APOB (apolipoprotein B) - Rat Genome Database

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Gene: APOB (apolipoprotein B) Pan paniscus
Analyze
Symbol: APOB
Name: apolipoprotein B
RGD ID: 12038647
Description: ENCODES a protein that exhibits cholesterol transfer activity (inferred); heparin binding (inferred); lipase binding (inferred); INVOLVED IN artery morphogenesis (ortholog); cellular response to prostaglandin stimulus (ortholog); cellular response to tumor necrosis factor (ortholog); PARTICIPATES IN altered lipoprotein metabolic pathway; forkhead class A signaling pathway; lipoprotein metabolic pathway; ASSOCIATED WITH aortic valve stenosis (ortholog); arteriosclerosis (ortholog); autosomal recessive hypercholesterolemia (ortholog); FOUND IN extracellular space (ortholog); high-density lipoprotein particle (ortholog); low-density lipoprotein particle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: apolipoprotein B (including Ag(x) antigen); apolipoprotein B-100
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212105,485,757 - 105,528,305 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A105,489,857 - 105,532,277 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A20,986,464 - 21,029,004 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A21,100,349 - 21,142,545 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A21,100,356 - 21,145,129 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
aortic valve stenosis  (ISO)
arteriosclerosis  (ISO)
autosomal recessive hypercholesterolemia  (ISO)
Behcet's disease  (ISO)
beta thalassemia  (ISO)
bile duct cancer  (ISO)
biliary tract cancer  (ISO)
cardiovascular system disease  (ISO)
celiac disease  (ISO)
cerebral infarction  (ISO)
common bile duct neoplasm  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
Coumarin Sensitivity  (ISO)
Death  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
dilated cardiomyopathy 1B  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Dyslipidemias  (ISO)
Endotoxemia  (ISO)
Experimental Diabetes Mellitus  (ISO)
familial combined hyperlipidemia  (ISO)
familial hypercholesterolemia  (ISO)
Familial Hypercholesterolemia due to Ligand-Defective Apolipoprotein B  (ISO)
familial hyperlipidemia  (ISO)
familial hypobetalipoproteinemia 1  (ISO)
familial hypobetalipoproteinemia 2  (ISO)
Familial Hypobetalipoproteinemia, Apolipoprotein B  (ISO)
familial isolated deficiency of vitamin E  (ISO)
gallbladder cancer  (ISO)
Hemorrhage  (ISO)
Hypercholesterolemia  (ISO)
Hypercholesterolemia, Autosomal Dominant, 3  (ISO)
Hyperlipoproteinemia Type II  (ISO)
Hypertriglyceridemia  (ISO)
hypobetalipoproteinemia  (ISO)
Isolated Systolic Hypertension  (ISO)
Marfanoid Mental Retardation Syndrome, Autosomal  (ISO)
Metabolic Syndrome  (ISO)
Myocardial Ischemia  (ISO)
nephrotic syndrome  (ISO)
obesity  (ISO)
ovarian cancer  (ISO)
sickle cell anemia  (ISO)
spastic ataxia  (ISO)
steatotic liver disease  (ISO)
Sudden Cardiac Death  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
warfarin resistance  (ISO)
warfarin sensitivity  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
APOB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212105,485,757 - 105,528,305 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A105,489,857 - 105,532,277 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A20,986,464 - 21,029,004 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A21,100,349 - 21,142,545 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A21,100,356 - 21,145,129 (-)Ensemblpanpan1.1panPan2
APOB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38221,001,429 - 21,044,073 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl221,001,429 - 21,044,073 (-)EnsemblGRCh38hg38GRCh38
GRCh37221,224,301 - 21,266,945 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36221,077,806 - 21,120,450 (-)NCBINCBI36Build 36hg18NCBI36
Build 34221,135,952 - 21,178,597NCBI
Celera221,063,779 - 21,106,429 (-)NCBICelera
Cytogenetic Map2p24.1NCBI
HuRef220,956,976 - 20,999,627 (-)NCBIHuRef
CHM1_1221,153,564 - 21,196,210 (-)NCBICHM1_1
T2T-CHM13v2.0221,034,648 - 21,077,293 (-)NCBIT2T-CHM13v2.0
Apob
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39128,027,629 - 8,066,839 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl128,027,648 - 8,066,835 (+)EnsemblGRCm39 Ensembl
GRCm38127,977,629 - 8,016,839 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl127,977,648 - 8,016,835 (+)EnsemblGRCm38mm10GRCm38
MGSCv37127,984,483 - 8,023,645 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36128,003,656 - 8,042,849 (+)NCBIMGSCv36mm8
Celera128,374,429 - 8,411,685 (+)NCBICelera
Cytogenetic Map12A1.1NCBI
cM Map123.53NCBI
Apob
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8636,563,704 - 36,603,300 (+)NCBIGRCr8
