adaptive immune response acts_upstream_of_or_within ISO RGD:737488 9068941 MGI:3829555 , PMID:17277142 MGI MGI:3829555 , PMID:17277142 antigen processing and presentation acts_upstream_of_or_within ISO RGD:737488 9068941 MGI:3054461 , PMID:15356141 MGI MGI:3054461 , PMID:15356141 apoptotic process acts_upstream_of_or_within ISO UniProtKB:P53355 9068941 PMID:7828849 MGI PMID:7828849 apoptotic process acts_upstream_of_or_within ISO UniProtKB:P51397 , UniProtKB:P53355 9068941 PMID:7828849 MGI PMID:7828849 apoptotic process involved_in IEA UniProtKB:P01579 , ensembl:ENSP00000229135150520179 Ensembl GO_REF:0000107 apoptotic process acts_upstream_of_or_within ISO UniProtKB:P51397 9068941 PMID:7828849 MGI PMID:7828849 astrocyte activation involved_in IEA UniProtKB:P01579 , ensembl:ENSP00000229135150520179 Ensembl GO_REF:0000107 CD8-positive, alpha-beta T cell differentiation involved in immune response acts_upstream_of_or_within ISO RGD:737488 9068941 MGI:3829555 , PMID:17277142 MGI MGI:3829555 , PMID:17277142 cellular response to interleukin-18 acts_upstream_of_or_within ISO RGD:737488 9068941 MGI:4355633 , PMID:19666510 MGI MGI:4355633 , PMID:19666510 cellular response to lipopolysaccharide acts_upstream_of_or_within ISO RGD:737488 9068941 MGI:3821815 , PMID:18791161 MGI MGI:3821815 , PMID:18791161 defense response to bacterium acts_upstream_of_or_within ISO RGD:737488 9068941 MGI:3051174 , PMID:15240719 MGI MGI:3051174 , PMID:15240719 defense response to Gram-positive bacterium acts_upstream_of_or_within ISO RGD:737488 9068941 MGI:6453663 , PMID:30248149 MGI MGI:6453663 , PMID:30248149 defense response to protozoan acts_upstream_of_or_within ISO MGI:1857184 9068941 MGI:3653161 , PMID:9348310 MGI MGI:3653161 , PMID:9348310 defense response to protozoan acts_upstream_of_or_within ISO RGD:737488 9068941 MGI:3820354 , PMID:19050265 MGI MGI:3820354 , PMID:19050265 defense response to virus acts_upstream_of_or_within ISO RGD:737488 9068941 MGI:4431293 more ... MGI MGI:4431293 more ... defense response to virus involved_in IEA UniProtKB-KW:KW-0051 150520179 UniProt GO_REF:0000043 defense response to virus acts_upstream_of_or_within ISO MGI:2384409 9068941 MGI:5644636 , PMID:25268627 MGI MGI:5644636 , PMID:25268627 endoplasmic reticulum unfolded protein response acts_upstream_of_or_within ISO RGD:737488 9068941 MGI:3583403 , PMID:15911877 MGI MGI:3583403 , PMID:15911877 extrinsic apoptotic signaling pathway involved_in IEA UniProtKB:P01579 , ensembl:ENSP00000229135150520179 Ensembl GO_REF:0000107 humoral immune response acts_upstream_of_or_within ISO RGD:737488 9068941 MGI:3829555 , PMID:17277142 MGI MGI:3829555 , PMID:17277142 immune response involved_in IEA InterPro:IPR002069 150520179 InterPro GO_REF:0000002 inflammatory cell apoptotic process acts_upstream_of_or_within ISO RGD:737488 9068941 MGI:3027059 , PMID:11457893 MGI MGI:3027059 , PMID:11457893 interferon-gamma-mediated signaling pathway involved_in IEA UniProtKB:P01579 , ensembl:ENSP00000229135150520179 Ensembl GO_REF:0000107 macrophage activation involved in immune response involved_in IEA UniProtKB:P01579 , ensembl:ENSP00000229135150520179 Ensembl GO_REF:0000107 macrophage differentiation involved_in IEA UniProtKB:P01579 , ensembl:ENSP00000229135150520179 Ensembl GO_REF:0000107 microglial cell activation involved_in IEA UniProtKB:P01579 , ensembl:ENSP00000229135150520179 Ensembl GO_REF:0000107 negative regulation of amyloid-beta clearance involved_in ISO RGD:737488 9068941 MGI:6304699 , PMID:29061364 ARUK-UCL MGI:6304699 , PMID:29061364 negative regulation of amyloid-beta clearance involved_in ISO UniProtKB:P06804 , UniProtKB:P15261 9068941 MGI:3697769 , PMID:17255335 ARUK-UCL MGI:3697769 , PMID:17255335 negative regulation of cell population proliferation ISO RGD:2866 9068941 RGD PMID:11940252 , REF_RGD_ID:1300182 negative regulation of epithelial cell differentiation involved_in ISO RGD:2866 9068941 PMID:20624457 BHF-UCL PMID:20624457 , REF_RGD_ID:8554478 negative regulation of fibroblast proliferation ISO RGD:2866 9068941 RGD PMID:1906384 , REF_RGD_ID:10755757 negative regulation of gene expression involved_in IEA UniProtKB:P01579 , ensembl:ENSP00000229135150520179 Ensembl GO_REF:0000107 negative regulation of glomerular mesangial cell proliferation ISO RGD:2866 9068941 RGD PMID:1906384 , REF_RGD_ID:10755757 negative regulation of interleukin-17 production involved_in IEA UniProtKB:P01579 , ensembl:ENSP00000229135150520179 Ensembl GO_REF:0000107 negative regulation of myelination acts_upstream_of_or_within ISO RGD:737488 9068941 MGI:3583403 , PMID:15911877 MGI MGI:3583403 , PMID:15911877 negative regulation of osteoclast differentiation acts_upstream_of_or_within ISO RGD:737488 9068941 MGI:3836131 , PMID:17442941 MGI MGI:3836131 , PMID:17442941 negative regulation of smooth muscle cell proliferation involved_in IEA UniProtKB:P01579 , ensembl:ENSP00000229135150520179 Ensembl GO_REF:0000107 negative regulation of tau-protein kinase activity involved_in IEA UniProtKB:P01579 , ensembl:ENSP00000229135150520179 Ensembl GO_REF:0000107 negative regulation of transcription by RNA polymerase II involved_in ISO RGD:2866 9068941 PMID:20624457 BHF-UCL PMID:20624457 , REF_RGD_ID:8554478 negative regulation of transcription, DNA-templated involved_in IEA UniProtKB:P01579 , ensembl:ENSP00000229135150520179 Ensembl GO_REF:0000107 neuroinflammatory response involved_in ISO RGD:2866 9068941 PMID:27235345 ARUK-UCL PMID:27235345 , REF_RGD_ID:14401572 neutrophil apoptotic process acts_upstream_of_or_within ISO MGI:1857184 9068941 MGI:2673020 , PMID:12925700 MGI MGI:2673020 , PMID:12925700 neutrophil chemotaxis acts_upstream_of_or_within ISO MGI:1857184 9068941 MGI:2673020 , PMID:12925700 MGI MGI:2673020 , PMID:12925700 neutrophil chemotaxis acts_upstream_of_or_within ISO RGD:737488 9068941 MGI:2673020 , PMID:12925700 MGI MGI:2673020 , PMID:12925700 nitric oxide biosynthetic process acts_upstream_of ISO RGD:737488 9068941 MGI:1930064 , PMID:11168643 MGI MGI:1930064 , PMID:11168643 positive regulation by host of viral process involved_in ISO UniProtKB:P09581 9068941 MGI:4840165 , PMID:20889566 ARUK-UCL MGI:4840165 , PMID:20889566 positive regulation of amyloid-beta formation involved_in IEA UniProtKB:P01579 , ensembl:ENSP00000229135150520179 Ensembl GO_REF:0000107 positive regulation of apoptotic process ISO RGD:2866 9068941 RGD PMID:12931271 , REF_RGD_ID:10755739 positive regulation of autophagy involved_in IEA UniProtKB:P01579 , ensembl:ENSP00000229135150520179 Ensembl GO_REF:0000107 positive regulation of calcidiol 1-monooxygenase activity involved_in IEA UniProtKB:P01579 , ensembl:ENSP00000229135150520179 Ensembl GO_REF:0000107 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response involved_in IEA UniProtKB:P01579 , ensembl:ENSP00000229135150520179 Ensembl GO_REF:0000107 positive regulation of cell adhesion ISO RGD:2866 9068941 RGD PMID:2509328 , REF_RGD_ID:2311500 positive regulation of cell population proliferation involved_in ISO RGD:2866 9068941 PMID:20624457 BHF-UCL PMID:20624457 , REF_RGD_ID:8554478 positive regulation of cellular respiration involved_in ISO RGD:737488 9068941 MGI:6304699 , PMID:29061364 ARUK-UCL MGI:6304699 , PMID:29061364 positive regulation of chemokine production acts_upstream_of_or_within ISO MGI:1857184 9068941 MGI:2673020 , PMID:12925700 MGI MGI:2673020 , PMID:12925700 positive regulation of chemokine production