RGD Reference Report - Prognostic importance of vascular endothelial growth factor and its receptors in the uterine sarcoma. - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Prognostic importance of vascular endothelial growth factor and its receptors in the uterine sarcoma.

Authors: Arita, S  Kikkawa, F  Kajiyama, H  Shibata, K  Kawai, M  Mizuno, K  Nagasaka, T  Ino, K  Nomura, S 
Citation: Arita S, etal., Int J Gynecol Cancer. 2005 Mar-Apr;15(2):329-36.
RGD ID: 2289964
Pubmed: (View Article at PubMed) PMID:15823121
DOI: Full-text: DOI:10.1111/j.1525-1438.2005.15225.x

Vascular endothelial growth factor (VEGF) and its receptors play an important role in tumor progression; however, there is no report regarding this factor in uterine sarcoma. Thirty-nine patients with uterine sarcoma, 14 carcinosarcomas, 4 endometrial stromal sarcomas, and 21 leiomyosarcomas, were studied. By immunohistochemical staining, VEGF was not detected in normal uterine smooth muscle, but VEGF receptor-1 (flt-1) and VEGF receptor-2 (flk-1) were observed in 14 and 4 of 14 normal smooth muscles, respectively. Of 39 sarcomas, 25 expressed VEGF, and 38 and 34 sarcomas expressed flt-1 and flk-1 at various intensities, respectively. The staining intensity of VEGF, flt-1, and flk-1 was significantly higher in sarcoma than in normal uterine smooth muscle, but that of phospho-flt-1 (p-flt-1) was significantly lower in sarcoma than in normal uterine smooth muscle. When sarcomas were divided into two groups according to staining intensity, a significant difference in survival curves was observed in only p-flt-1 of leiomyosarcoma (P= 0.008), and in all sarcomas, a lower survival curve was also observed in the high staining intensity group than in the low staining intensity group, although there was no significant difference (P= 0.102). In conclusion, VEGF and its receptors are suggested to be involved in progression of uterine sarcoma, but only the p-flt-1 level significantly affected the survival of leiomyosarcoma patients.

Annotation

Disease Annotations    
leiomyosarcoma  (IEP,ISO)
sarcoma  (IEP,ISO)
Uterine Neoplasms  (IEP,ISO)

Objects Annotated

Genes (Rattus norvegicus)
Flt1  (Fms related receptor tyrosine kinase 1)
Kdr  (kinase insert domain receptor)

Genes (Mus musculus)
Flt1  (FMS-like tyrosine kinase 1)
Kdr  (kinase insert domain protein receptor)

Genes (Homo sapiens)
FLT1  (fms related receptor tyrosine kinase 1)
KDR  (kinase insert domain receptor)


Additional Information