TBX2 (T-box transcription factor 2) - Rat Genome Database

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Pathways
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Gene: TBX2 (T-box transcription factor 2) Pan paniscus
Analyze
Symbol: TBX2
Name: T-box transcription factor 2
RGD ID: 11824981
Description: ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); INVOLVED IN cardiac muscle tissue development (ortholog); cellular response to dexamethasone stimulus (ortholog); cellular senescence (ortholog); ASSOCIATED WITH atrial heart septal defect (ortholog); Conotruncal Cardiac Defects (ortholog); coronary artery disease (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred); transcription regulator complex (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: T-box 2; T-box transcription factor TBX2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21977,598,977 - 77,608,279 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11782,410,276 - 82,419,751 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01755,501,932 - 55,511,537 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11760,617,169 - 60,631,148 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1760,622,098 - 60,630,189 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aorta morphogenesis  (IEA)
apoptotic process  (IEA)
atrioventricular canal development  (IEA)
atrioventricular canal morphogenesis  (IEA)
cardiac jelly development  (IEA)
cardiac muscle cell myoblast differentiation  (IEA)
cardiac muscle tissue development  (IEA,ISO)
cell fate specification  (IEA)
cellular response to dexamethasone stimulus  (ISO)
cellular senescence  (IEA,ISO)
cochlea morphogenesis  (IEA)
developmental growth involved in morphogenesis  (IEA,ISO)
embryonic camera-type eye morphogenesis  (IEA)
embryonic digit morphogenesis  (IEA)
endocardial cushion formation  (IEA)
endocardial cushion morphogenesis  (IEA)
epithelial tube branching involved in lung morphogenesis  (IEA)
fibroblast growth factor receptor signaling pathway  (IEA)
heart morphogenesis  (IEA,ISO)
mammary placode formation  (IEA,ISO)
melanocyte proliferation  (IEA)
mesenchymal cell proliferation involved in lung development  (IEA)
muscle cell fate determination  (IEA,ISO)
negative regulation of cardiac chamber formation  (IEA)
negative regulation of cellular senescence  (IEA)
negative regulation of DNA-templated transcription  (IEA,ISO)
negative regulation of heart looping  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
neurogenesis  (IEA)
Notch signaling pathway  (IEA,ISO)
outflow tract morphogenesis  (IEA)
outflow tract septum morphogenesis  (IEA)
pharyngeal system development  (IEA)
pigment metabolic process involved in pigmentation  (IEA,ISO)
positive regulation of cardiac muscle cell proliferation  (IEA)
positive regulation of cell cycle G1/S phase transition  (IEA)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA)
regulation of transcription by RNA polymerase II  (IEA)
response to retinoic acid  (IEA)
roof of mouth development  (IEA,ISO)
smooth muscle cell differentiation  (IEA,ISO)
ureteric peristalsis  (IEA,ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TBX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21977,598,977 - 77,608,279 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11782,410,276 - 82,419,751 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01755,501,932 - 55,511,537 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11760,617,169 - 60,631,148 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1760,622,098 - 60,630,189 (+)Ensemblpanpan1.1panPan2
TBX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381761,399,843 - 61,409,466 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1761,399,843 - 61,409,466 (+)EnsemblGRCh38hg38GRCh38
GRCh371759,477,204 - 59,486,827 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361756,832,039 - 56,841,609 (+)NCBINCBI36Build 36hg18NCBI36
Build 341756,832,038 - 56,841,607NCBI
Celera1758,578,306 - 58,587,856 (+)NCBICelera
Cytogenetic Map17q23.2NCBI
HuRef1754,844,115 - 54,856,411 (+)NCBIHuRef
CHM1_11759,541,779 - 59,551,327 (+)NCBICHM1_1
T2T-CHM13v2.01762,268,710 - 62,278,311 (+)NCBIT2T-CHM13v2.0
Tbx2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391185,723,441 - 85,732,774 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1185,723,377 - 85,732,774 (+)EnsemblGRCm39 Ensembl
GRCm381185,832,615 - 85,841,948 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1185,832,551 - 85,841,948 (+)EnsemblGRCm38mm10GRCm38
MGSCv371185,646,117 - 85,655,450 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361185,649,273 - 85,657,325 (+)NCBIMGSCv36mm8
Celera1195,458,950 - 95,468,278 (+)NCBICelera
