ENPP1 (ectonucleotide pyrophosphatase/phosphodiesterase 1) - Rat Genome Database

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Gene: ENPP1 (ectonucleotide pyrophosphatase/phosphodiesterase 1) Pan paniscus
Analyze
Symbol: ENPP1
Name: ectonucleotide pyrophosphatase/phosphodiesterase 1
RGD ID: 11740602
Description: ENCODES a protein that exhibits calcium ion binding (ortholog); identical protein binding (ortholog); phosphodiesterase I activity (ortholog); INVOLVED IN adipose tissue development (ortholog); adult locomotory behavior (ortholog); adult walking behavior (ortholog); PARTICIPATES IN insulin signaling pathway; niacin metabolic pathway; pantothenic acid metabolic pathway; ASSOCIATED WITH Aortic Calcification (ortholog); aortic valve disease 1 (ortholog); arterial calcification of infancy (ortholog); FOUND IN apical dendrite (ortholog); basal dendrite (ortholog); cell body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ectonucleotide pyrophosphatase/phosphodiesterase family member 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25151,797,817 - 151,882,874 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16149,704,715 - 149,789,744 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06129,591,858 - 129,673,000 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16133,698,904 - 133,783,644 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6133,698,640 - 133,783,644 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
3'-phosphoadenosine 5'-phosphosulfate metabolic process  (IEA)
adipose tissue development  (ISO)
adult locomotory behavior  (ISO)
adult walking behavior  (ISO)
aorta development  (ISO)
apoptotic process involved in development  (ISO)
artery development  (ISO)
articular cartilage development  (ISO)
ATP metabolic process  (IEA)
axon regeneration  (ISO)
B-1 B cell homeostasis  (ISO)
biomineral tissue development  (ISO)
bone development  (ISO)
bone growth  (ISO)
bone mineralization  (IEA,ISO)
bone mineralization involved in bone maturation  (ISO)
bone remodeling  (ISO)
bone resorption  (ISO)
bone trabecula formation  (ISO)
calcium ion homeostasis  (ISO)
cartilage development  (ISO)
cell morphogenesis  (ISO)
cell population proliferation  (ISO)
cellular homeostasis  (ISO)
cellular response to acidic pH  (ISO)
cellular response to cAMP  (ISO)
cellular response to insulin stimulus  (IEA)
cellular response to mechanical stimulus  (ISO)
cellular response to sodium phosphate  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cementum mineralization  (ISO)
central nervous system myelination  (ISO)
cerebellum development  (ISO)
cerebral cortex development  (ISO)
collagen-activated signaling pathway  (ISO)
D-glucose import  (ISO)
defense response to protozoan  (ISO)
determination of adult lifespan  (ISO)
diphosphate metabolic process  (ISO)
endochondral bone morphogenesis  (ISO)
endochondral ossification  (ISO)
establishment of localization in cell  (ISO)
fat cell differentiation  (ISO)
fat pad development  (ISO)
fatty acid metabolic process  (ISO)
fibroblast growth factor receptor signaling pathway  (ISO)
gene expression  (IEA,ISO)
generation of precursor metabolites and energy  (IEA)
glucose homeostasis  (ISO)
glycolytic process  (ISO)
heart development  (ISO)
hematopoietic stem cell migration to bone marrow  (ISO)
hippocampus development  (ISO)
hormone metabolic process  (ISO)
immune response  (IEA)
inflammatory response to antigenic stimulus  (ISO)
inhibition of non-skeletal tissue mineralization  (ISO)
inorganic diphosphate transport  (IEA)
intracellular phosphate ion homeostasis  (IEA)
kidney development  (ISO)
leukocyte activation involved in inflammatory response  (ISO)
ligamentous ossification  (ISO)
liver development  (ISO)
long-term synaptic potentiation  (ISO)
macrophage differentiation  (ISO)
magnesium ion homeostasis  (ISO)
melanocyte differentiation  (IEA)
microglia differentiation  (ISO)
microglial cell migration  (ISO)
middle ear morphogenesis  (ISO)
mitochondrion organization  (ISO)
morphogenesis of an epithelium  (ISO)
mRNA transcription by RNA polymerase II  (ISO)
mucus secretion  (ISO)
multicellular organism growth  (ISO)
muscle cell cellular homeostasis  (ISO)
negative regulation of bone mineralization  (ISO)
negative regulation of cell growth  (IEA)
