BAK1 (BCL2 antagonist/killer 1) - Rat Genome Database

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Gene: BAK1 (BCL2 antagonist/killer 1) Pan paniscus
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Symbol: BAK1
Name: BCL2 antagonist/killer 1
RGD ID: 12006233
Description: ENCODES a protein that exhibits BH domain binding (ortholog); heat shock protein binding (ortholog); identical protein binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); apoptotic process involved in blood vessel morphogenesis (ortholog); B cell apoptotic process (ortholog); PARTICIPATES IN intrinsic apoptotic pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); amyotrophic lateral sclerosis (ortholog); ataxia telangiectasia (ortholog); FOUND IN BAK complex (ortholog); Bcl-2 family protein complex (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: bcl-2 homologous antagonist/killer
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2548,052,701 - 48,060,642 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1643,919,864 - 43,927,610 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0633,146,998 - 33,154,755 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1634,255,769 - 34,263,211 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl634,255,769 - 34,263,211 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (ISO)
apoptotic process  (IEA)
apoptotic process involved in blood vessel morphogenesis  (ISO)
apoptotic signaling pathway  (IEA)
B cell apoptotic process  (ISO)
B cell homeostasis  (ISO)
B cell negative selection  (ISO)
blood vessel remodeling  (ISO)
calcium ion transport into cytosol  (ISO)
cellular response to mechanical stimulus  (IEA)
cellular response to UV  (IEA)
endocrine pancreas development  (ISO)
epithelial cell proliferation  (ISO)
establishment of localization in cell  (ISO)
establishment or maintenance of transmembrane electrochemical gradient  (IEA)
extrinsic apoptotic signaling pathway in absence of ligand  (IEA,ISO)
fibroblast apoptotic process  (ISO)
homeostasis of number of cells  (ISO)
intrinsic apoptotic signaling pathway  (IEA)
intrinsic apoptotic signaling pathway in response to DNA damage  (IEA,ISO)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (ISO)
leukocyte homeostasis  (ISO)
limb morphogenesis  (ISO)
mitochondrial fusion  (ISO)
myeloid cell homeostasis  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of endoplasmic reticulum calcium ion concentration  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway  (IEA)
negative regulation of peptidyl-serine phosphorylation  (ISO)
negative regulation of release of cytochrome c from mitochondria  (IEA)
positive regulation of apoptotic process  (IEA,ISO)
positive regulation of calcium ion transport into cytosol  (ISO)
positive regulation of endoplasmic reticulum unfolded protein response  (IEA)
positive regulation of protein-containing complex assembly  (IEA)
positive regulation of proteolysis  (IEA)
positive regulation of release of cytochrome c from mitochondria  (ISO)
post-embryonic camera-type eye morphogenesis  (ISO)
regulation of apoptotic process  (IEA)
regulation of apoptotic signaling pathway  (IEA)
regulation of cell cycle  (ISO)
regulation of mitochondrial membrane permeability  (IEA)
regulation of mitochondrial membrane potential  (IEA)
release of cytochrome c from mitochondria  (IEA,ISO)
response to ethanol  (ISO)
response to fungus  (ISO)
response to gamma radiation  (ISO)
response to hydrogen peroxide  (ISO)
response to mycotoxin  (ISO)
response to organic cyclic compound  (ISO)
response to stress  (IEA)
response to UV-C  (ISO)
response to xenobiotic stimulus  (ISO)
thymocyte apoptotic process  (ISO)
vagina development  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
BAK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2548,052,701 - 48,060,642 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1643,919,864 - 43,927,610 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0633,146,998 - 33,154,755 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1634,255,769 - 34,263,211 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl634,255,769 - 34,263,211 (-)Ensemblpanpan1.1panPan2
BAK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38633,572,552 - 33,580,276 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl633,572,547 - 33,580,293 (-)EnsemblGRCh38hg38GRCh38
GRCh37633,540,329 - 33,548,053 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36633,648,301 - 33,656,048 (-)NCBINCBI36Build 36hg18NCBI36
Build 34633,648,306 - 33,655,959NCBI
Celera635,094,701 - 35,102,448 (-)NCBICelera
Cytogenetic Map6p21.31NCBI
HuRef633,281,784 - 33,289,531 (-)NCBIHuRef
CHM1_1633,542,641 - 33,550,388 (-)NCBICHM1_1
T2T-CHM13v2.0633,393,742 - 33,401,466 (-)NCBIT2T-CHM13v2.0
Bak1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391727,238,786 - 27,247,601 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1727,238,784 - 27,247,983 (-)EnsemblGRCm39 Ensembl
GRCm381727,019,812 - 27,028,627 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1727,019,810 - 27,029,009 (-)EnsemblGRCm38mm10GRCm38
MGSCv371727,156,757 - 27,165,571 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361726,747,401 - 26,756,216 (-)NCBIMGSCv36mm8
Celera1727,556,267 - 27,565,056 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1713.65NCBI
Bak1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8205,102,334 - 5,111,615 (-)NCBIGRCr8
