KDR (kinase insert domain receptor) - Rat Genome Database

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Gene: KDR (kinase insert domain receptor) Homo sapiens
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Symbol: KDR
Name: kinase insert domain receptor
RGD ID: 731018
HGNC Page HGNC:6307
Description: Enables several functions, including cell adhesion molecule binding activity; vascular endothelial growth factor binding activity; and vascular endothelial growth factor receptor activity. Involved in several processes, including positive regulation of endothelial cell migration; positive regulation of intracellular signal transduction; and transmembrane receptor protein tyrosine kinase signaling pathway. Acts upstream of or within several processes, including branching involved in blood vessel morphogenesis; positive regulation of mitochondrial depolarization; and positive regulation of mitochondrial fission. Located in several cellular components, including Golgi apparatus; endosome; and membrane raft. Implicated in several diseases, including artery disease (multiple); breast angiosarcoma; gastrointestinal system cancer (multiple); macular degeneration (multiple); and pancreatic cancer (multiple). Biomarker of several diseases, including breast cancer (multiple); carcinoma (multiple); cerebrovascular disease (multiple); eye disease (multiple); and systemic scleroderma (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: CD309; fetal liver kinase 1; fetal liver kinase-1; FLK1; kinase insert domain receptor (a type III receptor tyrosine kinase); protein-tyrosine kinase receptor Flk-1; soluble VEGFR2; tyrosine kinase growth factor receptor; vascular endothelial growth factor receptor 2; VEGFR; VEGFR2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38455,078,481 - 55,125,595 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl455,078,481 - 55,125,595 (-)EnsemblGRCh38hg38GRCh38
GRCh37455,944,648 - 55,991,762 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36455,639,406 - 55,686,519 (-)NCBINCBI36Build 36hg18NCBI36
Build 34455,785,576 - 55,832,690NCBI
Celera453,446,341 - 53,493,673 (-)NCBICelera
Cytogenetic Map4q12NCBI
HuRef451,893,013 - 51,940,346 (-)NCBIHuRef
CHM1_1455,979,683 - 56,027,015 (-)NCBICHM1_1
T2T-CHM13v2.0458,566,962 - 58,614,067 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (ISO)
adenocarcinoma  (EXP)
adhesions of uterus  (IEP,ISO)
allergic contact dermatitis  (IEP)
amyotrophic lateral sclerosis  (IEP)
angiosarcoma  (EXP)
Animal Mammary Neoplasms  (ISO)
arteriosclerosis  (IEP,ISO)
arteriovenous malformations of the brain  (IEP)
asthma  (IEP,ISO)
atherosclerosis  (ISO)
brain glioma  (IEP)
Brain Hypoxia-Ischemia  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
breast angiosarcoma  (IAGP)
breast cancer  (IEP)
breast carcinoma  (IEP)
Breast Neoplasms  (EXP,ISO)
cerebral cavernous malformation  (IEP)
Cerebral Hemorrhage  (EXP)
Choroidal Neovascularization  (IDA,ISO)
chronic obstructive pulmonary disease  (IEP)
colitis  (ISO)
colon carcinoma  (IAGP,ISO)
Colonic Neoplasms  (ISO)
colorectal adenocarcinoma  (IDA,IMP)
colorectal cancer  (IAGP)
Colorectal Neoplasms  (EXP)
congenital disorder of glycosylation type IIk  (IAGP)
contact dermatitis  (ISO)
corneal neovascularization  (ISO)
Coronary Disease  (IEP)
Crohn's disease  (IEP)
cystitis  (ISO)
decubitus ulcer  (IEP)
Diabetic Nephropathies  (EXP)
diffuse scleroderma  (IEP)
Endometrial Neoplasms  (IEP)
Endometrioid Carcinomas  (IEP)
endometriosis  (ISO)
Esophageal Neoplasms  (EXP)
esophagus adenocarcinoma  (IAGP)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Neoplasms  (EXP)
Experimental Mammary Neoplasms  (IMP,ISO)
Eye Neoplasms  (EXP)
genetic disease  (IAGP)
glioblastoma  (IMP)
Hand-Foot Syndrome  (IAGP)
hemangiopericytoma  (IEP)
hepatoblastoma  (IAGP)
hepatocellular carcinoma  (IAGP,IEP)
herpes simplex virus keratitis  (ISO)
high grade glioma  (IEP,ISO)
High Myopia  (IAGP)
Hirschsprung's disease  (IAGP)
hydrophthalmos  (ISO)
hypertension  (IAGP,ISO)
impotence  (ISO)
Infantile Capillary Hemangioma  (EXP,IAGP)
inverted papilloma  (IEP)
Kidney Neoplasms  (ISO)
Kuhnt-Junius degeneration  (IAGP)
Lathyrism  (ISO)
limited scleroderma  (IEP)
liver cirrhosis  (IEP)
lung carcinoma  (ISO)
Lung Neoplasms  (EXP)
lung non-small cell carcinoma  (IAGP,IEP,ISO)
lymphangioma  (IEP)
Lymphatic Metastasis  (ISO)
macular degeneration  (IAGP,ISO)
macular retinal edema  (IEP)
melanoma  (IEP,ISO)
myocardial infarction  (IDA,ISO)
Myocardial Ischemia  (EXP)
Nasal Polyps  (IEP)
nasopharynx carcinoma  (IEP)
Neoplasm Metastasis  (IEP)
Neovascularization, Pathologic  (EXP)
Neuralgia  (ISO)
neurilemmoma  (IEP)
neurofibrosarcoma  (ISO)
osteochondrodysplasia  (EXP)
Otitis Media with Effusion  (ISO)
ovarian hyperstimulation syndrome  (ISO)
Ovarian Neoplasms  (EXP,IEP)
Oxygen-Induced Retinopathy  (ISO)
pancreatic cancer  (EXP,IDA)
pancreatic carcinoma  (IMP)
primary ovarian insufficiency  (IAGP)
prostate adenocarcinoma  (IEP,ISO)
prostate cancer  (IAGP)
prostatic hypertrophy  (ISO)
psoriasis  (IEP,ISO)
pterygium  (IEP)
renal cell carcinoma  (ISO)
Reperfusion Injury  (EXP,ISO)
retinal telangiectasia  (IEP)
retinopathy of prematurity  (IEP,ISO)
salivary gland carcinoma  (IEP)
sarcoma  (IEP)
schizophrenia  (EXP)
Seasonal Allergic Rhinitis  (IEP)
Spinal Cord Injuries  (ISO)
squamous cell carcinoma  (ISO)
stomach cancer  (IAGP)
Stroke  (ISO)
systemic scleroderma  (IEP)
temporal lobe epilepsy  (EXP)
teratoma  (IAGP)
tetralogy of Fallot  (IAGP)
thyroid gland carcinoma  (IEP)
tongue squamous cell carcinoma  (ISO)
transitional cell carcinoma  (IEP)
Transplant Rejection  (ISO)
Tufted Angioma  (IAGP)
type 2 diabetes mellitus  (IEP)
ulcerative colitis  (IEP)
uremia  (EXP)
urinary bladder cancer  (IEP,IMP)
Uterine Cervical Neoplasms  (IEP)
uveal melanoma  (IEP)
Venous Thrombosis  (EXP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2,4-trimethylbenzene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-benzoquinone  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,3-Bis(3-hydroxybenzyl)butane-1,4-diol  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-tert-butylhydroquinone  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',5,5'-tetraiodothyroacetic acid  (EXP)
3,3'-diindolylmethane  (EXP)
3,5,6-trichloro-2-pyridinol  (ISO)
3,5,6-trichloropyridine-2-one  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
afimoxifene  (EXP)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
amiodarone  (ISO)
amitrole  (ISO)
andrographolide  (EXP)
apigenin  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (EXP)
aspartame  (EXP)
Auriculasin  (EXP)
belinostat  (EXP)
benzbromarone  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzylpenicillin  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisdemethoxycurcumin  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
bisphenol F  (ISO)
bortezomib  (EXP)
cadmium atom  (EXP)
calcidiol  (ISO)
calcitriol  (ISO)
calcium atom  (EXP,ISO)
calcium silicate  (EXP)
calcium(0)  (EXP,ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
clofibrate  (ISO)
clofibric acid  (ISO)
clozapine  (EXP)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
cordycepin  (EXP)
corticosterone  (ISO)
coumarin  (EXP)
crocidolite asbestos  (EXP)
curcumin  (EXP,ISO)
Curcumol  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cypermethrin  (ISO)
D-glucose  (EXP,ISO)
deguelin  (EXP)
demethoxycurcumin  (EXP)
desferrioxamine B  (EXP)
diarsenic trioxide  (EXP)
diethylstilbestrol  (ISO)
dihydrogen  (ISO)
dioscin  (EXP)
dioxygen  (EXP,ISO)
diprotium  (ISO)
