ADRB2 (adrenoceptor beta 2) - Rat Genome Database

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Pathways
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Gene: ADRB2 (adrenoceptor beta 2) Pan paniscus
Analyze
Symbol: ADRB2
Name: adrenoceptor beta 2
RGD ID: 12011577
Description: ENCODES a protein that exhibits B2 bradykinin receptor binding (ortholog); beta2-adrenergic receptor activity (ortholog); G-protein alpha-subunit binding (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); associative learning (ortholog); bone resorption (ortholog); PARTICIPATES IN adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; epinephrine signaling pathway via adrenergic receptor beta; G protein mediated signaling pathway via Galphai family; ASSOCIATED WITH acute kidney failure (ortholog); AIDS Dementia Complex (ortholog); Angina Pectoris (ortholog); FOUND IN axon (ortholog); caveola (ortholog); dendrite (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: beta-2 adrenergic receptor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24144,063,792 - 144,193,838 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15142,203,567 - 142,333,375 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05144,259,756 - 144,398,421 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15150,267,321 - 150,269,339 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5150,267,554 - 150,315,892 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
AIDS Dementia Complex  (ISO)
Angina Pectoris  (ISO)
asthma  (ISO)
autism spectrum disorder  (ISO)
autistic disorder  (ISO)
bronchiolitis  (ISO)
cardiomyopathy  (ISO)
cholangiocarcinoma  (ISO)
chronic obstructive pulmonary disease  (ISO)
congestive heart failure  (ISO)
Coronary Disease  (ISO)
cystic fibrosis  (ISO)
dermatitis  (ISO)
dilated cardiomyopathy  (ISO)
disease of metabolism  (ISO)
end stage renal disease  (ISO)
Experimental Liver Cirrhosis  (ISO)
familial adenomatous polyposis 1  (ISO)
familial hyperlipidemia  (ISO)
Fibrosis  (ISO)
genetic disease  (ISO)
Graves' disease  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Hyperlipoproteinemia Type II  (ISO)
hypertension  (ISO)
hypokalemia  (ISO)
hypothyroidism  (ISO)
Insulin Resistance  (ISO)
interstitial cystitis  (ISO)
kidney disease  (ISO)
Left Ventricular Hypertrophy  (ISO)
Liver Injury  (ISO)
lung disease  (ISO)
Metabolic Syndrome  (ISO)
myasthenia gravis  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
myocarditis  (ISO)
Nasal Polyps  (ISO)
nervous system disease  (ISO)
Neurodevelopmental Disorders  (ISO)
obesity  (ISO)
open-angle glaucoma  (ISO)
Paroxysmal Dyspnea  (ISO)
pneumonia  (ISO)
polycystic ovary syndrome  (ISO)
primary open angle glaucoma  (ISO)
Prostatic Neoplasms  (ISO)
psoriasis  (ISO)
pulmonary edema  (ISO)
Reperfusion Injury  (ISO)
sciatic neuropathy  (ISO)
Sepsis  (ISO)
steatotic liver disease  (ISO)
Stomach Neoplasms  (ISO)
toxic shock syndrome  (ISO)
Tremor  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
urticaria  (ISO)
Ventricular Dysfunction, Left  (ISO)
Vestibulocochlear Nerve Injuries  (ISO)
viral encephalitis  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating adrenergic receptor signaling pathway  (IEA)
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IEA,ISO)
adrenergic receptor signaling pathway  (IEA)
associative learning  (ISO)
blood vessel diameter maintenance  (IEA)
bone resorption  (IEA,ISO)
brown fat cell differentiation  (IEA,ISO)
cellular response to amyloid-beta  (IEA)
cellular response to hypoxia  (ISO)
diaphragm contraction  (ISO)
diet induced thermogenesis  (IEA,ISO)
estrous cycle  (ISO)
excitatory postsynaptic potential  (ISO)
female pregnancy  (ISO)
G protein-coupled receptor signaling pathway  (IEA,ISO)
heat generation  (IEA,ISO)
liver development  (ISO)
liver regeneration  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of G protein-coupled receptor signaling pathway  (ISO)
negative regulation of interleukin-6 production  (ISO)
negative regulation of multicellular organism growth  (IEA,ISO)
negative regulation of ossification  (ISO)
negative regulation of smooth muscle contraction  (IEA,ISO)
negative regulation of tumor necrosis factor production  (ISO)
negative regulation of urine volume  (ISO)
norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure  (IEA,ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of ATP-dependent activity  (ISO)
positive regulation of autophagosome maturation  (IEA)
positive regulation of bone mineralization  (IEA,ISO)
positive regulation of calcium ion import across plasma membrane  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cold-induced thermogenesis  (IEA)
positive regulation of lipophagy  (IEA)
positive regulation of MAPK cascade  (IEA)
positive regulation of mini excitatory postsynaptic potential  (IEA)
positive regulation of potassium ion transport  (ISO)
positive regulation of protein kinase A signaling  (IEA)
positive regulation of skeletal muscle tissue growth  (ISO)
positive regulation of sodium ion transport  (ISO)
positive regulation of the force of heart contraction by epinephrine  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
presynaptic modulation of chemical synaptic transmission  (ISO)
receptor-mediated endocytosis  (IEA)
regulation of calcium ion transport  (ISO)
regulation of smooth muscle contraction  (IEA)
regulation of sodium ion transport  (IEA,ISO)
regulation of systemic arterial blood pressure by norepinephrine-epinephrine  (IEA,ISO)
regulation of vein smooth muscle contraction  (ISO)
response to catecholamine  (ISO)
response to cold  (IEA,ISO)
response to dexamethasone  (ISO)
response to estrogen  (ISO)
response to hypoxia  (ISO)
response to monoamine  (ISO)
response to progesterone  (ISO)
response to testosterone  (ISO)
smooth muscle contraction  (IEA,ISO)
synaptic transmission, glutamatergic  (ISO)
transcription by RNA polymerase II  (IEA,ISO)
vasodilation  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ADRB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24144,063,792 - 144,193,838 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15142,203,567 - 142,333,375 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05144,259,756 - 144,398,421 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15150,267,321 - 150,269,339 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5150,267,554 - 150,315,892 (+)Ensemblpanpan1.1panPan2
