NPR1 (natriuretic peptide receptor 1) - Rat Genome Database

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Gene: NPR1 (natriuretic peptide receptor 1) Pan paniscus
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Symbol: NPR1
Name: natriuretic peptide receptor 1
RGD ID: 11817112
Description: ENCODES a protein that exhibits guanylate cyclase activity (ortholog); INVOLVED IN cell surface receptor signaling pathway (ortholog); cGMP-mediated signaling (ortholog); dopamine metabolic process (ortholog); PARTICIPATES IN atrial natriuretic peptide signaling pathway; brain natriuretic peptide signaling pathway; ASSOCIATED WITH Aortic Rupture (ortholog); Cardiomegaly (ortholog); congestive heart failure (ortholog); FOUND IN ANPR-A receptor complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: atrial natriuretic peptide receptor 1; natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2196,138,643 - 96,160,742 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1195,873,841 - 95,889,322 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01129,034,972 - 129,050,439 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11132,663,941 - 132,679,905 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1132,664,948 - 132,679,327 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
NPR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2196,138,643 - 96,160,742 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1195,873,841 - 95,889,322 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01129,034,972 - 129,050,439 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11132,663,941 - 132,679,905 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1132,664,948 - 132,679,327 (+)Ensemblpanpan1.1panPan2
NPR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381153,678,688 - 153,693,992 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1153,678,688 - 153,693,992 (+)EnsemblGRCh38hg38GRCh38
GRCh371153,651,164 - 153,666,468 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361151,917,737 - 151,933,088 (+)NCBINCBI36Build 36hg18NCBI36
Build 341150,464,185 - 150,479,536NCBI
Celera1126,722,358 - 126,737,655 (+)NCBICelera
Cytogenetic Map1q21.3NCBI
HuRef1125,014,421 - 125,029,723 (+)NCBIHuRef
CHM1_11155,047,152 - 155,062,430 (+)NCBICHM1_1
T2T-CHM13v2.01152,815,953 - 152,831,256 (+)NCBIT2T-CHM13v2.0
Npr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39390,357,898 - 90,373,235 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl390,357,898 - 90,373,173 (-)EnsemblGRCm39 Ensembl
GRCm38390,450,591 - 90,465,928 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl390,450,591 - 90,465,866 (-)EnsemblGRCm38mm10GRCm38
MGSCv37390,254,514 - 90,269,788 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36390,536,519 - 90,552,265 (-)NCBIMGSCv36mm8
Celera390,488,131 - 90,503,567 (-)NCBICelera
Cytogenetic Map3F1NCBI
cM Map339.23NCBI
Npr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82178,231,766 - 178,247,591 (-)NCBIGRCr8
mRatBN7.22175,934,181 - 175,950,118 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2175,934,181 - 175,949,505 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2183,074,109 - 183,089,476 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02181,096,360 - 181,111,730 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02175,696,310 - 175,711,670 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02189,840,403 - 189,857,032 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2189,840,403 - 189,856,090 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02209,271,276 - 209,287,892 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42182,724,916 - 182,740,242 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12182,675,021 - 182,690,348 (-)NCBI
Celera2169,869,831 - 169,885,101 (-)NCBICelera
Cytogenetic Map2q34NCBI
Npr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955545323,956 - 338,097 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955545323,386 - 338,654 (+)NCBIChiLan1.0ChiLan1.0
NPR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1743,382,246 - 43,396,464 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl743,283,418 - 43,396,027 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha742,875,275 - 42,888,999 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0743,331,940 - 43,345,662 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl743,153,680 - 43,345,719 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1743,034,052 - 43,047,778 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0743,087,306 - 43,101,030 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0743,370,926 - 43,384,656 (-)NCBIUU_Cfam_GSD_1.0
Npr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505824,449,225 - 24,465,782 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365803,480,267 - 3,495,643 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365803,479,858 - 3,496,896 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl495,957,228 - 95,973,430 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1495,957,220 - 95,974,253 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24104,855,577 - 104,870,667 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NPR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12010,115,319 - 10,131,933 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2010,115,105 - 10,131,200 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660389,492,241 - 9,508,732 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Npr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248853,460,438 - 3,475,720 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248853,462,334 - 3,475,735 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000047457   ⟹   ENSPPAP00000024632
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1132,664,948 - 132,679,327 (+)Ensembl
RefSeq Acc Id: XM_003817147   ⟹   XP_003817195
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2196,138,643 - 96,160,741 (-)NCBI
NHGRI_mPanPan1195,873,841 - 95,889,322 (-)NCBI
Mhudiblu_PPA_v01129,034,972 - 129,050,439 (+)NCBI
PanPan1.11132,663,941 - 132,679,905 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034935870   ⟹   XP_034791761
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2196,138,643 - 96,160,742 (-)NCBI
NHGRI_mPanPan1195,873,841 - 95,888,812 (-)NCBI
Mhudiblu_PPA_v01129,034,972 - 129,050,439 (+)NCBI
Protein Sequences
Protein RefSeqs XP_003817195 (Get FASTA)   NCBI Sequence Viewer  
  XP_034791761 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000024632.1
RefSeq Acc Id: XP_003817195   ⟸   XM_003817147
- Peptide Label: isoform X1
- UniProtKB: A0A2R9B4X4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034791761   ⟸   XM_034935870
- Peptide Label: isoform X2
- UniProtKB: A0A2R9B4X4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSPPAP00000024632   ⟸   ENSPPAT00000047457
Protein Domains
Guanylate cyclase   Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000035430 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000047457.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.1230 UniProtKB/TrEMBL
  3.40.50.2300 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro A/G_cyclase UniProtKB/TrEMBL
  A/G_cyclase_CS UniProtKB/TrEMBL
  ANF_lig-bd_rcpt UniProtKB/TrEMBL
  ANPR/GUC UniProtKB/TrEMBL
  Cyclic_nucleotide_synthase UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Nucleotide_cyclase UniProtKB/TrEMBL
  Peripla_BP_I UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
NCBI Gene NPR1 ENTREZGENE
PANTHER ATRIAL NATRIURETIC PEPTIDE RECEPTOR 1 UniProtKB/TrEMBL
  GUANYLYL CYCLASE UniProtKB/TrEMBL
Pfam ANF_receptor UniProtKB/TrEMBL
  Guanylate_cyc UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/TrEMBL
PRINTS NATPEPTIDER UniProtKB/TrEMBL
PROSITE ANF_RECEPTORS UniProtKB/TrEMBL
  GUANYLATE_CYCLASE_1 UniProtKB/TrEMBL
  GUANYLATE_CYCLASE_2 UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
SMART CYCc UniProtKB/TrEMBL
Superfamily-SCOP SSF53822 UniProtKB/TrEMBL
  SSF55073 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A2R9B4X4 ENTREZGENE, UniProtKB/TrEMBL