diquat  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
embelin  (EXP)
enalapril  (ISO)
Enterolactone  (ISO)
entinostat  (EXP,ISO)
ethanol  (ISO)
ethyl trans-caffeate  (EXP)
flutamide  (ISO)
folic acid  (ISO)
fructose  (ISO)
fumonisin B1  (ISO)
furosemide  (ISO)
Fusaproliferin  (ISO)
galaxolide  (EXP)
gefitinib  (ISO)
genistein  (ISO)
gentamycin  (ISO)
geraniol  (ISO)
glafenine  (ISO)
glucose  (EXP,ISO)
glycidol  (ISO)
glyphosate  (EXP)
haloperidol  (EXP)
harmaline  (ISO)
hexachlorobenzene  (EXP)
indoles  (ISO)
isoprenaline  (ISO)
kaempferol  (ISO)
L-ascorbic acid  (EXP)
L-ethionine  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
losartan  (ISO)
medroxyprogesterone acetate  (EXP)
melatonin  (EXP)
melittin  (EXP)
methimazole  (ISO)
methoxychlor  (ISO)
methyl caffeate  (EXP)
methylisothiazolinone  (EXP)
methylmercury chloride  (EXP)
microcystin-LR  (EXP,ISO)
mifepristone  (ISO)
MK-2206  (ISO)
monocrotaline  (ISO)
monosodium L-glutamate  (ISO)
Morroniside  (ISO)
N-acetyl-L-cysteine  (EXP)
N-acetylsphingosine  (EXP,ISO)
N-ethyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
nicotine  (ISO)
nicotinic acid  (ISO)
nitrofen  (ISO)
O-methyleugenol  (EXP)
omeprazole  (ISO)
orantinib  (EXP)
orlistat  (EXP)
oxaliplatin  (ISO)
ozone  (ISO)
p-menthan-3-ol  (EXP)
panobinostat  (EXP)
paracetamol  (EXP,ISO)
PCB138  (ISO)
PD123319  (ISO)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenylephrine  (ISO)
phenytoin  (ISO)
phosgene  (ISO)
pirinixic acid  (ISO)
platycodin D  (EXP)
ponatinib  (EXP)
Ponicidin  (EXP)
potassium dichromate  (ISO)
progesterone  (EXP,ISO)
quercetin  (EXP)
quercitrin  (EXP)
quinacrine  (EXP)
quinazolines  (EXP)
resveratrol  (EXP)
riddelliine  (ISO)
rosuvastatin calcium  (ISO)
rotenone  (ISO)
saccharin  (ISO)
sarpogrelate  (ISO)
SB 431542  (EXP)
semaxanib  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenite  (EXP,ISO)
sorafenib  (EXP)
sphingosine 1-phosphate  (EXP)
streptozocin  (ISO)
sulfadimethoxine  (ISO)
sunitinib  (EXP)
superoxide  (EXP)
tanespimycin  (EXP,ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thalidomide  (EXP)
thioacetamide  (ISO)
thyroxine  (ISO)
titanium dioxide  (ISO)
toluene  (ISO)
topotecan  (ISO)
trichloroethene  (ISO)
triclosan  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
undecane  (ISO)
urea  (EXP)
urethane  (ISO)
valproic acid  (EXP,ISO)
valsartan  (EXP,ISO)
vinclozolin  (ISO)
vorinostat  (EXP)
WIN 55212-2  (ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IBA,IEA,TAS)
blood vessel endothelial cell differentiation  (IEA,ISO)
branching involved in blood vessel morphogenesis  (IMP)
branching morphogenesis of an epithelial tube  (IEA,ISO)
calcium ion homeostasis  (IEA,ISO)
cell differentiation  (IEA)
cell fate commitment  (IEA,ISO)
cell migration  (IBA,IEA,ISO)
cell migration involved in sprouting angiogenesis  (IEA,ISS)
cell surface receptor protein tyrosine kinase signaling pathway  (IEA,TAS)
cellular response to hydrogen sulfide  (IDA)
cellular response to vascular endothelial growth factor stimulus  (IDA)
embryonic hemopoiesis  (IEA,ISS)
endocardium development  (IEA)
endochondral bone growth  (ISO)
endothelial cell differentiation  (IBA,IEA,ISO)
endothelial tube morphogenesis  (ISO)
endothelium development  (IEA,ISS)
epithelial cell maturation  (IEA,ISO)
epithelial cell proliferation  (IEA,ISO)
hemopoiesis  (IEA,ISO)
lung alveolus development  (IEA,ISO)
lung development  (IEA,ISO)
lymph vessel development  (IEA,ISO)
male gonad development  (ISO)
mesenchymal cell proliferation  (IEA,ISO)
negative regulation of endothelial cell apoptotic process  (IDA)
negative regulation of gene expression  (IDA)
negative regulation of neuron apoptotic process  (IEA,ISO)
negative regulation of systemic arterial blood pressure  (ISO)
neuron projection morphogenesis  (ISO)
ovarian follicle development  (IEA,ISO)
positive regulation of angiogenesis  (IBA,IDA,IEA,IMP,ISO)
positive regulation of blood vessel endothelial cell migration  (IMP)
positive regulation of BMP signaling pathway  (IEA)
positive regulation of calcium-mediated signaling  (ISO)
positive regulation of cell migration  (IBA,IDA,IEA,ISO)
positive regulation of cell migration involved in sprouting angiogenesis  (IMP)
positive regulation of cell population proliferation  (IDA,ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of endothelial cell chemotaxis  (IDA)
positive regulation of endothelial cell migration  (IMP)
positive regulation of endothelial cell proliferation  (IMP,ISO)
positive regulation of epithelial cell proliferation  (IEA,ISO)
positive regulation of ERK1 and ERK2 cascade  (IMP)
positive regulation of focal adhesion assembly  (IDA)
positive regulation of long-term neuronal synaptic plasticity  (ISO)
positive regulation of macroautophagy  (IGI)
positive regulation of MAPK cascade  (IDA)
positive regulation of mesenchymal cell proliferation  (IEA,ISO)
positive regulation of mitochondrial depolarization  (IGI)
positive regulation of mitochondrial fission  (IGI)
positive regulation of neurogenesis  (ISO)
positive regulation of nitric-oxide synthase biosynthetic process  (IDA,IMP)
positive regulation of phosphate metabolic process  (IEA)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IDA,IMP,ISO)
positive regulation of positive chemotaxis  (IDA)
positive regulation of protein modification process  (IEA)
positive regulation of protein phosphorylation  (IDA)
positive regulation of stem cell proliferation  (IEA,ISO)
positive regulation of TOR signaling  (ISO)
positive regulation of vasculogenesis  (IEA,ISS)
post-embryonic camera-type eye morphogenesis  (IEA,ISO)
protein autophosphorylation  (ISO)
regulation of bone development  (IEA,ISO)
regulation of cell shape  (IDA)
regulation of hematopoietic progenitor cell differentiation  (IEA,ISO)
regulation of MAPK cascade  (IBA,IEA)
response to axon injury  (ISO)
response to hypoxia  (ISO)
response to oxygen levels  (ISO)
response to xenobiotic stimulus  (ISO)
semaphorin-plexin signaling pathway  (IEA)
stem cell proliferation  (IEA,ISO)
surfactant homeostasis  (IEA,ISO)
vascular endothelial growth factor receptor signaling pathway  (IDA,IEA,IMP,ISO,TAS)
vascular endothelial growth factor receptor-2 signaling pathway  (IMP)
vascular endothelial growth factor signaling pathway  (IDA,IEA,IMP)
vascular wound healing  (IMP)
vasculogenesis  (IEA,ISO,ISS)
vasodilation  (ISO)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Inhibition of angiogenesis by blocking activation of the vascular endothelial growth factor receptor 2 leads to decreased growth of neurogenic sarcomas. Angelov L, etal., Cancer Res. 1999 Nov 1;59(21):5536-41.
2. Prognostic importance of vascular endothelial growth factor and its receptors in the uterine sarcoma. Arita S, etal., Int J Gynecol Cancer. 2005 Mar-Apr;15(2):329-36.
3. Vascular endothelial growth factor receptor 2 expression in non-tumorous cirrhotic liver is higher when hepatoma is beyond Milan criteria. Aucejo F, etal., Liver Transpl. 2009 Feb;15(2):169-76. doi: 10.1002/lt.21678.
4. Post-infarct treatment with [Pyr(1)]apelin-13 improves myocardial function by increasing neovascularization and overexpression of angiogenic growth factors in rats. Azizi Y, etal., Eur J Pharmacol. 2015 Aug 15;761:101-8. doi: 10.1016/j.ejphar.2015.04.034. Epub 2015 May 1.
5. EGFR and VEGFR2 protein expressions in bone metastases of clear cell renal cancer. Badalian G, etal., Anticancer Res. 2007 Mar-Apr;27(2):889-94.
6. [Expression of kinase insert domain-containing receptor in prostate adenocarcinoma] Bai AS, etal., Zhonghua Nan Ke Xue. 2007 Apr;13(4):324-6.
