IFNG (interferon gamma) - Rat Genome Database

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Gene: IFNG (interferon gamma) Pan paniscus
Symbol: IFNG
Name: interferon gamma
RGD ID: 11930963
Description: ENCODES a protein that exhibits cytokine activity (inferred); type II interferon receptor binding (inferred); INVOLVED IN adaptive immune response (ortholog); antigen processing and presentation (ortholog); apoptotic process (ortholog); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-2 signaling pathway; interleukin-23 signaling pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); acquired immunodeficiency syndrome (ortholog); acute disseminated encephalomyelitis (ortholog); FOUND IN external side of plasma membrane (ortholog); extracellular space (ortholog); perikaryon (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan11276,167,040 - 76,171,890 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01265,663,764 - 65,668,732 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11268,448,861 - 68,453,829 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1268,448,861 - 68,453,829 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
acquired immunodeficiency syndrome  (ISO)
acute disseminated encephalomyelitis  (ISO)
Acute Lung Injury  (ISO)
acute lymphoblastic leukemia  (ISO)
acute myocardial infarction  (ISO)
acute promyelocytic leukemia  (ISO)
acute retinal necrosis syndrome  (ISO)
adrenoleukodystrophy  (ISO)
adult T-cell leukemia/lymphoma  (ISO)
Alcoholic Intoxication  (ISO)
allergic conjunctivitis  (ISO)
allergic contact dermatitis  (ISO)
allergic disease  (ISO)
allergic rhinitis  (ISO)
Animal Disease Models  (ISO)
anterior uveitis  (ISO)
aplastic anemia  (ISO)
appendicitis  (ISO)
asthma  (ISO)
ataxia telangiectasia  (ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
autistic disorder  (ISO)
autoimmune disease  (ISO)
autoimmune hepatitis  (ISO)
autoimmune thyroiditis  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
bacterial pneumonia  (ISO)
Behcet's disease  (ISO)
brain disease  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Bronchial Hyperreactivity  (ISO)
bronchiolitis obliterans  (ISO)
bronchitis  (ISO)
brucellosis  (ISO)
cardiac arrest  (ISO)
cataract  (ISO)
celiac disease  (ISO)
Chagas disease  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chills  (ISO)
chlamydia  (ISO)
choroiditis  (ISO)
chromoblastomycosis  (ISO)
chronic granulomatous disease  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Pancreatitis  (ISO)
Chronic Thyroiditis  (ISO)
colitis  (ISO)
Colonic Neoplasms  (ISO)
colorectal carcinoma  (ISO)
congestive heart failure  (ISO)
Corneal Perforation  (ISO)
Coronavirus infectious disease  (ISO)
Crohn's disease  (ISO)
cutaneous leishmaniasis  (ISO)
Delayed Hypersensitivity  (ISO)
dermatomyositis  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
disease of cellular proliferation  (ISO)
Drug Eruptions  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
dry eye syndrome  (ISO)
Dyspepsia  (ISO)
eczema herpeticum  (ISO)
endometriosis  (ISO)
endophthalmitis  (ISO)
Endotoxemia  (ISO)
Entamoebiasis  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Uveoretinitis  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Neoplasms  (ISO)
Experimental Radiation Injuries  (ISO)
Experimental Sarcoma  (ISO)
eyelid disease  (ISO)
factor VIII deficiency  (ISO)
Fanconi anemia  (ISO)
Fever  (ISO)
genetic disease  (ISO)
genital herpes  (ISO)
glomerulonephritis  (ISO)
glucosephosphate dehydrogenase deficiency  (ISO)
graft-versus-host disease  (ISO)
Graves ophthalmopathy  (ISO)
Graves' disease  (ISO)
Hantavirus hemorrhagic fever with renal syndrome  (ISO)
Hashimoto Disease  (ISO)
Helicobacter Infections  (ISO)
Hemorrhagic Shock  (ISO)
