F2 (coagulation factor II, thrombin) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: F2 (coagulation factor II, thrombin) Pan paniscus
Analyze
Symbol: F2
Name: coagulation factor II, thrombin
RGD ID: 12014166
Description: ENCODES a protein that exhibits heparin binding (ortholog); lipopolysaccharide binding (ortholog); peptidase activity (ortholog); INVOLVED IN antimicrobial humoral immune response mediated by antimicrobial peptide (ortholog); blood coagulation (ortholog); cell surface receptor signaling pathway (ortholog); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; ASSOCIATED WITH acquired angioedema (ortholog); Acute Coronary Syndrome (ortholog); Acute Lung Injury (ortholog); FOUND IN collagen-containing extracellular matrix (ortholog); external side of plasma membrane (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: prothrombin
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11147,227,891 - 47,249,157 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1147,227,891 - 47,249,157 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01146,669,925 - 46,690,391 (+)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acquired angioedema  (ISO)
Acute Coronary Syndrome  (ISO)
Acute Lung Injury  (ISO)
allergic rhinitis  (ISO)
Alzheimer's disease  (ISO)
appendicitis  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
autoimmune hepatitis  (ISO)
bacterial pneumonia  (ISO)
blood coagulation disease  (ISO)
brain edema  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
bullous pemphigoid  (ISO)
calcium oxalate nephrolithiasis  (ISO)
carotid stenosis  (ISO)
celiac disease  (ISO)
Cerebral Hemorrhage  (ISO)
cerebral infarction  (ISO)
Chagas disease  (ISO)
chronic obstructive pulmonary disease  (ISO)
clear cell renal cell carcinoma  (ISO)
congenital disorder of glycosylation type IIc  (ISO)
Congenital Prothrombin Deficiency  (ISO)
Contusions  (ISO)
coronary artery disease  (ISO)
COVID-19  (ISO)
Crohn's disease  (ISO)
dengue disease  (ISO)
Diabetic Nephropathies  (ISO)
disseminated intravascular coagulation  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
eye disease  (ISO)
factor VIII deficiency  (ISO)
Familial Amyloid Polyneuropathies  (ISO)
familial Mediterranean fever  (ISO)
fatty liver disease  (ISO)
Femur Head Necrosis  (ISO)
genetic disease  (ISO)
glomerulonephritis  (ISO)
hemolytic-uremic syndrome  (ISO)
hemophilia B  (ISO)
Hemorrhage  (ISO)
Hemorrhagic Shock  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
hereditary angioedema  (ISO)
herpes zoster  (ISO)
high grade glioma  (ISO)
Human Viral Hepatitis  (ISO)
Huntington's disease  (ISO)
Hyperalgesia  (ISO)
hyperglycemia  (ISO)
hyperhomocysteinemia  (ISO)
Hypertrophy  (ISO)
intellectual disability  (ISO)
intracranial sinus thrombosis  (ISO)
Kidney Calculi  (ISO)
Knee Osteoarthritis  (ISO)
leptospirosis  (ISO)
liver cirrhosis  (ISO)
Liver Failure  (ISO)
Mesenteric Ischemia  (ISO)
middle cerebral artery infarction  (ISO)
myocardial infarction  (ISO)
Neoplasm Metastasis  (ISO)
nephrosis  (ISO)
Nerve Degeneration  (ISO)
non-alcoholic fatty liver disease  (ISO)
obesity  (ISO)
ovarian cancer  (ISO)
Paratuberculosis  (ISO)
Pediatric Crohn's Disease  (ISO)
portal vein thrombosis  (ISO)
pre-eclampsia  (ISO)
prostate cancer  (ISO)
prothrombin deficiency  (ISO)
pulmonary embolism  (ISO)
pulmonary fibrosis  (ISO)
Reperfusion Injury  (ISO)
retinal vein occlusion  (ISO)
rheumatoid arthritis  (ISO)
schizophrenia  (ISO)
sensorineural hearing loss  (ISO)
Sepsis  (ISO)
Septic Peritonitis  (ISO)
sickle cell anemia  (ISO)
Spinal Cord Injuries  (ISO)
Spontaneous Abortions  (ISO)
Stroke  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
Thromboembolism  (ISO)
thrombophilia  (ISO)
thrombophilia due to thrombin defect  (ISO)
thrombosis  (ISO)
toxic shock syndrome  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
urinary bladder cancer  (ISO)
Urinary Calculi  (ISO)
urticaria  (ISO)
vascular skin disease  (ISO)
Venous Thromboembolism  (ISO)
Venous Thrombosis  (ISO)
Ventricular Dysfunction, Left  (ISO)
Ventricular Fibrillation  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
antimicrobial humoral immune response mediated by antimicrobial peptide  (ISO)
blood coagulation  (ISO)
cell surface receptor signaling pathway  (ISO)
cellular response to mechanical stimulus  (ISO)
cytolysis by host of symbiont cells  (ISO)
fibrinolysis  (ISO)
negative regulation of astrocyte differentiation  (ISO)
negative regulation of cytokine production involved in inflammatory response  (ISO)
negative regulation of proteolysis  (ISO)
neutrophil-mediated killing of gram-negative bacterium  (ISO)
platelet activation  (ISO)
positive regulation of blood coagulation  (ISO)
positive regulation of cell growth  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of collagen biosynthetic process  (ISO)
positive regulation of lipid kinase activity  (ISO)
positive regulation of phosphatidylinositol 3-kinase signaling  (ISO)
positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway  (ISO)
positive regulation of protein localization to nucleus  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of reactive oxygen species metabolic process  (ISO)
positive regulation of release of sequestered calcium ion into cytosol  (ISO)
regulation of cell shape  (ISO)
regulation of cytosolic calcium ion concentration  (ISO)
regulation of gene expression  (ISO)
response to inactivity  (ISO)
response to Thyroglobulin triiodothyronine  (ISO)
response to thyrotropin-releasing hormone  (ISO)
response to thyroxine  (ISO)
response to wounding  (ISO)

