CCR2 (C-C motif chemokine receptor 2) - Rat Genome Database

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Gene: CCR2 (C-C motif chemokine receptor 2) Pan paniscus
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Symbol: CCR2
Name: C-C motif chemokine receptor 2
RGD ID: 11891835
Description: ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN blood vessel remodeling (ortholog); cellular defense response (ortholog); chemokine-mediated signaling pathway (ortholog); ASSOCIATED WITH age related macular degeneration (ortholog); aggressive periodontitis (ortholog); Alcoholic Fatty Liver (ortholog); FOUND IN dendrite (ortholog); neuronal cell body (ortholog); perikaryon (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: C-C chemokine receptor type 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2246,315,650 - 46,320,292 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1346,320,418 - 46,325,060 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0346,255,725 - 46,263,285 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1347,361,118 - 47,368,312 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl347,361,124 - 47,368,312 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
age related macular degeneration  (ISO)
aggressive periodontitis  (ISO)
Alcoholic Fatty Liver  (ISO)
allergic bronchopulmonary aspergillosis  (ISO)
allergic contact dermatitis  (ISO)
allergic disease  (ISO)
Alveolar Bone Loss  (ISO)
amyotrophic lateral sclerosis  (ISO)
Animal Toxoplasmosis  (ISO)
anxiety disorder  (ISO)
asthma  (ISO)
atopic dermatitis  (ISO)
bacterial pneumonia  (ISO)
Brain Hypoxia-Ischemia  (ISO)
Bronchial Hyperreactivity  (ISO)
bronchiolitis obliterans  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Choroidal Neovascularization  (ISO)
Chronic Periodontitis  (ISO)
congestive heart failure  (ISO)
corneal neovascularization  (ISO)
coronary artery disease  (ISO)
Coronavirus infectious disease  (ISO)
COVID-19  (ISO)
cutaneous leishmaniasis  (ISO)
Cystic Disease of Lung  (ISO)
demyelinating disease  (ISO)
dermatomyositis  (ISO)
Diabetic Nephropathies  (ISO)
dry eye syndrome  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Uveitis  (ISO)
Experimental Autoimmune Uveoretinitis  (ISO)
fungal infectious disease  (ISO)
Geographic Atrophy  (ISO)
Hearing Loss, Noise-Induced  (ISO)
Herpes Simplex Encephalitis  (ISO)
Herpesviridae Infections  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Hyperalgesia  (ISO)
ileitis  (ISO)
inclusion body myositis  (ISO)
intermediate uveitis  (ISO)
interstitial lung disease  (ISO)
Intervertebral Disc Disease  (ISO)
Intimal Hyperplasia  (ISO)
Kawasaki disease  (ISO)
Knee Osteoarthritis  (ISO)
Kuhnt-Junius degeneration  (ISO)
leishmaniasis  (ISO)
limited scleroderma  (ISO)
lipoatrophic diabetes mellitus  (ISO)
liver disease  (ISO)
Liver Reperfusion Injury  (ISO)
lung disease  (ISO)
macular degeneration  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Mouth Neoplasms  (ISO)
myeloid sarcoma  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
Nasal Polyps  (ISO)
oral squamous cell carcinoma  (ISO)
Pain  (ISO)
Perennial Allergic Rhinitis  (ISO)
Peri-Implantitis  (ISO)
Periapical Diseases  (ISO)
periapical granuloma  (ISO)
periapical periodontitis  (ISO)
Periodontal Cyst  (ISO)
pleural tuberculosis  (ISO)
pneumonia  (ISO)
polymyositis  (ISO)
posterior uveitis  (ISO)
prediabetes syndrome  (ISO)
Progressive Microcephaly with Seizures and Cerebral and Cerebellar Atrophy  (ISO)
psoriasis  (ISO)
psoriatic arthritis  (ISO)
pulmonary fibrosis  (ISO)
pulmonary tuberculosis  (ISO)
retinal degeneration  (ISO)
retinitis  (ISO)
rhinitis  (ISO)
sarcoidosis  (ISO)
sciatic neuropathy  (ISO)
sialadenitis  (ISO)
Spinal Cord Injuries  (ISO)
status epilepticus  (ISO)
systemic scleroderma  (ISO)
Thoracic Injuries  (ISO)
Transplant Rejection  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
urticaria  (ISO)
vasculitis  (ISO)
visceral leishmaniasis  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
blood vessel remodeling  (IEA,ISO)
calcium-mediated signaling  (IEA)
cell chemotaxis  (IEA)
cellular defense response  (IEA,ISO)
cellular homeostasis  (IEA)
chemokine-mediated signaling pathway  (IEA,ISO)
chemotaxis  (IEA)
cytokine-mediated signaling pathway  (IEA,ISO)
G protein-coupled receptor signaling pathway  (IEA,ISO)
hemopoiesis  (IEA,ISO)
homeostasis of number of cells within a tissue  (IEA,ISO)
humoral immune response  (IEA,ISO)
immune response  (IEA,ISO)
inflammatory response  (IEA,ISO)
inflammatory response to antigenic stimulus  (ISO)
inflammatory response to wounding  (IEA)
intracellular calcium ion homeostasis  (ISO)
leukocyte adhesion to vascular endothelial cell  (IEA,ISO)
macrophage migration  (IEA)
monocyte chemotaxis  (IEA,ISO)
monocyte extravasation  (IEA)
negative regulation of angiogenesis  (IEA)
negative regulation of eosinophil degranulation  (IEA)
negative regulation of type 2 immune response  (IEA)
neutrophil clearance  (IEA,ISO)
positive regulation of alpha-beta T cell proliferation  (IEA)
positive regulation of astrocyte chemotaxis  (IEA)
positive regulation of CD8-positive, alpha-beta T cell extravasation  (IEA)
positive regulation of cold-induced thermogenesis  (IEA)
positive regulation of cytosolic calcium ion concentration  (IEA)
positive regulation of hematopoietic stem cell migration  (IEA)
positive regulation of immune complex clearance by monocytes and macrophages  (IEA)
positive regulation of inflammatory response  (IEA)
positive regulation of interleukin-2 production  (IEA)
positive regulation of leukocyte tethering or rolling  (IEA,ISO)
positive regulation of monocyte chemotaxis  (IEA)
positive regulation of monocyte extravasation  (IEA)
positive regulation of NMDA glutamate receptor activity  (ISO)
positive regulation of p38MAPK cascade  (ISO)
positive regulation of synaptic transmission, glutamatergic  (IEA)
positive regulation of T cell activation  (IEA)
positive regulation of T cell chemotaxis  (IEA)
positive regulation of T-helper 1 type immune response  (IEA)
positive regulation of thymocyte migration  (IEA)
positive regulation of tumor necrosis factor production  (IEA,ISO)
positive regulation of type II interferon production  (IEA)
regulation of inflammatory response  (IEA)
regulation of macrophage migration  (IEA,ISO)
regulation of mononuclear cell migration  (IEA,ISO)
regulation of T cell cytokine production  (IEA)
regulation of T cell differentiation  (IEA)
regulation of T cell migration  (IEA,ISO)
regulation of vascular endothelial growth factor production  (IEA)
response to hyperoxia  (ISO)
response to hypoxia  (ISO)
sensory perception of pain  (IEA,ISO)
T-helper 17 cell chemotaxis  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CCR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2246,315,650 - 46,320,292 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1346,320,418 - 46,325,060 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0346,255,725 - 46,263,285 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1347,361,118 - 47,368,312 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl347,361,124 - 47,368,312 (+)Ensemblpanpan1.1panPan2
CCR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38346,354,111 - 46,360,940 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl346,353,864 - 46,360,940 (+)EnsemblGRCh38hg38GRCh38
GRCh37346,395,602 - 46,402,431 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36346,370,364 - 46,377,432 (+)NCBINCBI36Build 36hg18NCBI36
Celera346,332,557 - 46,339,734 (+)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef346,438,874 - 46,446,051 (+)NCBIHuRef
CHM1_1346,345,233 - 46,352,410 (+)NCBICHM1_1
T2T-CHM13v2.0346,369,948 - 46,376,777 (+)NCBIT2T-CHM13v2.0
Ccr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399123,901,954 - 123,913,594 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9123,901,987 - 123,913,594 (+)EnsemblGRCm39 Ensembl
GRCm389124,101,918 - 124,109,140 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9124,101,950 - 124,113,557 (+)EnsemblGRCm38mm10GRCm38
MGSCv379124,016,922 - 124,023,879 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369123,950,982 - 123,957,349 (+)NCBIMGSCv36mm8
Celera9124,890,502 - 124,897,441 (-)NCBICelera
Cytogenetic Map9F4NCBI
cM Map975.05NCBI
Ccr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88132,611,883 - 132,619,106 (+)NCBIGRCr8
mRatBN7.28123,734,465 - 123,742,483 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8123,734,430 - 123,742,100 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8129,328,887 - 129,330,008 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08127,528,007 - 127,529,128 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08125,345,931 - 125,347,052 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
RGSC_v3.48128,892,784 - 128,893,905 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18128,912,520 - 128,913,642 (+)NCBI
Celera8122,833,545 - 122,834,666 (+)NCBICelera
Cytogenetic Map8q32NCBI
Ccr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542025,641,184 - 25,664,413 (-)NCBIChiLan1.0ChiLan1.0
CCR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12042,305,344 - 42,313,258 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2042,307,580 - 42,308,698 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2042,220,658 - 42,229,191 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02042,787,203 - 42,795,751 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2042,787,205 - 42,793,246 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12042,028,417 - 42,036,962 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02042,429,835 - 42,438,385 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02042,710,738 - 42,719,282 (-)NCBIUU_Cfam_GSD_1.0
CCR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1329,285,012 - 29,376,343 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11329,368,735 - 29,374,564 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21332,532,565 - 32,538,394 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CCR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1227,795,192 - 7,801,242 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl227,798,646 - 7,799,728 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041159,351,063 - 159,358,108 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Sequence


