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Gene: KDR (kinase insert domain receptor) Pan paniscus

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Symbol:

KDR

Name:

kinase insert domain receptor

RGD ID:

11868560

Description:

ENCODES a protein that exhibits growth factor binding (ortholog); vascular endothelial growth factor receptor activity (ortholog); INVOLVED IN blood vessel endothelial cell differentiation (ortholog); branching involved in blood vessel morphogenesis (ortholog); branching morphogenesis of an epithelial tube (ortholog); PARTICIPATES IN altered vascular endothelial growth factor signaling pathway involving proteins affecting its expression; altered vascular endothelial growth factor signaling pathway involving the main players; axitinib pharmacodynamics pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); adenocarcinoma (ortholog); adhesions of uterus (ortholog); FOUND IN neuronal cell body (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

kinase insert domain receptor (a type III receptor tyrosine kinase); vascular endothelial growth factor receptor 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	74,668,536 - 74,715,699 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	74,872,484 - 74,922,704 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	68,813,894 - 68,861,018 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	75,377,847 - 75,424,927 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	75,377,375 - 75,427,109 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Acute Lung Injury (ISO)

adenocarcinoma (ISO)

adhesions of uterus (ISO)

allergic contact dermatitis (ISO)

amyotrophic lateral sclerosis (ISO)

angiosarcoma (ISO)

Animal Mammary Neoplasms (ISO)

arteriosclerosis (ISO)

arteriovenous malformations of the brain (ISO)

asthma (ISO)

atherosclerosis (ISO)

brain glioma (ISO)

Brain Hypoxia-Ischemia (ISO)

Brain Injuries (ISO)

brain ischemia (ISO)

breast angiosarcoma (ISO)

breast cancer (ISO)

breast carcinoma (ISO)

Breast Neoplasms (ISO)

cerebral cavernous malformation (ISO)

Cerebral Hemorrhage (ISO)

Choroidal Neovascularization (ISO)

chronic obstructive pulmonary disease (ISO)

colitis (ISO)

colon carcinoma (ISO)

Colonic Neoplasms (ISO)

colorectal adenocarcinoma (ISO)

colorectal cancer (ISO)

Colorectal Neoplasms (ISO)

congenital disorder of glycosylation type IIk (ISO)

contact dermatitis (ISO)

corneal neovascularization (ISO)

Coronary Disease (ISO)

Crohn's disease (ISO)

cystitis (ISO)

decubitus ulcer (ISO)

Diabetic Nephropathies (ISO)

diffuse scleroderma (ISO)

Endometrial Neoplasms (ISO)

Endometrioid Carcinomas (ISO)

endometriosis (ISO)

Esophageal Neoplasms (ISO)

esophagus adenocarcinoma (ISO)

Experimental Autoimmune Encephalomyelitis (ISO)

Experimental Colitis (ISO)

Experimental Diabetes Mellitus (ISO)

Experimental Liver Neoplasms (ISO)

Experimental Mammary Neoplasms (ISO)

Eye Neoplasms (ISO)

gastrointestinal stromal tumor (ISO)

glioblastoma (ISO)

Hand-Foot Syndrome (ISO)

hemangiopericytoma (ISO)

hepatoblastoma (ISO)

hepatocellular carcinoma (ISO)

herpes simplex virus keratitis (ISO)

high grade glioma (ISO)

High Myopia (ISO)

Hirschsprung's disease (ISO)

hydrophthalmos (ISO)

hypertension (ISO)

impotence (ISO)

Infantile Capillary Hemangioma (ISO)

inverted papilloma (ISO)

Kidney Neoplasms (ISO)

Kuhnt-Junius degeneration (ISO)

Lathyrism (ISO)

limited scleroderma (ISO)

liver cirrhosis (ISO)

lung carcinoma (ISO)

Lung Neoplasms (ISO)

lung non-small cell carcinoma (ISO)

lymphangioma (ISO)

Lymphatic Metastasis (ISO)

macular degeneration (ISO)

macular retinal edema (ISO)

melanoma (ISO)

myocardial infarction (ISO)

Myocardial Ischemia (ISO)

Nasal Polyps (ISO)

nasopharynx carcinoma (ISO)

Neoplasm Metastasis (ISO)