hepatitis  (ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
herpes simplex virus keratitis  (ISO)
high grade glioma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
hyper IgE syndrome  (ISO)
hypersensitivity reaction type III disease  (ISO)
Hyponatremia  (ISO)
Hypotension  (ISO)
hypothyroidism  (ISO)
immunodeficiency 69  (ISO)
Inflammation  (ISO)
inflammatory bowel disease  (ISO)
Intestinal Helminthiasis  (ISO)
Kidney Calculi  (ISO)
kidney failure  (ISO)
Kidney Reperfusion Injury  (ISO)
Legionnaires' disease  (ISO)
leishmaniasis  (ISO)
lichen planus  (ISO)
liver cirrhosis  (ISO)
lung disease  (ISO)
Lung Neoplasms  (ISO)
lupus nephritis  (ISO)
lymphoproliferative syndrome  (ISO)
malaria  (ISO)
malignant mesothelioma  (ISO)
Manganese Poisoning  (ISO)
melanoma  (ISO)
Mesothelioma  (ISO)
metabolic dysfunction-associated steatohepatitis  (ISO)
Middle East respiratory syndrome  (ISO)
mixed connective tissue disease  (ISO)
mucocutaneous leishmaniasis  (ISO)
multiple sclerosis  (ISO)
Mycobacterium Infections  (ISO)
Mycoplasma pneumoniae pneumonia  (ISO)
myeloid leukemia  (ISO)
Nasal Polyps  (ISO)
Nausea  (ISO)
Necrosis  (ISO)
nephritis  (ISO)
Nerve Degeneration  (ISO)
neural tube defect  (ISO)
obesity  (ISO)
oral submucous fibrosis  (ISO)
otitis media  (ISO)
Otitis Media with Effusion  (ISO)
pancreatic cancer  (ISO)
panuveitis  (ISO)
peritonitis  (ISO)
pleural disease  (ISO)
pneumonia  (ISO)
polymyositis  (ISO)
primary biliary cholangitis  (ISO)
proteinuria  (ISO)
Pulmonary Arterial Hypertension  (ISO)
pulpitis  (ISO)
relapsing polychondritis  (ISO)
renal fibrosis  (ISO)
Reperfusion Injury  (ISO)
respiratory syncytial virus infectious disease  (ISO)
respiratory system disease  (ISO)
rheumatoid arthritis  (ISO)
Salmonella Infections, Animal  (ISO)
sarcoma  (ISO)
selective IgG deficiency disease  (ISO)
sensorineural hearing loss  (ISO)
Sepsis  (ISO)
septic arthritis  (ISO)
severe acute respiratory syndrome  (ISO)
Sjogren's syndrome  (ISO)
status asthmaticus  (ISO)
Stevens-Johnson syndrome  (ISO)
Streptococcus pneumonia  (ISO)
Stroke  (ISO)
suppurative otitis media  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
temporal arteritis  (ISO)
tongue squamous cell carcinoma  (ISO)
toxic shock syndrome  (ISO)
Transplant Rejection  (ISO)
trichuriasis  (ISO)
tuberculosis  (ISO)
tuberous sclerosis  (ISO)
tuberous sclerosis 2  (ISO)
tularemia  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (ISO)
urinary bladder cancer  (ISO)
uveitis  (ISO)
vesicoureteral reflux  (ISO)
viral hepatitis  (ISO)
Viral Myocarditis  (ISO)
visceral leishmaniasis  (ISO)
visual epilepsy  (ISO)
vitiligo  (ISO)
Vogt-Koyanagi-Harada disease  (ISO)
Vomiting  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive immune response  (ISO)
antigen processing and presentation  (ISO)
apoptotic process  (IEA,ISO)
astrocyte activation  (IEA)
CD8-positive, alpha-beta T cell differentiation involved in immune response  (ISO)
cellular response to interleukin-18  (ISO)
cellular response to lipopolysaccharide  (ISO)
defense response to bacterium  (ISO)
defense response to Gram-positive bacterium  (ISO)
defense response to protozoan  (ISO)
defense response to virus  (IEA,ISO)
endoplasmic reticulum unfolded protein response  (ISO)
extrinsic apoptotic signaling pathway  (IEA)
humoral immune response  (ISO)
immune response  (IEA)
inflammatory cell apoptotic process  (ISO)
macrophage activation involved in immune response  (IEA)
macrophage differentiation  (IEA)
microglial cell activation  (IEA)
negative regulation of amyloid-beta clearance  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of DNA-templated transcription  (IEA)
negative regulation of epithelial cell differentiation  (ISO)
negative regulation of fibroblast proliferation  (ISO)
