RGD Reference Report - C771G (His241Gln) polymorphism of MLXIPL gene, TG levels and coronary artery disease: a case control study. - Rat Genome Database

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C771G (His241Gln) polymorphism of MLXIPL gene, TG levels and coronary artery disease: a case control study.

Authors: Ghasemi, Asghar  Aghajani, Hasan  Fallah, Soudabeh  Assadi, Mehrdad  Seifi, Morteza 
Citation: Ghasemi A, etal., Anatol J Cardiol. 2015 Jan;15(1):8-12. doi: 10.5152/akd.2014.5135. Epub 2014 Feb 10.
RGD ID: 401794581
Pubmed: PMID:25179879   (View Abstract at PubMed)
PMCID: PMC5336913   (View Article at PubMed Central)
DOI: DOI:10.5152/akd.2014.5135   (Journal Full-text)


OBJECTIVE: It is suggested that C771G (His241Gln) polymorphism of MLXIPL gene might be a genetic risk factor for coronary artery disease (CAD); therefore, the aim of the present study was to investigate the association between C771G polymorphism of MLXIPL gene and the pathogenesis of CAD in Iranian patients with coronary artery stenosis and control subjects.
METHODS: Two hundred and five patients with coronary artery stenosis and 195 healthy control subjects were included in this study. MLXIPL genotypes were determined by polymerase chain reaction and restriction fragment length polymorphism (RFLP).
RESULTS: There was an association between the MLXIPL polymorphism and quantitative lipid traits in patient group. Distribution of the CC genotype of MLXIPL was more frequent in patients, (χ2=5.13; p<0.005) and after adjustment for classical CAD risk factors, the MLXIPL CC genotype was independently associated with CAD (OR=1.98, 95% CI, 1.12-4.11; p=0.02). Distribution of MLXIPL genotypes were significantly different as compared with the severity of stenosis (χ2=6.34; p<0.05).
CONCLUSION: These results suggest that C771G polymorphism of MLXIPL gene is associated with stenosis and its severity.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MLXIPLHumancoronary artery disease susceptibilityIAGP DNA:SNP:cds: C771G and H241QRGD 
MlxiplRatcoronary artery disease susceptibilityISOMLXIPL (Homo sapiens)DNA:SNP:cds: C771G and H241QRGD 
MlxiplMousecoronary artery disease susceptibilityISOMLXIPL (Homo sapiens)DNA:SNP:cds: C771G and H241QRGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MLXIPLHumanCoronary artery atherosclerosis susceptibilityIAGP DNA:SNP:cds: C771G and H241QRGD 
Objects Annotated

Genes (Rattus norvegicus)
Mlxipl  (MLX interacting protein-like)

Genes (Mus musculus)
Mlxipl  (MLX interacting protein-like)

Genes (Homo sapiens)
MLXIPL  (MLX interacting protein like)


Additional Information