7. Primary mammary angiosarcomas harbor frequent mutations in KDR and PIK3CA and show evidence of distinct pathogenesis. Beca F, etal., Mod Pathol. 2020 Aug;33(8):1518-1526. doi: 10.1038/s41379-020-0511-6. Epub 2020 Mar 2.
8. Meta-analysis of contribution of genetic polymorphisms in drug-metabolizing enzymes or transporters to axitinib pharmacokinetics. Brennan M, etal., Eur J Clin Pharmacol. 2012 May;68(5):645-55. Epub 2011 Dec 15.
9. Expression of vascular endothelial growth factor and its receptors in the central nervous system in amyotrophic lateral sclerosis. Brockington A, etal., J Neuropathol Exp Neurol. 2006 Jan;65(1):26-36.
10. Overexpression of vascular permeability factor (VPF/VEGF) and its endothelial cell receptors in delayed hypersensitivity skin reactions. Brown LF, etal., J Immunol. 1995 Mar 15;154(6):2801-7.
11. Combined administration of G-CSF and GM-CSF stimulates monocyte-derived pro-angiogenic cells in patients with acute myocardial infarction. Bruno S, etal., Cytokine. 2006 Apr;34(1-2):56-65. Epub 2006 May 15.
12. The VEGFR2, COX-2 and MMP-2 polymorphisms are associated with clinical outcome of patients with inoperable non-small cell lung cancer. Butkiewicz D, etal., Int J Cancer. 2015 Nov 15;137(10):2332-42. doi: 10.1002/ijc.29605. Epub 2015 Jun 3.
13. Evidence for reduced angiogenesis in bone marrow in SSc: immunohistochemistry and multiparametric computerized imaging analysis. Carrai V, etal., Rheumatology (Oxford). 2012 Jun;51(6):1042-8. doi: 10.1093/rheumatology/ker447. Epub 2012 Jan 23.
14. KDR activation in astrocytic neoplasms. Carroll RS, etal., Cancer. 1999 Oct 1;86(7):1335-41.
15. Angiopoietin-2 interferes with anti-VEGFR2-induced vessel normalization and survival benefit in mice bearing gliomas. Chae SS, etal., Clin Cancer Res. 2010 Jul 15;16(14):3618-27. Epub 2010 May 25.
16. Expression of vascular endothelial growth factor receptors in experimental otitis media in the rat. Chae SW, etal., Acta Otolaryngol. 2003 Jun;123(5):559-63.
17. The role of KDR in intrauterine adhesions may involve the TGF-β1/Smads signaling pathway. Chen JX, etal., Braz J Med Biol Res. 2019 Oct 7;52(10):e8324. doi: 10.1590/1414-431X20198324. eCollection 2019.
18. Upregulation of vascular endothelial growth factor receptors Flt-1 and Flk-1 following acute spinal cord contusion in rats. Choi JS, etal., J Histochem Cytochem. 2007 Aug;55(8):821-30. Epub 2007 Apr 4.
19. Upregulation of vascular endothelial growth factor receptors Flt-1 and Flk-1 in rat hippocampus after transient forebrain ischemia. Choi JS, etal., J Neurotrauma. 2007 Mar;24(3):521-31.
20. Antiangiogenic and antitumor activity of a novel vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor ZD6474 in a metastatic human pancreatic tumor model. Conrad C, etal., Anticancer Drugs. 2007 Jun;18(5):569-79. doi: 10.1097/CAD.0b013e3280147d13.
21. rAAV-mediated long-term liver-generated expression of an angiogenesis inhibitor can restrict renal tumor growth in mice. Davidoff AM, etal., Cancer Res. 2002 Jun 1;62(11):3077-83.
22. Arteriogenic erectile dysfunction alters protein expression within the cavernosal tissue in an animal model. De Young L, etal., J Sex Med. 2005 Mar;2(2):199-206.
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24. Expression of VEGFR2 and NRP-1 in non-small cell lung cancer and their clinical significance. Ding M, etal., Chin J Cancer Res. 2014 Dec;26(6):669-77. doi: 10.3978/j.issn.1000-9604.2014.12.04.
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PMID:35240013   PMID:35241527   PMID:35313079   PMID:35326447   PMID:35384245   PMID:35428537   PMID:35518568   PMID:35605916   PMID:35876388   PMID:35970387   PMID:35984546   PMID:36243803  
PMID:36281948   PMID:36371601   PMID:36376833   PMID:36430232   PMID:36708576   PMID:36740182   PMID:36768878   PMID:36928770   PMID:37165911   PMID:37226882   PMID:37341071   PMID:37381118  
PMID:37392242   PMID:37393757   PMID:37499788   PMID:37610648   PMID:37647140   PMID:37651195   PMID:37803932   PMID:37924452   PMID:38072992   PMID:38324585   PMID:38363405   PMID:38491522  


Genomics

Comparative Map Data
KDR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38455,078,481 - 55,125,595 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl455,078,481 - 55,125,595 (-)EnsemblGRCh38hg38GRCh38
GRCh37455,944,648 - 55,991,762 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36455,639,406 - 55,686,519 (-)NCBINCBI36Build 36hg18NCBI36
Build 34455,785,576 - 55,832,690NCBI
Celera453,446,341 - 53,493,673 (-)NCBICelera
Cytogenetic Map4q12NCBI
HuRef451,893,013 - 51,940,346 (-)NCBIHuRef
CHM1_1455,979,683 - 56,027,015 (-)NCBICHM1_1
T2T-CHM13v2.0458,566,962 - 58,614,067 (-)NCBIT2T-CHM13v2.0
Kdr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39576,093,487 - 76,139,880 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl576,093,487 - 76,139,118 (-)EnsemblGRCm39 Ensembl
GRCm38575,932,827 - 75,979,072 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl575,932,827 - 75,978,458 (-)EnsemblGRCm38mm10GRCm38
MGSCv37576,329,290 - 76,374,453 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36576,214,962 - 76,260,125 (-)NCBIMGSCv36mm8
Celera573,218,468 - 73,263,674 (-)NCBICelera
Cytogenetic Map5C3.3NCBI
cM Map540.23NCBI
Kdr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81432,572,031 - 32,615,204 (+)NCBIGRCr8
mRatBN7.21432,217,871 - 32,261,018 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1432,217,871 - 32,261,018 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1432,577,934 - 32,621,098 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01433,885,873 - 33,929,041 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01432,370,973 - 32,414,143 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01434,727,677 - 34,787,127 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1434,727,623 - 34,787,183 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01434,557,361 - 34,618,112 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1431,512,534 - 31,554,989 (+)NCBICelera
Cytogenetic Map14p11NCBI
Kdr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544715,810,815 - 15,853,583 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544715,810,816 - 15,851,702 (+)NCBIChiLan1.0ChiLan1.0
KDR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2374,668,536 - 74,715,699 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1474,872,484 - 74,922,704 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0468,813,894 - 68,861,018 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1475,377,847 - 75,424,927 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl475,377,375 - 75,427,109 (+)Ensemblpanpan1.1panPan2
KDR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11347,442,861 - 47,484,574 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1347,442,764 - 47,485,042 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1347,400,610 - 47,442,293 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01348,053,730 - 48,095,387 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1348,053,595 - 48,095,437 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11347,729,487 - 47,771,112 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01347,258,117 - 47,299,735 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01348,206,381 - 48,248,022 (-)NCBIUU_Cfam_GSD_1.0
