RGD Reference Report - Associations of genetic polymorphisms of arachidonate 5-lipoxygenase-activating protein with risk of coronary artery disease in a European-American population.

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Associations of genetic polymorphisms of arachidonate 5-lipoxygenase-activating protein with risk of coronary artery disease in a European-American population.
Authors:	Tsai, AK Li, N Hanson, NQ Tsai, MY Tang, W
Citation:	Tsai AK, etal., Atherosclerosis. 2009 Jun 18.
RGD ID:	2313883
Pubmed:	PMID:19596330 (View Abstract at PubMed)
DOI:	DOI:10.1016/j.atherosclerosis.2009.06.018 (Journal Full-text)
OBJECTIVE: To examine whether genetic polymorphisms in the 5-lipoxygenase activating protein (ALOX5AP) confer an increased risk to angiographically proven coronary artery disease (CAD) in a case-control study of a Midwestern population in the US. METHODS: We genotyped 7 SNPs (SG13S25, SG13S89, SG13S41, SG13S377, SG13S35, SG13S114, and SG13S32) in the ALOX5AP gene in 500 angiographically proven coronary artery disease (CAD) cases and 500 age- and gender-matched controls of European-American ancestry living in upper-Midwest US. Genotypes were determined using a multiplexing application of SEQUENOM((R)) methodology for homogenous MassEXTEND assay. Two haplotypes (HapA and HapB) that were previously identified to be associated with the risk of myocardial infarction (MI) in the Icelandic or British populations of the original deCODE study were analyzed along with individual SNPs. RESULTS: HapB was significantly associated with the risk of premature CAD, independent of the influence of age, gender, total and HDL cholesterol (ORs of 2.06 without covariate adjustment; 2.05 after multivariable adjustment). SNP SG13S377, one of the SNPs used to define HapB, was also independently and significantly associated with the risk of premature CAD. CONCLUSION: Our study suggests a significant but modest contribution of the ALOX5AP gene variants to the susceptibility of premature CAD in an US Midwestern population of European-American ancestry.

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Object Symbol	Species	Term	Qualifier	Evidence	With	Notes	Source	Original Reference(s)
ALOX5AP	Human	coronary artery disease		IAGP		DNA:snps:multiple (human)	RGD
Alox5ap	Rat	coronary artery disease		ISO	ALOX5AP (Homo sapiens)	DNA:snps:multiple (human)	RGD
Alox5ap	Mouse	coronary artery disease		ISO	ALOX5AP (Homo sapiens)	DNA:snps:multiple (human)	RGD

Objects Annotated

Genes (Rattus norvegicus)

Alox5ap (arachidonate 5-lipoxygenase activating protein)

Genes (Mus musculus)

Alox5ap (arachidonate 5-lipoxygenase activating protein)

Genes (Homo sapiens)

ALOX5AP (arachidonate 5-lipoxygenase activating protein)

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Associations of genetic polymorphisms of arachidonate 5-lipoxygenase-activating protein with risk of coronary artery disease in a European-American population.