involved_in IEA UniProtKB:P01579 , ensembl:ENSP00000229135150520179 Ensembl GO_REF:0000107 positive regulation of chemokine production acts_upstream_of_or_within ISO RGD:737488 9068941 MGI:2673020 , PMID:12925700 MGI MGI:2673020 , PMID:12925700 positive regulation of core promoter binding involved_in IEA UniProtKB:P01579 , ensembl:ENSP00000229135150520179 Ensembl GO_REF:0000107 positive regulation of cytokine production involved_in IEA UniProtKB:P01579 , ensembl:ENSP00000229135150520179 Ensembl GO_REF:0000107 positive regulation of epithelial cell migration involved_in IEA UniProtKB:P01579 , ensembl:ENSP00000229135150520179 Ensembl GO_REF:0000107 positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity involved_in IEA UniProtKB:P01579 , ensembl:ENSP00000229135150520179 Ensembl GO_REF:0000107 positive regulation of fructose 1,6-bisphosphate metabolic process involved_in IEA UniProtKB:P01579 , ensembl:ENSP00000229135150520179 Ensembl GO_REF:0000107 positive regulation of gene expression acts_upstream_of_or_within ISO RGD:737487 9068941 PMID:20164187 ARUK-UCL PMID:20164187 positive regulation of gene expression involved_in IEA UniProtKB:P01579 , ensembl:ENSP00000229135150520179 Ensembl GO_REF:0000107 positive regulation of glycolytic process involved_in ISO RGD:737488 9068941 MGI:6304699 , PMID:29061364 ARUK-UCL MGI:6304699 , PMID:29061364 positive regulation of inflammatory response involved_in IEA UniProtKB:P01579 , ensembl:ENSP00000229135150520179 Ensembl GO_REF:0000107 positive regulation of interleukin-1 beta production involved_in ISO RGD:737488 9068941 MGI:5776417 , PMID:26227742 ARUK-UCL MGI:5776417 , PMID:26227742 positive regulation of interleukin-1 beta production acts_upstream_of_or_within ISO MGI:1857184 9068941 MGI:2673020 , PMID:12925700 MGI MGI:2673020 , PMID:12925700 positive regulation of interleukin-12 production acts_upstream_of_or_within ISO RGD:737488 9068941 MGI:2679145 more ... MGI MGI:2679145 more ... positive regulation of interleukin-12 production involved_in IEA UniProtKB:P01579 , ensembl:ENSP00000229135150520179 Ensembl GO_REF:0000107 positive regulation of interleukin-23 production involved_in IEA UniProtKB:P01579 , ensembl:ENSP00000229135150520179 Ensembl GO_REF:0000107 positive regulation of interleukin-6 production acts_upstream_of_or_within ISO MGI:1857184 9068941 MGI:2673020 , PMID:12925700 MGI MGI:2673020 , PMID:12925700 positive regulation of interleukin-6 production involved_in IEA UniProtKB:P01579 , ensembl:ENSP00000229135150520179 Ensembl GO_REF:0000107 positive regulation of interleukin-6 production acts_upstream_of_or_within ISO RGD:737488 9068941 MGI:2673020 , PMID:12925700 MGI MGI:2673020 , PMID:12925700 positive regulation of iron ion import across plasma membrane involved_in ISO RGD:737488 9068941 MGI:6304699 , PMID:29061364 ARUK-UCL MGI:6304699 , PMID:29061364 positive regulation of isotype switching to IgG isotypes acts_upstream_of_or_within ISO RGD:737488 9068941 MGI:2670820 , PMID:12882831 MGI MGI:2670820 , PMID:12882831 positive regulation of killing of cells of another organism involved_in IEA UniProtKB:P01579 , ensembl:ENSP00000229135150520179 Ensembl GO_REF:0000107 positive regulation of macrophage cytokine production acts_upstream_of_or_within ISO RGD:737488 9068941 MGI:3653161 , PMID:9348310 MGI MGI:3653161 , PMID:9348310 positive regulation of membrane protein ectodomain proteolysis involved_in IEA UniProtKB:P01579 , ensembl:ENSP00000229135150520179 Ensembl GO_REF:0000107 positive regulation of MHC class II biosynthetic process ISO RGD:2866 9068941 RGD PMID:3127329 , REF_RGD_ID:8547557 positive regulation of MHC class II biosynthetic process involved_in ISO RGD:737488 9068941 MGI:4942276 more ... BHF-UCL MGI:4942276 more ... positive regulation of MHC class II biosynthetic process involved_in ISO UniProtKB:P05067 , UniProtKB:P49768 9068941 MGI:5776417 , PMID:26227742 ARUK-UCL MGI:5776417 , PMID:26227742 positive regulation of MHC class II biosynthetic process acts_upstream_of_or_within ISO RGD:737488 9068941 MGI:3033882 , PMID:11027433 MGI MGI:3033882 , PMID:11027433 positive regulation of neurogenesis involved_in IEA UniProtKB:P01579 , ensembl:ENSP00000229135150520179 Ensembl GO_REF:0000107 positive regulation of neuron death involved_in IEA UniProtKB:P01579 , ensembl:ENSP00000229135150520179 Ensembl GO_REF:0000107 positive regulation of neuron differentiation ISO RGD:2866 9068941 RGD PMID:19355840 , REF_RGD_ID:2311496 positive regulation of nitric oxide biosynthetic process acts_upstream_of_or_within ISO RGD:737488 9068941 MGI:1930064 , PMID:11168643 MGI MGI:1930064 , PMID:11168643 positive regulation of nitric oxide biosynthetic process involved_in IEA UniProtKB:P01579 , ensembl:ENSP00000229135150520179 Ensembl GO_REF:0000107 positive regulation of nitric-oxide synthase biosynthetic process involved_in ISO UniProtKB:P05067 , UniProtKB:P49768 9068941 MGI:5776417 , PMID:26227742 ARUK-UCL MGI:5776417 , PMID:26227742 positive regulation of nitric-oxide synthase biosynthetic process involved_in ISO RGD:737488 9068941 MGI:6304699 , PMID:29061364 ARUK-UCL MGI:6304699 , PMID:29061364 positive regulation of nitrogen compound metabolic process involved_in IEA UniProtKB:P01579 , ensembl:ENSP00000229135150520179 Ensembl GO_REF:0000107 positive regulation of NMDA glutamate receptor activity involved_in ISO UniProtKB:D4A109 , UniProtKB:Q6P6T3 9068941 PMID:27094552 ARUK-UCL PMID:27094552 , REF_RGD_ID:14397550 positive regulation of osteoclast differentiation involved_in IEA UniProtKB:P01579 , ensembl:ENSP00000229135150520179 Ensembl GO_REF:0000107 positive regulation of peptidyl-serine phosphorylation of STAT protein acts_upstream_of_or_within ISO RGD:737487 9068941 PMID:16280321 MGI PMID:16280321 positive regulation of peptidyl-serine phosphorylation of STAT protein involved_in IEA UniProtKB:P01579 , ensembl:ENSP00000229135150520179 Ensembl GO_REF:0000107 positive regulation of phagocytosis involved_in ISO RGD:737488 9068941 MGI:4454469 , PMID:20368278 ARUK-UCL MGI:4454469 , PMID:20368278 positive regulation of protein deacetylation involved_in IEA UniProtKB:P01579 , ensembl:ENSP00000229135150520179 Ensembl GO_REF:0000107 positive regulation of protein import into nucleus involved_in IEA UniProtKB:P01579 , ensembl:ENSP00000229135150520179 Ensembl GO_REF:0000107 positive regulation of protein phosphorylation involved_in IEA UniProtKB:P01579 , ensembl:ENSP00000229135150520179 Ensembl GO_REF:0000107 positive regulation of protein serine/threonine kinase activity involved_in IEA UniProtKB:P01579 , ensembl:ENSP00000229135150520179 Ensembl GO_REF:0000107 positive regulation of protein-containing complex assembly involved_in IEA UniProtKB:P01579 , ensembl:ENSP00000229135150520179 Ensembl GO_REF:0000107 positive regulation of signaling receptor activity involved_in ISO UniProtKB:P05067 , UniProtKB:P49768 9068941 MGI:5776417 , PMID:26227742 ARUK-UCL MGI:5776417 , PMID:26227742 positive regulation of smooth muscle cell apoptotic process involved_in IEA UniProtKB:P01579 , ensembl:ENSP00000229135150520179 Ensembl GO_REF:0000107 positive regulation of synaptic transmission, cholinergic ISO RGD:2866 9068941 RGD PMID:1900518 , REF_RGD_ID:2311499 positive regulation of T cell proliferation acts_upstream_of_or_within ISO RGD:737488 9068941 MGI:3621255 , PMID:16280321 MGI MGI:3621255 , PMID:16280321 positive regulation of transcription by RNA polymerase II