IFNG (interferon gamma) - Rat Genome Database

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Gene: IFNG (interferon gamma) Pan paniscus
Analyze
Symbol: IFNG
Name: interferon gamma
RGD ID: 11930963
Description: ENCODES a protein that exhibits cytokine activity (inferred); interferon-gamma receptor binding (inferred); INVOLVED IN adaptive immune response (ortholog); antigen processing and presentation (ortholog); apoptotic process (ortholog); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-2 signaling pathway; interleukin-23 signaling pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); acquired immunodeficiency syndrome (ortholog); acute disseminated encephalomyelitis (ortholog); FOUND IN cytoplasm (ortholog); external side of plasma membrane (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11268,448,861 - 68,453,829 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1268,448,861 - 68,453,829 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01265,663,764 - 65,668,732 (-)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
acquired immunodeficiency syndrome  (ISO)
acute disseminated encephalomyelitis  (ISO)
Acute Lung Injury  (ISO)
acute lymphoblastic leukemia  (ISO)
acute promyelocytic leukemia  (ISO)
acute retinal necrosis syndrome  (ISO)
adrenoleukodystrophy  (ISO)
adult T-cell leukemia  (ISO)
Alcoholic Intoxication  (ISO)
allergic conjunctivitis  (ISO)
allergic contact dermatitis  (ISO)
allergic disease  (ISO)
allergic rhinitis  (ISO)
Animal Disease Models  (ISO)
anterior uveitis  (ISO)
aplastic anemia  (ISO)
appendicitis  (ISO)
asthma  (ISO)
ataxia telangiectasia  (ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
autistic disorder  (ISO)
autoimmune disease  (ISO)
autoimmune hepatitis  (ISO)
autoimmune thyroiditis  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
bacterial pneumonia  (ISO)
Behcet's disease  (ISO)
brain disease  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Bronchial Hyperreactivity  (ISO)
bronchiolitis obliterans  (ISO)
bronchitis  (ISO)
brucellosis  (ISO)
cardiac arrest  (ISO)
cataract  (ISO)
celiac disease  (ISO)
Chagas disease  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chills  (ISO)
chlamydia  (ISO)
choroiditis  (ISO)
chromoblastomycosis  (ISO)
chronic granulomatous disease  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Pancreatitis  (ISO)
Chronic Thyroiditis  (ISO)
colitis  (ISO)
Colonic Neoplasms  (ISO)
colorectal carcinoma  (ISO)
congestive heart failure  (ISO)
Corneal Perforation  (ISO)
Coronavirus infectious disease  (ISO)
COVID-19  (ISO)
Crohn's disease  (ISO)
cutaneous leishmaniasis  (ISO)
Delayed Hypersensitivity  (ISO)
dermatomyositis  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
disease of cellular proliferation  (ISO)
Drug Eruptions  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
dry eye syndrome  (ISO)
Dyspepsia  (ISO)
eczema herpeticum  (ISO)
endometriosis  (ISO)
endophthalmitis  (ISO)
Endotoxemia  (ISO)
Entamoebiasis  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Uveoretinitis  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Neoplasms  (ISO)
Experimental Sarcoma  (ISO)
eyelid disease  (ISO)
factor VIII deficiency  (ISO)
Fanconi anemia  (ISO)
Fever  (ISO)
genital herpes  (ISO)
glomerulonephritis  (ISO)
glucosephosphate dehydrogenase deficiency  (ISO)
Graft vs Host Disease  (ISO)
Graves Ophthalmopathy  (ISO)
Graves' disease  (ISO)
Hantavirus hemorrhagic fever with renal syndrome  (ISO)
Hashimoto Disease  (ISO)
Helicobacter Infections  (ISO)
Hemorrhagic Shock  (ISO)
hepatitis  (ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
herpes simplex virus keratitis  (ISO)
high grade glioma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
hyper IgE syndrome  (ISO)
hypersensitivity reaction type III disease  (ISO)
Hyponatremia  (ISO)
Hypotension  (ISO)
