CXCL10 (C-X-C motif chemokine ligand 10)

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Gene: CXCL10 (C-X-C motif chemokine ligand 10) Pan paniscus

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Symbol:

CXCL10

Name:

C-X-C motif chemokine ligand 10

RGD ID:

11955774

Description:

ENCODES a protein that exhibits chemokine activity (ortholog); INVOLVED IN antimicrobial humoral immune response mediated by antimicrobial peptide (ortholog); cellular response to heat (ortholog); cellular response to lipopolysaccharide (ortholog); ASSOCIATED WITH Acute Liver Failure (ortholog); Acute-On-Chronic Liver Failure (ortholog); adult respiratory distress syndrome (ortholog); FOUND IN extracellular space (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

C-X-C motif chemokine 10

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	54,049,643 - 54,052,033 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	54,239,397 - 54,241,786 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	48,182,355 - 48,184,733 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	54,020,204 - 54,022,606 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	54,020,204 - 54,022,606 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Acute Liver Failure (ISO)

Acute-On-Chronic Liver Failure (ISO)

adult respiratory distress syndrome (ISO)

alopecia areata (ISO)

asthma (ISO)

atopic dermatitis (ISO)

bacterial pneumonia (ISO)

boutonneuse fever (ISO)

brain infarction (ISO)

Brain Injuries (ISO)

brain ischemia (ISO)

bronchiolitis obliterans (ISO)

cardiovascular system disease (ISO)

Carrington Syndrome (ISO)

celiac disease (ISO)

cerebrovascular disease (ISO)

Chemical and Drug Induced Liver Injury (ISO)

cholestasis (ISO)

Chronic Hepatitis B (ISO)

Chronic Hepatitis C (ISO)

chronic obstructive pulmonary disease (ISO)

colon carcinoma (ISO)

Colonic Neoplasms (ISO)

common cold (ISO)

coronary restenosis (ISO)

Coronavirus infectious disease (ISO)

COVID-19 (ISO)

cryoglobulinemia (ISO)

Cytomegalovirus Infections (ISO)

Diabetic Nephropathies (ISO)

diabetic retinopathy (ISO)

encephalitis (ISO)

Experimental Autoimmune Myasthenia Gravis (ISO)

Experimental Diabetes Mellitus (ISO)

Experimental Liver Cirrhosis (ISO)

extrinsic allergic alveolitis (ISO)

Foot Ulcer (ISO)

graft-versus-host disease (ISO)

hepatitis B (ISO)

hepatitis C (ISO)

hepatocellular carcinoma (ISO)

human immunodeficiency virus infectious disease (ISO)

Human Influenza (ISO)

Hypothermia (ISO)

inhalation anthrax (ISO)

interstitial cystitis (ISO)

interstitial lung disease (ISO)

ischemia (ISO)

liver cirrhosis (ISO)

Liver Metastasis (ISO)

Liver Reperfusion Injury (ISO)

metabolic dysfunction-associated steatohepatitis (ISO)

metabolic dysfunction-associated steatotic liver disease (ISO)

middle cerebral artery infarction (ISO)

Middle East respiratory syndrome (ISO)

myasthenia gravis (ISO)

Myocardial Ischemia (ISO)

myocarditis (ISO)

pleurisy (ISO)

pneumonia (ISO)

primary biliary cholangitis (ISO)

progressive myoclonus epilepsy (ISO)

proteinuria (ISO)

pulmonary emphysema (ISO)

pulmonary sarcoidosis (ISO)

pulmonary tuberculosis (ISO)

renovascular hypertension (ISO)

Reperfusion Injury (ISO)

respiratory syncytial virus infectious disease (ISO)

Respiratory Tract Granuloma (ISO)

severe acute respiratory syndrome (ISO)

Spinal Cord Injuries (ISO)

Spontaneous Abortions (ISO)

steatotic liver disease (ISO)

systemic scleroderma (ISO)

thoracic aortic aneurysm (ISO)

Thyroid Neoplasms (ISO)

Transplant Rejection (ISO)

traumatic brain injury (ISO)

type 1 diabetes mellitus (ISO)

type 2 diabetes mellitus (ISO)

uveitis (ISO)

Viral Bronchiolitis (ISO)

viral pneumonia (ISO)

visceral leishmaniasis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenylate cyclase-activating G protein-coupled receptor signaling pathway (IEA)

antimicrobial humoral immune response mediated by antimicrobial peptide (ISO)

antiviral innate immune response (IEA)

cellular response to heat (ISO)

cellular response to interleukin-17 (IEA)

cellular response to lipopolysaccharide (IEA,ISO)

cellular response to virus (IEA)

chemokine-mediated signaling pathway (IEA)

chemotaxis (IEA)

defense response (IEA)

defense response to virus (IEA,ISO)

endothelial cell activation (IEA)