Kdr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528528,716,920 - 28,760,830 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648217,538,864 - 17,581,002 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648217,537,697 - 17,581,320 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KDR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl841,809,122 - 41,856,336 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1841,809,116 - 41,856,379 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2843,919,330 - 43,966,984 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KDR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1713,435,059 - 13,482,236 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl713,435,096 - 13,482,771 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606614,207,326 - 14,254,753 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kdr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476114,330,489 - 14,379,051 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476114,330,224 - 14,380,680 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in KDR
102 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_002253.4(KDR):c.3439C>T (p.Pro1147Ser) single nucleotide variant Capillary infantile hemangioma [RCV000013110]|not specified [RCV000121300] Chr4:55088939 [GRCh38]
Chr4:55955106 [GRCh37]
Chr4:4q12		 pathogenic|other|not provided
NM_002253.4(KDR):c.1444T>C (p.Cys482Arg) single nucleotide variant Capillary infantile hemangioma [RCV000013111]|not provided [RCV001355593]|not specified [RCV000121295] Chr4:55106779 [GRCh38]
Chr4:55972946 [GRCh37]
Chr4:4q12		 risk factor|likely benign|not provided
GRCh38/hg38 4q12(chr4:51870025-55102392)x1 copy number loss See cases [RCV000050988] Chr4:51870025..55102392 [GRCh38]
Chr4:52736191..55968559 [GRCh37]
Chr4:52430948..55663316 [NCBI36]
Chr4:4q12		 pathogenic
GRCh38/hg38 4p13-q13.1(chr4:44356201-62245882)x3 copy number gain See cases [RCV000050683] Chr4:44356201..62245882 [GRCh38]
Chr4:44358218..63111600 [GRCh37]
Chr4:44052975..62794195 [NCBI36]
Chr4:4p13-q13.1		 pathogenic
GRCh38/hg38 4q12-13.2(chr4:51831622-66991489)x3 copy number gain See cases [RCV000051771] Chr4:51831622..66991489 [GRCh38]
Chr4:52697788..67857207 [GRCh37]
Chr4:52392545..67539802 [NCBI36]
Chr4:4q12-13.2		 pathogenic
GRCh38/hg38 4q12-22.3(chr4:51831622-97505618)x3 copy number gain See cases [RCV000051772] Chr4:51831622..97505618 [GRCh38]
Chr4:52697788..98426769 [GRCh37]
Chr4:52392545..98645792 [NCBI36]
Chr4:4q12-22.3		 pathogenic
GRCh38/hg38 4q12-13.1(chr4:51899860-59984479)x3 copy number gain See cases [RCV000051773] Chr4:51899860..59984479 [GRCh38]
Chr4:52766026..60850197 [GRCh37]
Chr4:52460783..60532792 [NCBI36]
Chr4:4q12-13.1		 pathogenic
GRCh38/hg38 4q12-13.1(chr4:52639018-59984479)x1 copy number loss See cases [RCV000053265] Chr4:52639018..59984479 [GRCh38]
Chr4:53505185..60850197 [GRCh37]
Chr4:53199942..60532792 [NCBI36]
Chr4:4q12-13.1		 pathogenic
GRCh38/hg38 4q12-13.1(chr4:54198601-62270115)x1 copy number loss See cases [RCV000053266] Chr4:54198601..62270115 [GRCh38]
Chr4:55064768..63135833 [GRCh37]
Chr4:54759525..62818428 [NCBI36]
Chr4:4q12-13.1		 pathogenic
NM_002253.2(KDR):c.3357G>A (p.Leu1119=) single nucleotide variant Malignant melanoma [RCV000066459] Chr4:55089421 [GRCh38]
Chr4:55955588 [GRCh37]
Chr4:55650345 [NCBI36]
Chr4:4q12		 not provided
NM_002253.2(KDR):c.3728C>T (p.Pro1243Leu) single nucleotide variant Malignant melanoma [RCV000061012] Chr4:55082570 [GRCh38]
Chr4:55948737 [GRCh37]
Chr4:55643494 [NCBI36]
Chr4:4q12		 not provided
NM_002253.2(KDR):c.1338G>A (p.Thr446=) single nucleotide variant Malignant melanoma [RCV000061013] Chr4:55107811 [GRCh38]
Chr4:55973978 [GRCh37]
Chr4:55668735 [NCBI36]
Chr4:4q12		 not provided
NM_002253.4(KDR):c.1384T>G (p.Leu462Val) single nucleotide variant not provided [RCV000861138]|not specified [RCV000121292] Chr4:55107765 [GRCh38]
Chr4:55973932 [GRCh37]
Chr4:4q12		 benign|likely benign|not provided
NM_002253.4(KDR):c.1416A>T (p.Gln472His) single nucleotide variant KDR-related condition [RCV003975077]|not specified [RCV000121293] Chr4:55106807 [GRCh38]
Chr4:55972974 [GRCh37]
Chr4:4q12		 benign|not provided
NM_002253.4(KDR):c.1493A>T (p.Glu498Val) single nucleotide variant not specified [RCV000121294] Chr4:55106730 [GRCh38]
Chr4:55972897 [GRCh37]
Chr4:4q12		 not provided
NM_002253.4(KDR):c.1615G>A (p.Gly539Arg) single nucleotide variant not provided [RCV000862412]|not specified [RCV000121296] Chr4:55105862 [GRCh38]
Chr4:55972029 [GRCh37]
Chr4:4q12		 likely benign|not provided
NM_002253.4(KDR):c.2066C>T (p.Thr689Met) single nucleotide variant Hirschsprung disease, susceptibility to, 1 [RCV000201301]|not provided [RCV000861134]|not specified [RCV000121297] Chr4:55102430 [GRCh38]
Chr4:55968597 [GRCh37]
Chr4:4q12		 benign|uncertain significance|not provided
NM_002253.4(KDR):c.2305G>A (p.Val769Ile) single nucleotide variant not specified [RCV000121298] Chr4:55098765 [GRCh38]
Chr4:55964932 [GRCh37]
Chr4:4q12		 not provided
NM_002253.4(KDR):c.2674A>G (p.Ile892Val) single nucleotide variant not specified [RCV000121299] Chr4:55096283 [GRCh38]
Chr4:55962450 [GRCh37]
Chr4:4q12		 not provided
NM_002253.4(KDR):c.3808A>C (p.Lys1270Gln) single nucleotide variant not specified [RCV000121301] Chr4:55081996 [GRCh38]
Chr4:55948163 [GRCh37]
Chr4:4q12		 not provided
NM_002253.4(KDR):c.170G>C (p.Arg57Thr) single nucleotide variant not provided [RCV001356648]|not specified [RCV000121302] Chr4:55118792 [GRCh38]
Chr4:55984959 [GRCh37]
Chr4:4q12		 uncertain significance|not provided
NM_002253.4(KDR):c.406G>A (p.Val136Met) single nucleotide variant not provided [RCV000861192]|not specified [RCV000121303] Chr4:55115364 [GRCh38]
Chr4:55981531 [GRCh37]
Chr4:4q12		 benign|not provided
NM_002253.4(KDR):c.724C>T (p.Leu242Phe) single nucleotide variant Premature ovarian failure [RCV001270196]|not specified [RCV000121304] Chr4:55114200 [GRCh38]
Chr4:55980367 [GRCh37]
Chr4:4q12		 likely pathogenic|not provided
NM_002253.4(KDR):c.787C>T (p.Pro263Ser) single nucleotide variant not specified [RCV000121305] Chr4:55114137 [GRCh38]
Chr4:55980304 [GRCh37]
Chr4:4q12		 not provided
NM_002253.4(KDR):c.794C>T (p.Ser265Leu) single nucleotide variant not specified [RCV000121306] Chr4:55114130 [GRCh38]
Chr4:55980297 [GRCh37]
Chr4:4q12		 not provided
NM_002253.4(KDR):c.895C>T (p.Arg299Trp) single nucleotide variant not specified [RCV000121307] Chr4:55113385 [GRCh38]
Chr4:55979552 [GRCh37]
Chr4:4q12		 not provided
NM_002253.4(KDR):c.889G>A (p.Val297Ile) single nucleotide variant KDR-related condition [RCV003975078]|not specified [RCV000121308] Chr4:55113391 [GRCh38]
Chr4:55979558 [GRCh37]
Chr4:4q12		 benign|not provided
NM_002253.4(KDR):c.1055C>T (p.Ala352Val) single nucleotide variant not provided [RCV000865154]|not specified [RCV000121309] Chr4:55110690 [GRCh38]
Chr4:55976857 [GRCh37]
Chr4:4q12		 benign|not provided
NM_002253.4(KDR):c.1151C>T (p.Thr384Met) single nucleotide variant not provided [RCV001460346]|not specified [RCV000121310] Chr4:55110507 [GRCh38]
Chr4:55976674 [GRCh37]
Chr4:4q12		 likely benign|not provided
NM_002253.4(KDR):c.1116G>C (p.Glu372Asp) single nucleotide variant not provided [RCV000861936]|not specified [RCV000121311] Chr4:55110542 [GRCh38]
Chr4:55976709 [GRCh37]
Chr4:4q12		 benign|not provided
NM_002253.4(KDR):c.1192G>A (p.Val398Ile) single nucleotide variant not specified [RCV000121312] Chr4:55110466 [GRCh38]
Chr4:55976633 [GRCh37]
Chr4:4q12		 not provided