ADRB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385148,826,611 - 148,828,623 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5148,826,611 - 148,828,623 (+)EnsemblGRCh38hg38GRCh38
GRCh375148,206,174 - 148,208,186 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365148,186,349 - 148,188,381 (+)NCBINCBI36Build 36hg18NCBI36
Build 345148,186,368 - 148,188,379NCBI
Celera5144,288,206 - 144,290,248 (+)NCBICelera
Cytogenetic Map5q32NCBI
HuRef5143,352,751 - 143,354,793 (+)NCBIHuRef
CHM1_15147,638,640 - 147,640,684 (+)NCBICHM1_1
T2T-CHM13v2.05149,361,444 - 149,363,456 (+)NCBIT2T-CHM13v2.0
Adrb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391862,310,784 - 62,313,052 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1862,310,887 - 62,313,030 (-)EnsemblGRCm39 Ensembl
GRCm381862,177,713 - 62,179,981 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1862,177,816 - 62,179,959 (-)EnsemblGRCm38mm10GRCm38
MGSCv371862,337,470 - 62,339,613 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361862,303,185 - 62,305,328 (-)NCBIMGSCv36mm8
Celera1863,462,804 - 63,464,949 (-)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1835.1NCBI
Adrb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81857,912,760 - 57,914,802 (-)NCBIGRCr8
mRatBN7.21855,642,459 - 55,644,501 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1855,502,903 - 55,644,512 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1857,735,062 - 57,737,132 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01858,450,067 - 58,452,145 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01856,266,287 - 56,268,329 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01857,513,792 - 57,515,834 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1857,513,793 - 57,515,834 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01856,739,990 - 56,742,032 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41858,174,958 - 58,177,000 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11858,247,190 - 58,249,232 (-)NCBI
Celera1853,789,848 - 53,791,890 (-)NCBICelera
RH 3.4 Map18542.9RGD
Cytogenetic Map18q12.1NCBI
Adrb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554155,515,697 - 5,516,980 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554155,515,157 - 5,517,198 (-)NCBIChiLan1.0ChiLan1.0
ADRB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1460,048,502 - 60,050,447 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl459,941,517 - 60,050,298 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha459,812,943 - 59,814,888 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0460,537,283 - 60,539,228 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1460,317,278 - 60,319,223 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0460,444,286 - 60,446,231 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0460,962,485 - 60,964,430 (-)NCBIUU_Cfam_GSD_1.0
Adrb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213144,411,444 - 144,414,154 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365045,985,960 - 5,987,210 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365045,985,407 - 5,987,453 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADRB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2150,033,579 - 150,040,731 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12150,032,649 - 150,035,591 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ADRB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12351,445,920 - 51,447,942 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2351,446,154 - 51,447,401 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603426,307,284 - 26,309,305 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adrb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247748,211,984 - 8,213,240 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247748,211,723 - 8,215,962 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000049861   ⟹   ENSPPAP00000027025
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl5150,267,554 - 150,315,892 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000049862   ⟹   ENSPPAP00000027026
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl5150,267,554 - 150,304,867 (+)Ensembl
RefSeq Acc Id: XM_034960754   ⟹   XP_034816645
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v24144,063,793 - 144,082,883 (+)NCBI
NHGRI_mPanPan15142,203,660 - 142,214,115 (+)NCBI
Mhudiblu_PPA_v05144,259,849 - 144,310,549 (+)NCBI
RefSeq Acc Id: XM_055112776   ⟹   XP_054968751
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v24144,063,792 - 144,193,838 (+)NCBI
NHGRI_mPanPan15142,203,567 - 142,333,375 (+)NCBI
RefSeq Acc Id: XM_063604671   ⟹   XP_063460741
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v24144,063,795 - 144,146,404 (+)NCBI
Protein Sequences
Protein RefSeqs XP_034816645 (Get FASTA)   NCBI Sequence Viewer  
  XP_054968751 (Get FASTA)   NCBI Sequence Viewer  
  XP_063460741 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000027025.1
  ENSPPAP00000027026.1
Reference Protein Sequences
RefSeq Acc Id: XP_034816645   ⟸   XM_034960754
- Peptide Label: isoform X2
- UniProtKB: A0A2R9BJW0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000027025   ⟸   ENSPPAT00000049861
RefSeq Acc Id: ENSPPAP00000027026   ⟸   ENSPPAT00000049862
RefSeq Acc Id: XP_054968751   ⟸   XM_055112776
- Peptide Label: isoform X1
- UniProtKB: A0A2R9BJW0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063460741   ⟸   XM_063604671
- Peptide Label: isoform X3
Protein Domains
G-protein coupled receptors family 1 profile


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000036592 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000049861.1 UniProtKB/TrEMBL
  ENSPPAT00000049862.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro ADR_fam UniProtKB/TrEMBL
  ADRB2_rcpt UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
NCBI Gene ADRB2 ENTREZGENE
PANTHER ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/TrEMBL
  PTHR24248:SF21 UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PRINTS ADRENERGICR UniProtKB/TrEMBL
  ADRENRGCB2AR UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A2R9BFF4_PANPA UniProtKB/TrEMBL
  A0A2R9BJW0 ENTREZGENE, UniProtKB/TrEMBL