Neovascularization, Pathologic (ISO)

Neuralgia (ISO)

neurilemmoma (ISO)

neurofibrosarcoma (ISO)

osteochondrodysplasia (ISO)

Otitis Media with Effusion (ISO)

ovarian hyperstimulation syndrome (ISO)

Ovarian Neoplasms (ISO)

Oxygen-Induced Retinopathy (ISO)

pancreatic cancer (ISO)

pancreatic carcinoma (ISO)

primary ovarian insufficiency (ISO)

prostate adenocarcinoma (ISO)

prostate cancer (ISO)

prostatic hypertrophy (ISO)

psoriasis (ISO)

pterygium (ISO)

renal cell carcinoma (ISO)

Reperfusion Injury (ISO)

retinal telangiectasia (ISO)

retinopathy of prematurity (ISO)

salivary gland carcinoma (ISO)

sarcoma (ISO)

schizophrenia (ISO)

Seasonal Allergic Rhinitis (ISO)

Spinal Cord Injuries (ISO)

squamous cell carcinoma (ISO)

stomach cancer (ISO)

Stroke (ISO)

systemic scleroderma (ISO)

temporal lobe epilepsy (ISO)

teratoma (ISO)

tetralogy of Fallot (ISO)

thyroid gland carcinoma (ISO)

tongue squamous cell carcinoma (ISO)

transitional cell carcinoma (ISO)

Transplant Rejection (ISO)

Tufted Angioma (ISO)

type 2 diabetes mellitus (ISO)

ulcerative colitis (ISO)

uremia (ISO)

urinary bladder cancer (ISO)

Uterine Cervical Neoplasms (ISO)

uveal melanoma (ISO)

Venous Thrombosis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

angiogenesis (IEA)

blood vessel endothelial cell differentiation (IEA,ISO)

brain-derived neurotrophic factor receptor signaling pathway (IEA)

branching involved in blood vessel morphogenesis (IEA,ISO)

branching morphogenesis of an epithelial tube (IEA,ISO)

calcium ion homeostasis (IEA,ISO)

cell fate commitment (IEA,ISO)

cell migration (IEA,ISO)

cell migration involved in sprouting angiogenesis (IEA)

cell surface receptor protein tyrosine kinase signaling pathway (IEA)

cellular response to hydrogen sulfide (IEA)

cellular response to vascular endothelial growth factor stimulus (IEA)

collagen-activated tyrosine kinase receptor signaling pathway (IEA)

embryonic hemopoiesis (IEA)

endocardium development (IEA)

endochondral bone growth (ISO)

endothelial cell differentiation (IEA,ISO)

endothelial tube morphogenesis (ISO)

endothelium development (IEA)

ephrin receptor signaling pathway (IEA)

epidermal growth factor receptor signaling pathway (IEA)

epithelial cell maturation (IEA,ISO)

epithelial cell proliferation (IEA,ISO)

fibroblast growth factor receptor signaling pathway (IEA)

hemopoiesis (IEA,ISO)

hepatocyte growth factor receptor signaling pathway (IEA)

insulin receptor signaling pathway (IEA)

insulin-like growth factor receptor signaling pathway (IEA)

Kit signaling pathway (IEA)

lung alveolus development (IEA,ISO)

lung development (IEA,ISO)

lymph vessel development (IEA,ISO)

macrophage colony-stimulating factor signaling pathway (IEA)

male gonad development (ISO)

mesenchymal cell proliferation (IEA,ISO)

negative regulation of endothelial cell apoptotic process (IEA)

negative regulation of gene expression (IEA)

negative regulation of neuron apoptotic process (IEA,ISO)

negative regulation of systemic arterial blood pressure (ISO)

neuron projection morphogenesis (ISO)

ovarian follicle development (IEA,ISO)

peptidyl-tyrosine autophosphorylation (ISO)

peptidyl-tyrosine phosphorylation (ISO)

platelet-derived growth factor receptor-alpha signaling pathway (IEA)

platelet-derived growth factor receptor-beta signaling pathway (IEA)

positive regulation of angiogenesis (IEA,ISO)

positive regulation of blood vessel endothelial cell migration (IEA)

positive regulation of BMP signaling pathway (IEA)

