGGGTGAGGGGACCCGAAGTCCTGAGGCGCGCCGGCAGGGCTAGCGGTCCCAGCATACCCC
GCGGCCCCTTGGGCCGTCTCACAACTCGCGTCCGGCGGAGACCACAATTCCCGGCATTCGTGGG
GCGGGGAGGAGTCGGCCTCCCGGAATCCTGGTCCCGGCGTGCACTTCTGAAGGACTTCAGGTAC
CGGCGTGCCCCGCGTCCTACTGTCCGCCTGCTCGCGTCCTGGGTGCCGCCTCTGAGTAGGGCGG
GCGAGGAGGCAGCCAAGGCGGAGCTGATGGCTGCGCCGAGGGCGGGGCGGGGTGCAGGCTGGAG
CCTTCGGGCATGGCGGGCTTTGGGGGGCATTCGCTGGGGGAGGAGACCCCGTTTGACCCCTGAC
CTCCGGGCCCTGCTGACGTCAGGAACTTCTGACCCCCGGGCCCGAGTGACTTATGGGACCCCCA
GTCTCTGGGCCCGGTTGTCTGTTGGGGTCACTGAACCCCGAGCATGCCTAACGTCTGGGACCCC
GGGTCCCCGGGCACAACTGACTGCGGTGACCCCAGATACCAGGACCCGGGAGGCCTCAGAGAAC
TCTGGAACCCGTTCGCGCGCGTGGCTGGCGGTGACGCTGGGCGCTGGGGGGGCAGTGCTGTTGT
TGCTGTGGGGCGGGGGTCGGGGTCCTCCGGCCGTCCTCGCCGCCGTCCCTGGCCCGCCGCCCGC
TTCTCCCCGGAGTCAGTACAACTTCATCGCAGATGTGGTGGAGAAGACAGCACCTGCCGTGGTC
TATATCGAGATCCTGGACCGGCACCCTTTCTTGGGCCGCGAGGTCCCTATCTCGAACGGCTCAG
GATTCGTGGTGGCTGCCGATGGGCTCATTGTCACCAACGCCCATGTGGTGGCTGATCGGCGCAG
AGTCCGTGTGAGACTGCTAAGCGGCGACACGTATGAGGCCGTGGTCACAGCTGTGGATCCCGTG
GCAGACATCGCAACGCTGAGGATTCAGACTAAGGAGCCTCTCCCCACGCTGCCTCTGGGACGCT
CAGCTGATGTCCGGCAAGGGGAGTTTGTTGTTGCCATGGGAAGTCCCTTTGCACTGCAGAACAC
GATCACATCCGGCATTGTTAGCTCTGCTCAGCGTCCAGCCAGAGACCTGGGACTCCCCCAAACC
AATGTGGAATACATTCAAACTGATGCAGCTATTGATTTTGGAAACTCTGGAGGTCCCCTGGTTA
ACCTGGATGGGGAGGTGATTGGAGTGAACACCATGAAGGTCACAGCTGGAATCTCCTTTGCCAT
CCCTTCTGATCGTCTTCGAGAGTTTCTGCATCGTGGGGAAAAGAAGAATTCCTCCTCCGGAATC
AGTGGGTCCCAGCGGCGCTACATTGGGGTGATGATGCTGACCCTGAGTCCCAGCATCCTTGCTG
AACTACAGCTTCGAGAACCAAGCTTTCCCGATGTTCAGCATGGTGTACTCATCCATAAAGTCAT
CCTGGGCTCCCCTGCACACCGGGCTGGTCTGCGGCCTGGTGATGTGATTTTGGCCATTGGGGAG
CAGATGGTACAAAATGCTGAAGATGTTTATGAAGCTGTTCGAACCCAATCCCAGCTGGCAGTGC
AGATCCGGCGGGGACGAGAAACACTGACCTTATATGTGACCCCTGAGGTCACAGAATGAATAGA
TCACCAAGACTATGAGGCTCCTGCTCTGATTTCCTCCTTGCCTTCCTGGCTGAGGCTCTGAGGG
CACCGAGACAGAGGGTTAAATGAACCAGTGGGGGCAGGTCCCTCCAACCACCAGCACTGACTCC
TGGGCTCTGAAGAATCACAGAAACACTTTTTATATAAAATAAAATTATACCTAGCAACATATTA
TAGTAAAAAATGAGGTGGGAGGGCTGGATCTTTTCCCCCACCAAAAGGCTAGAGGTAAAGCTGT
ATCCCCCTAAACTTAGGGGAGATACTGGAGCTGACCATCCTGACCTCCTATTAAAGAAAATAAG
CTGCTGCCA

hide sequence

RefSeq Acc Id:

