AXITINIB PHARMACODYNAMICS PATHWAY (PW:0001125)

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Description

Axitinib is a selective inhibitor of vascular endothelial growth factor (VEGF) signaling pathway used in the treatment of renal cell carcinoma and several other tumors. The drug belongs to a class of tyrosine kinase receptor inhibitors (TKI) designed to compete with ATP for binding into the ATP binding pocket of the receptor, thus inhibiting its kinase activity and the signaling events downstream of it. Axitinib is selective for VEGF receptor1, 2 and 3; it can also act as a weaker inhibitor for

Pathway Diagram:

Ariadne Genomics Inc. renal cell carcinoma pathway Carcinoma, Renal Cell Flt4 ---| vascular endothelial growth factor signaling pathway Kdr ---| vascular endothelial growth factor signaling pathway Flt1 ---| vascular endothelial growth factor signaling pathway axitinib ---- Flt1 axitinib ---- Kdr axitinib ---- Flt4 Flt1 Kdr ATP ---| Flt1 ATP ---| Kdr ATP Flt4 ATP ---| Flt4 vascular endothelial growth factor signaling pathway ---| renal cell carcinoma pathway vascular endothelial growth factor signaling pathway ---| Carcinoma, Renal Cell vascular endothelial growth factor signaling pathway axitinib
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Genes in Pathway:

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axitinib pharmacodynamics pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Flt1 FMS-related tyrosine kinase 1 JBrowse link 12 9,033,993 9,205,886 RGD:6907361
G Flt4 fms-related tyrosine kinase 4 JBrowse link 10 35,078,782 35,120,296 RGD:6907361
G Kdr kinase insert domain receptor JBrowse link 14 34,727,677 34,787,127 RGD:6907361

Pathway Gene Annotations

Disease Annotations Associated with Genes in the axitinib pharmacodynamics pathway
Disease TermsGene Symbols
Acute Lung InjuryFlt1 , Kdr
adenocarcinomaKdr
allergic contact dermatitisFlt1 , Kdr
amyotrophic lateral sclerosisKdr
angiosarcomaFlt1 , Kdr
Animal Mammary NeoplasmsKdr
arteriosclerosisKdr
arteriovenous malformations of the brainFlt1 , Kdr
asthmaKdr
atherosclerosisKdr
atrial fibrillationFlt1
background diabetic retinopathyFlt1
Brain InjuriesKdr
brain ischemiaKdr
Breast NeoplasmsFlt1 , Kdr
Bronchopulmonary DysplasiaFlt1
Capillary Hemangioma, InfantileFlt4 , Kdr
cerebral cavernous malformationFlt1 , Kdr
Cerebral HemorrhageFlt1 , Kdr
Chemical and Drug Induced Liver InjuryFlt1
Choroidal NeovascularizationFlt1 , Kdr
chronic obstructive pulmonary diseaseFlt1 , Kdr
clear cell renal cell carcinomaFlt4
colitisKdr
colon carcinomaFlt1 , Flt4 , Kdr
Colonic NeoplasmsKdr
Colorectal NeoplasmsKdr
contact dermatitisKdr
corneal neovascularizationFlt1 , Kdr
Coronary DiseaseFlt1 , Kdr
Crohn's diseaseKdr
cystitisKdr
decubitus ulcerKdr
Diabetes Mellitus, Experimental Flt1 , Kdr
Diabetic NephropathiesFlt1 , Kdr
diabetic retinopathyFlt1
diffuse sclerodermaKdr
Disease ProgressionFlt1
ductal carcinoma in situFlt1
Endometrial NeoplasmsFlt1 , Kdr
Endometrioid CarcinomasKdr
endometriosisKdr
Esophageal NeoplasmsKdr
Experimental ArthritisFlt1
Experimental Autoimmune EncephalomyelitisFlt1 , Kdr
Experimental ColitisKdr
Experimental Liver NeoplasmsKdr
genetic diseaseFlt4
Hand-Foot SyndromeKdr
hereditary lymphedemaFlt4
hereditary lymphedema IFlt4
hereditary lymphedema IAFlt4
herpes simplex virus keratitisKdr
Hirschsprung Disease 1Kdr
hydrophthalmosFlt1 , Kdr
hypertensionKdr
Hypoxia-Ischemia, BrainKdr
impotenceKdr
inverted papillomaKdr
ischemiaFlt1
Kawasaki diseaseFlt1
Kidney NeoplasmsFlt1 , Kdr
Kuhnt-Junius degenerationFlt1 , Kdr
LathyrismKdr
leiomyosarcomaFlt1
Leydig cell tumorFlt1
limited sclerodermaKdr
liver cirrhosisFlt1
lymphangiomaFlt4 , Kdr
Lymphatic MetastasisKdr
lymphedemaFlt4
macular degenerationFlt1 , Kdr
macular retinal edemaFlt1 , Kdr
malignant gliomaKdr
Mammary Neoplasms, ExperimentalKdr
melanomaFlt1 , Kdr
myocardial infarctionFlt1 , Kdr
Myocardial IschemiaKdr
Nasal PolypsKdr
NeointimaFlt1
Neoplasm MetastasisFlt1 , Kdr
Neovascularization, PathologicKdr
nephroblastomaFlt1
NeuralgiaKdr
neurilemmomaKdr
neurofibrosarcomaKdr
osteoarthritisFlt1
Osteoarthritis, ExperimentalFlt1
osteochondrodysplasiaFlt1 , Kdr
Otitis Media with EffusionFlt1 , Kdr
Ovarian NeoplasmsFlt1 , Kdr
Oxygen-Induced RetinopathyKdr
pancreatic cancerKdr
polycystic ovary syndromeFlt4
pre-eclampsiaFlt1
proliferative diabetic retinopathyFlt1
prostate cancerKdr
prostate carcinoma in situFlt1
prostatic hypertrophyKdr
Prostatic NeoplasmsFlt1 , Kdr
psoriasisFlt1 , Kdr
pterygiumKdr
RecurrenceFlt1
renal cell carcinomaFlt1 , Kdr
Reperfusion InjuryKdr
retinal telangiectasiaKdr
retinopathy of prematurityFlt1 , Kdr
sarcomaKdr
schizophreniaKdr
Seasonal Allergic RhinitisKdr
SepsisFlt1
Skin NeoplasmsFlt1
Spinal Cord InjuriesFlt1 , Kdr
squamous cell carcinomaKdr
StrokeKdr
systemic sclerodermaFlt4 , Kdr
temporal lobe epilepsyKdr
tetralogy of FallotFlt4
tongue squamous cell carcinomaKdr
transient cerebral ischemiaFlt1
transitional cell carcinomaKdr
Transplant RejectionKdr
type 2 diabetes mellitusFlt1 , Kdr
ulcerative colitisKdr
uremiaFlt1 , Kdr
urinary bladder cancerKdr
Uterine Cervical NeoplasmsFlt1 , Kdr
Uterine NeoplasmsFlt1
uveal melanomaKdr
vascular dementiaFlt1
Venous ThrombosisKdr
Pathway Annotations Associated with Genes in the axitinib pharmacodynamics pathway
Phenotype Annotations Associated with Genes in the axitinib pharmacodynamics pathway

References Associated with the axitinib pharmacodynamics pathway:

Ontology Path Diagram:

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