negative regulation of D-glucose import  (IEA)
negative regulation of fat cell differentiation  (IEA)
negative regulation of glycogen biosynthetic process  (IEA)
negative regulation of hh target transcription factor activity  (ISO)
negative regulation of insulin receptor signaling pathway  (IEA)
negative regulation of ossification  (ISO)
negative regulation of protein autophosphorylation  (ISO)
neuron apoptotic process  (ISO)
nucleoside triphosphate catabolic process  (IEA)
odontogenesis  (ISO)
olfactory bulb development  (ISO)
oligodendrocyte apoptotic process  (ISO)
organic phosphonate metabolic process  (ISO)
ossification  (ISO)
osteoblast differentiation  (ISO)
osteoclast differentiation  (ISO)
phosphate ion homeostasis  (IEA)
phosphate-containing compound metabolic process  (IEA)
plasma cell differentiation  (ISO)
post-embryonic forelimb morphogenesis  (ISO)
protein poly-ADP-ribosylation  (ISO)
regulation of bone mineralization  (IEA)
response to ATP  (IEA)
response to dietary excess  (ISO)
response to Gram-positive bacterium  (ISO)
response to insulin  (ISO)
response to magnesium ion  (ISO)
response to mechanical stimulus  (ISO)
response to platelet-derived growth factor  (ISO)
response to sodium phosphate  (ISO)
response to vitamin B6  (ISO)
response to wounding  (ISO)
sensory perception of mechanical stimulus  (ISO)
sensory perception of sound  (ISO)
sensory perception of temperature stimulus  (ISO)
sequestering of triglyceride  (IEA)
skin development  (ISO)
smoothened signaling pathway  (ISO)
spinal cord development  (ISO)
striatum development  (ISO)
T cell differentiation  (ISO)
tooth mineralization  (ISO)
vascular associated smooth muscle cell migration  (ISO)
vascular associated smooth muscle cell proliferation  (ISO)
vasculogenesis  (ISO)
vesicle-mediated transport  (IEA)
vitamin D3 metabolic process  (ISO)
Wnt signaling pathway  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ENPP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25151,797,817 - 151,882,874 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16149,704,715 - 149,789,744 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06129,591,858 - 129,673,000 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16133,698,904 - 133,783,644 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6133,698,640 - 133,783,644 (+)Ensemblpanpan1.1panPan2
ENPP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386131,808,020 - 131,895,155 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6131,808,016 - 131,895,155 (+)EnsemblGRCh38hg38GRCh38
GRCh376132,129,160 - 132,216,295 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366132,170,853 - 132,254,043 (+)NCBINCBI36Build 36hg18NCBI36
Build 346132,170,852 - 132,254,043NCBI
Celera6132,876,272 - 132,963,416 (+)NCBICelera
Cytogenetic Map6q23.2NCBI
HuRef6129,704,724 - 129,791,900 (+)NCBIHuRef
CHM1_16132,392,926 - 132,480,050 (+)NCBICHM1_1
T2T-CHM13v2.06133,002,962 - 133,090,181 (+)NCBIT2T-CHM13v2.0
Enpp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391024,513,812 - 24,588,057 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1024,513,812 - 24,588,057 (-)EnsemblGRCm39 Ensembl
GRCm381024,637,914 - 24,712,159 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1024,637,914 - 24,712,159 (-)EnsemblGRCm38mm10GRCm38
MGSCv371024,361,217 - 24,431,908 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361024,330,827 - 24,401,518 (-)NCBIMGSCv36mm8
Celera1025,583,320 - 25,641,223 (-)NCBICelera
Cytogenetic Map10A4NCBI
cM Map1012.26NCBI
Enpp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8122,518,051 - 22,583,044 (+)NCBIGRCr8
mRatBN7.2120,698,746 - 20,763,741 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl120,698,764 - 20,763,715 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx120,475,435 - 20,539,162 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0126,475,432 - 26,539,171 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0120,675,339 - 20,739,097 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0121,748,201 - 21,813,205 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl121,748,261 - 21,813,371 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0123,228,262 - 23,292,896 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4121,223,678 - 21,287,411 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1121,223,940 - 21,288,766 (+)NCBI
