RGD Reference Report - The VEGFR-2 protein and the VEGFR-2 rs1870377 A>T genetic polymorphism are prognostic factors for gastric cancer. - Rat Genome Database

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The VEGFR-2 protein and the VEGFR-2 rs1870377 A>T genetic polymorphism are prognostic factors for gastric cancer.

Authors: Zhu, Xueru  Wang, Yiwei  Xue, Wenji  Wang, Ruifen  Wang, Lifeng  Zhu, Mei-Ling  Zheng, Leizhen 
Citation: Zhu X, etal., Cancer Biol Ther. 2019;20(4):497-504. doi: 10.1080/15384047.2018.1537575. Epub 2018 Oct 31.
RGD ID: 126907999
Pubmed: PMID:30380970   (View Abstract at PubMed)
PMCID: PMC6422475   (View Article at PubMed Central)
DOI: DOI:10.1080/15384047.2018.1537575   (Journal Full-text)


OBJECTIVE: Angiogenesis is one of the key processes in the development of malignant tumors. The vascular endothelial growth factor (VEGF) and VEGF receptor-2 (VEGFR-2) signaling pathway regulates branching angiogenesis in cancer. In this study, we analyzed the associations of VEGF/VEGFR-2 proteins and VEGFR-2 genetic variations with the prognosis of gastric cancer (GC).
METHOD: We collected the clinical information of patients with GC and extracted genomic DNA from paraffin-embedded tissues. Immunohistochemical methods were used to detect the expression of VEGF and VEGFR-2 in GC tissues. Four single nucleotide polymorphisms of VEGFR-2 were detected by the TaqMan assay. The Kaplan-Meier method and Cox regression model were applied to analyze the associations between clinicopathological characteristics, VEGFR-2 polymorphisms and GC prognosis.
RESULTS: A total of 256 cases of GC were included in our study. VEGFR-2 (+) and VEGFR-2 (++/+++) protein expression levels were detected in 83 and 135 cases, respectively. High expression of the VEGFR-2 protein was associated with the poor prognosis of GC (log-rank test P = 0.026). No statistical significance was observed for the association between VEGF and the prognosis of GC. The VEGFR-2 rs1870377 A > T genetic polymorphism was discovered to be associated with the prognosis of GC (AA vs. AT, HR = 1.69, 95% CI = 1.06-2.68, P = 0.027).
CONCLUSION: Our study suggested that the high expression of VEGFR-2, as well as the VEGFR-2 rs1870377 A > T genetic polymorphism, may be prognostic markers for GC.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
stomach cancer disease_progressionIAGP 126907999DNA:SNP: :rs1870377 (human)RGD 
stomach cancer no_associationIAGP 126907999DNA:SNPs: :rs7667298 more ...RGD 
stomach cancer disease_progressionISOKDR (Homo sapiens)126907999; 126907999DNA:SNP: :rs1870377 (human)RGD 
stomach cancer no_associationISOKDR (Homo sapiens)126907999; 126907999DNA:SNPs: :rs7667298 more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Kdr  (kinase insert domain receptor)

Genes (Mus musculus)
Kdr  (kinase insert domain protein receptor)

Genes (Homo sapiens)
KDR  (kinase insert domain receptor)


Additional Information