ITIH4 (inter-alpha-trypsin inhibitor heavy chain 4) - Rat Genome Database

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Gene: ITIH4 (inter-alpha-trypsin inhibitor heavy chain 4) Pan paniscus
Analyze
Symbol: ITIH4
Name: inter-alpha-trypsin inhibitor heavy chain 4
RGD ID: 11902127
Description: ENCODES a protein that exhibits calcium ion binding (ortholog); hyaluronic acid binding (ortholog); INVOLVED IN acute-phase response (inferred); hyaluronan metabolic process (inferred); response to cytokine (inferred); ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); Bacteremia (ortholog); Chronic Hepatitis B (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: inter-alpha-trypsin inhibitor heavy chain family member 4; inter-alpha-trypsin inhibitor heavy chain H4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2252,807,762 - 52,827,998 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1352,807,876 - 52,832,769 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0352,754,664 - 52,774,867 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1353,980,529 - 54,000,560 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl353,980,668 - 53,998,038 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
ITIH4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2252,807,762 - 52,827,998 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1352,807,876 - 52,832,769 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0352,754,664 - 52,774,867 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1353,980,529 - 54,000,560 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl353,980,668 - 53,998,038 (-)Ensemblpanpan1.1panPan2
ITIH4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38352,812,962 - 52,830,672 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl352,812,962 - 52,830,688 (-)EnsemblGRCh38hg38GRCh38
GRCh37352,846,978 - 52,864,688 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36352,822,046 - 52,839,734 (-)NCBINCBI36Build 36hg18NCBI36
Build 34352,822,045 - 52,839,734NCBI
Celera352,825,723 - 52,843,435 (-)NCBICelera
Cytogenetic Map3p21.1NCBI
HuRef352,908,665 - 52,926,377 (-)NCBIHuRef
CHM1_1352,799,205 - 52,816,916 (-)NCBICHM1_1
T2T-CHM13v2.0352,845,872 - 52,863,582 (-)NCBIT2T-CHM13v2.0
Itih4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391430,608,433 - 30,623,943 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1430,608,433 - 30,624,310 (+)EnsemblGRCm39 Ensembl
GRCm381430,886,476 - 30,901,986 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1430,886,476 - 30,902,353 (+)EnsemblGRCm38mm10GRCm38
MGSCv371431,699,678 - 31,715,169 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361429,715,522 - 29,730,858 (+)NCBIMGSCv36mm8
Celera1427,143,865 - 27,159,266 (+)NCBICelera
Cytogenetic Map14BNCBI
cM Map1419.09NCBI
Itih4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8166,086,985 - 6,102,162 (+)NCBIGRCr8
mRatBN7.2166,080,539 - 6,095,710 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl166,080,539 - 6,095,708 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx166,091,889 - 6,107,055 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0167,237,346 - 7,252,512 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0166,099,223 - 6,114,442 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0166,970,367 - 6,985,538 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl166,970,342 - 6,985,579 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0166,896,782 - 6,912,274 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4166,319,608 - 6,334,782 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1166,319,608 - 6,334,777 (+)NCBI
Celera169,093,866 - 9,109,046 (-)NCBICelera
Cytogenetic Map16p16NCBI
Itih4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554302,770,373 - 2,789,131 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554302,772,064 - 2,787,912 (-)NCBIChiLan1.0ChiLan1.0
ITIH4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha2036,984,232 - 36,999,685 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02037,352,995 - 37,368,452 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2037,352,366 - 37,401,740 (+)EnsemblROS_Cfam_1.0 Ensembl
UNSW_CanFamBas_1.02037,125,001 - 37,140,491 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02037,402,544 - 37,418,024 (+)NCBIUU_Cfam_GSD_1.0
Itih4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118170,434,701 - 170,450,834 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364733,573,384 - 3,589,345 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364733,573,282 - 3,589,345 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITIH4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1334,928,439 - 34,948,229 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11334,928,455 - 34,948,250 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21338,197,507 - 38,209,005 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ITIH4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12214,194,979 - 14,216,180 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2214,195,701 - 14,213,603 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041152,684,251 - 152,702,173 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itih4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248224,397,744 - 4,411,406 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248224,397,704 - 4,411,562 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_014344242 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034956654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034956655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063602435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063602436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063602437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063602438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063602439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063602441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063602442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063602443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063602444 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063602445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063602446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063602447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSPPAT00000057315   ⟹   ENSPPAP00000034433
