RGD Reference Report - [Prognostic significance of serum level of vascular endothelial growth factor receptor-2 in hepatocellular carcinoma patients after transcatheter arterial chemoembolization].

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[Prognostic significance of serum level of vascular endothelial growth factor receptor-2 in hepatocellular carcinoma patients after transcatheter arterial chemoembolization].
Authors:	Meng, Qing-wen Li, Yong Hu, Bao-shan Shao, Pei-jian Zhan, Mei-xiao Yu, Xian-yi Lu, Li-gong
Citation:	Meng QW, etal., Zhonghua Yi Xue Za Zhi. 2013 Jan 29;93(5):341-4.
RGD ID:	126848813
Pubmed:	PMID:23660204 (View Abstract at PubMed)
OBJECTIVE: To explore the prognostic significance of serum vascular endothelial growth factor receptor-2 (VEGFR-2) in patients with hepatocellular carcinoma (HCC) after transcatheter arterial chemoembolization (TACE). METHODS: A total of 69 HCC patients undergoing TACE from October 2008 to April 2012 were recruited and examined. Their serum level of VEGFR-2 level was measured by enzyme-linked immunosorbent assay (ELISA). The relationship between VEGFR-2 and their clinicopathologic features were observed. Prognostic significance of VEGFR-2 was assessed for their survival. RESULTS: Significant differences existed when the serum level of VEGFR-2 was categorized by tumor number and liver cirrhosis (P = 0.021, P = 0.049). The post-treatment serum level of VEGFR-2 was significant higher than that at pre-treatment (P = 0.045). When the mean pre-treatment serum level of VEGFR-2 (8709 ng/L) was used as a cut-off point, the patients with a low serum level of VEGFR-2 had better overall and progression-free survival than those with a high serum level of VEGF (17 vs. 28 months, P = 0.001 and 10 vs. 15 months P = 0.031 respectively). As revealed by multivariate Cox analysis, the pre-treatment serum level of VEGFR-2 was an independent and significant prognostic factor of survival for HCC patients at post-TACE. CONCLUSION: The pre-treatment serum level of VEGFR-2 may predict the post-TACE prognosis in HCC patients.

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Object Symbol	Species	Term	Qualifier	Evidence	With	Notes	Source	Original Reference(s)
KDR	Human	hepatocellular carcinoma	treatment	IEP			RGD
Kdr	Rat	hepatocellular carcinoma	treatment	ISO	KDR (Homo sapiens)		RGD
Kdr	Mouse	hepatocellular carcinoma	treatment	ISO	KDR (Homo sapiens)		RGD

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Genes (Rattus norvegicus)

Kdr (kinase insert domain receptor)

Genes (Mus musculus)

Kdr (kinase insert domain protein receptor)

Genes (Homo sapiens)

KDR (kinase insert domain receptor)

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[Prognostic significance of serum level of vascular endothelial growth factor receptor-2 in hepatocellular carcinoma patients after transcatheter arterial chemoembolization].