RGD Reference Report - Phenanthrene exposure causes cardiac arrhythmia in embryonic zebrafish via perturbing calcium handling. - Rat Genome Database

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Phenanthrene exposure causes cardiac arrhythmia in embryonic zebrafish via perturbing calcium handling.

Authors: Zhang, Y  Huang, L  Zuo, Z  Chen, Y  Wang, C 
Citation: Zhang Y, etal., Aquat Toxicol. 2013 Jul 29;142-143C:26-32. doi: 10.1016/j.aquatox.2013.07.014.
RGD ID: 7327215
Pubmed: PMID:23948075   (View Abstract at PubMed)
DOI: DOI:10.1016/j.aquatox.2013.07.014   (Journal Full-text)

Phenanthrene (Phe) is one of the most abundant and ubiquitous polycyclic aromatic hydrocarbons in the aquatic environment. It is known that Phe has cardiotoxic effects, but knowledge concerning the mechanism of cardiac dysfunction caused by Phe is still limited. In this study, zebrafish embryos were exposed to environmentally relevant concentrations of Phe, and an increase of an irregular rhythm was observed in Phe treated embryos. Disordered calcium (Ca2+) handling characterized by impaired sarcoplasmic reticulum Ca2+ uptake, and obvious Ca2+ accumulation in the cytoplasm was observed in rat embryonic cardiac myoblasts (H9C2) exposed to Phe. The mRNA level as well as protein expression of the SERCA2a Ca2+ pump in zebrafish hearts or H9C2 cells was significantly decreased by Phe exposure. The activity of Ca2+-ATPase in H9C2 cells was inhibited by Phe. Both the mRNA and protein levels of TBX5, a direct regulator of SERCA2a, were significantly decreased by Phe exposure. These results suggested that exposure to Phe could lead to arrhythmia in zebrafish embryos via perturbing the calcium handling pathway.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Gata4Rattransdifferentiation  IMP  RGD 
Mef2cRattransdifferentiation  IMP  RGD 
Tbx5Rattransdifferentiation  IMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gata4  (GATA binding protein 4)
Mef2c  (myocyte enhancer factor 2C)
Tbx5  (T-box transcription factor 5)

Genes (Mus musculus)
Gata4  (GATA binding protein 4)
Mef2c  (myocyte enhancer factor 2C)
Tbx5  (T-box 5)

Genes (Homo sapiens)
GATA4  (GATA binding protein 4)
MEF2C  (myocyte enhancer factor 2C)
TBX5  (T-box transcription factor 5)


Additional Information