ADRB2 (adrenoceptor beta 2) - Rat Genome Database

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Gene: ADRB2 (adrenoceptor beta 2) Pan paniscus
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Symbol: ADRB2
Name: adrenoceptor beta 2
RGD ID: 12011577
Description: ENCODES a protein that exhibits adenylate cyclase binding (ortholog); amyloid-beta binding (ortholog); B2 bradykinin receptor binding (ortholog); INVOLVED IN activation of adenylate cyclase activity (ortholog); adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); adrenergic receptor signaling pathway (ortholog); PARTICIPATES IN adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; epinephrine signaling pathway via adrenergic receptor beta; G protein mediated signaling pathway via Galphai family; ASSOCIATED WITH acute kidney failure (ortholog); AIDS Dementia Complex (ortholog); Angina Pectoris (ortholog); FOUND IN apical plasma membrane (ortholog); axon (ortholog); caveola (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: beta-2 adrenergic receptor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15150,267,321 - 150,269,339 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5150,267,554 - 150,315,892 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05144,259,756 - 144,398,421 (+)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
AIDS Dementia Complex  (ISO)
Angina Pectoris  (ISO)
asthma  (ISO)
autistic disorder  (ISO)
bronchiolitis  (ISO)
cardiomyopathy  (ISO)
cholangiocarcinoma  (ISO)
chronic obstructive pulmonary disease  (ISO)
congestive heart failure  (ISO)
Coronary Disease  (ISO)
cystic fibrosis  (ISO)
dermatitis  (ISO)
dilated cardiomyopathy  (ISO)
disease of metabolism  (ISO)
end stage renal disease  (ISO)
Experimental Liver Cirrhosis  (ISO)
familial adenomatous polyposis 1  (ISO)
familial hyperlipidemia  (ISO)
fatty liver disease  (ISO)
Fibrosis  (ISO)
Graves' disease  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Hyperlipoproteinemia Type II  (ISO)
hypertension  (ISO)
hypokalemia  (ISO)
hypothyroidism  (ISO)
Insulin Resistance  (ISO)
interstitial cystitis  (ISO)
kidney disease  (ISO)
Left Ventricular Hypertrophy  (ISO)
Liver Injury  (ISO)
lung disease  (ISO)
Metabolic Syndrome  (ISO)
myasthenia gravis  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
myocarditis  (ISO)
Nasal Polyps  (ISO)
nervous system disease  (ISO)
Neurodevelopmental Disorders  (ISO)
obesity  (ISO)
open-angle glaucoma  (ISO)
Paroxysmal Dyspnea  (ISO)
pneumonia  (ISO)
polycystic ovary syndrome  (ISO)
primary open angle glaucoma  (ISO)
Prostatic Neoplasms  (ISO)
psoriasis  (ISO)
pulmonary edema  (ISO)
Reperfusion Injury  (ISO)
sciatic neuropathy  (ISO)
Sepsis  (ISO)
Stomach Neoplasms  (ISO)
toxic shock syndrome  (ISO)
Tremor  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
urticaria  (ISO)
Ventricular Dysfunction, Left  (ISO)
Vestibulocochlear Nerve Injuries  (ISO)
viral encephalitis  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of adenylate cyclase activity  (ISO)
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (ISO)
adrenergic receptor signaling pathway  (ISO)
aging  (ISO)
associative learning  (ISO)
bone resorption  (ISO)
brown fat cell differentiation  (ISO)
cellular response to amyloid-beta  (ISO)
cellular response to hypoxia  (ISO)
desensitization of G protein-coupled receptor signaling pathway by arrestin  (ISO)
diaphragm contraction  (ISO)
diet induced thermogenesis  (ISO)
estrous cycle  (ISO)
excitatory postsynaptic potential  (ISO)
female pregnancy  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
heat generation  (ISO)
liver development  (ISO)
liver regeneration  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of interleukin-6 production  (ISO)
negative regulation of multicellular organism growth  (ISO)
negative regulation of ossification  (ISO)
negative regulation of platelet aggregation  (ISO)
negative regulation of smooth muscle contraction  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
negative regulation of urine volume  (ISO)
norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure  (ISO)
positive regulation of AMPA receptor activity  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of ATPase activity  (ISO)
positive regulation of autophagosome maturation  (ISO)
positive regulation of bone mineralization  (ISO)
positive regulation of calcium ion import across plasma membrane  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cold-induced thermogenesis  (ISO)
positive regulation of heart contraction  (ISO)
positive regulation of lipophagy  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of mini excitatory postsynaptic potential  (ISO)
positive regulation of potassium ion transport  (ISO)
positive regulation of protein kinase A signaling  (ISO)
positive regulation of protein serine/threonine kinase activity  (ISO)
positive regulation of skeletal muscle tissue growth  (ISO)
positive regulation of sodium ion transport  (ISO)
positive regulation of the force of heart contraction by epinephrine  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
receptor-mediated endocytosis  (ISO)
regulation of calcium ion transport  (ISO)
regulation of sensory perception of pain  (ISO)
regulation of sodium ion transport  (ISO)
regulation of synaptic vesicle exocytosis  (ISO)
regulation of systemic arterial blood pressure by norepinephrine-epinephrine  (ISO)
regulation of vein smooth muscle contraction  (ISO)
response to catecholamine  (ISO)
response to cold  (ISO)
response to dexamethasone  (ISO)
response to estrogen  (ISO)
response to hypoxia  (ISO)
response to monoamine  (ISO)
response to progesterone  (ISO)
response to testosterone  (ISO)
synaptic transmission, glutamatergic  (ISO)
vasodilation  (ISO)
wound healing  (ISO)