hypothyroidism  (ISO)
immunodeficiency 69  (ISO)
Inflammation  (ISO)
inflammatory bowel disease  (ISO)
Intestinal Helminthiasis  (ISO)
Kidney Calculi  (ISO)
kidney failure  (ISO)
Kidney Reperfusion Injury  (ISO)
Legionnaires' disease  (ISO)
leishmaniasis  (ISO)
lichen planus  (ISO)
liver cirrhosis  (ISO)
lung disease  (ISO)
Lung Neoplasms  (ISO)
lupus nephritis  (ISO)
lymphoproliferative syndrome  (ISO)
malignant mesothelioma  (ISO)
Manganese Poisoning  (ISO)
melanoma  (ISO)
Mesothelioma  (ISO)
Middle East respiratory syndrome  (ISO)
mixed connective tissue disease  (ISO)
mucocutaneous leishmaniasis  (ISO)
multiple sclerosis  (ISO)
Mycobacterium Infections  (ISO)
Mycoplasma pneumoniae pneumonia  (ISO)
myeloid leukemia  (ISO)
Nasal Polyps  (ISO)
Nausea  (ISO)
Necrosis  (ISO)
nephritis  (ISO)
Nerve Degeneration  (ISO)
neural tube defect  (ISO)
non-alcoholic steatohepatitis  (ISO)
obesity  (ISO)
oral submucous fibrosis  (ISO)
otitis media  (ISO)
Otitis Media with Effusion  (ISO)
pancreatic cancer  (ISO)
panuveitis  (ISO)
peritonitis  (ISO)
pleural disease  (ISO)
pneumonia  (ISO)
polymyositis  (ISO)
primary biliary cholangitis  (ISO)
proteinuria  (ISO)
pulpitis  (ISO)
Radiation Injuries, Experimental  (ISO)
relapsing polychondritis  (ISO)
renal fibrosis  (ISO)
Reperfusion Injury  (ISO)
respiratory syncytial virus infectious disease  (ISO)
respiratory system disease  (ISO)
rheumatoid arthritis  (ISO)
Salmonella Infections, Animal  (ISO)
sarcoma  (ISO)
selective IgG deficiency disease  (ISO)
sensorineural hearing loss  (ISO)
Sepsis  (ISO)
septic arthritis  (ISO)
severe acute respiratory syndrome  (ISO)
Sjogren's syndrome  (ISO)
status asthmaticus  (ISO)
Stevens-Johnson syndrome  (ISO)
Streptococcus pneumonia  (ISO)
suppurative otitis media  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
temporal arteritis  (ISO)
tongue squamous cell carcinoma  (ISO)
toxic shock syndrome  (ISO)
Transplant Rejection  (ISO)
trichuriasis  (ISO)
tuberculosis  (ISO)
tuberous sclerosis  (ISO)
tuberous sclerosis 2  (ISO)
tularemia  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (ISO)
urinary bladder cancer  (ISO)
uveitis  (ISO)
vesicoureteral reflux  (ISO)
viral hepatitis  (ISO)
Viral Myocarditis  (ISO)
visceral leishmaniasis  (ISO)
visual epilepsy  (ISO)
vitiligo  (ISO)
Vogt-Koyanagi-Harada disease  (ISO)
Vomiting  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive immune response  (ISO)
antigen processing and presentation  (ISO)
apoptotic process  (IEA,ISO)
astrocyte activation  (IEA)
CD8-positive, alpha-beta T cell differentiation involved in immune response  (ISO)
cellular response to interleukin-18  (ISO)
cellular response to lipopolysaccharide  (ISO)
defense response to bacterium  (ISO)
defense response to Gram-positive bacterium  (ISO)
defense response to protozoan  (ISO)
defense response to virus  (IEA,ISO)
endoplasmic reticulum unfolded protein response  (ISO)
extrinsic apoptotic signaling pathway  (IEA)
humoral immune response  (ISO)
immune response  (IEA)
inflammatory cell apoptotic process  (ISO)
interferon-gamma-mediated signaling pathway  (IEA)
macrophage activation involved in immune response  (IEA)
macrophage differentiation  (IEA)
microglial cell activation  (IEA)
negative regulation of amyloid-beta clearance  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of epithelial cell differentiation  (ISO)
negative regulation of fibroblast proliferation  (ISO)
negative regulation of gene expression  (IEA)
negative regulation of glomerular mesangial cell proliferation  (ISO)
negative regulation of interleukin-17 production  (IEA)
negative regulation of myelination  (ISO)
negative regulation of osteoclast differentiation  (ISO)
negative regulation of smooth muscle cell proliferation  (IEA)
