GSK3B (glycogen synthase kinase 3 beta) - Rat Genome Database

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Gene: GSK3B (glycogen synthase kinase 3 beta) Pan paniscus
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Symbol: GSK3B
Name: glycogen synthase kinase 3 beta
RGD ID: 11978412
Description: ENCODES a protein that exhibits ATP binding (ortholog); beta-catenin binding (ortholog); dynactin binding (ortholog); INVOLVED IN aging (ortholog); animal organ morphogenesis (ortholog); axonogenesis (ortholog); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; glycogen biosynthetic pathway; Hedgehog signaling pathway; ASSOCIATED WITH Aberrant Crypt Foci (ortholog); acute kidney failure (ortholog); acute myocardial infarction (ortholog); FOUND IN axon (ortholog); beta-catenin destruction complex (ortholog); cell body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: glycogen synthase kinase-3 beta
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13123,856,047 - 124,126,747 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3123,861,379 - 124,126,771 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03116,943,205 - 117,215,001 (-)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
animal organ morphogenesis  (ISO)
axonogenesis  (ISO)
bone remodeling  (ISO)
canonical Wnt signaling pathway  (ISO)
cell growth involved in cardiac muscle cell development  (ISO)
cell migration  (ISO)
cellular response to amyloid-beta  (ISO)
cellular response to dopamine  (ISO)
cellular response to erythropoietin  (ISO)
cellular response to hepatocyte growth factor stimulus  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to interleukin-3  (ISO)
cellular response to iron(II) ion  (ISO)
cellular response to lithium ion  (ISO)
cellular response to mechanical stimulus  (ISO)
circadian rhythm  (ISO)
epithelial to mesenchymal transition  (ISO)
ER overload response  (ISO)
establishment of cell polarity  (ISO)
establishment or maintenance of cell polarity  (ISO)
extrinsic apoptotic signaling pathway  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
fat cell differentiation  (ISO)
glycogen metabolic process  (ISO)
hepatic stellate cell activation  (ISO)
hepatocyte apoptotic process  (ISO)
hippocampus development  (ISO)
hypermethylation of CpG island  (ISO)
insulin receptor signaling pathway  (ISO)
intracellular signal transduction  (ISO)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (ISO)
maintenance of cell polarity  (ISO)
myoblast fusion  (ISO)
myotube differentiation  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of calcineurin-NFAT signaling cascade  (ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cardiac muscle hypertrophy  (ISO)
negative regulation of dendrite development  (ISO)
negative regulation of dendrite morphogenesis  (ISO)
negative regulation of dopaminergic neuron differentiation  (ISO)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
negative regulation of MAP kinase activity  (ISO)
negative regulation of neuron death  (ISO)
negative regulation of neuron maturation  (ISO)
negative regulation of neuron migration  (ISO)
negative regulation of neuron projection development  (ISO)
negative regulation of nitric-oxide synthase activity  (ISO)
negative regulation of protein acetylation  (ISO)
negative regulation of protein binding  (ISO)
negative regulation of protein localization to centrosome  (ISO)
