MSTN (myostatin) - Rat Genome Database

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Gene: MSTN (myostatin) Pan paniscus
Analyze
Symbol: MSTN
Name: myostatin
RGD ID: 11848157
Description: ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN cellular response to dexamethasone stimulus (ortholog); cellular response to hypoxia (ortholog); myoblast migration involved in skeletal muscle regeneration (ortholog); ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); Burns (ortholog); Cachexia (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: GDF-8; GDF8; Growth/differentiation factor 8
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21392,751,094 - 92,761,026 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B92,765,891 - 92,773,149 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B77,364,927 - 77,452,426 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B195,283,903 - 195,290,922 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B195,283,903 - 195,290,922 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:17186467   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MSTN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21392,751,094 - 92,761,026 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B92,765,891 - 92,773,149 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B77,364,927 - 77,452,426 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B195,283,903 - 195,290,922 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B195,283,903 - 195,290,922 (-)Ensemblpanpan1.1panPan2
MSTN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382190,055,700 - 190,062,729 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2190,055,700 - 190,062,729 (-)EnsemblGRCh38hg38GRCh38
GRCh372190,920,426 - 190,927,455 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362190,628,671 - 190,635,700 (-)NCBINCBI36Build 36hg18NCBI36
Build 342190,745,932 - 190,752,961NCBI
Celera2184,515,357 - 184,522,386 (-)NCBICelera
Cytogenetic Map2q32.2NCBI
HuRef2182,780,433 - 182,787,462 (-)NCBIHuRef
CHM1_12190,926,378 - 190,933,407 (-)NCBICHM1_1
T2T-CHM13v2.02190,545,060 - 190,552,089 (-)NCBIT2T-CHM13v2.0
Mstn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39153,100,799 - 53,107,238 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl153,100,799 - 53,107,238 (+)EnsemblGRCm39 Ensembl
GRCm38153,061,640 - 53,068,079 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl153,061,640 - 53,068,079 (+)EnsemblGRCm38mm10GRCm38
MGSCv37153,118,507 - 53,124,923 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36153,006,208 - 53,012,624 (+)NCBIMGSCv36mm8
Celera153,601,512 - 53,607,928 (+)NCBICelera
Cytogenetic Map1C1.1NCBI
cM Map126.99NCBI
Mstn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8955,944,513 - 55,950,913 (-)NCBIGRCr8
mRatBN7.2948,452,533 - 48,458,933 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl948,452,533 - 48,458,933 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx956,995,653 - 57,000,498 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0962,118,483 - 62,123,328 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0960,414,473 - 60,419,318 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0953,310,977 - 53,315,804 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl953,309,598 - 53,315,915 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0952,977,371 - 52,982,198 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4945,426,831 - 45,431,658 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1945,428,244 - 45,433,072 (-)NCBI
Celera946,124,738 - 46,129,565 (-)NCBICelera
Cytogenetic Map9q22NCBI
Mstn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554038,914,482 - 8,923,465 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554038,914,505 - 8,921,190 (+)NCBIChiLan1.0ChiLan1.0
MSTN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.137729,172 - 734,255 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl37729,172 - 734,362 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha371,685,007 - 1,690,090 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.037623,197 - 628,235 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl37621,860 - 628,368 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.137633,617 - 638,697 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.037601,655 - 606,733 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.037629,871 - 634,951 (-)NCBIUU_Cfam_GSD_1.0
Mstn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303148,842,726 - 148,849,304 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365067,988,718 - 7,996,971 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365067,988,879 - 7,996,260 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MSTN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1594,620,270 - 94,628,545 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11594,623,526 - 94,628,440 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215105,734,309 - 105,739,223 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MSTN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11075,564,816 - 75,570,956 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1075,565,152 - 75,570,528 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040123,900,932 - 123,908,109 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mstn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248545,892,938 - 5,899,473 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248545,893,051 - 5,899,380 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000047822   ⟹   ENSPPAP00000024996
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2B195,283,903 - 195,290,922 (-)Ensembl
RefSeq Acc Id: XM_055108884   ⟹   XP_054964859
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21392,751,094 - 92,761,026 (-)NCBI
NHGRI_mPanPan12B92,765,891 - 92,773,149 (-)NCBI
Protein Sequences
Protein RefSeqs XP_054964859 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein A1C2U7 (Get FASTA)   NCBI Sequence Viewer  
  ABI48519 (Get FASTA)   NCBI Sequence Viewer  
  ABI48520 (Get FASTA)   NCBI Sequence Viewer  
  ABI48521 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000024996.1
Reference Protein Sequences
RefSeq Acc Id: ENSPPAP00000024996   ⟸   ENSPPAT00000047822
RefSeq Acc Id: XP_054964859   ⟸   XM_055108884
- UniProtKB: A1C2U7 (UniProtKB/Swiss-Prot)
Protein Domains
TGF-beta family profile


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000035642 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000047822.1 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.120.970 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-b_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-b_propeptide UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-beta-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFb_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene MSTN ENTREZGENE
PANTHER PTHR11848 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11848:SF150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TGF_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFb_propeptide UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TGF_BETA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF_BETA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART TGFB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A2R9B7F6_PANPA UniProtKB/TrEMBL
  A1C2U7 ENTREZGENE, UniProtKB/Swiss-Prot