Cytogenetic Map11CNCBI
cM Map1151.34NCBI
Tbx2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81071,177,082 - 71,186,275 (+)NCBIGRCr8
mRatBN7.21070,679,670 - 70,688,868 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1070,679,518 - 70,688,529 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1075,299,645 - 75,308,837 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01074,804,435 - 74,813,625 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01070,269,072 - 70,278,263 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01073,278,932 - 73,290,764 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1073,279,119 - 73,289,921 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01073,184,210 - 73,193,085 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41074,085,203 - 74,092,988 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11074,096,142 - 74,107,239 (+)NCBI
Celera1069,604,924 - 69,612,748 (+)NCBICelera
Cytogenetic Map10q26NCBI
Tbx2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554512,457,568 - 2,466,639 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554512,458,612 - 2,466,264 (+)NCBIChiLan1.0ChiLan1.0
TBX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1935,237,323 - 35,245,066 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl935,235,649 - 35,245,736 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha934,466,401 - 34,475,666 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0936,048,354 - 36,057,619 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl936,049,321 - 36,057,591 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1934,829,267 - 34,838,524 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0935,114,884 - 35,124,167 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0935,202,696 - 35,211,975 (-)NCBIUU_Cfam_GSD_1.0
Tbx2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560234,296,708 - 34,306,109 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364902,769,231 - 2,805,238 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364902,769,264 - 2,778,342 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TBX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1236,878,675 - 36,887,513 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11236,878,662 - 36,887,513 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21238,329,004 - 38,337,845 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TBX2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11632,627,296 - 32,636,797 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1632,627,819 - 32,636,880 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660773,378,641 - 3,388,263 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tbx2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248712,429,407 - 2,437,447 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248712,428,757 - 2,437,447 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_034942637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSPPAT00000037781   ⟹   ENSPPAP00000015093
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1760,622,098 - 60,630,189 (+)Ensembl
RefSeq Acc Id: XM_034942637   ⟹   XP_034798528
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21977,598,977 - 77,608,279 (+)NCBI
NHGRI_mPanPan11782,410,276 - 82,419,751 (+)NCBI
Mhudiblu_PPA_v01755,501,932 - 55,511,537 (+)NCBI
Protein Sequences
Protein RefSeqs XP_034798528 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000015093.1
Reference Protein Sequences
RefSeq Acc Id: XP_034798528   ⟸   XM_034942637
RefSeq Acc Id: ENSPPAP00000015093   ⟸   ENSPPAT00000037781
Protein Domains
T-box


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000030701 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000037781.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.820 UniProtKB/TrEMBL
InterPro p53-like_TF_DNA-bd UniProtKB/TrEMBL
  T-box_DNA-bd UniProtKB/TrEMBL
  T-box_sf UniProtKB/TrEMBL
  TBX UniProtKB/TrEMBL
  TBX2_3_RD UniProtKB/TrEMBL
  TF_Brachyury UniProtKB/TrEMBL
  TF_T-box UniProtKB/TrEMBL
  TF_T-box_CS UniProtKB/TrEMBL
NCBI Gene TBX2 ENTREZGENE
PANTHER PTHR11267 UniProtKB/TrEMBL
  T-BOX TRANSCRIPTION FACTOR TBX2 UniProtKB/TrEMBL
Pfam T-box UniProtKB/TrEMBL
  TBX UniProtKB/TrEMBL
  TBX2-3_RD UniProtKB/TrEMBL
PRINTS BRACHYURY UniProtKB/TrEMBL
  TBOX UniProtKB/TrEMBL
PROSITE TBOX_1 UniProtKB/TrEMBL
  TBOX_2 UniProtKB/TrEMBL
  TBOX_3 UniProtKB/TrEMBL
SMART TBOX UniProtKB/TrEMBL
Superfamily-SCOP SSF49417 UniProtKB/TrEMBL
UniProt A0A2R9AHR8_PANPA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-06-11 TBX2  T-box transcription factor 2  TBX2  T-box 2  Symbol and/or name change 5135510 APPROVED