XM_008962679 ⟹ XP_008960927

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	12	51,856,074 - 51,859,242 (-)	NCBI
NHGRI_mPanPan1	2A	51,858,033 - 51,861,996 (-)	NCBI
Mhudiblu_PPA_v0	2A	74,596,020 - 74,599,790 (+)	NCBI
PanPan1.1	2A	76,102,240 - 76,106,169 (+)	NCBI

Sequence:

show sequence

CGTGGATCCCGAGAAAGAGGCGCAGGACGAGGAGGCAGAACCCGACTGGCGCGTAGAGCAGCAG
CGCGAGCAGGAGGAAGCAGTCACCCGGGAGCCTGGGGGCGAGAGGCGAAGTGGTCAGGCGCCGA
AGGCCGAGAGGACGCGGGGATCGGTCTCTTCCCGCCGGGTCTCTTACCGGTGCGAGTCAAAGAG
CCGCTCCGGCCCCGGCCCTGAGGGAAGCTCCATAACTGCTGCTTCAGGAGCGCCCGGCCGTCGC
CGCCGCCGCCATCTTCGCGCCCGGCCGCAGGGGCTCTTGGGAAGGCGGAGTCTTTGGGCATCCG
CCCGGGGTGAGGGGACCCGAAGTCCTGAGGCGCGCCGGCAGGGCTAGCGGTCCCAGCATACCCC
GCGGCCCCTTGGGCCGTCTCACAACTCGCGTCCGGCGGAGACCACAATTCCCGGCATTCGTGGG
GCGGGGAGGAGTCGGCCTCCCGGAATCCTGGTCCCGGCGTGCACTTCTGAAGGACTTCAGGTAC
CGGCGTGCCCCGCGTCCTACTGTCCGCCTGCTCGCGTCCTGGGTGCCGCCTCTGAGTAGGGCGG
GCGAGGAGGCAGCCAAGGCGGAGCTGATGGCTGCGCCGAGGGCGGGGCGGGGTGCAGGCTGGAG
CCTTCGGGCATGGCGGGCTTTGGGGGGCATTCGCTGGGGGAGGAGACCCCGTTTGACCCCTGAC
CTCCGGGCCCTGCTGACGTCAGGAACTTCTGACCCCCGGGCCCGAGTGACTTATGGGACCCCCA
GTCTCTGGGCCCGGTTGTCTGTTGGGGTCACTGAACCCCGAGCATGCCTAACGTCTGGGACCCC
GGGTCCCCGGGCACAACTGACTGCGGTGACCCCAGATACCAGGACCCGGGAGGCCTCAGAGAAC
TCTGGAACCCGTTCGCGCGCGTGGCTGGCGGTGACGCTGGGCGCTGGGGGGGCAGTGCTGTTGT
TGCTGTGGGGCGGGGGTCGGGGTCCTCCGGCCGTCCTCGCCGCCGTCCCTGGCCCGCCGCCCGC
TTCTCCCCGGAGTCAGTACAACTTCATCGCAGATGTGGTGGAGAAGACAGCACCTGCCGTGGTC
TATATCGAGATCCTGGACCGGCACCCTTTCTTGGGCCGCGAGGTCCCTATCTCGAACGGCTCAG
GATTCGTGGTGGCTGCCGATGGGCTCATTGTCACCAACGCCCATGTGGTGGCTGATCGGCGCAG
AGTCCGTGTGAGACTGCTAAGCGGCGACACGTATGAGGCCGTGGTCACAGCTGTGGATCCCGTG
GCAGACATCGCAACGCTGAGGATTCAGACTAAGGAGCCTCTCCCCACGCTGCCTCTGGGACGCT
CAGCTGATGTCCGGCAAGGGGAGTTTGTTGTTGCCATGGGAAGTCCCTTTGCACTGCAGAACAC
GATCACATCCGGCATTGTTAGCTCTGCTCAGCGTCCAGCCAGAGACCTGGGACTCCCCCAAACC
AATGTGGAATACATTCAAACTGATGCAGCTATTGATTTTGGAAACTCTGGAGGTCCCCTGGTTA
ACCTGGATGGGGAGGTGATTGGAGTGAACACCATGAAGGTCACAGCTGGAATCTCCTTTGCCAT
CCCTTCTGATCGTCTTCGAGAGTTTCTGCATCGTGGGGAAAAGAAGAATTCCTCCTCCGGAATC
AGTGGGTCCCAGCGGCGCTACATTGGGGTGATGATGCTGACCCTGAGTCCCAGGGCTGGTCTGC
GGCCTGGTGATGTGATTTTGGCCATTGGGGAGCAGATGGTACAAAATGCTGAAGATGTTTATGA
AGCTGTTCGAACCCAATCCCAGCTGGCAGTGCAGATCCGGCGGGGACGAGAAACACTGACCTTA
TATGTGACCCCTGAGGTCACAGAATGAATAGATCACCAAGACTATGAGGCTCCTGCTCTGATTT
CCTCCTTGCCTTCCTGGCTGAGGCTCTGAGGGCACCGAGACAGAGGGTTAAATGAACCAGTGGG
GGCAGGTCCCTCCAACCACCAGCACTGACTCCTGGGCTCTGAAGAATCACAGAAACACTTTTTA
TATAAAATAAAATTATACCTAGCAACATATTATAGTAAAAAATGAGGTGGGAGGGCTGGATCTT
TTCCCCCACCAAAAGGCTAGAGGTAAAGCTGTATCCCCCTAAACTTAGGGGAGATACTGGAGCT
GACCATCCTGACCTCCTATTAAAGAAAATAAGCTGCTGCCATCTTTTGTGGGCAGTTA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003810376	(Get FASTA)	NCBI Sequence Viewer
	XP_008960927	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000036077
	ENSPPAP00000036077.1