mRatBN7.2630,844,386 - 30,883,983 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl630,844,368 - 30,892,497 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx631,136,522 - 31,176,112 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0631,452,442 - 31,492,039 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0630,926,947 - 30,966,539 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0633,176,826 - 33,216,381 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl633,176,778 - 33,224,997 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0642,956,372 - 42,995,922 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4631,508,060 - 31,548,083 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1631,546,139 - 31,550,758 (+)NCBI
Celera630,299,724 - 30,339,330 (+)NCBICelera
Cytogenetic Map6q14NCBI
Apob
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554693,436,450 - 3,478,424 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554693,437,422 - 3,478,408 (-)NCBIChiLan1.0ChiLan1.0
APOB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11715,877,937 - 15,916,032 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1715,878,244 - 15,915,135 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1715,842,555 - 15,879,853 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01716,030,075 - 16,067,405 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1716,030,161 - 16,067,623 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11715,883,776 - 15,920,986 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01715,891,112 - 15,928,422 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01715,923,305 - 15,960,613 (-)NCBIUU_Cfam_GSD_1.0
Apob
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629260,290,128 - 60,327,775 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649310,509,118 - 10,549,144 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649310,509,118 - 10,549,144 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APOB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3117,250,096 - 117,316,200 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13117,250,096 - 117,316,200 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Pig Cytomap3q24-qterNCBI
APOB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11486,624,209 - 86,669,175 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1486,624,332 - 86,668,704 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604525,515,337 - 25,558,432 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Apob
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247383,580,033 - 3,620,192 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247383,579,747 - 3,622,508 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000013215   ⟹   ENSPPAP00000002804
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2A21,100,356 - 21,142,545 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000013234   ⟹   ENSPPAP00000002809
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2A21,100,650 - 21,145,129 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000013254   ⟹   ENSPPAP00000002812
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2A21,123,650 - 21,142,411 (-)Ensembl
RefSeq Acc Id: XM_034952688   ⟹   XP_034808579
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v212105,485,757 - 105,528,305 (+)NCBI
NHGRI_mPanPan12A105,489,857 - 105,532,277 (+)NCBI
Mhudiblu_PPA_v02A20,986,464 - 21,029,004 (-)NCBI
Protein Sequences
Protein RefSeqs XP_034808579 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF75236 (Get FASTA)   NCBI Sequence Viewer  
  AAF75237 (Get FASTA)   NCBI Sequence Viewer  
  AAF75238 (Get FASTA)   NCBI Sequence Viewer  
  AAO19602 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000002804.1
  ENSPPAP00000002809.1
  ENSPPAP00000002812.1
RefSeq Acc Id: XP_034808579   ⟸   XM_034952688
- UniProtKB: A0A2R8ZJE1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSPPAP00000002804   ⟸   ENSPPAT00000013215
Ensembl Acc Id: ENSPPAP00000002812   ⟸   ENSPPAT00000013254
Ensembl Acc Id: ENSPPAP00000002809   ⟸   ENSPPAT00000013234
Protein Domains
Lipid transport open beta-sheet   Vitellogenin


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000011975 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000013215.1 UniProtKB/TrEMBL
  ENSPPAT00000013234.1 UniProtKB/TrEMBL
  ENSPPAT00000013254.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.20 UniProtKB/TrEMBL
  2.20.50.20 UniProtKB/TrEMBL
  Lipovitellin-phosvitin complex, chain A, domain 4 UniProtKB/TrEMBL
InterPro ApoB100_C UniProtKB/TrEMBL
  Apolipoprotein_B UniProtKB/TrEMBL
  Lipid_transp_b-sht_shell UniProtKB/TrEMBL
  Lipid_transpt_N UniProtKB/TrEMBL
  Lipid_transpt_open_b-sht UniProtKB/TrEMBL
  Lipovitellin_superhlx_dom UniProtKB/TrEMBL
  Vitellinogen_b-sht_N UniProtKB/TrEMBL
  Vitellinogen_open_b-sht UniProtKB/TrEMBL
  Vitellinogen_open_b-sht_sub1 UniProtKB/TrEMBL
NCBI Gene APOB ENTREZGENE
PANTHER APOLIPOPROTEIN B UniProtKB/TrEMBL
  APOLIPOPROTEIN B-100 UniProtKB/TrEMBL
Pfam ApoB100_C UniProtKB/TrEMBL
  DUF1081 UniProtKB/TrEMBL
  DUF1943 UniProtKB/TrEMBL
  Vitellogenin_N UniProtKB/TrEMBL
PROSITE VITELLOGENIN UniProtKB/TrEMBL
SMART DUF1943 UniProtKB/TrEMBL
  LPD_N UniProtKB/TrEMBL
Superfamily-SCOP SSF48431 UniProtKB/TrEMBL
UniProt A0A2R8ZD43_PANPA UniProtKB/TrEMBL
  A0A2R8ZJE1 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R8ZJE7_PANPA UniProtKB/TrEMBL
  Q866M2_PANPA UniProtKB/TrEMBL
  Q9MYL8_PANPA UniProtKB/TrEMBL