positive regulation of calcium-mediated signaling (ISO)

positive regulation of cell migration (IEA,ISO)

positive regulation of cell migration involved in sprouting angiogenesis (IEA)

positive regulation of cell population proliferation (IEA,ISO)

positive regulation of cytosolic calcium ion concentration (ISO)

positive regulation of endothelial cell chemotaxis (IEA)

positive regulation of endothelial cell migration (IEA)

positive regulation of endothelial cell proliferation (IEA,ISO)

positive regulation of epithelial cell proliferation (IEA,ISO)

positive regulation of ERK1 and ERK2 cascade (IEA)

positive regulation of focal adhesion assembly (IEA)

positive regulation of long-term neuronal synaptic plasticity (ISO)

positive regulation of macroautophagy (IEA,ISO)

positive regulation of MAPK cascade (IEA)

positive regulation of mesenchymal cell proliferation (IEA,ISO)

positive regulation of mitochondrial depolarization (IEA,ISO)

positive regulation of mitochondrial fission (IEA,ISO)

positive regulation of neurogenesis (ISO)

positive regulation of nitric oxide-cGMP mediated signal transduction (IEA,ISO)

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (IEA,ISO)

positive regulation of positive chemotaxis (IEA)

positive regulation of protein phosphorylation (ISO)

positive regulation of stem cell proliferation (IEA,ISO)

positive regulation of TOR signaling (ISO)

positive regulation of vasculogenesis (IEA)

post-embryonic camera-type eye morphogenesis (IEA,ISO)

protein autophosphorylation (ISO)

regulation of bone development (IEA,ISO)

regulation of cell population proliferation (IEA)

regulation of cell shape (IEA)

regulation of hematopoietic progenitor cell differentiation (IEA,ISO)

regulation of MAPK cascade (IEA)

response to axon injury (ISO)

response to hypoxia (ISO)

response to oxygen levels (ISO)

response to xenobiotic stimulus (ISO)

semaphorin-plexin signaling pathway (IEA)

stem cell proliferation (IEA,ISO)

surfactant homeostasis (IEA,ISO)

vascular endothelial growth factor receptor signaling pathway (IEA,ISO)

vascular endothelial growth factor receptor-1 signaling pathway (IEA)

vascular endothelial growth factor receptor-2 signaling pathway (IEA)

vascular endothelial growth factor signaling pathway (IEA)

vascular wound healing (IEA)

vasculogenesis (IEA,ISO)

vasodilation (ISO)

Cellular Component

cell junction (IEA)

cell periphery (IEA)

cell surface (IEA)

cytoplasm (IEA)

early endosome (IEA)

endoplasmic reticulum (IEA)

endosome (IEA)

external side of plasma membrane (IEA)

Golgi apparatus (IEA)

membrane (IEA)

membrane raft (IEA)

neuronal cell body (ISO)

nucleus (IEA)

plasma membrane (IEA)

receptor complex (IEA)

sorting endosome (IEA)

Molecular Function

ATP binding (IEA)

boss receptor activity (IEA)

brain-derived neurotrophic factor receptor activity (IEA)

cadherin binding (IEA)

coreceptor activity (IEA)

epidermal growth factor receptor activity (IEA)

fibroblast growth factor receptor activity (IEA)

GPI-linked ephrin receptor activity (IEA)

growth factor binding (IEA,ISO)

hepatocyte growth factor receptor activity (IEA)

identical protein binding (IEA)

insulin receptor activity (IEA)

insulin-like growth factor receptor activity (IEA)

integrin binding (IEA)

macrophage colony-stimulating factor receptor activity (IEA)

metal ion binding (IEA)

placental growth factor receptor activity (IEA)

platelet-derived growth factor alpha-receptor activity (IEA)

platelet-derived growth factor beta-receptor activity (IEA)

protein binding (ISO)

protein tyrosine kinase activity (IEA)

protein tyrosine kinase collagen receptor activity (IEA)

stem cell factor receptor activity (IEA)

transmembrane-ephrin receptor activity (IEA)

vascular endothelial growth factor binding (IEA)

vascular endothelial growth factor receptor activity (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

altered vascular endothelial growth factor signaling pathway involving proteins affecting its expression (ISO)

altered vascular endothelial growth factor signaling pathway involving the main players (ISO)

axitinib pharmacodynamics pathway (ISO)

bevacizumab pharmacodynamics pathway (ISO)

hypoxia inducible factor pathway (ISO)

sphingosine 1-phosphate signaling pathway (ISO)

vascular endothelial growth factor signaling pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

