RGD Reference Report - Increased expression of LIGHT/TNFSF14 and its receptors in experimental and clinical heart failure. - Rat Genome Database

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Increased expression of LIGHT/TNFSF14 and its receptors in experimental and clinical heart failure.

Authors: Dahl, CP  Gullestad, L  Fevang, B  Holm, AM  Landro, L  Vinge, LE  Fiane, AE  Sandberg, WJ  Otterdal, K  Froland, SS  Damas, JK  Halvorsen, B  Aukrust, P  Oie, E  Yndestad, A 
Citation: Dahl CP, etal., Eur J Heart Fail. 2008 Apr;10(4):352-9. Epub 2008 Mar 18.
RGD ID: 2317281
Pubmed: PMID:18353719   (View Abstract at PubMed)
DOI: DOI:10.1016/j.ejheart.2008.02.010   (Journal Full-text)

BACKGROUND: Clinical and experimental studies suggest a pathogenic role for inflammation in chronic heart failure (HF). LIGHT is a member of the tumour necrosis factor superfamily involved in innate and adaptive immune responses. AIMS: We sought to investigate a potential pathogenic role of LIGHT in chronic HF. METHODS: We used various clinical and experimental approaches including studies in post-infarction HF rats and in vitro studies of endothelial cells and peripheral blood mononuclear cells (PBMC). RESULTS: Our main findings were: (i) LIGHT and its receptors (i.e., HVEM and lymphotoxin-beta receptor) were regulated during experimental HF, with strong expression in the infarcted area accompanied by up-regulation of HVEM in cardiomyocytes and endothelial cells also in the non-ischaemic part of the left ventricle. (ii) Patients with chronic HF had significantly increased expression of LIGHT on CD3(+) T-cells accompanied by increased expression of HVEM on monocytes and within the failing myocardium. (iii) LIGHT induced interleukin (IL)-6 expression in endothelial cells. In HF patients, but not in healthy controls, such an IL-6-inducing effect was also seen in LIGHT activated PBMC. CONCLUSION: Our findings in both clinical and experimental HF may suggest a role for LIGHT signalling pathways in the progression of chronic HF involving IL-6-related mechanisms.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
myocardial infarction  ISOTnfrsf14 (Rattus norvegicus)2317281; 2317281protein:increased expression:heart more ...RGD 
myocardial infarction  IEP 2317281protein:increased expression:heart more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tnfrsf14  (TNF receptor superfamily member 14)

Genes (Mus musculus)
Tnfrsf14  (tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator))

Genes (Homo sapiens)
TNFRSF14  (TNF receptor superfamily member 14)


Additional Information