RGD Reference Report - Atherosclerosis and PTPN22: a study in coronary artery disease. - Rat Genome Database

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Atherosclerosis and PTPN22: a study in coronary artery disease.

Authors: Saccucci, P  Banci, M  Cozzoli, E  Neri, A  Magrini, A  Bottini, E  Gloria-Bottini, F 
Citation: Saccucci P, etal., Cardiology. 2011;119(1):54-6. Epub 2011 Aug 12.
RGD ID: 6484553
Pubmed: PMID:21846984   (View Abstract at PubMed)
DOI: DOI:10.1159/000329919   (Journal Full-text)

OBJECTIVES: Recently, it has been shown that PTPN22 genetic polymorphism is associated with phenotypes related to the risk of atherosclerosis. In the present note, we have searched for a possible association of PTPN22 polymorphism with coronary artery disease (CAD). METHODS: One hundred and thirty-four non-diabetic subjects admitted to hospital for CAD and 174 healthy subjects (blood donors) were studied. PTPN22 genotypes were determined by DNA analysis. Statistical analyses were performed by SPSS programs. RESULTS: In CAD patients, the proportion of carriers of the *T allele of PTPN22 is significantly higher compared to healthy controls (OR 2.66; 95% CI 1.07-6.72). CONCLUSIONS: The present observation confirms the association of PTPN22 phenotype with atherosclerosis and suggests a role of immune mechanism in the pathogenesis of CAD.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
coronary artery disease  IAGP 6484553DNA: snp: cds: rs2476601RGD 
coronary artery disease  ISOPTPN22 (Homo sapiens)6484553; 6484553DNA: snp: cds: rs2476601RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ptpn22  (protein tyrosine phosphatase, non-receptor type 22)

Genes (Mus musculus)
Ptpn22  (protein tyrosine phosphatase, non-receptor type 22 (lymphoid))

Genes (Homo sapiens)
PTPN22  (protein tyrosine phosphatase non-receptor type 22)


Additional Information