References

Genomics

Comparative Map Data
ADRB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15150,267,321 - 150,269,339 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5150,267,554 - 150,315,892 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05144,259,756 - 144,398,421 (+)NCBIMhudiblu_PPA_v0panPan3
ADRB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl5148,826,611 - 148,828,623 (+)EnsemblGRCh38hg38GRCh38
GRCh385148,826,611 - 148,828,623 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh375148,206,174 - 148,208,186 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365148,186,349 - 148,188,381 (+)NCBINCBI36hg18NCBI36
Build 345148,186,368 - 148,188,379NCBI
Celera5144,288,206 - 144,290,248 (+)NCBI
Cytogenetic Map5q32NCBI
HuRef5143,352,751 - 143,354,793 (+)NCBIHuRef
CHM1_15147,638,640 - 147,640,684 (+)NCBICHM1_1
Adrb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391862,310,784 - 62,313,052 (-)NCBIGRCm39mm39
GRCm39 Ensembl1862,310,887 - 62,313,030 (-)Ensembl
GRCm381862,177,713 - 62,179,981 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1862,177,816 - 62,179,959 (-)EnsemblGRCm38mm10GRCm38
MGSCv371862,337,470 - 62,339,613 (-)NCBIGRCm37mm9NCBIm37
MGSCv361862,303,185 - 62,305,328 (-)NCBImm8
Celera1863,462,804 - 63,464,949 (-)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1835.1NCBI
Adrb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21855,642,459 - 55,644,501 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1855,502,903 - 55,644,512 (-)Ensembl
Rnor_6.01857,513,792 - 57,515,834 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1857,513,793 - 57,515,834 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01856,739,990 - 56,742,032 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41858,174,958 - 58,177,000 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11858,247,190 - 58,249,232 (-)NCBI
Celera1853,789,848 - 53,791,890 (-)NCBICelera
RH 3.4 Map18542.9RGD
Cytogenetic Map18q12.1NCBI
Adrb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554155,515,697 - 5,516,980 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554155,515,157 - 5,517,198 (-)NCBIChiLan1.0ChiLan1.0
ADRB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1460,048,502 - 60,050,447 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl459,941,517 - 60,050,298 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha459,812,943 - 59,814,888 (-)NCBI
ROS_Cfam_1.0460,537,283 - 60,539,228 (-)NCBI
UMICH_Zoey_3.1460,317,278 - 60,319,223 (-)NCBI
UNSW_CanFamBas_1.0460,444,286 - 60,446,231 (-)NCBI
UU_Cfam_GSD_1.0460,962,485 - 60,964,430 (-)NCBI
Adrb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213144,411,444 - 144,414,154 (-)NCBI
SpeTri2.0NW_0049365045,985,407 - 5,987,453 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADRB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2150,032,782 - 150,035,591 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12150,032,649 - 150,035,591 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ADRB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12351,445,920 - 51,447,942 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2351,446,154 - 51,447,401 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603426,307,284 - 26,309,305 (-)NCBIVero_WHO_p1.0
Adrb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247748,211,723 - 8,215,962 (+)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000049861   ⟹   ENSPPAP00000027025
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl5150,267,554 - 150,315,892 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000049862   ⟹   ENSPPAP00000027026
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl5150,267,554 - 150,304,867 (+)Ensembl
RefSeq Acc Id: XM_003829053   ⟹   XP_003829101
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.15150,267,321 - 150,269,339 (+)NCBI
Mhudiblu_PPA_v05144,259,756 - 144,398,421 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034960754   ⟹   XP_034816645
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v05144,259,849 - 144,310,549 (+)NCBI
RefSeq Acc Id: XM_034960755   ⟹   XP_034816646
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v05144,259,849 - 144,341,967 (+)NCBI
Protein Sequences
Protein RefSeqs XP_003829101 (Get FASTA)   NCBI Sequence Viewer  
  XP_034816645 (Get FASTA)   NCBI Sequence Viewer  
  XP_034816646 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003829101   ⟸   XM_003829053
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_034816646   ⟸   XM_034960755
- Peptide Label: isoform X2
RefSeq Acc Id: XP_034816645   ⟸   XM_034960754
- Peptide Label: isoform X1
RefSeq Acc Id: ENSPPAP00000027025   ⟸   ENSPPAT00000049861
RefSeq Acc Id: ENSPPAP00000027026   ⟸   ENSPPAT00000049862


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000036592 Ensembl
NCBI Gene ADRB2 ENTREZGENE