KDR
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	74,668,536 - 74,715,699 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	74,872,484 - 74,922,704 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	68,813,894 - 68,861,018 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	75,377,847 - 75,424,927 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	75,377,375 - 75,427,109 (+)	Ensembl	panpan1.1		panPan2

KDR
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	55,078,481 - 55,125,595 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	55,078,481 - 55,125,595 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	55,944,648 - 55,991,762 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	55,639,406 - 55,686,519 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	55,785,576 - 55,832,690	NCBI
Celera	4	53,446,341 - 53,493,673 (-)	NCBI		Celera
Cytogenetic Map	4	q12	NCBI
HuRef	4	51,893,013 - 51,940,346 (-)	NCBI		HuRef
CHM1_1	4	55,979,683 - 56,027,015 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	58,566,962 - 58,614,067 (-)	NCBI		T2T-CHM13v2.0

Kdr
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	76,093,487 - 76,139,880 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	76,093,487 - 76,139,118 (-)	Ensembl		GRCm39 Ensembl
GRCm38	5	75,932,827 - 75,979,072 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	75,932,827 - 75,978,458 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	76,329,290 - 76,374,453 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	76,214,962 - 76,260,125 (-)	NCBI		MGSCv36	mm8
Celera	5	73,218,468 - 73,263,674 (-)	NCBI		Celera
Cytogenetic Map	5	C3.3	NCBI
cM Map	5	40.23	NCBI

Kdr
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	32,572,031 - 32,615,204 (+)	NCBI		GRCr8
mRatBN7.2	14	32,217,871 - 32,261,018 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	32,217,871 - 32,261,018 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	32,577,934 - 32,621,098 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	33,885,873 - 33,929,041 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	32,370,973 - 32,414,143 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	34,727,677 - 34,787,127 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	34,727,623 - 34,787,183 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	34,557,361 - 34,618,112 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	14	31,512,534 - 31,554,989 (+)	NCBI		Celera
Cytogenetic Map	14	p11	NCBI

Kdr
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955447	15,810,815 - 15,853,583 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955447	15,810,816 - 15,851,702 (+)	NCBI	ChiLan1.0	ChiLan1.0

KDR
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	13	47,442,861 - 47,484,574 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	13	47,442,764 - 47,485,042 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	13	47,400,610 - 47,442,293 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	13	48,053,730 - 48,095,387 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	13	48,053,595 - 48,095,437 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	13	47,729,487 - 47,771,112 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	13	47,258,117 - 47,299,735 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	13	48,206,381 - 48,248,022 (-)	NCBI		UU_Cfam_GSD_1.0

Kdr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	28,716,920 - 28,760,830 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936482	17,538,864 - 17,581,002 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936482	17,537,697 - 17,581,320 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

KDR
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	41,809,122 - 41,856,336 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	41,809,116 - 41,856,379 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	43,919,330 - 43,966,984 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

KDR
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	13,435,059 - 13,482,236 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	13,435,096 - 13,482,771 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666066	14,207,326 - 14,254,753 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Kdr
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624761	14,330,489 - 14,379,051 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624761	14,330,224 - 14,380,680 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003806471	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000063159 ⟹ ENSPPAP00000040244

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	4	75,377,375 - 75,427,109 (+)	Ensembl

RefSeq Acc Id:

XM_003806471 ⟹ XP_003806519

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	3	74,668,536 - 74,715,699 (+)	NCBI
NHGRI_mPanPan1	4	74,872,484 - 74,922,704 (+)	NCBI
Mhudiblu_PPA_v0	4	68,813,894 - 68,861,018 (+)	NCBI
PanPan1.1	4	75,377,847 - 75,424,927 (+)	NCBI

