RGD Reference Report - MicroRNA-210 alleviates oxidative stress-associated cardiomyocyte apoptosis by regulating BNIP3. - Rat Genome Database

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MicroRNA-210 alleviates oxidative stress-associated cardiomyocyte apoptosis by regulating BNIP3.

Authors: Diao, Hongying  Liu, Bin  Shi, Yongfeng  Song, Chunli  Guo, Ziyuan  Liu, Ning  Song, Xianjing  Lu, Yang  Lin, Xiaoye  Li, Zhuoran 
Citation: Diao H, etal., Biosci Biotechnol Biochem. 2017 Sep;81(9):1712-1720. doi: 10.1080/09168451.2017.1343118. Epub 2017 Jun 29.
RGD ID: 155260328
Pubmed: PMID:28661226   (View Abstract at PubMed)
DOI: DOI:10.1080/09168451.2017.1343118   (Journal Full-text)

Oxidative stress-induced myocardial apoptosis and necrosis are involved in ischemia/reperfusion (I/R) injury. This study was performed to investigate microRNA (miR)-210's role in oxidative stress-related myocardial damage. The expression of miR-210 was upregulated in myocardial tissues of I/R rats, while that of Bcl-2 adenovirus E1B 19kDa-interacting protein 3 (BNIP3) was downregulated. To simulate in vivo oxidative stress, H9c2 cells were treated with H2O2 for 48 h. MiR-210 level was increased upon H2O2 stimulation, peaked at 8 h, and then decreased. An opposite expression pattern of BNIP3 was observed. BNIP3 was demonstrated as a direct target of miR-210 via luciferase reporter assay. H2O2-induced cell apoptosis was attenuated by miR-210 mimics, whereas aggravated by miR-210 inhibitor. MiR-210 knockdown-induced cell apoptosis in presence of H2O2 was attenuated by BNIP3 siRNA. Our work demonstrates that miR-210 plays a protective role in H2O2-induced cardiomyocyte apoptosis at least by regulating the pro-apoptotic BNIP3.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Myocardial Reperfusion Injury  ISOBnip3 (Rattus norvegicus)155260328; 155260328protein:decreased expression:myocardium (human)RGD 
Myocardial Reperfusion Injury  IEP 155260328protein:decreased expression:myocardium (human)RGD 
Myocardial Reperfusion Injury  ISOMir210 (Rattus norvegicus)155260328; 155260328miRNA:increased expression:myocardium (human)RGD 
Myocardial Reperfusion Injury  IEP 155260328miRNA:increased expression:myocardium (human)RGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

Objects Annotated

Genes (Rattus norvegicus)
Bnip3  (BCL2 interacting protein 3)
Mir210  (microRNA 210)

Genes (Mus musculus)
Bnip3  (BCL2/adenovirus E1B interacting protein 3)
Mir210  (microRNA 210)

Genes (Homo sapiens)
BNIP3  (BCL2 interacting protein 3)
MIR210  (microRNA 210)


Additional Information