IL33 (interleukin 33) - Rat Genome Database

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Gene: IL33 (interleukin 33) Pan paniscus
Analyze
Symbol: IL33
Name: interleukin 33
RGD ID: 12041432
Description: ENCODES a protein that exhibits cytokine activity (inferred); interleukin-33 receptor binding (inferred); INVOLVED IN cellular response to mechanical stimulus (ortholog); defense response to virus (ortholog); extrinsic apoptotic signaling pathway (ortholog); ASSOCIATED WITH acute myocardial infarction (ortholog); Alzheimer's disease (ortholog); angiostrongyliasis (ortholog); FOUND IN cytoplasm (ortholog); extracellular space (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: interleukin-33
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v211118,322,326 - 118,364,362 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan19118,328,274 - 118,370,309 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v096,027,014 - 6,069,540 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.196,208,479 - 6,250,433 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl96,234,178 - 6,248,624 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute myocardial infarction  (ISO)
Alzheimer's disease  (ISO)
angiostrongyliasis  (ISO)
aortic atherosclerosis  (ISO)
asthma  (ISO)
atopic dermatitis  (ISO)
candidiasis  (ISO)
Cardiomegaly  (ISO)
Cardiovirus Infections  (ISO)
cerebral malaria  (ISO)
chromosome 9p deletion syndrome  (ISO)
Chronic Hepatitis B  (ISO)
chronic obstructive pulmonary disease  (ISO)
Chronic Periodontitis  (ISO)
clonorchiasis  (ISO)
Clostridium difficile colitis  (ISO)
colitis  (ISO)
colon cancer  (ISO)
common cold  (ISO)
cryptococcosis  (ISO)
dengue disease  (ISO)
diabetes mellitus  (ISO)
Experimental Arthritis  (ISO)
Experimental Colitis  (ISO)
Experimental Liver Cirrhosis  (ISO)
familial hemophagocytic lymphohistiocytosis 2  (ISO)
Fungal Lung Diseases  (ISO)
gout  (ISO)
Hantavirus hemorrhagic fever with renal syndrome  (ISO)
Helicobacter Infections  (ISO)
Hemolysis  (ISO)
herpes simplex  (ISO)
Hookworm Infections  (ISO)
Hyperalgesia  (ISO)
Immediate Hypersensitivity  (ISO)
inflammatory bowel disease  (ISO)
influenza  (ISO)
Intervertebral Disc Displacement  (ISO)
irritable bowel syndrome  (ISO)
kidney disease  (ISO)
listeriosis  (ISO)
liver cirrhosis  (ISO)
malaria  (ISO)
Nematode Infections  (ISO)
paracoccidioidomycosis  (ISO)
parasitic helminthiasis infectious disease  (ISO)
peptic ulcer disease  (ISO)
periodontitis  (ISO)
pleural tuberculosis  (ISO)
pneumocystosis  (ISO)
pneumonia  (ISO)
prostate cancer  (ISO)
Pseudomonas Infections  (ISO)
pulmonary edema  (ISO)
pulmonary tuberculosis  (ISO)
respiratory allergy  (ISO)
respiratory syncytial virus infectious disease  (ISO)
schistosomiasis  (ISO)
Schistosomiasis Japonica  (ISO)
Sepsis  (ISO)
Staphylococcal Pneumonia  (ISO)
Staphylococcal Skin Infections  (ISO)
Strongylida Infections  (ISO)
Superinfection  (ISO)
tongue squamous cell carcinoma  (ISO)
tuberculosis  (ISO)
ulcerative colitis  (ISO)
Viral Bronchiolitis  (ISO)
viral encephalitis  (ISO)
Viral Myocarditis  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
antibacterial innate immune response  (IEA)
cellular response to mechanical stimulus  (ISO)
defense response to virus  (IEA,ISO)
extrinsic apoptotic signaling pathway  (IEA,ISO)
gene expression  (IEA,ISO)
interleukin-33-mediated signaling pathway  (IEA)
macrophage activation involved in immune response  (IEA)
macrophage differentiation  (IEA)
microglial cell activation involved in immune response  (IEA)
microglial cell proliferation  (IEA)
negative regulation of immunoglobulin production  (IEA)
negative regulation of inflammatory response to wounding  (IEA)
negative regulation of leukocyte migration  (IEA)
negative regulation of macrophage proliferation  (IEA,ISO)
negative regulation of T-helper 1 type immune response  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA)
negative regulation of type II interferon production  (IEA)
positive regulation of CD80 production  (IEA,ISO)
positive regulation of CD86 production  (IEA,ISO)
positive regulation of cellular defense response  (IEA,ISO)
positive regulation of chemokine production  (IEA)
positive regulation of cytokine production  (IEA)
positive regulation of gene expression  (IEA,ISO)
positive regulation of immunoglobulin production  (IEA)
positive regulation of inflammatory response  (IEA)
positive regulation of interleukin-13 production  (IEA)