Sequence:

show sequence

TCCCGGGACCCCGGGAGAGCGGTCAATGTGTGGTCGCTGCGTTTCCTCTGCCTGCGCCGGGCAT
CACTTGCGCGCCGCAGAAAGCCCGTCTGGCAGCCTGGATATCCTCTCCTACCGGCACCCGCAGA
CGCCCCTGCAGCCGCGGTCGGCGCCCGGGCTCCCTAGCCCTGTGCGCTCAACTGTCCTGCGCTG
AGGGGTGCCGCGAGTTCCACCTCCGCGCCTCCTTCTCTAGACAGGCGCTGGGAGAAAGAACCGG
CTCCCGAGTTCTGGGCATTTCGCCCGGCTCGAGGTGCAGGATGCAGAGCAAGGTGCTGCTGGCC
GTCGCCCTGTGGCTCTGCGTGGAGACCCGGGCCGCCTCTGTGGGTTTGCCTAGTGTTTCTCTTG
ATCTGCCCAGGCTCAGCATACAAAAAGACATACTTACAATTAAGGCTAATACAACTCTTCAAAT
TACTTGCAGGGGACAGAGGGACTTGGACTGGCTTTGGCCCAATAATCAGAGTGGCAGTGAGCAA
AGGGTGGAGGTGACTGAGTGCAGCGATGGCCTCTTCTGTAAGACACTCACAATTCCAAAAGTGA
TCGGAAATGACACTGGAGCCTACAAGTGCTTCTACCGGGAAACTGACTTGGCCTCGGTCATTTA
TGTCTATGTTCAAGATTACAGATCTCCATTTATTGCTTCTGTTAGTGACCAACATGGAGTCGTG
TACATTACTGAGAACAAAAACAAAACTGTGGTGATTCCATGTCTCGGGTCCATTTCAAATCTCA
ACGTGTCACTTTGTGCAAGATACCCAGAAAAGAGATTTGTTCCTGATGGTAACAGAATTTCCTG
GGACAGCAAGAAGGGCTTTACTATTCCCAGCTACATGATCAGCTATGCTGGCATGGTCTTCTGT
GAAGCAAAAATTAATGATGAAAGTTACCAGTCTATTATGTACATAGTTGTCGTTGTAGGGTATA
GGATTTATGATGTGGTTCTGAGTCCGTCTCATGGAATTGAACTATCTGTTGGAGAAAAGCTTGT
CTTAAATTGTACAGCAAGAACTGAACTAAATGTGGGGATTGACTTCAACTGGGAATACCCTTCT
TCGAAGCATCAGCATAAGAAACTTGTAAACCGAGACCTAAAAACCCAGTCTGGGAGTGAGATGA
AGAAATTTTTGAGCACCTTAACTATAGATGGTGTAACCCGGAGTGACCAAGGATTGTACACCTG
TGCAGCGTCCAGTGGGCTGATGACCAAGAAGAACAGCACATTTGTCAGGGTCCACGAAAAACCT
TTTGTTGCTTTTGGAAGTGGCATGGAATCTCTGGTGGAAGCCACGGTGGGGGAGCGTGTCAGAA
TCCCAGTGAAGTACCTTGGTTACCCACCCCCAGAAATAAAATGGTATAAAAATGGAATACCCCT
TGAGTCCAATCACACAATTAAAGCAGGGCATGTACTGACGATTATGGAAGTGAGTGAAAGAGAC
ACAGGAAATTATACTGTCATCCTTACCAATCCCATTTCAAAGGAGAAGCAGAGCCATGTGGTCT
CTCTGGTTGTGTATGTCCCACCCCAGATTGGTGAGAAATCTCTAATCTCTCCTGTGGATTCCTA
CCAGTACGGCACCACTCAAACACTGACATGTACGGTCTATGCCATTCCTCCCCCGCATCACATC
CACTGGTATTGGCAGTTGGAGGAAGAGTGCCCCAACGAGCCCAGCCAAGCTGTCTCAGTGACAA
ATCCATACCCTTGTGAAGAATGGAGAAGTGTGGAGGACTTCCAGGGAGGAAATAAAATTGAAGT
TAATAAAAATCAATTTGCTCTAATTGAAGGAAAAAACAAAACTGTAAGTACCCTTGTTATCCAA
GCGGCAAATGTGTCAGCTTTGTACAAATGTGAAGCGGTCAACAAAGTCGGGAGAGGAGAGAGGG