G protein-coupled receptor signaling pathway (IEA)

immune response (IEA,ISO)

negative regulation of angiogenesis (IEA,ISO)

negative regulation of myoblast differentiation (IEA,ISO)

negative regulation of myoblast fusion (IEA,ISO)

positive chemotaxis (IEA)

positive regulation of cell migration (ISO)

positive regulation of cell population proliferation (ISO)

positive regulation of leukocyte chemotaxis (ISO)

positive regulation of monocyte chemotaxis (IEA)

positive regulation of release of sequestered calcium ion into cytosol (IEA)

positive regulation of T cell migration (IEA,ISO)

regulation of apoptotic process (IEA)

regulation of cell population proliferation (IEA)

regulation of endothelial tube morphogenesis (IEA)

regulation of T cell chemotaxis (IEA)

response to auditory stimulus (ISO)

response to bacterium (IEA,ISO)

response to gamma radiation (ISO)

response to lipopolysaccharide (ISO)

response to vitamin D (ISO)

T cell chemotaxis (IEA)

Cellular Component

external side of plasma membrane (IEA)

extracellular region (IEA)

extracellular space (IEA,ISO)

Molecular Function

chemoattractant activity (IEA)

chemokine activity (IEA,ISO)

CXCR3 chemokine receptor binding (IEA)

cytokine activity (IEA)

heparin binding (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

CXCL10
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	54,049,643 - 54,052,033 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	54,239,397 - 54,241,786 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	48,182,355 - 48,184,733 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	54,020,204 - 54,022,606 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	54,020,204 - 54,022,606 (+)	Ensembl	panpan1.1		panPan2

CXCL10
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	76,021,118 - 76,023,497 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	76,021,118 - 76,023,497 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	76,942,271 - 76,944,650 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	77,161,295 - 77,163,674 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	77,299,451 - 77,301,829	NCBI
Celera	4	74,243,028 - 74,245,407 (-)	NCBI		Celera
Cytogenetic Map	4	q21.1	NCBI
HuRef	4	72,694,720 - 72,697,139 (-)	NCBI		HuRef
CHM1_1	4	76,918,847 - 76,921,265 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	79,361,779 - 79,364,158 (-)	NCBI		T2T-CHM13v2.0

Cxcl10
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	92,494,497 - 92,496,748 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	92,494,497 - 92,496,748 (-)	Ensembl		GRCm39 Ensembl
GRCm38	5	92,346,638 - 92,348,889 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	92,346,638 - 92,348,889 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	92,775,667 - 92,777,880 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	93,421,841 - 93,424,054 (-)	NCBI		MGSCv36	mm8
Celera	5	90,490,436 - 90,492,644 (-)	NCBI		Celera
Cytogenetic Map	5	E2	NCBI
cM Map	5	46.57	NCBI

Cxcl10
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	15,989,066 - 15,991,263 (+)	NCBI		GRCr8
mRatBN7.2	14	15,704,772 - 15,706,969 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	15,704,758 - 15,706,975 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	15,712,934 - 15,715,131 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	17,031,780 - 17,033,977 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	15,727,209 - 15,729,406 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	17,210,733 - 17,212,930 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	17,210,733 - 17,212,930 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	17,126,865 - 17,129,062 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	17,265,986 - 17,268,183 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	17,265,985 - 17,268,183 (+)	NCBI
Celera	14	15,099,217 - 15,101,414 (+)	NCBI		Celera
RH 3.4 Map	14	182.09	RGD
Cytogenetic Map	14	p22	NCBI

Cxcl10
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955433	748,284 - 750,927 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955433	748,392 - 750,890 (-)	NCBI	ChiLan1.0	ChiLan1.0

CXCL10
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	32	598,406 - 599,925 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	32	597,987 - 599,979 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	32	41,282,571 - 41,284,090 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	32	623,230 - 624,745 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	32	622,462 - 624,803 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	32	622,982 - 624,501 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	32	577,290 - 578,808 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	32	39,590,894 - 39,592,413 (+)	NCBI		UU_Cfam_GSD_1.0

Cxcl10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	11,442,665 - 11,446,615 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936676	60,621 - 63,106 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936676	60,869 - 63,028 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CXCL10
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	71,693,339 - 71,695,948 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	71,693,641 - 71,695,948 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	75,829,909 - 75,831,236 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3
Sscrofa10.2	8	75,881,457 - 75,882,217 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CXCL10
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	24,526,657 - 24,529,193 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	24,526,680 - 24,529,130 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	2,868,983 - 2,871,422 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cxcl10
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624757	14,989,084 - 14,991,910 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624757	14,989,241 - 14,991,650 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003832298	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000053224 ⟹ ENSPPAP00000030363

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	4	54,020,204 - 54,022,606 (+)	Ensembl

RefSeq Acc Id:

