RGD Reference Report - Decreased plasma gelsolin concentrations in acute liver failure, myocardial infarction, septic shock, and myonecrosis. - Rat Genome Database

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Decreased plasma gelsolin concentrations in acute liver failure, myocardial infarction, septic shock, and myonecrosis.

Authors: Suhler, E  Lin, W  Yin, H L  Lee, W M 
Citation: Suhler E, etal., Crit Care Med. 1997 Apr;25(4):594-8. doi: 10.1097/00003246-199704000-00007.
RGD ID: 329333022
Pubmed: PMID:9142022   (View Abstract at PubMed)
DOI: DOI:10.1097/00003246-199704000-00007   (Journal Full-text)


OBJECTIVE: To quantitate gelsolin concentrations in serum of patients with a variety of conditions involving actin release into the circulation.
DESIGN: Prospective evaluation of sera on consecutive patients.
SETTING: Metropolitan county hospital.
PATIENTS: Ninety hospital patients with a variety of well-characterized diseases.
INTERVENTIONS: None.
MEASUREMENTS AND MAIN RESULTS: Sera were studied from patients with acute liver failure (n = 18), chronic hepatitis (n = 17), cirrhosis of varying etiology (n = 17), pancreatitis (n = 10), acute myocardial infarction (n = 10), myonecrosis due either to polymyositis or crush injuries (n = 12), and septic shock (n = 6); results were compared with sera from healthy individuals (n = 25). Gelsolin was quantified by Western blotting with monoclonal anti-gelsolin and laser densitometry. Significant reductions in mean gelsolin concentrations compared with healthy controls were observed in patients with acute liver failure (47%), myocardial infarction (69%), sepsis (51%), and myonecrosis (66%). An inverse correlation was observed between gelsolin concentration and severity of illness, as indicated by the magnitude of serum enzyme concentrations.
CONCLUSIONS: Gelsolin depletion occurs in a variety of tissue injury syndromes. Depletion of actin-scavenger capacity in the presence of continued actin release may affect outcome in situations of severe organ damage.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
GSNHumanAcute Liver Failure  IEP protein:decreased expression:blood serum (human)RGD 
GsnRatAcute Liver Failure  ISOGSN (Homo sapiens)protein:decreased expression:blood serum (human)RGD 
GsnMouseAcute Liver Failure  ISOGSN (Homo sapiens)protein:decreased expression:blood serum (human)RGD 
GSNHumangas gangrene  IEP protein:decreased expression:blood serum (human)RGD 
GsnRatgas gangrene  ISOGSN (Homo sapiens)protein:decreased expression:blood serum (human)RGD 
GsnMousegas gangrene  ISOGSN (Homo sapiens)protein:decreased expression:blood serum (human)RGD 
GSNHumanmyocardial infarction  IEP protein:decreased expression:blood serum (human)RGD 
GsnRatmyocardial infarction  ISOGSN (Homo sapiens)protein:decreased expression:blood serum (human)RGD 
GsnMousemyocardial infarction  ISOGSN (Homo sapiens)protein:decreased expression:blood serum (human)RGD 
GSNHumanSepsis  IEP protein:decreased expression:blood serum (human)RGD 
GsnRatSepsis  ISOGSN (Homo sapiens)protein:decreased expression:blood serum (human)RGD 
GsnMouseSepsis  ISOGSN (Homo sapiens)protein:decreased expression:blood serum (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gsn  (gelsolin)

Genes (Mus musculus)
Gsn  (gelsolin)

Genes (Homo sapiens)
GSN  (gelsolin)


Additional Information