Ensembl Acc Id: ENSPPAT00000010713   ⟹   ENSPPAP00000002177
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl347,361,124 - 47,368,312 (+)Ensembl
RefSeq Acc Id: XM_057301713   ⟹   XP_057157696
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2246,315,650 - 46,320,292 (+)NCBI
NHGRI_mPanPan1346,320,418 - 46,325,060 (+)NCBI
Protein Sequences
Protein RefSeqs XP_057157696 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000002177.1
Ensembl Acc Id: ENSPPAP00000002177   ⟸   ENSPPAT00000010713
RefSeq Acc Id: XP_057157696   ⟸   XM_057301713
- UniProtKB: A0A2R8ZHL5 (UniProtKB/TrEMBL)
Protein Domains
G-protein coupled receptors family 1 profile


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000009840 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000010713.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro Chemokine_CCR2 UniProtKB/TrEMBL
  Chemokine_rcpt UniProtKB/TrEMBL
  GPCR1 UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
NCBI Gene CCR2 ENTREZGENE
PANTHER C-C CHEMOKINE RECEPTOR TYPE 2 UniProtKB/TrEMBL
  CELL ADHESION MOLECULE UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PRINTS CCCHEMOKINER UniProtKB/TrEMBL
  CHEMOKINER2 UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A2R8ZHL5 ENTREZGENE, UniProtKB/TrEMBL