negative regulation of gene expression  (IEA)
negative regulation of glomerular mesangial cell proliferation  (ISO)
negative regulation of interleukin-17 production  (IEA)
negative regulation of myelination  (ISO)
negative regulation of osteoclast differentiation  (ISO)
negative regulation of smooth muscle cell proliferation  (IEA)
negative regulation of transcription by RNA polymerase II  (ISO)
neuroinflammatory response  (ISO)
neutrophil apoptotic process  (ISO)
neutrophil chemotaxis  (ISO)
nitric oxide biosynthetic process  (ISO)
positive regulation by host of viral process  (ISO)
positive regulation of amyloid-beta formation  (IEA)
positive regulation of apoptotic process  (ISO)
positive regulation of autophagy  (IEA)
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response  (IEA)
positive regulation of cell adhesion  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cellular respiration  (ISO)
positive regulation of chemokine production  (IEA,ISO)
positive regulation of cytokine production  (IEA)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of epithelial cell migration  (IEA)
positive regulation of fructose 1,6-bisphosphate metabolic process  (IEA)
positive regulation of gene expression  (IEA,ISO)
positive regulation of glycolytic process  (ISO)
positive regulation of inflammatory response  (IEA)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of interleukin-12 production  (IEA,ISO)
positive regulation of interleukin-23 production  (IEA)
positive regulation of interleukin-6 production  (IEA,ISO)
positive regulation of iron ion import across plasma membrane  (ISO)
positive regulation of isotype switching to IgG isotypes  (ISO)
positive regulation of killing of cells of another organism  (IEA)
positive regulation of macrophage cytokine production  (ISO)
positive regulation of membrane protein ectodomain proteolysis  (IEA)
positive regulation of MHC class II biosynthetic process  (ISO)
positive regulation of neurogenesis  (IEA)
positive regulation of neuron differentiation  (ISO)
positive regulation of nitric oxide biosynthetic process  (IEA,ISO)
positive regulation of nitric-oxide synthase biosynthetic process  (ISO)
positive regulation of nitrogen compound metabolic process  (IEA)
positive regulation of osteoclast differentiation  (IEA)
positive regulation of peptidyl-serine phosphorylation of STAT protein  (IEA,ISO)
positive regulation of phagocytosis  (ISO)
positive regulation of protein deacetylation  (IEA)
positive regulation of protein import into nucleus  (IEA)
positive regulation of protein-containing complex assembly  (IEA)
positive regulation of smooth muscle cell apoptotic process  (IEA)
positive regulation of synaptic transmission, cholinergic  (ISO)
positive regulation of T cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of tumor necrosis factor (ligand) superfamily member 11 production  (IEA)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (IEA,ISO)
positive regulation of vitamin D biosynthetic process  (IEA)
receptor signaling pathway via JAK-STAT  (ISO)
regulation of defense response to virus by host  (ISO)
regulation of DNA-templated transcription  (ISO)
regulation of glial cell proliferation  (ISO)
regulation of hepatocyte proliferation  (ISO)
regulation of immune response  (ISO)
regulation of insulin secretion  (IEA)
regulation of neuronal action potential  (ISO)
regulation of the force of heart contraction  (ISO)
response to tacrolimus  (ISO)
response to virus  (IEA,ISO)
response to xenobiotic stimulus  (ISO)
sensory perception of mechanical stimulus  (ISO)
T cell proliferation  (ISO)
T cell receptor signaling pathway  (ISO)
type II interferon-mediated signaling pathway  (IEA)
type III interferon-mediated signaling pathway  (IEA)