TGATCTCCTTCCACGTGACCAGGGGTCCTGAAATTACTTTGCAACCTGACATGCAGCCCACTGA
GCAGGAGAGCGTGTCTTTGTGGTGCACTGCAGACAGATCTACGTTTGAGAACCTCACATGGTAC
AAGCTTGGCCCACAGCCTCTGCCAATCCATGTGGGAGAGTTGCCCACACCTGTTTGCAAGAACT
TGGATACTCTTTGGAAATTGAATGCCACCATGTTCTCTAATAGCACAAATGACATTTTGATCAT
GGAGCTTAAGAATGCATCCTTGCAGGACCAAGGAGACTATGTCTGCCTTGCTCAAGACAGGAAG
ACCAAGAAAAGACATTGCGTGGTCAGGCAGCTCACAGTCCTAGAGCGTGTGGCACCCACGATCA
CAGGAAACCTGGAGAATCAGACGACAAGTATTGGGGAAAGCATCGAAGTCTCATGCACGGCATC
TGGGAATCCCCCTCCACAGATCATGTGGTTTAAAGATAATGAGACCCTTGTAGAAGACTCAGGC
ATTGTATTGAAGGATGGGAACCGGAACCTCACTATCCGCAGAGTGAGGAAGGAGGACGAAGGCC
TCTACACCTGCCAGGCATGCAGTGTTCTTGGCTGTGCAAAAGTGGAGGCATTTTTCATAATAGA
AGGTGCCCAGGAAAAGACGAACTTGGAAATCATTATTCTAGTAGGCACGGCGGTGATTGCCATG
TTCTTCTGGCTACTTCTTGTCATCATCCTACGGACCGTTAAGCGGGCCAATGGAGGGGAACTGA
AGACAGGCTACTTGTCCATCGTCATGGATCCAGATGAACTCCCATTGGATGAACATTGTGAACG
ACTGCCTTATGATGCTAGCAAATGGGAATTCCCCAGAGACCGGCTGAAGCTAGGTAAGCCTCTT
GGCCGTGGTGCCTTTGGCCAAGTGATTGAAGCAGATGCCTTTGGAATTGACAAGACAGCAACTT
GCAGGACAGTAGCAGTCAAAATGTTGAAAGAAGGAGCAACACACAGTGAGCATCGAGCTCTCAT
GTCTGAACTCAAGATCCTCATTCATATTGGTCACCATCTCAATGTGGTCAACCTTCTAGGTGCC
TGTACCAAGCCAGGAGGGCCACTCATGGTGATTGTGGAATTCTGCAAATTTGGAAACCTATCCA
CTTACCTGAGGAGCAAGAGAAATGAATTTGTCCCCTACAAGACCAAAGGGGCACGATTCCGTCA
AGGGAAAGACTACGTTGGAGCAATCCCTGTGGATCTGAAACGGCGCTTGGACAGCATCACCAGT
AGCCAGAGCTCAGCCAGCTCTGGATTTGTGGAGGAGAAGTCCCTCAGTGATGTAGAAGAAGAGG
AAGCTCCTGAAGATCTGTATAAGGACTTCCTGACCTTGGAGCATCTCATCTGTTACAGCTTCCA
AGTGGCTAAGGGCATGGAGTTCTTGGCATCGCGAAAGTGTATCCACAGGGACCTGGCGGCACGA
AATATCCTCTTATCGGAGAAGAACGTGGTTAAAATCTGTGACTTTGGCTTGGCCCGGGATATTT
ATAAAGATCCAGATTATGTCAGAAAAGGAGATGCTCGCCTCCCTTTGAAATGGATGGCCCCAGA
AACAATTTTTGACAGAGTGTACACAATCCAGAGTGACGTCTGGTCTTTTGGTGTTTTGCTGTGG
GAAATATTTTCCTTAGGTGCTTCTCCATATCCTGGGGTAAAGATTGATGAAGAATTTTGTAGGC
GATTGAAAGAAGGAACTAGAATGAGGGCCCCTGATTATACTACACCAGAAATGTACCAGACCAT
GCTGGACTGCTGGCACGGGGAGCCCAGTCAGAGACCCACGTTTTCAGAGTTGGTGGAACATTTG
GGAAATCTCTTGCAAGCTAATGCTCAGCAGGATGGCAAAGACTACATTGTTCTTCCGATATCAG
AGACTTTGAGCATGGAAGAGGATTCTGGACTCTCTCTGCCTACCTCACCTGTTTCCTGTATGGA