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl353,980,668 - 53,998,038 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000057318   ⟹   ENSPPAP00000034436
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl353,980,668 - 53,998,038 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000057322   ⟹   ENSPPAP00000034440
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl353,980,668 - 53,998,038 (-)Ensembl
RefSeq Acc Id: XM_014344242   ⟹   XP_014199728
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2252,807,762 - 52,827,997 (-)NCBI
NHGRI_mPanPan1352,807,876 - 52,832,769 (-)NCBI
Mhudiblu_PPA_v0352,754,664 - 52,774,867 (-)NCBI
PanPan1.1353,980,529 - 54,000,560 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063602435   ⟹   XP_063458505
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2252,807,762 - 52,827,998 (-)NCBI
RefSeq Acc Id: XM_063602436   ⟹   XP_063458506
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2252,807,762 - 52,827,998 (-)NCBI
RefSeq Acc Id: XM_063602437   ⟹   XP_063458507
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2252,807,762 - 52,827,998 (-)NCBI
RefSeq Acc Id: XM_063602438   ⟹   XP_063458508
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2252,807,762 - 52,827,998 (-)NCBI
RefSeq Acc Id: XM_063602439   ⟹   XP_063458509
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2252,807,762 - 52,827,998 (-)NCBI
RefSeq Acc Id: XM_063602441   ⟹   XP_063458511
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2252,807,762 - 52,827,997 (-)NCBI
RefSeq Acc Id: XM_063602442   ⟹   XP_063458512
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2252,807,762 - 52,827,998 (-)NCBI
RefSeq Acc Id: XM_063602443   ⟹   XP_063458513
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2252,807,762 - 52,827,998 (-)NCBI
RefSeq Acc Id: XM_063602444   ⟹   XP_063458514
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2252,808,850 - 52,827,998 (-)NCBI
RefSeq Acc Id: XM_063602445   ⟹   XP_063458515
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2252,807,919 - 52,827,998 (-)NCBI
RefSeq Acc Id: XM_063602446   ⟹   XP_063458516
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2252,807,762 - 52,827,998 (-)NCBI
RefSeq Acc Id: XM_063602447   ⟹   XP_063458517
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2252,807,762 - 52,826,122 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_014199728   ⟸   XM_014344242
- Peptide Label: isoform X1
- UniProtKB: A0A2R9BXM2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000034433   ⟸   ENSPPAT00000057315
RefSeq Acc Id: ENSPPAP00000034436   ⟸   ENSPPAT00000057318
RefSeq Acc Id: ENSPPAP00000034440   ⟸   ENSPPAT00000057322
RefSeq Acc Id: XP_063458516   ⟸   XM_063602446
- Peptide Label: isoform X10
RefSeq Acc Id: XP_063458512   ⟸   XM_063602442
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063458513   ⟸   XM_063602443
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063458508   ⟸   XM_063602438
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063458509   ⟸   XM_063602439
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063458506   ⟸   XM_063602436
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063458507   ⟸   XM_063602437
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063458505   ⟸   XM_063602435
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063458511   ⟸   XM_063602441
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063458517   ⟸   XM_063602447
- Peptide Label: isoform X11
RefSeq Acc Id: XP_063458515   ⟸   XM_063602445
- Peptide Label: isoform X9
RefSeq Acc Id: XP_063458514   ⟸   XM_063602444
- Peptide Label: isoform X8
Protein Domains
VIT   VWFA


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000040047 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000057315.1 UniProtKB/TrEMBL
  ENSPPAT00000057318.1 UniProtKB/TrEMBL
  ENSPPAT00000057322.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.410 UniProtKB/TrEMBL
InterPro ITI_HC_C UniProtKB/TrEMBL
  VIT UniProtKB/TrEMBL
  VWF_A UniProtKB/TrEMBL
  vWFA_dom_sf UniProtKB/TrEMBL
NCBI Gene ITIH4 ENTREZGENE
PANTHER INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER UniProtKB/TrEMBL
  INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H4 UniProtKB/TrEMBL
Pfam ITI_HC_C UniProtKB/TrEMBL
  VIT UniProtKB/TrEMBL
  VWA UniProtKB/TrEMBL
PROSITE VIT UniProtKB/TrEMBL
  VWFA UniProtKB/TrEMBL
SMART VIT UniProtKB/TrEMBL
  VWA UniProtKB/TrEMBL
Superfamily-SCOP SSF53300 UniProtKB/TrEMBL
UniProt A0A2R9BXM2 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BYA2_PANPA UniProtKB/TrEMBL
  A0A2R9C106_PANPA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-03-19 ITIH4  inter-alpha-trypsin inhibitor heavy chain 4    inter-alpha-trypsin inhibitor heavy chain family member 4  Symbol and/or name change 5135510 APPROVED