NM_002253.4(KDR):c.1987+28C>T single nucleotide variant not specified [RCV000122411] Chr4:55104615 [GRCh38]
Chr4:55970782 [GRCh37]
Chr4:4q12		 not provided
NM_002253.4(KDR):c.-1G>T single nucleotide variant KDR-related condition [RCV003975091]|not specified [RCV000122412] Chr4:55125294 [GRCh38]
Chr4:55991461 [GRCh37]
Chr4:4q12		 benign|not provided
NM_002253.4(KDR):c.3848+15T>C single nucleotide variant Capillary infantile hemangioma [RCV000612206]|not specified [RCV001701117] Chr4:55081941 [GRCh38]
Chr4:55948108 [GRCh37]
Chr4:4q12		 benign
NM_002253.4(KDR):c.2360G>A (p.Arg787Gln) single nucleotide variant Malignant tumor of prostate [RCV000149129] Chr4:55098710 [GRCh38]
Chr4:55964877 [GRCh37]
Chr4:4q12		 uncertain significance
NM_002253.4(KDR):c.2615-23C>T single nucleotide variant Carcinoma of colon [RCV000186516] Chr4:55096365 [GRCh38]
Chr4:55962532 [GRCh37]
Chr4:4q12		 uncertain significance
NM_002253.4(KDR):c.2656C>A (p.Leu886Ile) single nucleotide variant Carcinoma of colon [RCV000186517] Chr4:55096301 [GRCh38]
Chr4:55962468 [GRCh37]
Chr4:4q12		 uncertain significance
NM_002253.4(KDR):c.2676T>A (p.Ile892=) single nucleotide variant Carcinoma of colon [RCV000186518] Chr4:55096281 [GRCh38]
Chr4:55962448 [GRCh37]
Chr4:4q12		 uncertain significance
NM_002253.4(KDR):c.2705T>A (p.Leu902Gln) single nucleotide variant Carcinoma of colon [RCV000186519] Chr4:55096252 [GRCh38]
Chr4:55962419 [GRCh37]
Chr4:4q12		 uncertain significance
NM_002253.4(KDR):c.2721G>C (p.Lys907Asn) single nucleotide variant Carcinoma of colon [RCV000186520] Chr4:55096236 [GRCh38]
Chr4:55962403 [GRCh37]
Chr4:4q12		 uncertain significance
NM_002253.4(KDR):c.2380G>A (p.Gly794Arg) single nucleotide variant Carcinoma of colon [RCV000186521] Chr4:55098266 [GRCh38]
Chr4:55964433 [GRCh37]
Chr4:4q12		 uncertain significance
NM_002253.4(KDR):c.2509+20T>A single nucleotide variant Carcinoma of colon [RCV000186522] Chr4:55098117 [GRCh38]
Chr4:55964284 [GRCh37]
Chr4:4q12		 uncertain significance
NM_002253.4(KDR):c.2510-27del deletion Carcinoma of colon [RCV000186523] Chr4:55097793 [GRCh38]
Chr4:55963960 [GRCh37]
Chr4:4q12		 uncertain significance
NM_002253.4(KDR):c.2544G>T (p.Val848=) single nucleotide variant Carcinoma of colon [RCV000186524] Chr4:55097732 [GRCh38]
Chr4:55963899 [GRCh37]
Chr4:4q12		 uncertain significance
NM_002253.4(KDR):c.2598A>C (p.Ala866=) single nucleotide variant Carcinoma of colon [RCV000186525] Chr4:55097678 [GRCh38]
Chr4:55963845 [GRCh37]
Chr4:4q12		 uncertain significance
NM_002253.4(KDR):c.3405-4C>T single nucleotide variant Carcinoma of colon [RCV000186526] Chr4:55088977 [GRCh38]
Chr4:55955144 [GRCh37]
Chr4:4q12		 uncertain significance
NM_002253.4(KDR):c.3441C>G (p.Pro1147=) single nucleotide variant Carcinoma of colon [RCV000186527] Chr4:55088937 [GRCh38]
Chr4:55955104 [GRCh37]
Chr4:4q12		 uncertain significance
NM_002253.4(KDR):c.3465G>A (p.Glu1155=) single nucleotide variant Carcinoma of colon [RCV000186528] Chr4:55088913 [GRCh38]
Chr4:55955080 [GRCh37]
Chr4:4q12		 uncertain significance
NM_002253.4(KDR):c.3487C>T (p.Leu1163Phe) single nucleotide variant Carcinoma of colon [RCV000186529] Chr4:55088891 [GRCh38]
Chr4:55955058 [GRCh37]
Chr4:4q12		 uncertain significance
GRCh37/hg19 4p16.3-q35.2(chr4:12440-190904441)x3 copy number gain See cases [RCV000446653] Chr4:12440..190904441 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
NM_002253.4(KDR):c.2266+1G>T single nucleotide variant not provided [RCV000426580] Chr4:55101896 [GRCh38]
Chr4:55968063 [GRCh37]
Chr4:4q12		 uncertain significance
NM_002253.4(KDR):c.2971+3A>G single nucleotide variant not provided [RCV000483185] Chr4:55094799 [GRCh38]
Chr4:55960966 [GRCh37]
Chr4:4q12		 uncertain significance
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473) copy number gain See cases [RCV000510453] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
GRCh37/hg19 4p16.3-q13.1(chr4:68345-66440622)x3 copy number gain See cases [RCV000511193] Chr4:68345..66440622 [GRCh37]
Chr4:4p16.3-q13.1		 pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473)x3 copy number gain See cases [RCV000512241] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190915650)x3 copy number gain not provided [RCV000743155] Chr4:49450..190915650 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190963766)x3 copy number gain not provided [RCV000743156] Chr4:49450..190963766 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:11525-191028879)x3 copy number gain not provided [RCV000743147] Chr4:11525..191028879 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
NM_002253.4(KDR):c.2743A>G (p.Ile915Val) single nucleotide variant not provided [RCV000861318] Chr4:55095651 [GRCh38]
Chr4:55961818 [GRCh37]
Chr4:4q12		 likely benign
NM_002253.4(KDR):c.1137G>A (p.Ala379=) single nucleotide variant not provided [RCV000866539] Chr4:55110521 [GRCh38]
Chr4:55976688 [GRCh37]
Chr4:4q12		 likely benign
NM_002253.4(KDR):c.2022G>C (p.Glu674Asp) single nucleotide variant not provided [RCV000868619] Chr4:55102474 [GRCh38]
Chr4:55968641 [GRCh37]
Chr4:4q12		 likely benign
NM_002253.4(KDR):c.2556T>C (p.Asp852=) single nucleotide variant not provided [RCV000867925] Chr4:55097720 [GRCh38]
Chr4:55963887 [GRCh37]
Chr4:4q12		 likely benign
NM_002253.4(KDR):c.837C>T (p.Thr279=) single nucleotide variant not provided [RCV000926263] Chr4:55113443 [GRCh38]
Chr4:55979610 [GRCh37]
Chr4:4q12		 benign
NM_002253.4(KDR):c.1092-6T>C single nucleotide variant not provided [RCV000864481] Chr4:55110572 [GRCh38]
Chr4:55976739 [GRCh37]
Chr4:4q12		 benign
NM_002253.4(KDR):c.1440C>T (p.Tyr480=) single nucleotide variant not provided [RCV000943497] Chr4:55106783 [GRCh38]
Chr4:55972950 [GRCh37]
Chr4:4q12		 likely benign
NM_002253.4(KDR):c.1593A>G (p.Glu531=) single nucleotide variant not provided [RCV000924663] Chr4:55105884 [GRCh38]
Chr4:55972051 [GRCh37]
Chr4:4q12		 likely benign
NM_002253.4(KDR):c.3888T>A (p.Ser1296=) single nucleotide variant KDR-related condition [RCV003965729]|not provided [RCV000869240] Chr4:55080124 [GRCh38]
Chr4:55946291 [GRCh37]
Chr4:4q12		 likely benign
NM_002253.4(KDR):c.3132C>A (p.Ile1044=) single nucleotide variant not provided [RCV000862377] Chr4:55090016 [GRCh38]
Chr4:55956183 [GRCh37]
Chr4:4q12		 benign
NM_002253.4(KDR):c.1256-10C>T single nucleotide variant not provided [RCV000860953] Chr4:55107903 [GRCh38]
Chr4:55974070 [GRCh37]
Chr4:4q12		 benign
NM_002253.4(KDR):c.1638C>T (p.His546=) single nucleotide variant not provided [RCV000863804] Chr4:55105839 [GRCh38]
Chr4:55972006 [GRCh37]
Chr4:4q12		 benign
GRCh37/hg19 4q12(chr4:53688710-56491447) copy number loss Piebaldism [RCV002280638] Chr4:53688710..56491447 [GRCh37]
Chr4:4q12		 pathogenic
NM_002253.4(KDR):c.2312C>T (p.Thr771Met) single nucleotide variant High myopia [RCV000785688]|Tufted angioma of skin [RCV001849436]|not provided [RCV000862978] Chr4:55098758 [GRCh38]
Chr4:55964925 [GRCh37]
Chr4:4q12		 likely pathogenic|likely benign|uncertain significance
NM_002253.4(KDR):c.3090G>A (p.Ala1030=) single nucleotide variant not provided [RCV000861204] Chr4:55090058 [GRCh38]
Chr4:55956225 [GRCh37]
Chr4:4q12		 benign
NM_002253.4(KDR):c.204T>C (p.Ser68=) single nucleotide variant KDR-related condition [RCV003965639]|not provided [RCV000861467] Chr4:55118758 [GRCh38]
Chr4:55984925 [GRCh37]
Chr4:4q12		 benign
NM_002253.4(KDR):c.1029G>A (p.Thr343=) single nucleotide variant KDR-related condition [RCV003938253]|not provided [RCV000863943] Chr4:55110716 [GRCh38]
Chr4:55976883 [GRCh37]