positive regulation of interleukin-4 production  (IEA)
positive regulation of interleukin-5 production  (IEA)
positive regulation of interleukin-6 production  (IEA,ISO)
positive regulation of macrophage activation  (IEA,ISO)
positive regulation of MHC class I biosynthetic process  (IEA,ISO)
positive regulation of MHC class II biosynthetic process  (IEA,ISO)
positive regulation of oligodendrocyte differentiation  (ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA)
positive regulation of tumor necrosis factor production  (IEA,ISO)
positive regulation of type 2 immune response  (IEA,ISO)
protein import into nucleus  (IEA)
response to wounding  (IEA,ISO)
signal transduction  (IEA)
type 2 immune response  (IEA,ISO)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
IL33
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v211118,322,326 - 118,364,362 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan19118,328,274 - 118,370,309 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v096,027,014 - 6,069,540 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.196,208,479 - 6,250,433 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl96,234,178 - 6,248,624 (+)Ensemblpanpan1.1panPan2
IL33
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3896,215,149 - 6,257,983 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl96,215,786 - 6,257,983 (+)EnsemblGRCh38hg38GRCh38
GRCh3796,215,149 - 6,257,983 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3696,231,678 - 6,247,982 (+)NCBINCBI36Build 36hg18NCBI36
Build 3496,231,677 - 6,247,982NCBI
Celera96,179,137 - 6,195,439 (+)NCBICelera
Cytogenetic Map9p24.1NCBI
HuRef96,171,374 - 6,213,493 (+)NCBIHuRef
CHM1_196,216,394 - 6,258,768 (+)NCBICHM1_1
T2T-CHM13v2.096,220,289 - 6,263,045 (+)NCBIT2T-CHM13v2.0
Il33
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391929,902,513 - 29,938,118 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1929,902,514 - 29,938,118 (+)EnsemblGRCm39 Ensembl
GRCm381929,925,113 - 29,960,718 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1929,925,114 - 29,960,718 (+)EnsemblGRCm38mm10GRCm38
MGSCv371929,999,604 - 30,035,205 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361930,015,647 - 30,026,715 (+)NCBIMGSCv36mm8
Celera1930,700,532 - 30,736,141 (+)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1924.56NCBI
Il33
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81237,115,478 - 237,149,897 (+)NCBIGRCr8
mRatBN7.21227,701,964 - 227,736,374 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1227,721,435 - 227,736,373 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1236,123,222 - 236,138,166 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01243,052,907 - 243,067,851 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01235,869,667 - 235,884,579 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01248,112,611 - 248,147,030 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1248,132,090 - 248,147,029 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01255,382,760 - 255,397,661 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41233,670,801 - 233,685,798 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11233,834,823 - 233,849,820 (+)NCBI
Celera1224,871,607 - 224,886,518 (+)NCBICelera
Cytogenetic Map1q52NCBI
Il33
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543410,171,812 - 10,188,948 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543410,145,449 - 10,187,595 (+)NCBIChiLan1.0ChiLan1.0
IL33
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11127,219,878 - 27,256,723 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1127,219,878 - 27,256,721 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1125,988,860 - 26,025,714 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01128,069,676 - 28,106,564 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1128,069,663 - 28,108,194 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11126,788,250 - 26,825,127 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01126,610,673 - 26,647,647 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01127,281,817 - 27,318,668 (+)NCBIUU_Cfam_GSD_1.0
Il33
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947142,170,523 - 142,338,788 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936539623,248 - 791,470 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936539763,755 - 791,461 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL33
