FASN (fatty acid synthase) - Rat Genome Database

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Gene: FASN (fatty acid synthase) Pan paniscus
Analyze
Symbol: FASN
Name: fatty acid synthase
RGD ID: 11758649
Description: ENCODES a protein that exhibits fatty acid synthase activity (ortholog); identical protein binding (ortholog); small molecule binding (ortholog); INVOLVED IN acetyl-CoA metabolic process (ortholog); cellular response to interleukin-4 (ortholog); establishment of endothelial intestinal barrier (ortholog); PARTICIPATES IN fatty acid biosynthetic pathway; ASSOCIATED WITH Acute Coronary Syndrome (ortholog); Animal Disease Models (ortholog); autism spectrum disorder (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); glycogen granule (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21998,613,649 - 98,633,697 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan117103,514,379 - 103,534,420 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01776,483,108 - 76,503,148 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11782,187,516 - 82,205,647 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1782,187,516 - 82,205,647 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
FASN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21998,613,649 - 98,633,697 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan117103,514,379 - 103,534,420 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01776,483,108 - 76,503,148 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11782,187,516 - 82,205,647 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1782,187,516 - 82,205,647 (-)Ensemblpanpan1.1panPan2
FASN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381782,078,338 - 82,098,236 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1782,078,338 - 82,098,294 (-)EnsemblGRCh38hg38GRCh38
GRCh371780,036,214 - 80,056,112 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361777,629,503 - 77,649,395 (-)NCBINCBI36Build 36hg18NCBI36
Build 341777,629,503 - 77,649,395NCBI
Celera1776,630,560 - 76,648,850 (-)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1775,436,168 - 75,456,057 (-)NCBIHuRef
CHM1_11780,122,440 - 80,142,272 (-)NCBICHM1_1
T2T-CHM13v2.01782,945,493 - 82,965,389 (-)NCBIT2T-CHM13v2.0
Fasn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911120,696,784 - 120,715,992 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11120,696,672 - 120,715,373 (-)EnsemblGRCm39 Ensembl
GRCm3811120,805,958 - 120,825,166 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11120,805,846 - 120,824,547 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711120,667,272 - 120,685,861 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611120,623,167 - 120,640,332 (-)NCBIMGSCv36mm8
Celera11132,542,449 - 132,561,038 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1184.56NCBI
Fasn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810106,570,415 - 106,588,581 (-)NCBIGRCr8
mRatBN7.210106,072,093 - 106,090,259 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10106,072,091 - 106,090,261 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10111,176,141 - 111,194,306 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010110,639,183 - 110,657,348 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010105,992,540 - 106,010,706 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010109,987,735 - 110,005,901 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10109,987,735 - 110,005,901 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010109,579,051 - 109,597,217 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera10104,615,873 - 104,634,039 (-)NCBICelera
Cytogenetic Map10q32.3NCBI
Fasn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555061,063,002 - 1,079,939 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555061,063,002 - 1,079,939 (+)NCBIChiLan1.0ChiLan1.0
FASN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.19233,105 - 249,573 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl9232,963 - 249,092 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha9835,096 - 852,365 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.09826,552 - 843,813 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl9825,448 - 843,670 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.19851,506 - 868,761 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.09978,401 - 995,678 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.091,056,702 - 1,073,992 (+)NCBIUU_Cfam_GSD_1.0