negative regulation of protein localization to nucleus  (ISO)
negative regulation of protein-containing complex assembly  (ISO)
negative regulation of smooth muscle cell apoptotic process  (ISO)
negative regulation of synaptic assembly at neuromuscular junction  (ISO)
negative regulation of TOR signaling  (ISO)
neuron projection development  (ISO)
neuron projection organization  (ISO)
peptidyl-serine phosphorylation  (ISO)
peptidyl-threonine phosphorylation  (ISO)
phosphorylation  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of autophagy  (ISO)
positive regulation of axon extension  (ISO)
positive regulation of cardiac muscle cell differentiation  (ISO)
positive regulation of cell-matrix adhesion  (ISO)
positive regulation of DNA biosynthetic process  (ISO)
positive regulation of excitatory postsynaptic potential  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of GTPase activity  (ISO)
positive regulation of mitochondrial membrane potential  (ISO)
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway  (ISO)
positive regulation of mitochondrion organization  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of neuron death  (ISO)
positive regulation of osteoblast proliferation  (ISO)
positive regulation of osteoclast differentiation  (ISO)
positive regulation of osteoclast proliferation  (ISO)
positive regulation of peptidyl-threonine phosphorylation  (ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (ISO)
positive regulation of protein binding  (ISO)
positive regulation of protein catabolic process  (ISO)
positive regulation of protein export from nucleus  (ISO)
positive regulation of protein localization to centrosome  (ISO)
positive regulation of protein-containing complex assembly  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of stem cell differentiation  (ISO)
positive regulation of synaptic assembly at neuromuscular junction  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
protein autophosphorylation  (ISO)
protein export from nucleus  (ISO)
protein localization to microtubule  (ISO)
protein phosphorylation  (ISO)
re-entry into mitotic cell cycle  (ISO)
regulation of apoptotic process  (ISO)
regulation of axon extension  (ISO)
regulation of axonogenesis  (ISO)
regulation of cell growth  (ISO)
regulation of circadian rhythm  (ISO)
regulation of dendrite morphogenesis  (ISO)
regulation of gene expression by genetic imprinting  (ISO)
regulation of long-term synaptic potentiation  (ISO)
regulation of microtubule anchoring at centrosome  (ISO)
regulation of microtubule cytoskeleton organization  (ISO)
regulation of microtubule-based process  (ISO)
regulation of modification of postsynaptic structure  (ISO)
regulation of neuron projection development  (ISO)
regulation of neuronal synaptic plasticity  (ISO)
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane  (ISO)
regulation of osteoblast differentiation  (ISO)
regulation of synaptic vesicle exocytosis  (ISO)
response to activity  (ISO)
response to angiotensin  (ISO)
response to epinephrine  (ISO)
response to estradiol  (ISO)
response to insulin  (ISO)
response to insulin-like growth factor stimulus  (ISO)
response to L-glutamate  (ISO)
response to lithium ion  (ISO)
response to ultrasound  (ISO)
response to xenobiotic stimulus  (ISO)
response to zinc ion  (ISO)
superior temporal gyrus development  (ISO)
Wnt signaling pathway  (ISO)

