ALDH2 (aldehyde dehydrogenase 2 family member) - Rat Genome Database

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Gene: ALDH2 (aldehyde dehydrogenase 2 family member) Pan paniscus
Analyze
Symbol: ALDH2
Name: aldehyde dehydrogenase 2 family member
RGD ID: 11810530
Description: ENCODES a protein that exhibits aldehyde dehydrogenase (NAD+) activity (ortholog); identical protein binding (ortholog); NADH binding (ortholog); INVOLVED IN acetaldehyde metabolic process (ortholog); apoptotic mitochondrial changes (ortholog); behavioral response to ethanol (ortholog); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; ASSOCIATED WITH Acute Alcohol Sensitivity (ortholog); alcohol dependence (ortholog); alcohol use disorder (ortholog); FOUND IN mitochondrial matrix (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: aldehyde dehydrogenase 2 family (mitochondrial); aldehyde dehydrogenase, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210119,836,914 - 119,879,015 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112119,833,358 - 119,875,410 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012109,343,020 - 109,385,060 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112112,734,243 - 112,776,471 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12112,734,243 - 112,776,471 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
ALDH2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210119,836,914 - 119,879,015 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112119,833,358 - 119,875,410 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012109,343,020 - 109,385,060 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112112,734,243 - 112,776,471 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12112,734,243 - 112,776,471 (+)Ensemblpanpan1.1panPan2
ALDH2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812111,766,933 - 111,817,532 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12111,766,887 - 111,817,532 (+)EnsemblGRCh38hg38GRCh38
GRCh3712112,204,737 - 112,255,336 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612110,688,729 - 110,732,167 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412110,667,065 - 110,710,502NCBI
Celera12111,829,810 - 111,873,247 (+)NCBICelera
Cytogenetic Map12q24.12NCBI
HuRef12109,218,289 - 109,261,129 (+)NCBIHuRef
CHM1_112112,172,628 - 112,215,725 (+)NCBICHM1_1
T2T-CHM13v2.012111,743,846 - 111,794,443 (+)NCBIT2T-CHM13v2.0
Aldh2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395121,704,090 - 121,731,887 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5121,704,090 - 121,731,887 (-)EnsemblGRCm39 Ensembl
GRCm385121,566,027 - 121,593,824 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5121,566,027 - 121,593,824 (-)EnsemblGRCm38mm10GRCm38
MGSCv375122,017,696 - 122,043,833 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365121,828,319 - 121,854,203 (-)NCBIMGSCv36mm8
Celera5118,657,638 - 118,683,765 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map561.86NCBI
Aldh2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81240,610,244 - 40,643,220 (+)NCBIGRCr8
mRatBN7.21234,949,549 - 34,982,527 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1234,901,219 - 34,982,521 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1236,122,427 - 36,155,172 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01236,733,638 - 36,766,383 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01235,786,091 - 35,818,829 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01240,466,418 - 40,498,813 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1240,466,495 - 40,498,752 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01242,334,057 - 42,366,049 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41236,081,778 - 36,116,445 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11235,945,165 - 35,979,833 (+)NCBI
Celera1236,614,188 - 36,647,218 (+)NCBICelera
Cytogenetic Map12q16NCBI
Aldh2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554828,352,569 - 8,384,899 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554828,352,569 - 8,383,097 (+)NCBIChiLan1.0ChiLan1.0
ALDH2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1269,319,109 - 9,361,021 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha269,481,407 - 9,518,893 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0269,578,697 - 9,616,338 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1269,534,133 - 9,571,615 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0269,596,947 - 9,634,535 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0269,550,188 - 9,587,685 (+)NCBIUU_Cfam_GSD_1.0
Aldh2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118155,091,721 - 155,116,690 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365584,362,654 - 4,390,414 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365584,362,693 - 4,387,705 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALDH2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1439,896,565 - 39,933,124 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11439,902,317 - 39,933,113 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21442,378,891 - 42,409,676 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ALDH2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111107,019,015 - 107,060,784 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11107,019,111 - 107,060,374 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037138,033,968 - 138,076,544 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aldh2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474720,403,717 - 20,438,690 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474720,407,190 - 20,438,605 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_003832460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSPPAT00000012568   ⟹   ENSPPAP00000002652
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl12112,734,243 - 112,776,471 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000012606   ⟹   ENSPPAP00000002656
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl12112,734,248 - 112,776,062 (+)Ensembl
RefSeq Acc Id: XM_003832460   ⟹   XP_003832508
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v210119,836,914 - 119,879,015 (+)NCBI
NHGRI_mPanPan112119,833,358 - 119,875,410 (+)NCBI
Mhudiblu_PPA_v012109,343,020 - 109,385,060 (+)NCBI
PanPan1.112112,734,243 - 112,776,471 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003832508 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000002652
  ENSPPAP00000002652.1
  ENSPPAP00000002656.1
RefSeq Acc Id: XP_003832508   ⟸   XM_003832460
- UniProtKB: A0A2R8ZCP2 (UniProtKB/TrEMBL),   A0A2R8ZC71 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000002656   ⟸   ENSPPAT00000012606
RefSeq Acc Id: ENSPPAP00000002652   ⟸   ENSPPAT00000012568
Protein Domains
Aldehyde dehydrogenase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000011365 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000012568.1 UniProtKB/TrEMBL
  ENSPPAT00000012606.1 UniProtKB/TrEMBL
InterPro Ald_DH/histidinol_DH UniProtKB/TrEMBL
  Ald_DH_C UniProtKB/TrEMBL
  Ald_DH_CS_CYS UniProtKB/TrEMBL
  Ald_DH_CS_GLU UniProtKB/TrEMBL
  Ald_DH_N UniProtKB/TrEMBL
  Aldehyde_DH_dom UniProtKB/TrEMBL
KEGG Report pps:100970208 UniProtKB/TrEMBL
NCBI Gene ALDH2 ENTREZGENE
PANTHER ALDEHYDE DEHYDROGENASE, MITOCHONDRIAL UniProtKB/TrEMBL
  ALDEHYDE DEHYDROGENASE-RELATED UniProtKB/TrEMBL
Pfam Aldedh UniProtKB/TrEMBL
PROSITE ALDEHYDE_DEHYDR_CYS UniProtKB/TrEMBL
  ALDEHYDE_DEHYDR_GLU UniProtKB/TrEMBL
Superfamily-SCOP SSF53720 UniProtKB/TrEMBL
UniProt A0A2R8ZC71 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R8ZCP2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-02-13 ALDH2  aldehyde dehydrogenase 2 family member    aldehyde dehydrogenase 2 family (mitochondrial)  Symbol and/or name change 5135510 APPROVED