Chr4:4q12		 benign|likely benign
NM_002253.4(KDR):c.2012G>A (p.Gly671Glu) single nucleotide variant Inborn genetic diseases [RCV002561074]|not provided [RCV001200283] Chr4:55102484 [GRCh38]
Chr4:55968651 [GRCh37]
Chr4:4q12		 conflicting interpretations of pathogenicity|uncertain significance
NM_002253.4(KDR):c.304A>G (p.Lys102Glu) single nucleotide variant Inborn genetic diseases [RCV003291628] Chr4:55118658 [GRCh38]
Chr4:55984825 [GRCh37]
Chr4:4q12		 uncertain significance
NM_002253.4(KDR):c.2258T>A (p.Ile753Lys) single nucleotide variant Inborn genetic diseases [RCV003273810] Chr4:55101905 [GRCh38]
Chr4:55968072 [GRCh37]
Chr4:4q12		 uncertain significance
NM_002253.4(KDR):c.1326G>A (p.Thr442=) single nucleotide variant not provided [RCV000865952] Chr4:55107823 [GRCh38]
Chr4:55973990 [GRCh37]
Chr4:4q12		 likely benign
NM_002253.4(KDR):c.1575A>G (p.Ser525=) single nucleotide variant not provided [RCV000867420] Chr4:55105902 [GRCh38]
Chr4:55972069 [GRCh37]
Chr4:4q12		 benign
NM_002253.4(KDR):c.1834T>C (p.Leu612=) single nucleotide variant not provided [RCV000861395] Chr4:55104796 [GRCh38]
Chr4:55970963 [GRCh37]
Chr4:4q12		 benign
NM_002253.4(KDR):c.1596G>A (p.Ala532=) single nucleotide variant KDR-related condition [RCV003965638]|not provided [RCV000861466] Chr4:55105881 [GRCh38]
Chr4:55972048 [GRCh37]
Chr4:4q12		 benign
NM_002253.4(KDR):c.1176C>G (p.Asp392Glu) single nucleotide variant Inborn genetic diseases [RCV003276429] Chr4:55110482 [GRCh38]
Chr4:55976649 [GRCh37]
Chr4:4q12		 uncertain significance
NM_002253.4(KDR):c.3445C>G (p.Gln1149Glu) single nucleotide variant not provided [RCV001357814] Chr4:55088933 [GRCh38]
Chr4:55955100 [GRCh37]
Chr4:4q12		 uncertain significance
GRCh38/hg38 4q12-21.1(chr4:51891814-76009719)x1 copy number loss Piebaldism [RCV001420508] Chr4:51891814..76009719 [GRCh38]
Chr4:4q12-21.1		 pathogenic
NM_002253.4(KDR):c.2525G>A (p.Arg842His) single nucleotide variant Hepatoblastoma [RCV001843588]|not provided [RCV001437104] Chr4:55097751 [GRCh38]
Chr4:55963918 [GRCh37]
Chr4:4q12		 likely benign|uncertain significance
NM_002253.4(KDR):c.1621A>T (p.Arg541Trp) single nucleotide variant Inborn genetic diseases [RCV003276778] Chr4:55105856 [GRCh38]
Chr4:55972023 [GRCh37]
Chr4:4q12		 uncertain significance
GRCh37/hg19 4q11-12(chr4:52685685-58104722)x1 copy number loss not provided [RCV001829079] Chr4:52685685..58104722 [GRCh37]
Chr4:4q11-12		 pathogenic
GRCh37/hg19 4q12-31.21(chr4:52866944-143582507)x3 copy number gain not provided [RCV001827738] Chr4:52866944..143582507 [GRCh37]
Chr4:4q12-31.21		 pathogenic
NC_000004.11:g.(?_55124936)_(57798318_?)dup duplication TMEM165-congenital disorder of glycosylation [RCV003120758]|not provided [RCV001944395] Chr4:55124936..57798318 [GRCh37]
Chr4:4q12		 uncertain significance|no classifications from unflagged records
NC_000004.11:g.(?_55124936)_(57368027_?)del deletion TMEM165-congenital disorder of glycosylation [RCV003119917]|not provided [RCV003119918] Chr4:55124936..57368027 [GRCh37]
Chr4:4q12		 pathogenic|uncertain significance|no classifications from unflagged records
NM_002253.4(KDR):c.3006G>C (p.Leu1002Phe) single nucleotide variant Capillary infantile hemangioma [RCV002291137] Chr4:55092680 [GRCh38]
Chr4:55958847 [GRCh37]
Chr4:4q12		 uncertain significance
GRCh37/hg19 4q11-12(chr4:52685980-59272025)x3 copy number gain not provided [RCV002473779] Chr4:52685980..59272025 [GRCh37]
Chr4:4q11-12		 uncertain significance
GRCh37/hg19 4q12(chr4:55800120-55960636)x1 copy number loss not provided [RCV002474980] Chr4:55800120..55960636 [GRCh37]
Chr4:4q12		 uncertain significance
NM_002253.4(KDR):c.2078A>C (p.Asn693Thr) single nucleotide variant Inborn genetic diseases [RCV002733340] Chr4:55102418 [GRCh38]
Chr4:55968585 [GRCh37]
Chr4:4q12		 uncertain significance
NM_002253.4(KDR):c.3496G>A (p.Ala1166Thr) single nucleotide variant Inborn genetic diseases [RCV002880091] Chr4:55088882 [GRCh38]
Chr4:55955049 [GRCh37]
Chr4:4q12		 uncertain significance
NM_002253.4(KDR):c.1930G>A (p.Ala644Thr) single nucleotide variant Inborn genetic diseases [RCV002990521] Chr4:55104700 [GRCh38]
Chr4:55970867 [GRCh37]
Chr4:4q12		 uncertain significance
NM_002253.4(KDR):c.350A>G (p.Tyr117Cys) single nucleotide variant Inborn genetic diseases [RCV002840952] Chr4:55118612 [GRCh38]
Chr4:55984779 [GRCh37]
Chr4:4q12		 uncertain significance
NM_002253.4(KDR):c.259A>G (p.Thr87Ala) single nucleotide variant Inborn genetic diseases [RCV002777184] Chr4:55118703 [GRCh38]
Chr4:55984870 [GRCh37]
Chr4:4q12		 uncertain significance
NM_002253.4(KDR):c.1216A>G (p.Lys406Glu) single nucleotide variant Inborn genetic diseases [RCV002732328] Chr4:55110442 [GRCh38]
Chr4:55976609 [GRCh37]
Chr4:4q12		 uncertain significance
NM_002253.4(KDR):c.1697G>A (p.Ser566Asn) single nucleotide variant Inborn genetic diseases [RCV002707174] Chr4:55104933 [GRCh38]
Chr4:55971100 [GRCh37]
Chr4:4q12		 uncertain significance
NM_002253.4(KDR):c.2374G>A (p.Ala792Thr) single nucleotide variant Inborn genetic diseases [RCV002739733] Chr4:55098272 [GRCh38]
Chr4:55964439 [GRCh37]
Chr4:4q12		 uncertain significance
NM_002253.4(KDR):c.4010G>A (p.Gly1337Asp) single nucleotide variant Inborn genetic diseases [RCV002787748] Chr4:55080002 [GRCh38]
Chr4:55946169 [GRCh37]
Chr4:4q12		 uncertain significance
NM_002253.4(KDR):c.1674C>A (p.Asp558Glu) single nucleotide variant Inborn genetic diseases [RCV002921646] Chr4:55104956 [GRCh38]
Chr4:55971123 [GRCh37]
Chr4:4q12		 uncertain significance
NM_002253.4(KDR):c.2549A>C (p.Glu850Ala) single nucleotide variant Inborn genetic diseases [RCV002960037] Chr4:55097727 [GRCh38]
Chr4:55963894 [GRCh37]
Chr4:4q12		 uncertain significance
NM_002253.4(KDR):c.3817G>C (p.Glu1273Gln) single nucleotide variant Inborn genetic diseases [RCV002718222] Chr4:55081987 [GRCh38]
Chr4:55948154 [GRCh37]
Chr4:4q12		 uncertain significance
NM_002253.4(KDR):c.2270C>G (p.Ala757Gly) single nucleotide variant Inborn genetic diseases [RCV002941784] Chr4:55098800 [GRCh38]
Chr4:55964967 [GRCh37]
Chr4:4q12		 uncertain significance
NM_002253.4(KDR):c.3686G>A (p.Arg1229Gln) single nucleotide variant Inborn genetic diseases [RCV002678484] Chr4:55082612 [GRCh38]
Chr4:55948779 [GRCh37]
Chr4:4q12		 uncertain significance
NM_002253.4(KDR):c.1978A>G (p.Thr660Ala) single nucleotide variant Inborn genetic diseases [RCV002680327] Chr4:55104652 [GRCh38]
Chr4:55970819 [GRCh37]
Chr4:4q12		 uncertain significance
NM_002253.4(KDR):c.1362T>A (p.His454Gln) single nucleotide variant Inborn genetic diseases [RCV002678697] Chr4:55107787 [GRCh38]
Chr4:55973954 [GRCh37]
Chr4:4q12		 uncertain significance
NM_002253.4(KDR):c.716G>A (p.Gly239Glu) single nucleotide variant Inborn genetic diseases [RCV002723180] Chr4:55114208 [GRCh38]
Chr4:55980375 [GRCh37]
Chr4:4q12		 uncertain significance
NM_002253.4(KDR):c.3475C>T (p.His1159Tyr) single nucleotide variant Inborn genetic diseases [RCV002656829] Chr4:55088903 [GRCh38]
Chr4:55955070 [GRCh37]
Chr4:4q12		 uncertain significance
NM_002253.4(KDR):c.3773C>T (p.Thr1258Met) single nucleotide variant Teratoma [RCV003221389] Chr4:55082031 [GRCh38]
Chr4:55948198 [GRCh37]
Chr4:4q12		 uncertain significance
NM_002253.4(KDR):c.3790C>T (p.Leu1264Phe) single nucleotide variant Inborn genetic diseases [RCV003204169] Chr4:55082014 [GRCh38]
Chr4:55948181 [GRCh37]
Chr4:4q12		 uncertain significance
NM_002253.4(KDR):c.1745C>G (p.Thr582Arg) single nucleotide variant Inborn genetic diseases [RCV003300416] Chr4:55104885 [GRCh38]
