HSPA1A (heat shock protein family A (Hsp70) member 1A) - Rat Genome Database

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Gene: HSPA1A (heat shock protein family A (Hsp70) member 1A) Pan paniscus
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Symbol: HSPA1A
Name: heat shock protein family A (Hsp70) member 1A
RGD ID: 11946970
Description: ENCODES a protein that exhibits ATP binding (ortholog); ATP hydrolysis activity (ortholog); ATP-dependent protein disaggregase activity (ortholog); INVOLVED IN ATP metabolic process (ortholog); cellular heat acclimation (ortholog); cellular response to heat (ortholog); ASSOCIATED WITH Acute Coronary Syndrome (ortholog); acute kidney failure (ortholog); Alzheimer's disease (ortholog); FOUND IN aggresome (ortholog); centriole (ortholog); centrosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: heat shock 70 kDa protein 1; heat shock 70 kDa protein 1A; LOC100975983
RGD Orthologs
Human
Mouse
Rat
Squirrel
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2546,292,775 - 46,294,988 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1642,254,270 - 42,256,491 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0631,476,710 - 31,491,411 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1632,363,499 - 32,366,005 (+)NCBIpanpan1.1PanPan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
ATP metabolic process  (ISO)
cellular heat acclimation  (ISO)
cellular response to heat  (ISO)
cellular response to unfolded protein  (ISO)
chaperone-mediated protein complex assembly  (ISO)
DNA repair  (ISO)
lysosomal transport  (ISO)
mRNA catabolic process  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (ISO)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
negative regulation of inclusion body assembly  (ISO)
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway  (ISO)
negative regulation of protein ubiquitination  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
neuron differentiation  (ISO)
positive regulation of erythrocyte differentiation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of microtubule nucleation  (ISO)
positive regulation of neuron differentiation  (ISO)
positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway  (ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (ISO)
positive regulation of RNA splicing  (ISO)
positive regulation of tumor necrosis factor-mediated signaling pathway  (ISO)
protein folding  (ISO)
protein refolding  (ISO)
protein stabilization  (ISO)
regulation of mitotic spindle assembly  (ISO)
regulation of protein ubiquitination  (ISO)
response to ethanol  (ISO)
response to heat  (ISO)
response to ischemia  (ISO)
response to mechanical stimulus  (ISO)
response to unfolded protein  (ISO)
telomere maintenance  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
HSPA1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2546,292,775 - 46,294,988 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1642,254,270 - 42,256,491 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0631,476,710 - 31,491,411 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1632,363,499 - 32,366,005 (+)NCBIpanpan1.1PanPan1.1panPan2
HSPA1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38631,815,543 - 31,817,942 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl631,815,543 - 31,817,946 (+)EnsemblGRCh38hg38GRCh38
GRCh37631,783,320 - 31,785,719 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36631,891,316 - 31,893,698 (+)NCBINCBI36Build 36hg18NCBI36
Build 34631,891,315 - 31,893,698NCBI
Celera633,381,540 - 33,383,968 (+)NCBICelera
Cytogenetic Map6p21.33NCBI
HuRef631,569,698 - 31,572,209 (+)NCBIHuRef
CHM1_1631,785,425 - 31,787,853 (+)NCBICHM1_1
T2T-CHM13v2.0631,668,600 - 31,670,999 (+)NCBIT2T-CHM13v2.0
Hspa1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391735,188,335 - 35,191,132 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1735,188,166 - 35,191,132 (-)EnsemblGRCm39 Ensembl
GRCm381734,969,359 - 34,972,156 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,969,190 - 34,972,156 (-)EnsemblGRCm38mm10GRCm38
MGSCv371735,106,304 - 35,109,101 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361734,577,246 - 34,580,180 (-)NCBIMGSCv36mm8
Celera1738,065,583 - 38,068,380 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.51NCBI
Hspa1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8203,875,411 - 3,877,866 (+)NCBIGRCr8
mRatBN7.2203,870,765 - 3,873,221 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl203,856,006 - 3,873,227 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx204,554,562 - 4,558,670 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0203,916,620 - 3,920,728 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0204,454,457 - 4,458,467 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0202,699,707 - 2,701,856 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl202,699,712 - 2,701,815 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,877,324 - 4,879,779 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,956,234 - 6,962,151 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4203,945,716 - 3,959,552 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera204,152,570 - 4,158,467 (-)NCBICelera
Cytogenetic Map20p12NCBI
LOC101956126
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494635,825,952 - 35,828,975 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049367271,732,323 - 1,735,128 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC103221745
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11740,203,647 - 40,206,028 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1740,203,936 - 40,205,858 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236679469,302 - 10,259 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_034961779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: XM_034961779   ⟹   XP_034817670
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2546,292,775 - 46,294,988 (+)NCBI
NHGRI_mPanPan1642,254,270 - 42,256,491 (+)NCBI
Mhudiblu_PPA_v0631,476,710 - 31,491,411 (+)NCBI
Protein Sequences
Protein RefSeqs XP_034817670 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_034817670   ⟸   XM_034961779


Additional Information

Database Acc Id Source(s)
NCBI Gene LOC100975983 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-07-01 HSPA1A  heat shock protein family A (Hsp70) member 1A  LOC100975983  heat shock 70 kDa protein 1  Symbol and/or name change 5135510 APPROVED