Fasn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602802,978 - 820,174 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365945,592,609 - 5,608,972 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365945,591,785 - 5,609,886 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FASN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl12920,509 - 937,561 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.112922,405 - 937,560 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2121,023,512 - 1,032,662 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FASN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11673,988,410 - 74,008,374 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1673,982,899 - 74,006,551 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607745,523,735 - 45,543,679 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fasn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480110,909,647 - 10,927,547 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480110,910,022 - 10,926,505 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000063753   ⟹   ENSPPAP00000040833
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1782,187,516 - 82,205,647 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000063769   ⟹   ENSPPAP00000040848
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1782,188,311 - 82,205,643 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000063776   ⟹   ENSPPAP00000040855
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1782,188,311 - 82,205,643 (-)Ensembl
RefSeq Acc Id: XM_034943193   ⟹   XP_034799084
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21998,613,649 - 98,633,697 (-)NCBI
NHGRI_mPanPan117103,514,379 - 103,534,420 (-)NCBI
Mhudiblu_PPA_v01776,483,108 - 76,503,148 (-)NCBI
RefSeq Acc Id: XM_034943194   ⟹   XP_034799085
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21998,613,649 - 98,633,697 (-)NCBI
NHGRI_mPanPan117103,514,379 - 103,534,420 (-)NCBI
Mhudiblu_PPA_v01776,483,108 - 76,503,148 (-)NCBI
Protein Sequences
Protein RefSeqs XP_034799084 (Get FASTA)   NCBI Sequence Viewer  
  XP_034799085 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000040833.1
  ENSPPAP00000040848.1
  ENSPPAP00000040855.1
Reference Protein Sequences
RefSeq Acc Id: XP_034799085   ⟸   XM_034943194
- UniProtKB: A0A2R9CIH4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034799084   ⟸   XM_034943193
- UniProtKB: A0A2R9CIH4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000040833   ⟸   ENSPPAT00000063753
RefSeq Acc Id: ENSPPAP00000040848   ⟸   ENSPPAT00000063769
RefSeq Acc Id: ENSPPAP00000040855   ⟸   ENSPPAT00000063776
Protein Domains
Carrier   Ketosynthase family 3 (KS3)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000042987 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000063753.1 UniProtKB/TrEMBL
  ENSPPAT00000063769.1 UniProtKB/TrEMBL
  ENSPPAT00000063776.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1200.10 UniProtKB/TrEMBL
  3.10.129.110 UniProtKB/TrEMBL
  3.30.70.3290 UniProtKB/TrEMBL
  3.40.366.10 UniProtKB/TrEMBL
  3.40.47.10 UniProtKB/TrEMBL
  3.40.50.150 UniProtKB/TrEMBL
  3.40.50.1820 UniProtKB/TrEMBL
  Medium-chain alcohol dehydrogenases, catalytic domain UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/TrEMBL
  Ac_transferase_dom_sf UniProtKB/TrEMBL
  ACP-like_sf UniProtKB/TrEMBL
  Acyl_transferase UniProtKB/TrEMBL
  Acyl_Trfase/lysoPLipase UniProtKB/TrEMBL
  ADH_C UniProtKB/TrEMBL
  FAS_pseudo-KR UniProtKB/TrEMBL
  GroES-like_sf UniProtKB/TrEMBL
  Ketoacyl_synth_AS UniProtKB/TrEMBL
  Ketoacyl_synth_C UniProtKB/TrEMBL
  Ketoacyl_synth_N UniProtKB/TrEMBL
  Malonyl_transacylase_ACP-bd UniProtKB/TrEMBL
  Methyltransf_12 UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
  PKS_assoc UniProtKB/TrEMBL
  PKS_Beta-ketoAc_synthase_dom UniProtKB/TrEMBL
  PKS_dehydratase UniProtKB/TrEMBL
  PKS_dehydratase_sf UniProtKB/TrEMBL
  PKS_DH_N UniProtKB/TrEMBL
  PKS_ER UniProtKB/TrEMBL
  PKS_KR UniProtKB/TrEMBL
  PKS_PP-bd UniProtKB/TrEMBL
  PP-bd_ACP UniProtKB/TrEMBL
  Ppantetheine_attach_site UniProtKB/TrEMBL
  SAM-dependent_MTases UniProtKB/TrEMBL
  Thioesterase UniProtKB/TrEMBL
  Thiolase-like UniProtKB/TrEMBL
NCBI Gene FASN ENTREZGENE
PANTHER FATTY ACID SYNTHASE UniProtKB/TrEMBL
  FATTY ACID SYNTHASE UniProtKB/TrEMBL
Pfam Acyl_transf_1 UniProtKB/TrEMBL
  ADH_zinc_N UniProtKB/TrEMBL
  FAS_pseudo-KR UniProtKB/TrEMBL
  KAsynt_C_assoc UniProtKB/TrEMBL
  ketoacyl-synt UniProtKB/TrEMBL
  Ketoacyl-synt_C UniProtKB/TrEMBL
  Methyltransf_12 UniProtKB/TrEMBL
  PF08659 UniProtKB/TrEMBL
  PKS_DH_N UniProtKB/TrEMBL
  PP-binding UniProtKB/TrEMBL
  Thioesterase UniProtKB/TrEMBL
PROSITE B_KETOACYL_SYNTHASE UniProtKB/TrEMBL
  CARRIER UniProtKB/TrEMBL
  KS3_2 UniProtKB/TrEMBL
  PHOSPHOPANTETHEINE UniProtKB/TrEMBL
SMART PKS_AT UniProtKB/TrEMBL
  PKS_DH UniProtKB/TrEMBL
  PKS_ER UniProtKB/TrEMBL
  PKS_KR UniProtKB/TrEMBL
  PKS_KS UniProtKB/TrEMBL
  PKS_PP UniProtKB/TrEMBL
Superfamily-SCOP SSF47336 UniProtKB/TrEMBL
  SSF50129 UniProtKB/TrEMBL
  SSF51735 UniProtKB/TrEMBL
  SSF52151 UniProtKB/TrEMBL
  SSF53335 UniProtKB/TrEMBL
  SSF53474 UniProtKB/TrEMBL
  SSF53901 UniProtKB/TrEMBL
  SSF55048 UniProtKB/TrEMBL
UniProt A0A2R9CFY3_PANPA UniProtKB/TrEMBL
  A0A2R9CIH4 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9CII5_PANPA UniProtKB/TrEMBL