Cellular Component

Molecular Function

Additional References at PubMed
PMID:22301074   PMID:30032202  


Comparative Map Data
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan11276,167,040 - 76,171,890 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01265,663,764 - 65,668,732 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11268,448,861 - 68,453,829 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1268,448,861 - 68,453,829 (-)Ensemblpanpan1.1panPan2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381268,154,768 - 68,159,740 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1268,154,768 - 68,159,740 (-)EnsemblGRCh38hg38GRCh38
GRCh371268,548,548 - 68,553,520 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361266,834,817 - 66,839,788 (-)NCBINCBI36Build 36hg18NCBI36
Build 341266,834,816 - 66,839,788NCBI
Celera1268,212,600 - 68,217,569 (-)NCBICelera
Cytogenetic Map12q15NCBI
HuRef1265,599,188 - 65,604,157 (-)NCBIHuRef
CHM1_11268,516,525 - 68,521,498 (-)NCBICHM1_1
T2T-CHM13v2.01268,134,280 - 68,139,252 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3910118,276,951 - 118,281,799 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10118,276,951 - 118,281,797 (+)EnsemblGRCm39 Ensembl
GRCm3810118,441,046 - 118,445,894 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10118,441,046 - 118,445,892 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710117,878,103 - 117,882,948 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610117,844,040 - 117,848,885 (+)NCBIMGSCv36mm8
Celera10120,821,579 - 120,826,426 (+)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1066.75NCBI
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2753,903,339 - 53,907,375 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl753,903,337 - 53,907,375 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx755,810,041 - 55,814,077 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0758,013,127 - 58,017,163 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0757,790,977 - 57,795,013 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0761,337,383 - 61,341,419 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl761,337,381 - 61,341,419 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0761,333,604 - 61,337,640 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4757,621,756 - 57,625,792 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1757,642,485 - 57,646,522 (+)NCBI
Celera750,671,237 - 50,675,273 (+)NCBICelera
RH 3.4 Map7479.11RGD
Cytogenetic Map7q22NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495545814,643,313 - 14,648,045 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545814,643,333 - 14,648,020 (-)NCBIChiLan1.0ChiLan1.0
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11010,406,866 - 10,411,698 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1010,406,867 - 10,411,698 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1010,340,127 - 10,344,948 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01010,530,420 - 10,535,258 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1010,530,421 - 10,535,258 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11010,399,244 - 10,404,067 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01010,645,481 - 10,650,291 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01010,768,058 - 10,772,882 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494547,965,684 - 47,971,000 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365456,139,116 - 6,148,452 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365456,139,130 - 6,144,543 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl532,477,906 - 32,482,670 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1532,477,906 - 32,482,670 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2535,374,421 - 35,379,185 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap5p1.2-q1.1NCBI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11163,785,493 - 63,791,071 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1163,786,041 - 63,790,473 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037181,915,432 - 181,941,492 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_004624802163,261 - 166,534 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624802163,261 - 166,534 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2



Nucleotide Sequences
RefSeq Transcripts XM_003808705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSPPAT00000061512   ⟹   ENSPPAP00000038608
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1268,448,861 - 68,453,829 (-)Ensembl
RefSeq Acc Id: XM_003808705   ⟹   XP_003808753
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan11276,167,040 - 76,171,890 (-)NCBI
Mhudiblu_PPA_v01265,663,764 - 65,668,732 (-)NCBI
PanPan1.11268,448,861 - 68,453,829 (-)NCBI
Protein Sequences
Protein RefSeqs XP_003808753 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000038608
RefSeq Acc Id: XP_003808753   ⟸   XM_003808705
- UniProtKB: A0A2R9CC85 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000038608   ⟸   ENSPPAT00000061512

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000042020 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000061512.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.10 UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/TrEMBL
  Interferon_gamma UniProtKB/TrEMBL
KEGG Report pps:100991779 UniProtKB/TrEMBL
  PTHR11419 UniProtKB/TrEMBL
Pfam IFN-gamma UniProtKB/TrEMBL
Superfamily-SCOP SSF47266 UniProtKB/TrEMBL