Chr4:55971052 [GRCh37]
Chr4:4q12		 uncertain significance
NM_002253.4(KDR):c.2182A>G (p.Arg728Gly) single nucleotide variant Inborn genetic diseases [RCV003304263] Chr4:55101981 [GRCh38]
Chr4:55968148 [GRCh37]
Chr4:4q12		 uncertain significance
NM_002253.4(KDR):c.548A>G (p.Lys183Arg) single nucleotide variant Inborn genetic diseases [RCV003260753] Chr4:55114984 [GRCh38]
Chr4:55981151 [GRCh37]
Chr4:4q12		 uncertain significance
GRCh38/hg38 4p16.3-q12(chr4:85624-57073230)x3 copy number gain Neurodevelopmental disorder [RCV003327613] Chr4:85624..57073230 [GRCh38]
Chr4:4p16.3-q12		 pathogenic
NM_002253.4(KDR):c.2243T>G (p.Val748Gly) single nucleotide variant Inborn genetic diseases [RCV003375748] Chr4:55101920 [GRCh38]
Chr4:55968087 [GRCh37]
Chr4:4q12		 uncertain significance
GRCh37/hg19 4q11-13.1(chr4:52685685-61903883)x1 copy number loss not provided [RCV003485416] Chr4:52685685..61903883 [GRCh37]
Chr4:4q11-13.1		 pathogenic
GRCh37/hg19 4q12(chr4:55517082-56227984)x4 copy number gain not provided [RCV003485346] Chr4:55517082..56227984 [GRCh37]
Chr4:4q12		 uncertain significance
NM_002253.4(KDR):c.3663T>C (p.Ser1221=) single nucleotide variant Capillary infantile hemangioma [RCV003455881] Chr4:55082635 [GRCh38]
Chr4:55948802 [GRCh37]
Chr4:4q12		 uncertain significance
NM_002253.4(KDR):c.3872G>T (p.Arg1291Met) single nucleotide variant not provided [RCV003439312] Chr4:55080140 [GRCh38]
Chr4:55946307 [GRCh37]
Chr4:4q12		 uncertain significance
NM_002253.4(KDR):c.1768C>T (p.Pro590Ser) single nucleotide variant not provided [RCV003439313] Chr4:55104862 [GRCh38]
Chr4:55971029 [GRCh37]
Chr4:4q12		 likely benign
NM_002253.4(KDR):c.1136C>T (p.Ala379Val) single nucleotide variant Tufted angioma of skin [RCV003459019] Chr4:55110522 [GRCh38]
Chr4:55976689 [GRCh37]
Chr4:4q12		 uncertain significance
NM_002253.4(KDR):c.3274G>C (p.Gly1092Arg) single nucleotide variant KDR-related condition [RCV003493380] Chr4:55089721 [GRCh38]
Chr4:55955888 [GRCh37]
Chr4:4q12		 uncertain significance
NM_002253.4(KDR):c.3456G>A (p.Thr1152=) single nucleotide variant KDR-related condition [RCV003971623] Chr4:55088922 [GRCh38]
Chr4:55955089 [GRCh37]
Chr4:4q12		 likely benign
NM_002253.4(KDR):c.3510+10C>T single nucleotide variant KDR-related condition [RCV003981391] Chr4:55088858 [GRCh38]
Chr4:55955025 [GRCh37]
Chr4:4q12		 likely benign
NM_002253.4(KDR):c.3988A>T (p.Ile1330Leu) single nucleotide variant KDR-related condition [RCV003924093] Chr4:55080024 [GRCh38]
Chr4:55946191 [GRCh37]
Chr4:4q12		 benign
NM_002253.4(KDR):c.3933C>T (p.Ser1311=) single nucleotide variant KDR-related condition [RCV003964768] Chr4:55080079 [GRCh38]
Chr4:55946246 [GRCh37]
Chr4:4q12		 likely benign
NM_002253.4(KDR):c.1537-6G>A single nucleotide variant KDR-related condition [RCV003944780] Chr4:55105946 [GRCh38]
Chr4:55972113 [GRCh37]
Chr4:4q12		 likely benign
NM_002253.4(KDR):c.2868T>G (p.Pro956=) single nucleotide variant KDR-related condition [RCV003967319] Chr4:55094905 [GRCh38]
Chr4:55961072 [GRCh37]
Chr4:4q12		 likely benign
NM_002253.4(KDR):c.2823A>G (p.Lys941=) single nucleotide variant KDR-related condition [RCV003944006] Chr4:55094950 [GRCh38]
Chr4:55961117 [GRCh37]
Chr4:4q12		 likely benign
NM_002253.4(KDR):c.2614+1G>A single nucleotide variant Tetralogy of Fallot [RCV003985127] Chr4:55097661 [GRCh38]
Chr4:55963828 [GRCh37]
Chr4:4q12		 likely pathogenic
GRCh37/hg19 4p12-q35.2(chr4:45455621-191003541)x3 copy number gain not provided [RCV003885507] Chr4:45455621..191003541 [GRCh37]
Chr4:4p12-q35.2		 pathogenic
NM_002253.4(KDR):c.3849T>A (p.Gly1283=) single nucleotide variant KDR-related condition [RCV003919554] Chr4:55080163 [GRCh38]
Chr4:55946330 [GRCh37]
Chr4:4q12		 likely benign
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR424hsa-miR-424-5pMirecordsexternal_info{changed}NA21885851
MIR200Bhsa-miR-200b-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI21544626

Predicted Target Of
Summary Value
Count of predictions:1226
Count of miRNA genes:603
Interacting mature miRNAs:671
Transcripts:ENST00000263923, ENST00000509309, ENST00000512566
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH70435  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37455,973,881 - 55,974,055UniSTSGRCh37
Build 36455,668,638 - 55,668,812RGDNCBI36
Celera453,475,795 - 53,475,969RGD
Cytogenetic Map4q11-q12UniSTS
HuRef451,922,466 - 51,922,640UniSTS
GeneMap99-GB4 RH Map4333.98UniSTS
NCBI RH Map4579.4UniSTS
GDB:626090  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37455,970,871 - 55,971,086UniSTSGRCh37
Build 36455,665,628 - 55,665,843RGDNCBI36
Celera453,472,785 - 53,473,000RGD
Cytogenetic Map4q11-q12UniSTS
HuRef451,919,456 - 51,919,671UniSTS
GDB:626093  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37455,945,968 - 55,946,110UniSTSGRCh37
Build 36455,640,725 - 55,640,867RGDNCBI36
Celera453,447,883 - 53,448,025RGD
Cytogenetic Map4q11-q12UniSTS
HuRef451,894,555 - 51,894,697UniSTS
KDR  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37455,946,175 - 55,946,251UniSTSGRCh37
GRCh37455,955,082 - 55,955,574UniSTSGRCh37
Build 36455,640,932 - 55,641,008RGDNCBI36
Celera453,456,997 - 53,457,489UniSTS
Celera453,448,090 - 53,448,166RGD
HuRef451,894,762 - 51,894,838UniSTS
HuRef451,903,669 - 51,904,161UniSTS
SHGC-50925  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37455,945,993 - 55,946,083UniSTSGRCh37
Build 36455,640,750 - 55,640,840RGDNCBI36
Celera453,447,908 - 53,447,998RGD
Cytogenetic Map4q11-q12UniSTS
HuRef451,894,580 - 51,894,670UniSTS
SHGC-59525  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37455,946,150 - 55,946,296UniSTSGRCh37
Build 36455,640,907 - 55,641,053RGDNCBI36
Celera453,448,065 - 53,448,211RGD
Cytogenetic Map4q11-q12UniSTS
HuRef451,894,737 - 51,894,883UniSTS
GeneMap99-GB4 RH Map4329.6UniSTS
NCBI RH Map4580.8UniSTS
G20520  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37455,944,821 - 55,945,026UniSTSGRCh37
Build 36455,639,578 - 55,639,783RGDNCBI36
Celera453,446,736 - 53,446,941RGD
Cytogenetic Map4q11-q12UniSTS
HuRef451,893,408 - 51,893,613UniSTS
A005U41  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37455,944,821 - 55,945,026UniSTSGRCh37
Build 36455,639,578 - 55,639,783RGDNCBI36
Celera453,446,736 - 53,446,941RGD
Cytogenetic Map4q11-q12UniSTS
HuRef451,893,408 - 51,893,613UniSTS
GeneMap99-GB4 RH Map4316.26UniSTS
NCBI RH Map4580.8UniSTS
SHGC-59221  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4q11-q12UniSTS
GeneMap99-GB4 RH Map4335.57UniSTS
Whitehead-RH Map4417.1UniSTS
NCBI RH Map4680.6UniSTS
KDR  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37455,946,175 - 55,946,251UniSTSGRCh37
GRCh37455,955,082 - 55,955,574UniSTSGRCh37
Build 36455,640,932 - 55,641,008RGDNCBI36
Celera453,456,997 - 53,457,489UniSTS
Celera453,448,090 - 53,448,166RGD
HuRef451,894,762 - 51,894,838UniSTS
HuRef451,903,669 - 51,904,161UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 1342 1320 1280 206 212 154 2582 1015 940 274 721 1347 55 1 1202 1529 4
Low 978 926 410 392 369 281 1747 1132 2734 102 665 109 112 2 1259 2