GGAGGAGGAAGTATGTGACCCCAAATTCCATTATGACAACACAGCAGGAATCAGTCAGTATCTG
CAGAACAGTAAGCGAAAGAGCCGGCCTGTGAGTGTAAAAACATTTGAAGATATCCCATTAGAAG
AACCAGAAGTAAAAGTAATCCCAGATGACAACCAGACGGACAGTGGTATGGTTCTTGCCTCAGA
AGAGCTGAAAACTTTGGAAGACAGAACCAAATTATCTCCATCTTTTGGTGGAATGGTGCCCAGC
AAAAGCAGGGAGTCTGTGGCATCTGAAGGCTCAAACCAGACAAGCGGCTACCAGTCCGGATATC
ACTCCGATGACACAGACACCACTGTGTACTCCAGTGAGGAAGCAGAACTTTTAAAGCTGATAGA
GATTGGAGTGCAAACCGGTAGCACAGCCCAGATTCTCCAGCCTGACTCGGGGACCACACTGAGC
TCTCCTCCTGTTTAAAAGGAAGCATCCACACCCCCAACTCCCGGACATCACATGAGAGGTGCTG
CTCAGATTTTCAAGTGTTGTTCTTTCCACCAGCAGGAAGTAGCCGCATTTGATTTTCATTTCGA
CAACAAAAAAAGGACCTCAGACTGCAGGGAGCTAGTCTTCTAGGCATATCCTGGAAGAGGCTTG
TGACCCAAGAATGTGTCTGTGTCTTCTCCCAGTGTTGACCTGATCCTCTTTTTCATTCATTTAA
AAAGCATTTATCATGCCCCTTGCTGCGGGTCTCACCATGGGTTAGAACAAAGACATTCAAGAAA
TGGCCCCATCCTCAAAGAAGTAGCAGTACCTGGGGAGTTGACACTTCTGTAAAACTAGAAGATA
AACCAGGCAATGTAAGTGTTCGAGGTGTTGAAGATGGGAAGGATTTGCAGGGCTGAGTCTATCC
AAGAGGCTTTGTTTAGGACGTGGGTCCCAAGCCAAGCCTTAAGTGTGGAATTCGGATTGATAGA
AAGGAAGACTAACGTTACCTTGCTTTGGAGAGTACTGGAGCCTGCAAATGCATTGTGTTTGCTC
CGGTGGAGGTGGGCATGGGGTCTGTTCTGAAATGTAAAGGGTTCAGACGGGGTTTCTGGTTTTA
GAAGGTTGCGTGTTCTTCGAGTTGGGCTAAAGTAGAGTTCGTTGTGCTGTTTCTGACTCCTAAT
GAGAGTTCCTTCCAGACCGTTACGTGTCTCCTGGCCAAGCCCCAGGAAGGAAATGATGCAGCTC
TGGCTCCTTGTCTCCCAGGCTGATCCTTTATTCAGAATACCACAAAGAAAGGACATTCAGCTCA
AGGCTCCCTGCCGTGTTGAAGAGTTCTGACTGCACAAACCAGCTTCTGGTTTCTTCTGGATGAA
TACCCTCATATCTGTCCTGATGTGATATGTCTGAGACTGAATGCGGGAGGTTCAATGTGAAGCT
GTGTGTGGTGTCAAAGTTTCAGGAAGGATTTTACCCTTTTGTTCTTCTCCCTGTCCCCAACCCA
CTCTCACCCCGCAACCCATCAGTATTTTAGTTATTTGGCCTCTACACTCCAGTAAACCTGATTG
GGTTTGTTCACTCTCTGAATGATTATTAGCCAGACTTCAAAATTATTTTATAGCCCAAATTATA
ACATCTATTGTATTATTTAGACTTTTAACATATAGAGCTATTTCTACTGATTTTTGCCCTTGTT
CTGTCCTTTTTTTCGAAAAAGAAAATGTGTTTTTTGTTTGGTACCATAGTGTGAAATGCTGGGA
ACAATGACTATAAGACATGCTATGGCACATATATTTATAGTCTGTTTATGTAGAAACAAATGTA
ATATATTAAAGCCTTATATTATATATAATGAACTTTGTACTATTCACATTTTGTATCAGTATTA
TGTAGCATAACAAAGGTCATAATGCTTTCAGCAATTGATGTCATTTTATTAAAGAACATTGAAA
AACTTGAAG

