CDKN2B (cyclin dependent kinase inhibitor 2B) - Rat Genome Database

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Gene: CDKN2B (cyclin dependent kinase inhibitor 2B) Pan paniscus
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Symbol: CDKN2B
Name: cyclin dependent kinase inhibitor 2B
RGD ID: 11770467
Description: ENCODES a protein that exhibits cyclin-dependent protein serine/threonine kinase inhibitor activity (inferred); protein kinase binding (inferred); INVOLVED IN cellular response to transforming growth factor beta stimulus (ortholog); cellular senescence (ortholog); liver development (ortholog); PARTICIPATES IN G1/S transition pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); acute myeloid leukemia (ortholog); acute myelomonocytic leukemia (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cyclin-dependent kinase 4 inhibitor B
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v211102,545,185 - 102,554,222 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan19102,550,897 - 102,560,167 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0921,838,902 - 21,845,355 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1922,455,662 - 22,462,156 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl922,455,662 - 22,462,156 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
nucleus  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
CDKN2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v211102,545,185 - 102,554,222 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan19102,550,897 - 102,560,167 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0921,838,902 - 21,845,355 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1922,455,662 - 22,462,156 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl922,455,662 - 22,462,156 (-)Ensemblpanpan1.1panPan2
CDKN2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38922,002,903 - 22,009,313 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl922,002,903 - 22,009,305 (-)EnsemblGRCh38hg38GRCh38
GRCh37922,002,902 - 22,009,312 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36921,992,902 - 21,999,312 (-)NCBINCBI36Build 36hg18NCBI36
Build 34921,992,902 - 21,999,312NCBI
Celera921,941,270 - 21,947,682 (-)NCBICelera
Cytogenetic Map9p21.3NCBI
HuRef921,966,171 - 21,972,582 (-)NCBIHuRef
CHM1_1922,002,731 - 22,009,141 (-)NCBICHM1_1
T2T-CHM13v2.0922,017,276 - 22,023,690 (-)NCBIT2T-CHM13v2.0
Cdkn2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39489,224,526 - 89,229,269 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl489,224,536 - 89,229,276 (-)EnsemblGRCm39 Ensembl
GRCm38489,306,289 - 89,311,032 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl489,306,299 - 89,311,039 (-)EnsemblGRCm38mm10GRCm38
MGSCv37488,952,198 - 88,956,941 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36488,777,556 - 88,782,190 (-)NCBIMGSCv36mm8
Celera487,792,244 - 87,797,039 (-)NCBICelera
Cytogenetic Map4C4NCBI
cM Map442.15NCBI
Cdkn2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85109,123,308 - 109,134,906 (-)NCBIGRCr8
mRatBN7.25104,009,839 - 104,019,082 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5104,010,680 - 104,019,050 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5106,447,506 - 106,453,182 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05108,177,120 - 108,182,796 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05108,257,644 - 108,263,335 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05107,834,353 - 107,857,428 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5107,845,951 - 107,858,104 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05111,817,188 - 111,826,334 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45108,939,669 - 108,945,293 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15108,946,492 - 108,950,551 (-)NCBI
Celera5102,728,741 - 102,734,427 (-)NCBICelera
Cytogenetic Map5q32NCBI
Cdkn2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547212,275,544 - 12,280,528 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495547212,275,613 - 12,280,141 (+)NCBIChiLan1.0ChiLan1.0
CDKN2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11141,259,627 - 41,264,832 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1139,933,406 - 39,936,568 (-)NCBIDog10K_Boxer_Tasha
Dog10K_Boxer_Tasha1139,895,530 - 39,924,805 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01142,165,720 - 42,207,150 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1142,165,719 - 42,206,773 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11140,873,681 - 40,876,835 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01140,723,758 - 40,752,953 (-)NCBIUNSW_CanFamBas_1.0
UNSW_CanFamBas_1.01140,761,542 - 40,764,705 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01141,374,892 - 41,378,057 (-)NCBIUU_Cfam_GSD_1.0
Cdkn2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947155,907,481 - 155,911,659 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366523,538,986 - 3,581,159 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366523,576,975 - 3,582,790 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDKN2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1200,761,004 - 200,766,056 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11200,666,250 - 200,770,880 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21223,955,554 - 223,960,641 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Cdkn2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473625,926,668 - 25,933,440 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473625,929,314 - 25,933,318 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_003830687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSPPAT00000050851   ⟹   ENSPPAP00000028007
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl922,455,662 - 22,462,156 (-)Ensembl
RefSeq Acc Id: XM_003830687   ⟹   XP_003830735
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v211102,545,185 - 102,554,222 (+)NCBI
NHGRI_mPanPan19102,550,897 - 102,560,167 (+)NCBI
Mhudiblu_PPA_v0921,838,902 - 21,845,355 (-)NCBI
PanPan1.1922,455,662 - 22,462,156 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003830735 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000028007
  ENSPPAP00000028007.1
RefSeq Acc Id: XP_003830735   ⟸   XM_003830687
- UniProtKB: A0A2R9BIA4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000028007   ⟸   ENSPPAT00000050851


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000037066 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000050851.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/TrEMBL
InterPro Ank_Repeat/CDKN_Inhibitor UniProtKB/TrEMBL
  Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
KEGG Report pps:100976219 UniProtKB/TrEMBL
NCBI Gene CDKN2B ENTREZGENE
PANTHER ANK_REP_REGION DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  CYCLIN-DEPENDENT KINASE 4 INHIBITOR B UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF48403 UniProtKB/TrEMBL
UniProt A0A2R9BIA4 ENTREZGENE, UniProtKB/TrEMBL