negative regulation of tau-protein kinase activity  (IEA)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transcription, DNA-templated  (IEA)
neuroinflammatory response  (ISO)
neutrophil apoptotic process  (ISO)
neutrophil chemotaxis  (ISO)
nitric oxide biosynthetic process  (ISO)
positive regulation by host of viral process  (ISO)
positive regulation of amyloid-beta formation  (IEA)
positive regulation of apoptotic process  (ISO)
positive regulation of autophagy  (IEA)
positive regulation of calcidiol 1-monooxygenase activity  (IEA)
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response  (IEA)
positive regulation of cell adhesion  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cellular respiration  (ISO)
positive regulation of chemokine production  (IEA,ISO)
positive regulation of core promoter binding  (IEA)
positive regulation of cytokine production  (IEA)
positive regulation of epithelial cell migration  (IEA)
positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity  (IEA)
positive regulation of fructose 1,6-bisphosphate metabolic process  (IEA)
positive regulation of gene expression  (IEA,ISO)
positive regulation of glycolytic process  (ISO)
positive regulation of inflammatory response  (IEA)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of interleukin-12 production  (IEA,ISO)
positive regulation of interleukin-23 production  (IEA)
positive regulation of interleukin-6 production  (IEA,ISO)
positive regulation of iron ion import across plasma membrane  (ISO)
positive regulation of isotype switching to IgG isotypes  (ISO)
positive regulation of killing of cells of another organism  (IEA)
positive regulation of macrophage cytokine production  (ISO)
positive regulation of membrane protein ectodomain proteolysis  (IEA)
positive regulation of MHC class II biosynthetic process  (ISO)
positive regulation of neurogenesis  (IEA)
positive regulation of neuron death  (IEA)
positive regulation of neuron differentiation  (ISO)
positive regulation of nitric oxide biosynthetic process  (IEA,ISO)
positive regulation of nitric-oxide synthase biosynthetic process  (ISO)
positive regulation of nitrogen compound metabolic process  (IEA)
positive regulation of NMDA glutamate receptor activity  (ISO)
positive regulation of osteoclast differentiation  (IEA)
positive regulation of peptidyl-serine phosphorylation of STAT protein  (IEA,ISO)
positive regulation of phagocytosis  (ISO)
positive regulation of protein deacetylation  (IEA)
positive regulation of protein import into nucleus  (IEA)
positive regulation of protein phosphorylation  (IEA)
positive regulation of protein serine/threonine kinase activity  (IEA)
positive regulation of protein-containing complex assembly  (IEA)
positive regulation of signaling receptor activity  (ISO)
positive regulation of smooth muscle cell apoptotic process  (IEA)
positive regulation of synaptic transmission, cholinergic  (ISO)
positive regulation of T cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
positive regulation of tumor necrosis factor (ligand) superfamily member 11 production  (IEA)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (IEA,ISO)
positive regulation of vitamin D biosynthetic process  (IEA)
receptor signaling pathway via JAK-STAT  (ISO)
regulation of defense response to virus by host  (ISO)
regulation of glial cell proliferation  (ISO)
regulation of growth  (IEA)
regulation of hepatocyte proliferation  (ISO)
regulation of immune response  (ISO)
regulation of insulin secretion  (IEA)
regulation of neuronal action potential  (ISO)
regulation of protein ADP-ribosylation  (IEA)
regulation of the force of heart contraction  (ISO)
regulation of transcription, DNA-templated  (ISO)
response to virus  (IEA,ISO)
response to xenobiotic stimulus  (ISO)
sensory perception of mechanical stimulus  (ISO)
T cell proliferation  (ISO)
T cell receptor signaling pathway  (ISO)