mRatBN7.2205,100,480 - 5,109,669 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl205,100,480 - 5,109,264 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx205,826,258 - 5,834,812 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0205,188,000 - 5,196,555 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0205,666,112 - 5,674,701 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0205,609,620 - 5,618,899 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,609,625 - 5,618,260 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0207,675,062 - 7,683,731 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4205,255,954 - 5,264,593 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1205,256,180 - 5,264,820 (-)NCBI
Celera206,681,267 - 6,689,805 (-)NCBICelera
Cytogenetic Map20p12NCBI
Bak1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554372,036,415 - 2,041,997 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554372,036,415 - 2,041,997 (-)NCBIChiLan1.0ChiLan1.0
BAK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1122,950,359 - 2,957,604 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl122,948,364 - 2,957,018 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha122,967,686 - 2,970,924 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0123,282,315 - 3,289,076 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl123,280,333 - 3,289,013 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1122,950,651 - 2,953,887 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0123,031,622 - 3,034,860 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0123,129,752 - 3,132,990 (-)NCBIUU_Cfam_GSD_1.0
Bak1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494638,605,488 - 38,612,704 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647625,347,545 - 25,355,789 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647625,347,608 - 25,354,772 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BAK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1729,808,849 - 29,815,345 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2734,279,191 - 34,286,287 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BAK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11738,492,776 - 38,502,534 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1738,492,858 - 38,501,281 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604433,412,290 - 33,419,643 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bak1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475423,296,800 - 23,301,223 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475423,297,077 - 23,302,366 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSPPAT00000035608   ⟹   ENSPPAP00000012940
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl634,255,769 - 34,263,211 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000035611   ⟹   ENSPPAP00000012943
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl634,257,020 - 34,260,516 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000035613   ⟹   ENSPPAP00000012945
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl634,257,340 - 34,260,516 (-)Ensembl
RefSeq Acc Id: XM_003808559   ⟹   XP_003808607
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2548,052,701 - 48,060,642 (-)NCBI
NHGRI_mPanPan1643,919,864 - 43,927,610 (-)NCBI
Mhudiblu_PPA_v0633,146,998 - 33,154,754 (-)NCBI
PanPan1.1634,255,769 - 34,263,211 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034961863   ⟹   XP_034817754
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2548,052,701 - 48,060,404 (-)NCBI
NHGRI_mPanPan1643,919,864 - 43,927,568 (-)NCBI
Mhudiblu_PPA_v0633,146,998 - 33,154,755 (-)NCBI
Protein Sequences
Protein RefSeqs XP_003808607 (Get FASTA)   NCBI Sequence Viewer  
  XP_034817754 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000012940
  ENSPPAP00000012940.1
  ENSPPAP00000012943.1
  ENSPPAP00000012945.1
RefSeq Acc Id: XP_003808607   ⟸   XM_003808559
- Peptide Label: isoform X1
- UniProtKB: A0A2R9A7S4 (UniProtKB/TrEMBL),   A0A2R9A6M3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034817754   ⟸   XM_034961863
- Peptide Label: isoform X2
RefSeq Acc Id: ENSPPAP00000012940   ⟸   ENSPPAT00000035608
RefSeq Acc Id: ENSPPAP00000012945   ⟸   ENSPPAT00000035613
RefSeq Acc Id: ENSPPAP00000012943   ⟸   ENSPPAT00000035611

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000029631 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000035608.1 UniProtKB/TrEMBL
  ENSPPAT00000035611.1 UniProtKB/TrEMBL
  ENSPPAT00000035613.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.437.10 UniProtKB/TrEMBL
InterPro Bcl-2-like_sf UniProtKB/TrEMBL
  Bcl-2_BH1-3 UniProtKB/TrEMBL
  Bcl-2_fam UniProtKB/TrEMBL
  Bcl2-like UniProtKB/TrEMBL
  Bcl2_BH1_motif_CS UniProtKB/TrEMBL
  Bcl2_BH2_motif_CS UniProtKB/TrEMBL
  Bcl2_BH3_motif_CS UniProtKB/TrEMBL
KEGG Report pps:100983246 UniProtKB/TrEMBL
NCBI Gene BAK1 ENTREZGENE
PANTHER PTHR11256 UniProtKB/TrEMBL
  PTHR11256:SF41 UniProtKB/TrEMBL
Pfam Bcl-2 UniProtKB/TrEMBL
PRINTS BCL2FAMILY UniProtKB/TrEMBL
PROSITE BCL2_FAMILY UniProtKB/TrEMBL
  BH1 UniProtKB/TrEMBL
  BH2 UniProtKB/TrEMBL
  BH3 UniProtKB/TrEMBL
SMART BCL UniProtKB/TrEMBL
Superfamily-SCOP SSF56854 UniProtKB/TrEMBL
UniProt A0A2R9A6M3 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9A7S4 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9A7S8_PANPA UniProtKB/TrEMBL