Celera119,451,097 - 19,514,516 (+)NCBICelera
Cytogenetic Map1p12NCBI
Enpp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543612,415,737 - 12,480,359 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543612,416,147 - 12,477,214 (+)NCBIChiLan1.0ChiLan1.0
ENPP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11251,985 - 322,081 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1252,103 - 322,718 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha11,243,885 - 1,317,644 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0144,146 - 117,941 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl148,283 - 118,098 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1193,290 - 167,054 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0138,450 - 112,214 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01209,085 - 282,880 (-)NCBIUU_Cfam_GSD_1.0
Enpp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946120,195,622 - 120,237,836 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004937067194,375 - 246,607 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ENPP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl131,722,721 - 31,796,595 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1131,724,290 - 31,796,594 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2135,240,330 - 35,281,377 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ENPP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11341,670,416 - 41,755,549 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604013,807,051 - 13,921,708 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Enpp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247535,917,689 - 5,982,308 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247535,918,005 - 5,983,480 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_003827660 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSPPAT00000039591   ⟹   ENSPPAP00000016892
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl6133,698,640 - 133,779,020 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000039592   ⟹   ENSPPAP00000016893
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl6133,698,699 - 133,783,644 (+)Ensembl
RefSeq Acc Id: XM_003827660   ⟹   XP_003827708
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v25151,797,817 - 151,882,874 (+)NCBI
NHGRI_mPanPan16149,704,715 - 149,789,744 (+)NCBI
Mhudiblu_PPA_v06129,591,858 - 129,673,000 (+)NCBI
PanPan1.16133,698,904 - 133,783,644 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003827708 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000016892.1
  ENSPPAP00000016893.1
RefSeq Acc Id: XP_003827708   ⟸   XM_003827660
- UniProtKB: A0A2R9AIM7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000016892   ⟸   ENSPPAT00000039591
Ensembl Acc Id: ENSPPAP00000016893   ⟸   ENSPPAT00000039592
Protein Domains
SMB


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000031536 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000039591.1 UniProtKB/TrEMBL
  ENSPPAT00000039592.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.570.10 UniProtKB/TrEMBL
  3.40.720.10 UniProtKB/TrEMBL
  4.10.410.20 UniProtKB/TrEMBL
InterPro Alkaline_phosphatase_core_sf UniProtKB/TrEMBL
  DNA/RNA_non-sp_Endonuclease UniProtKB/TrEMBL
  DNA/RNA_non-sp_Endonuclease_sf UniProtKB/TrEMBL
  Extracellular_endonuc_su_A UniProtKB/TrEMBL
  His-Me_finger_sf UniProtKB/TrEMBL
  Phosphodiest/P_Trfase UniProtKB/TrEMBL
  Somatomedin_B-like_dom_sf UniProtKB/TrEMBL
  Somatomedin_B_chordata UniProtKB/TrEMBL
  Somatomedin_B_dom UniProtKB/TrEMBL
KEGG Report pps:100973949 UniProtKB/TrEMBL
NCBI Gene ENPP1 ENTREZGENE
PANTHER ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE UniProtKB/TrEMBL
  PTHR10151:SF77 UniProtKB/TrEMBL
Pfam Endonuclease_NS UniProtKB/TrEMBL
  Phosphodiest UniProtKB/TrEMBL
  Somatomedin_B UniProtKB/TrEMBL
PRINTS SOMATOMEDINB UniProtKB/TrEMBL
PROSITE SMB_1 UniProtKB/TrEMBL
  SMB_2 UniProtKB/TrEMBL
SMART Endonuclease_NS UniProtKB/TrEMBL
  NUC UniProtKB/TrEMBL
  SM00201 UniProtKB/TrEMBL
Superfamily-SCOP SSF53649 UniProtKB/TrEMBL
  SSF54060 UniProtKB/TrEMBL
  SSF90188 UniProtKB/TrEMBL
UniProt A0A2R9AHR7_PANPA UniProtKB/TrEMBL
  A0A2R9AIM7 ENTREZGENE, UniProtKB/TrEMBL