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1215,899,436 - 215,941,840 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11215,899,830 - 215,941,944 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21241,454,091 - 241,496,130 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IL33
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11273,235,585 - 73,283,665 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1273,237,406 - 73,252,436 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603861,612,048 - 61,659,928 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il33
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473610,764,486 - 10,784,864 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473610,733,944 - 10,786,188 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000034529   ⟹   ENSPPAP00000011867
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl96,234,178 - 6,248,624 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000034530   ⟹   ENSPPAP00000011868
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl96,234,178 - 6,248,624 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000034531   ⟹   ENSPPAP00000011869
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl96,234,178 - 6,248,624 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000034534   ⟹   ENSPPAP00000011871
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl96,234,178 - 6,248,624 (+)Ensembl
RefSeq Acc Id: XM_003823384   ⟹   XP_003823432
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v211118,322,326 - 118,364,361 (-)NCBI
NHGRI_mPanPan19118,328,274 - 118,370,307 (-)NCBI
Mhudiblu_PPA_v096,027,646 - 6,069,540 (+)NCBI
PanPan1.196,208,479 - 6,250,433 (+)NCBI
Sequence:
RefSeq Acc Id: XM_014346087   ⟹   XP_014201573
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v211118,322,326 - 118,363,168 (-)NCBI
NHGRI_mPanPan19118,328,274 - 118,370,138 (-)NCBI
Mhudiblu_PPA_v096,028,778 - 6,069,540 (+)NCBI
PanPan1.196,209,679 - 6,250,433 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034967117   ⟹   XP_034823008
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v211118,322,326 - 118,364,285 (-)NCBI
NHGRI_mPanPan19118,328,274 - 118,370,226 (-)NCBI
Mhudiblu_PPA_v096,027,697 - 6,069,540 (+)NCBI
RefSeq Acc Id: XM_034967120   ⟹   XP_034823011
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v211118,322,326 - 118,364,362 (-)NCBI
NHGRI_mPanPan19118,328,274 - 118,370,309 (-)NCBI
Mhudiblu_PPA_v096,027,642 - 6,069,540 (+)NCBI
RefSeq Acc Id: XM_055092176   ⟹   XP_054948151
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v211118,322,326 - 118,364,229 (-)NCBI
NHGRI_mPanPan19118,328,274 - 118,370,177 (-)NCBI
RefSeq Acc Id: XP_003823432   ⟸   XM_003823384
- Peptide Label: isoform X1
- UniProtKB: A0A2R9A3H2 (UniProtKB/TrEMBL),   A0A2R9A3K0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_014201573   ⟸   XM_014346087
- Peptide Label: isoform X1
- UniProtKB: A0A2R9A3H2 (UniProtKB/TrEMBL),   A0A2R9A3K0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034823011   ⟸   XM_034967120
- Peptide Label: isoform X2
- UniProtKB: A0A2R9A3K0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034823008   ⟸   XM_034967117
- Peptide Label: isoform X1
- UniProtKB: A0A2R9A3H2 (UniProtKB/TrEMBL),   A0A2R9A3K0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSPPAP00000011871   ⟸   ENSPPAT00000034534
Ensembl Acc Id: ENSPPAP00000011868   ⟸   ENSPPAT00000034530
Ensembl Acc Id: ENSPPAP00000011869   ⟸   ENSPPAT00000034531
Ensembl Acc Id: ENSPPAP00000011867   ⟸   ENSPPAT00000034529
RefSeq Acc Id: XP_054948151   ⟸   XM_055092176
- Peptide Label: isoform X1
- UniProtKB: A0A2R9A3H2 (UniProtKB/TrEMBL),   A0A2R9A3K0 (UniProtKB/TrEMBL)
Protein Domains
Interleukin 33 C-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000029130 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000034529.1 UniProtKB/TrEMBL
  ENSPPAT00000034530.1 UniProtKB/TrEMBL
  ENSPPAT00000034531.1 UniProtKB/TrEMBL
  ENSPPAT00000034534.1 UniProtKB/TrEMBL
Gene3D-CATH 2.80.10.50 UniProtKB/TrEMBL
InterPro IL-33 UniProtKB/TrEMBL
  IL33_C UniProtKB/TrEMBL
KEGG Report pps:100987383 UniProtKB/TrEMBL
NCBI Gene IL33 ENTREZGENE
PANTHER INTERLEUKIN-33 UniProtKB/TrEMBL
  PTHR21114 UniProtKB/TrEMBL
Pfam IL33 UniProtKB/TrEMBL
UniProt A0A2R9A3H2 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9A3K0 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9A4R7_PANPA UniProtKB/TrEMBL
  A0A2R9A8X9_PANPA UniProtKB/TrEMBL