RefSeq Acc Id:	XP_003810376 ⟸ XM_003810328
- Peptide Label:	isoform X1
- UniProtKB:	A0A2R9CCL7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWARLSVG VTEPRACLTSGTPGPRAQLTAVTPDTRTREASENSGTRSRAWLAVTLGAGGAVLLLLWGGGRGP PAVLAAVPGPPPASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPISNGSGFVVAADGL IVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTKEPLPTLPLGRSADVRQGEF VVAMGSPFALQNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAAIDFGNSGGPLVNLDGEVIGV NTMKVTAGISFAIPSDRLREFLHRGEKKNSSSGISGSQRRYIGVMMLTLSPSILAELQLREPSF PDVQHGVLIHKVILGSPAHRAGLRPGDVILAIGEQMVQNAEDVYEAVRTQSQLAVQIRRGRETL TLYVTPEVTE hide sequence

RefSeq Acc Id:

XP_008960927 ⟸ XM_008962679

- Peptide Label:

isoform X2

- Sequence:

show sequence

MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWARLSVG
VTEPRACLTSGTPGPRAQLTAVTPDTRTREASENSGTRSRAWLAVTLGAGGAVLLLLWGGGRGP
PAVLAAVPGPPPASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPISNGSGFVVAADGL
IVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTKEPLPTLPLGRSADVRQGEF
VVAMGSPFALQNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAAIDFGNSGGPLVNLDGEVIGV
NTMKVTAGISFAIPSDRLREFLHRGEKKNSSSGISGSQRRYIGVMMLTLSPRAGLRPGDVILAI
GEQMVQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE

hide sequence

RefSeq Acc Id:

ENSPPAP00000036077 ⟸ ENSPPAT00000058967

Protein Domains

PDZ

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000040827	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000058967.1	UniProtKB/TrEMBL
Gene3D-CATH	2.30.42.10	UniProtKB/TrEMBL
	2.40.10.120	UniProtKB/TrEMBL
InterPro	PDZ	UniProtKB/TrEMBL
	PDZ_6	UniProtKB/TrEMBL
	PDZ_sf	UniProtKB/TrEMBL
	Peptidase_S1_PA	UniProtKB/TrEMBL
	Peptidase_S1C	UniProtKB/TrEMBL
KEGG Report	pps:100985283	UniProtKB/TrEMBL
NCBI Gene	HTRA2	ENTREZGENE
PANTHER	SERINE PROTEASE FAMILY S1C HTRA-RELATED	UniProtKB/TrEMBL
	SERINE PROTEASE HTRA2, MITOCHONDRIAL	UniProtKB/TrEMBL
Pfam	PDZ_6	UniProtKB/TrEMBL
	Trypsin_2	UniProtKB/TrEMBL
PRINTS	PROTEASES2C	UniProtKB/TrEMBL
PROSITE	PDZ	UniProtKB/TrEMBL
SMART	PDZ	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50156	UniProtKB/TrEMBL
	SSF50494	UniProtKB/TrEMBL
UniProt	A0A2R9CCL7	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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