hide sequence

Protein Sequences


Protein RefSeqs	XP_003806519	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000040244.1

RefSeq Acc Id:

XP_003806519 ⟸ XM_003806471

- UniProtKB:

A0A2R9CED2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWP
NNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIAS
VSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMI
SYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGI
DFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNST
FVRVHEKPFVAFGSGMESLVEATVGERVRIPVKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLT
IMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVY
AIPPPHHIHWYWQLEEECPNEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNK
TVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRS
TFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDY
VCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDN
ETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIIL
VGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRD
RLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHL
NVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLK
RRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKC
IHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDV
WSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPT
FSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDN
TAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSP
SFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQ
PDSGTTLSSPPV

hide sequence

Ensembl Acc Id:

ENSPPAP00000040244 ⟸ ENSPPAT00000063159

Protein Domains

Ig-like Protein kinase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000042774	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000063159.1	UniProtKB/TrEMBL
Gene3D-CATH	2.60.40.10	UniProtKB/TrEMBL
	Phosphorylase Kinase, domain 1	UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	Ig-like_dom	UniProtKB/TrEMBL
	Ig-like_dom_sf	UniProtKB/TrEMBL
	Ig-like_fold	UniProtKB/TrEMBL
	Ig_I-set	UniProtKB/TrEMBL
	Ig_sub	UniProtKB/TrEMBL
	Ig_sub2	UniProtKB/TrEMBL
	Immunoglobulin	UniProtKB/TrEMBL
	Kinase-like_dom_sf	UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/TrEMBL
	RTK	UniProtKB/TrEMBL
	Ser-Thr/Tyr_kinase_cat_dom	UniProtKB/TrEMBL
	Tyr_kinase_AS	UniProtKB/TrEMBL
	Tyr_kinase_cat_dom	UniProtKB/TrEMBL
	Tyr_kinase_rcpt_3_CS	UniProtKB/TrEMBL
	VEGFR-2_TMD	UniProtKB/TrEMBL
	VEGFR1-3_5th	UniProtKB/TrEMBL
	VEGFR1-3_N_Ig-like	UniProtKB/TrEMBL
	VEGFR2_rcpt	UniProtKB/TrEMBL
KEGG Report	pps:100986594	UniProtKB/TrEMBL
NCBI Gene	KDR	ENTREZGENE
PANTHER	TYROSINE-PROTEIN KINASE RECEPTOR	UniProtKB/TrEMBL
	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	UniProtKB/TrEMBL
Pfam	I-set	UniProtKB/TrEMBL
	Ig_2	UniProtKB/TrEMBL
	PF00047	UniProtKB/TrEMBL
	PK_Tyr_Ser-Thr	UniProtKB/TrEMBL
	VEGFR-1-like_5th	UniProtKB/TrEMBL
	VEGFR-1-like_Ig-like	UniProtKB/TrEMBL
	VEGFR-2_TMD	UniProtKB/TrEMBL
	VEGFR1-3_N_Ig-like	UniProtKB/TrEMBL
PIRSF	TyrPK_CSF1-R	UniProtKB/TrEMBL
PRINTS	VEGFRECEPTOR	UniProtKB/TrEMBL
	VEGFRECEPTR2	UniProtKB/TrEMBL
PROSITE	IG_LIKE	UniProtKB/TrEMBL
	PROTEIN_KINASE_ATP	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
	PROTEIN_KINASE_TYR	UniProtKB/TrEMBL
	RECEPTOR_TYR_KIN_III	UniProtKB/TrEMBL
SMART	IGc2	UniProtKB/TrEMBL
	SM00409	UniProtKB/TrEMBL
	TyrKc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48726	UniProtKB/TrEMBL
	SSF56112	UniProtKB/TrEMBL
UniProt	A0A2R9CED2	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - PID (archival)