References

Genomics

Comparative Map Data
GSK3B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13123,856,047 - 124,126,747 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3123,861,379 - 124,126,771 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03116,943,205 - 117,215,001 (-)NCBIMhudiblu_PPA_v0panPan3
GSK3B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3119,821,321 - 120,094,994 (-)EnsemblGRCh38hg38GRCh38
GRCh383119,821,321 - 120,095,823 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373119,540,168 - 119,813,294 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363121,028,233 - 121,295,203 (-)NCBINCBI36hg18NCBI36
Build 343121,028,237 - 121,295,203NCBI
Celera3117,949,905 - 118,223,017 (-)NCBI
Cytogenetic Map3q13.33NCBI
HuRef3116,916,542 - 117,189,344 (-)NCBIHuRef
CHM1_13119,504,331 - 119,776,722 (-)NCBICHM1_1
Gsk3b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391637,909,363 - 38,066,446 (+)NCBIGRCm39mm39
GRCm39 Ensembl1637,909,363 - 38,066,446 (+)Ensembl
GRCm381638,089,001 - 38,246,084 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1638,089,001 - 38,246,084 (+)EnsemblGRCm38mm10GRCm38
MGSCv371638,089,087 - 38,246,165 (+)NCBIGRCm37mm9NCBIm37
MGSCv361638,008,240 - 38,165,318 (+)NCBImm8
Celera1638,497,488 - 38,655,086 (+)NCBICelera
Cytogenetic Map16B3NCBI
Gsk3b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21162,498,997 - 62,648,665 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1162,504,316 - 62,648,646 (-)Ensembl
Rnor_6.01165,060,884 - 65,208,842 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1165,066,235 - 65,209,268 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01166,873,291 - 67,016,640 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41164,284,731 - 64,428,698 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11164,342,319 - 64,486,287 (-)NCBI
Celera1162,004,680 - 62,147,081 (-)NCBICelera
RH 3.4 Map11501.41RGD
Cytogenetic Map11q21NCBI
Gsk3b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542719,495,422 - 19,671,137 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542719,489,972 - 19,671,137 (-)NCBIChiLan1.0ChiLan1.0
GSK3B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13323,458,369 - 23,659,878 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3323,463,767 - 23,659,666 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3323,488,457 - 23,689,804 (-)NCBI
ROS_Cfam_1.03323,696,164 - 23,823,688 (-)NCBI
UMICH_Zoey_3.13323,500,322 - 23,702,303 (-)NCBI
UNSW_CanFamBas_1.03323,541,326 - 23,742,436 (-)NCBI
UU_Cfam_GSD_1.03324,104,403 - 24,306,119 (-)NCBI
Gsk3b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602130,628,163 - 130,791,946 (+)NCBI
SpeTri2.0NW_0049365366,730,070 - 6,893,818 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GSK3B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13140,136,158 - 140,369,574 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113140,136,109 - 140,370,197 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213149,599,661 - 149,702,154 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.213149,431,156 - 149,510,315 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GSK3B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12260,732,449 - 61,002,735 (+)NCBI
ChlSab1.1 Ensembl2260,733,465 - 60,997,239 (+)Ensembl
Vero_WHO_p1.0NW_023666041105,307,531 - 105,584,674 (-)NCBI
Gsk3b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473128,178,647 - 28,368,784 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000059319   ⟹   ENSPPAP00000036427
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl3123,861,379 - 124,125,772 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000059336   ⟹   ENSPPAP00000036444
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl3123,861,496 - 124,126,771 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000059340   ⟹   ENSPPAP00000036448
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl3123,861,496 - 124,126,771 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000059354   ⟹   ENSPPAP00000036462
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl3123,892,846 - 124,125,772 (-)Ensembl
RefSeq Acc Id: XM_003825159   ⟹   XP_003825207
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.13123,856,047 - 124,126,747 (-)NCBI
Mhudiblu_PPA_v03116,943,205 - 117,215,001 (-)NCBI
Sequence:
RefSeq Acc Id: XM_003825160   ⟹   XP_003825208
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.13123,856,047 - 124,126,747 (-)NCBI
Mhudiblu_PPA_v03116,943,205 - 117,215,001 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008950461   ⟹   XP_008948709
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.13123,856,047 - 124,126,108 (-)NCBI
Mhudiblu_PPA_v03116,943,205 - 117,214,830 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008950462   ⟹   XP_008948710
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.13123,856,047 - 124,126,747 (-)NCBI
Mhudiblu_PPA_v03116,943,205 - 117,215,001 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003825207 (Get FASTA)   NCBI Sequence Viewer  
  XP_003825208 (Get FASTA)   NCBI Sequence Viewer  
  XP_008948709 (Get FASTA)   NCBI Sequence Viewer  
  XP_008948710 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_008948710   ⟸   XM_008950462
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_003825207   ⟸   XM_003825159
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008948709   ⟸   XM_008950461
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_003825208   ⟸   XM_003825160
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSPPAP00000036444   ⟸   ENSPPAT00000059336
RefSeq Acc Id: ENSPPAP00000036448   ⟸   ENSPPAT00000059340
RefSeq Acc Id: ENSPPAP00000036462   ⟸   ENSPPAT00000059354
RefSeq Acc Id: ENSPPAP00000036427   ⟸   ENSPPAT00000059319


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000040976 Ensembl, ENTREZGENE
Ensembl Protein ENSPPAP00000036444 ENTREZGENE
  ENSPPAP00000036448 ENTREZGENE
  ENSPPAP00000036462 ENTREZGENE
NCBI Gene GSK3B ENTREZGENE