XM_003832298 ⟹ XP_003832346

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	3	54,049,643 - 54,052,033 (+)	NCBI
NHGRI_mPanPan1	4	54,239,397 - 54,241,786 (+)	NCBI
Mhudiblu_PPA_v0	4	48,182,355 - 48,184,733 (+)	NCBI
PanPan1.1	4	54,020,204 - 54,022,606 (+)	NCBI

Sequence:

show sequence

CTTTGCAGATAAATACGGCACACTAGCCCCACGTTTTCTGAGACATTCCTCAATTGCTTAGACA
TATTCTGAGCCTACAGCAGAGGAACCTCCAGTCTCAGCACCATGAATCAAACTGCCATTCTGAT
TTGCTGCCTTATCTTTCTAAGTGGCATTCAAGGAGTACCTCTCTCTAGAACTGTACGCTGTACC
TGCATCAGCATTAGTAATCAACCTGTTAATCCAAGGTCTTTAGAAAAACTTGAAATTATTCCTG
CAAGTCAATTTTGTCCACGTGTTGAGATCATTGCTACAATGAAAAAGAAGGGTGAGAAGAGATG
TCTGAATCCAGAATCGAAGGCCATCAAGAATTTACTGAAAGCAGTTAGCAAGGAAAGGTCTAAA
AGATCTCCTTAAAACCAGAGGGGAGCAAAATCGATGCAGTGCTTCCAAGGATGGACCACACAGA
GGCTGCCTCTCCCATCACTTCCCTACATGGAGTATATGTCAAGCCATAATTGTTCTTAGTTTGC
AGTTACACTAAAAGGTGACCAATCATGGTCACCAAATCAGCTGCTACTACTCCTGTAGGAAGGT
TAATGTTCATCATCCTAAGCTATTCAGTAATAACTCTACCCTGGCACTATAATGTAAGCTCTAC
TGAGGTGCTATGTTCTTAGTGGATGTTCTGACCCTGCTTCCAGTATTTCCCTCACCTTTCCCAT
CTTCCAAGGGTACTAAGGAATCTTTCTGCTTTGGGGTTTATCAGAATTCTCAGAATCTCAAATA
ACTAAAAGGTATGCAATCAAATCTGCTTTTTAAAGAATGCTCTTTACTTCATGGACTTCCACTG
CCATCCTCCCAAGGGGCCCAAATTCTTTCAGTGGCTACCTACATACAATTCCAAACACATACAG
GAAGGTAGAAATATCTGAAAATGTATGTGAAAGTATTCTTATTTAATGAAAGACTGTACAAAGT
AGAAGTCTTAGATGTACATATTTCCTATATTGTTTTCAGTGTACATGGAATAACATGTAATTAA
GTACTATGCATCAACGAGTAACAGGAAAATTTTAAAAATACAGATAGATATATGCTCTGCATGT
TACATAAGATAAATGTGCTGAATGGTTTTCAAAATAAAAATGAGGTACTCTCCTGGAAATATTA
AGAAAGACTATCTAAATGTTGAAAGACAAAAATGTTAATAAAGTAATTATAACTAAGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003832346	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000030363
	ENSPPAP00000030363.1

RefSeq Acc Id:	XP_003832346 ⟸ XM_003832298
- UniProtKB:	A0A2R9BLR2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MNQTAILICCLIFLSGIQGVPLSRTVRCTCISISNQPVNPRSLEKLEIIPASQFCPRVEIIATM KKKGEKRCLNPESKAIKNLLKAVSKERSKRSP hide sequence

Ensembl Acc Id:

ENSPPAP00000030363 ⟸ ENSPPAT00000053224

Protein Domains

Chemokine interleukin-8-like

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000038167	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000053224.1	UniProtKB/TrEMBL
Gene3D-CATH	2.40.50.40	UniProtKB/TrEMBL
InterPro	Chemokine_b/g/d	UniProtKB/TrEMBL
	Chemokine_CXC	UniProtKB/TrEMBL
	Chemokine_CXC_CS	UniProtKB/TrEMBL
	Chemokine_IL8-like_dom	UniProtKB/TrEMBL
	CXC_Chemokine_domain	UniProtKB/TrEMBL
	Interleukin_8-like_sf	UniProtKB/TrEMBL
KEGG Report	pps:100992984	UniProtKB/TrEMBL
NCBI Gene	CXCL10	ENTREZGENE
PANTHER	C-X-C MOTIF CHEMOKINE 10	UniProtKB/TrEMBL
	SMALL INDUCIBLE CYTOKINE A	UniProtKB/TrEMBL
Pfam	IL8	UniProtKB/TrEMBL
PRINTS	SMALLCYTKCXC	UniProtKB/TrEMBL
PROSITE	SMALL_CYTOKINES_CXC	UniProtKB/TrEMBL
SMART	SCY	UniProtKB/TrEMBL
Superfamily-SCOP	SSF54117	UniProtKB/TrEMBL
UniProt	A0A2R9BLR2	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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