Cellular Component

Molecular Function

References

Genomics

Comparative Map Data
F2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11147,227,891 - 47,249,157 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1147,227,891 - 47,249,157 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01146,669,925 - 46,690,391 (+)NCBIMhudiblu_PPA_v0panPan3
F2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1146,719,196 - 46,739,506 (+)EnsemblGRCh38hg38GRCh38
GRCh381146,719,213 - 46,739,506 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371146,740,763 - 46,761,056 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361146,697,331 - 46,717,631 (+)NCBINCBI36hg18NCBI36
Build 341146,697,330 - 46,717,631NCBI
Celera1146,888,702 - 46,909,014 (+)NCBI
Cytogenetic Map11p11.2NCBI
HuRef1146,446,660 - 46,466,973 (+)NCBIHuRef
CHM1_11146,739,149 - 46,759,462 (+)NCBICHM1_1
F2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39291,442,742 - 91,466,802 (-)NCBIGRCm39mm39
GRCm39 Ensembl291,455,665 - 91,466,759 (-)Ensembl
GRCm38291,612,397 - 91,636,457 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl291,625,320 - 91,636,414 (-)EnsemblGRCm38mm10GRCm38
MGSCv37291,465,477 - 91,476,571 (-)NCBIGRCm37mm9NCBIm37
MGSCv36291,426,159 - 91,437,253 (-)NCBImm8
Celera293,014,831 - 93,025,920 (-)NCBICelera
Cytogenetic Map2E1NCBI
cM Map250.63NCBI
F2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2377,596,196 - 77,609,486 (-)NCBImRatBN7.2
Rnor_6.0 Ensembl380,529,428 - 80,543,031 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0380,529,468 - 80,542,993 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0387,228,703 - 87,242,228 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4376,005,318 - 76,018,603 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1375,901,694 - 75,914,982 (-)NCBI
Celera376,801,000 - 76,814,280 (-)NCBICelera
Cytogenetic Map3q24NCBI
F2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554221,356,769 - 1,367,517 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554221,356,675 - 1,367,788 (-)NCBIChiLan1.0ChiLan1.0
F2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11842,782,744 - 42,799,531 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1842,782,751 - 42,799,459 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1841,511,662 - 41,528,485 (-)NCBI
ROS_Cfam_1.01843,438,760 - 43,455,850 (-)NCBI
UMICH_Zoey_3.11842,924,063 - 42,940,888 (-)NCBI
UNSW_CanFamBas_1.01842,479,219 - 42,496,510 (-)NCBI
UU_Cfam_GSD_1.01843,208,980 - 43,225,802 (-)NCBI
F2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494720,260,330 - 20,277,033 (-)NCBI
SpeTri2.0NW_0049365622,371,725 - 2,388,617 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
F2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl215,791,451 - 15,819,138 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1215,793,257 - 15,819,151 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2217,145,002 - 17,170,975 (-)NCBISscrofa10.2Sscrofa10.2susScr3
F2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247671,876,974 - 1,887,720 (-)NCBI


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_003815200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide SSBP01000173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSPPAT00000060434   ⟹   ENSPPAP00000037534
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1147,227,891 - 47,249,157 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000060439   ⟹   ENSPPAP00000037539
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1147,227,956 - 47,249,057 (+)Ensembl
RefSeq Acc Id: XM_003815200   ⟹   XP_003815248
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.11147,227,891 - 47,249,157 (+)NCBI
Mhudiblu_PPA_v01146,669,925 - 46,690,391 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003815248 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003815248   ⟸   XM_003815200
- Sequence:
RefSeq Acc Id: ENSPPAP00000037539   ⟸   ENSPPAT00000060439
RefSeq Acc Id: ENSPPAP00000037534   ⟸   ENSPPAT00000060434


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000041509 Ensembl, ENTREZGENE
Ensembl Protein ENSPPAP00000037534 ENTREZGENE
NCBI Gene F2 ENTREZGENE