acts_upstream_of_or_within ISO RGD:737488 9068941 MGI:4412460 , PMID:18025219 MGI MGI:4412460 , PMID:18025219 positive regulation of transcription by RNA polymerase II acts_upstream_of_or_within ISO MGI:104798 9068941 MGI:4412460 , PMID:18025219 MGI MGI:4412460 , PMID:18025219 positive regulation of transcription, DNA-templated acts_upstream_of_or_within ISO RGD:737488 9068941 MGI:2679145 , PMID:14568984 MGI MGI:2679145 , PMID:14568984 positive regulation of tumor necrosis factor (ligand) superfamily member 11 production involved_in IEA UniProtKB:P01579 , ensembl:ENSP00000229135150520179 Ensembl GO_REF:0000107 positive regulation of tumor necrosis factor production involved_in ISO ComplexPortal:CPX-1062 9068941 MGI:6305053 , PMID:7715705 ARUK-UCL MGI:6305053 , PMID:7715705 positive regulation of tumor necrosis factor production involved_in ISO UniProtKB:P05067 , UniProtKB:P49768 9068941 MGI:5776417 , PMID:26227742 ARUK-UCL MGI:5776417 , PMID:26227742 positive regulation of tumor necrosis factor production involved_in ISO RGD:737488 9068941 MGI:4942276 more ... BHF-UCL MGI:4942276 more ... positive regulation of tumor necrosis factor production involved_in ISO UniProtKB:P15261 9068941 MGI:3697769 , PMID:17255335 ARUK-UCL MGI:3697769 , PMID:17255335 positive regulation of tyrosine phosphorylation of STAT protein acts_upstream_of_or_within ISO RGD:737487 9068941 PMID:16280321 MGI PMID:16280321 positive regulation of tyrosine phosphorylation of STAT protein involved_in IEA UniProtKB:P01579 , ensembl:ENSP00000229135150520179 Ensembl GO_REF:0000107 positive regulation of vitamin D biosynthetic process involved_in IEA UniProtKB:P01579 , ensembl:ENSP00000229135150520179 Ensembl GO_REF:0000107 receptor signaling pathway via JAK-STAT involved_in ISO UniProtKB:Q62120 9068941 MGI:5776417 , PMID:26227742 ARUK-UCL MGI:5776417 , PMID:26227742 regulation of defense response to virus by host involved_in ISO RGD:737488 9068941 MGI:5583923 , PMID:24784232 CAFA MGI:5583923 , PMID:24784232 regulation of glial cell proliferation ISO RGD:2866 9068941 RGD PMID:10598324 , REF_RGD_ID:10755759 regulation of growth involved_in IEA UniProtKB-KW:KW-0341 150520179 UniProt GO_REF:0000043 regulation of hepatocyte proliferation ISO RGD:2866 9068941 RGD PMID:15799032 , REF_RGD_ID:8142374 regulation of immune response acts_upstream_of_or_within ISO RGD:737488 9068941 MGI:2670820 , PMID:12882831 MGI MGI:2670820 , PMID:12882831 regulation of insulin secretion involved_in IEA UniProtKB:P01579 , ensembl:ENSP00000229135150520179 Ensembl GO_REF:0000107 regulation of neuronal action potential ISO RGD:2866 9068941 RGD PMID:7715823 , REF_RGD_ID:8158038 regulation of protein ADP-ribosylation involved_in IEA UniProtKB:P01579 , ensembl:ENSP00000229135150520179 Ensembl GO_REF:0000107 regulation of the force of heart contraction ISO RGD:2866 9068941 RGD PMID:1900518 , REF_RGD_ID:2311499 regulation of transcription, DNA-templated acts_upstream_of_or_within ISO RGD:737488 9068941 MGI:2385392 , PMID:12050152 MGI MGI:2385392 , PMID:12050152 response to virus acts_upstream_of_or_within ISO RGD:737487 9068941 PMID:16280321 MGI PMID:16280321 response to virus involved_in IEA UniProtKB:P01579 , ensembl:ENSP00000229135150520179 Ensembl GO_REF:0000107 response to xenobiotic stimulus ISO RGD:2866 9068941 propofol RGD PMID:19439114 , REF_RGD_ID:2311495 sensory perception of mechanical stimulus ISO RGD:2866 9068941 RGD PMID:7715823 , REF_RGD_ID:8158038 T cell proliferation acts_upstream_of ISO RGD:737488 9068941 MGI:3621255 , PMID:16280321 MGI MGI:3621255 , PMID:16280321 T cell receptor signaling pathway acts_upstream_of_or_within ISO RGD:737488 9068941 MGI:5013687 , PMID:21444916 MGI MGI:5013687 , PMID:21444916