Cellular Component

Molecular Function

References

Genomics

Comparative Map Data
IFNG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11268,448,861 - 68,453,829 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1268,448,861 - 68,453,829 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01265,663,764 - 65,668,732 (-)NCBIMhudiblu_PPA_v0panPan3
IFNG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381268,154,768 - 68,159,740 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1268,154,768 - 68,159,740 (-)EnsemblGRCh38hg38GRCh38
GRCh371268,548,548 - 68,553,520 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361266,834,817 - 66,839,788 (-)NCBINCBI36hg18NCBI36
Build 341266,834,816 - 66,839,788NCBI
Celera1268,212,600 - 68,217,569 (-)NCBI
Cytogenetic Map12q15NCBI
HuRef1265,599,188 - 65,604,157 (-)NCBIHuRef
CHM1_11268,516,525 - 68,521,498 (-)NCBICHM1_1
Ifng
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910118,276,951 - 118,281,799 (+)NCBIGRCm39mm39
GRCm39 Ensembl10118,276,951 - 118,281,797 (+)Ensembl
GRCm3810118,441,046 - 118,445,894 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10118,441,046 - 118,445,892 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710117,878,103 - 117,882,948 (+)NCBIGRCm37mm9NCBIm37
MGSCv3610117,844,040 - 117,848,885 (+)NCBImm8
Celera10120,821,579 - 120,826,426 (+)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1066.75NCBI
Ifng
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2753,903,339 - 53,907,375 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl753,903,337 - 53,907,375 (+)Ensembl
Rnor_6.0761,337,383 - 61,341,419 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl761,337,381 - 61,341,419 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0761,333,604 - 61,337,640 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4757,621,756 - 57,625,792 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1757,642,485 - 57,646,522 (+)NCBI
Celera750,671,237 - 50,675,273 (+)NCBICelera
RH 3.4 Map7479.11RGD
Cytogenetic Map7q22NCBI
Ifng
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545814,643,313 - 14,648,045 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545814,643,333 - 14,648,020 (-)NCBIChiLan1.0ChiLan1.0
IFNG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11010,406,866 - 10,411,698 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1010,406,867 - 10,411,698 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1010,340,127 - 10,344,948 (-)NCBI
ROS_Cfam_1.01010,530,420 - 10,535,258 (-)NCBI
ROS_Cfam_1.0 Ensembl1010,530,421 - 10,535,258 (-)Ensembl
UMICH_Zoey_3.11010,399,244 - 10,404,067 (-)NCBI
UNSW_CanFamBas_1.01010,645,481 - 10,650,291 (-)NCBI
UU_Cfam_GSD_1.01010,768,058 - 10,772,882 (-)NCBI
Ifng
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494547,965,684 - 47,971,000 (+)NCBI
SpeTri2.0NW_0049365456,139,130 - 6,144,543 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IFNG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl532,477,848 - 32,482,752 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1532,477,906 - 32,482,670 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2535,374,421 - 35,379,185 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap5p1.2-q1.1NCBI
IFNG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11163,785,493 - 63,791,071 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1163,786,041 - 63,790,473 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037181,915,432 - 181,941,492 (+)NCBIVero_WHO_p1.0
Ifng
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624802163,261 - 166,534 (+)NCBIHetGla_female_1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_003808705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide SSBP01000051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSPPAT00000061512   ⟹   ENSPPAP00000038608
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1268,448,861 - 68,453,829 (-)Ensembl
RefSeq Acc Id: XM_003808705   ⟹   XP_003808753
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.11268,448,861 - 68,453,829 (-)NCBI
Mhudiblu_PPA_v01265,663,764 - 65,668,732 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003808753 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003808753   ⟸   XM_003808705
- Sequence:
RefSeq Acc Id: ENSPPAP00000038608   ⟸   ENSPPAT00000061512


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000042020 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000038608 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000061512 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.10 UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/TrEMBL
  Interferon_gamma UniProtKB/TrEMBL
KEGG Report pps:100991779 UniProtKB/TrEMBL
NCBI Gene IFNG ENTREZGENE
PANTHER PTHR11419 UniProtKB/TrEMBL
Pfam IFN-gamma UniProtKB/TrEMBL
PIRSF IFN-gamma UniProtKB/TrEMBL
Superfamily-SCOP SSF47266 UniProtKB/TrEMBL
UniProt A0A2R9CC85_PANPA UniProtKB/TrEMBL