Below cutoff 18 697 18 13 763 15 20 28 40 11 26 56 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_012004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB209901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC021220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC111194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF035121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF063658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK293668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC131822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM978033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP280621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU826563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ899739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP761779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP761780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP761781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP761782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP761783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP761784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP774600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP774601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP774602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT253184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT253185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT253186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT253187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT253188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT253189 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT253190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT253191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT253192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT585185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L04947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X61656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X89776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000263923   ⟹   ENSP00000263923
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl455,078,481 - 55,125,595 (-)Ensembl
RefSeq Acc Id: ENST00000509309
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl455,094,850 - 55,096,720 (-)Ensembl
RefSeq Acc Id: ENST00000512566
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl455,104,593 - 55,125,293 (-)Ensembl
RefSeq Acc Id: ENST00000647068
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl455,078,531 - 55,122,921 (-)Ensembl
RefSeq Acc Id: NM_002253   ⟹   NP_002244
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38455,078,481 - 55,125,595 (-)NCBI
GRCh37455,944,426 - 55,991,762 (-)ENTREZGENE
Build 36455,639,406 - 55,686,519 (-)NCBI Archive
HuRef451,893,013 - 51,940,346 (-)ENTREZGENE
CHM1_1455,979,683 - 56,027,015 (-)NCBI
T2T-CHM13v2.0458,566,962 - 58,614,067 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_002244 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA59459 (Get FASTA)   NCBI Sequence Viewer  
  AAB88005 (Get FASTA)   NCBI Sequence Viewer  
  AAC16450 (Get FASTA)   NCBI Sequence Viewer  
  AAI31823 (Get FASTA)   NCBI Sequence Viewer  
  ACF47599 (Get FASTA)   NCBI Sequence Viewer  
  ACR78514 (Get FASTA)   NCBI Sequence Viewer  
  AKN45942 (Get FASTA)   NCBI Sequence Viewer  
  AKN45943 (Get FASTA)   NCBI Sequence Viewer  
  AKN45944 (Get FASTA)   NCBI Sequence Viewer  
  AKN45945 (Get FASTA)   NCBI Sequence Viewer  
  AKN45946 (Get FASTA)   NCBI Sequence Viewer  
  AKN45947 (Get FASTA)   NCBI Sequence Viewer  
  AKN45948 (Get FASTA)   NCBI Sequence Viewer  
  AKN45949 (Get FASTA)   NCBI Sequence Viewer  
  AKN45950 (Get FASTA)   NCBI Sequence Viewer  
  ALS54733 (Get FASTA)   NCBI Sequence Viewer  
  ALS54734 (Get FASTA)   NCBI Sequence Viewer  
  ALS54735 (Get FASTA)   NCBI Sequence Viewer  
  ALS54736 (Get FASTA)   NCBI Sequence Viewer  
  ALS54737 (Get FASTA)   NCBI Sequence Viewer  
  ALS54738 (Get FASTA)   NCBI Sequence Viewer  
  ALS54739 (Get FASTA)   NCBI Sequence Viewer  
  ALS54740 (Get FASTA)   NCBI Sequence Viewer  
  ALS54741 (Get FASTA)   NCBI Sequence Viewer  
  BAD93138 (Get FASTA)   NCBI Sequence Viewer  
  BAG57114 (Get FASTA)   NCBI Sequence Viewer  
  CAA43837 (Get FASTA)   NCBI Sequence Viewer  
  CAA61916 (Get FASTA)   NCBI Sequence Viewer  
  EAX05462 (Get FASTA)   NCBI Sequence Viewer  
  EAX05463 (Get FASTA)   NCBI Sequence Viewer  
  EAX05464 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000263923
  ENSP00000263923.4
GenBank Protein P35968 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_002244   ⟸   NM_002253
- Peptide Label: precursor
- UniProtKB: O60723 (UniProtKB/Swiss-Prot),   C5IFA0 (UniProtKB/Swiss-Prot),   B5A925 (UniProtKB/Swiss-Prot),   A2RRS0 (UniProtKB/Swiss-Prot),   Q14178 (UniProtKB/Swiss-Prot),   P35968 (UniProtKB/Swiss-Prot),   Q59EB0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000263923   ⟸   ENST00000263923
Protein Domains
Ig-like   Ig-like C2-type   Protein kinase   Serine-threonine/tyrosine-protein kinase catalytic

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35968-F1-model_v2 AlphaFold P35968 1-1356 view protein structure

Promoters
RGD ID:6867474
Promoter ID:EPDNEW_H6902
Type:initiation region
Name:KDR_1
Description:kinase insert domain receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38455,125,595 - 55,125,655EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:6307 AgrOrtholog
COSMIC KDR COSMIC
Ensembl Genes ENSG00000128052 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000263923 ENTREZGENE
  ENST00000263923.5 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000128052 GTEx
HGNC ID HGNC:6307 ENTREZGENE
Human Proteome Map KDR Human Proteome Map
InterPro Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Immunoglobulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_rcpt_3_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VEGFR-2_TMD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VEGFR2_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:3791 UniProtKB/Swiss-Prot
NCBI Gene 3791 ENTREZGENE
OMIM 191306 OMIM
PANTHER TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00047 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VEGFR-1-like_Ig-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VEGFR-2_TMD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB KDR RGD, PharmGKB
PIRSF TyrPK_CSF1-R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS VEGFRECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VEGFRECEPTR2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_III UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IGc2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TyrKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Immunoglobulin UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0H4A777_HUMAN UniProtKB/TrEMBL
  A0A0H4A7S0_HUMAN UniProtKB/TrEMBL
  A0A0H4A7S4_HUMAN UniProtKB/TrEMBL
  A0A0H4ADZ1_HUMAN UniProtKB/TrEMBL
  A0A0H4AF76_HUMAN UniProtKB/TrEMBL
  A0A0H4AF85_HUMAN UniProtKB/TrEMBL
  A0A0U2VU55_HUMAN UniProtKB/TrEMBL
  A0A0U2WZU8_HUMAN UniProtKB/TrEMBL
  A0A0U2X4C8_HUMAN UniProtKB/TrEMBL
  A2RRS0 ENTREZGENE
  B5A925 ENTREZGENE
  C5IFA0 ENTREZGENE
  O60723 ENTREZGENE
  P35968 ENTREZGENE
  Q14178 ENTREZGENE
  Q59EB0 ENTREZGENE, UniProtKB/TrEMBL
  VGFR2_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary A2RRS0 UniProtKB/Swiss-Prot
  B5A925 UniProtKB/Swiss-Prot
  C5IFA0 UniProtKB/Swiss-Prot
  O60723 UniProtKB/Swiss-Prot
  Q14178 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-12-23 KDR  kinase insert domain receptor  KDR  kinase insert domain receptor (a type III receptor tyrosine kinase)  Symbol and/or name change 5135510 APPROVED