CYP2R1 (cytochrome P450 family 2 subfamily R member 1) - Rat Genome Database

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Gene: CYP2R1 (cytochrome P450 family 2 subfamily R member 1) Pan paniscus
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Symbol: CYP2R1
Name: cytochrome P450 family 2 subfamily R member 1
RGD ID: 11887892
Description: ENCODES a protein that exhibits D3 vitamins binding (inferred); heme binding (inferred); iron ion binding (inferred); INVOLVED IN response to cesium ion (ortholog); response to ionizing radiation (ortholog); response to metal ion (ortholog); ASSOCIATED WITH Abdominal Obesity (ortholog); autism spectrum disorder (ortholog); brain infarction (ortholog); FOUND IN cytoplasm (inferred); intracellular membrane-bounded organelle (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC100973299; vitamin D 25-hydroxylase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2917,241,939 - 17,263,565 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11117,200,836 - 17,224,415 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01114,960,651 - 14,989,083 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11114,656,939 - 14,671,584 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1114,656,939 - 14,671,584 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CYP2R1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2917,241,939 - 17,263,565 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11117,200,836 - 17,224,415 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01114,960,651 - 14,989,083 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11114,656,939 - 14,671,584 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1114,656,939 - 14,671,584 (-)Ensemblpanpan1.1panPan2
CYP2R1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381114,877,440 - 14,892,443 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1114,877,440 - 14,892,231 (-)EnsemblGRCh38hg38GRCh38
GRCh371114,898,986 - 14,913,989 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361114,856,131 - 14,870,327 (-)NCBINCBI36Build 36hg18NCBI36
Build 341114,856,183 - 14,870,327NCBI
Celera1115,026,672 - 15,040,868 (-)NCBICelera
Cytogenetic Map11p15.2NCBI
HuRef1114,581,996 - 14,596,194 (-)NCBIHuRef
CHM1_11114,898,541 - 14,912,738 (-)NCBICHM1_1
T2T-CHM13v2.01114,973,806 - 14,988,811 (-)NCBIT2T-CHM13v2.0
Cyp2r1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397114,149,358 - 114,162,283 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7114,148,917 - 114,162,207 (-)EnsemblGRCm39 Ensembl
GRCm387114,550,123 - 114,563,048 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7114,549,682 - 114,562,972 (-)EnsemblGRCm38mm10GRCm38
MGSCv377121,693,680 - 121,706,486 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367114,341,347 - 114,354,153 (-)NCBIMGSCv36mm8
Celera7114,506,181 - 114,518,984 (-)NCBICelera
Cytogenetic Map7F1NCBI
cM Map759.79NCBI
Cyp2r1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81178,166,984 - 178,232,191 (-)NCBIGRCr8
mRatBN7.21168,749,302 - 168,798,079 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1168,751,038 - 168,797,759 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1177,105,729 - 177,118,195 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01184,291,785 - 184,304,251 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01177,004,432 - 177,016,901 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01184,060,521 - 184,106,604 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1184,093,920 - 184,106,200 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01191,032,655 - 191,078,746 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41172,593,057 - 172,605,512 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11172,729,161 - 172,741,682 (-)NCBI
Celera1166,625,863 - 166,638,315 (-)NCBICelera
Cytogenetic Map1q34NCBI
LOC102024786
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541429,928,644 - 29,948,484 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541429,929,130 - 29,948,151 (-)NCBIChiLan1.0ChiLan1.0
CYP2R1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12137,553,883 - 37,579,744 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2137,552,732 - 37,606,725 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2137,053,097 - 37,079,853 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02138,647,594 - 38,674,701 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2138,649,539 - 38,674,887 (-)EnsemblROS_Cfam_1.0 Ensembl
LOC101972957
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494747,848,045 - 47,866,726 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365283,881,087 - 3,900,302 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365283,881,630 - 3,897,613 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP2R1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl244,375,520 - 44,396,334 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1244,375,432 - 44,394,122 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2247,676,732 - 47,695,293 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CYP2R1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1150,030,366 - 50,043,833 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl150,031,218 - 50,047,403 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038147,527,420 - 147,540,720 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101724787
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247666,667,234 - 6,677,992 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247666,667,662 - 6,678,045 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000063075   ⟹   ENSPPAP00000040161
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1114,656,939 - 14,671,584 (-)Ensembl
RefSeq Acc Id: XM_003818193   ⟹   XP_003818241
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2917,241,939 - 17,263,565 (-)NCBI
NHGRI_mPanPan11117,200,836 - 17,224,415 (-)NCBI
Mhudiblu_PPA_v01114,960,651 - 14,989,083 (-)NCBI
PanPan1.11114,656,939 - 14,671,584 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034932207   ⟹   XP_034788098
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2917,241,939 - 17,263,559 (-)NCBI
NHGRI_mPanPan11117,200,836 - 17,224,398 (-)NCBI
Mhudiblu_PPA_v01114,960,651 - 14,980,910 (-)NCBI
RefSeq Acc Id: XM_034932209   ⟹   XP_034788100
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2917,241,939 - 17,263,559 (-)NCBI
NHGRI_mPanPan11117,200,836 - 17,224,399 (-)NCBI
Mhudiblu_PPA_v01114,960,651 - 14,980,910 (-)NCBI
RefSeq Acc Id: XM_055094146   ⟹   XP_054950121
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2917,241,939 - 17,263,565 (-)NCBI
NHGRI_mPanPan11117,200,836 - 17,224,414 (-)NCBI
Protein Sequences
Protein RefSeqs XP_003818241 (Get FASTA)   NCBI Sequence Viewer  
  XP_034788098 (Get FASTA)   NCBI Sequence Viewer  
  XP_034788100 (Get FASTA)   NCBI Sequence Viewer  
  XP_054950121 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000040161
  ENSPPAP00000040161.1
RefSeq Acc Id: XP_003818241   ⟸   XM_003818193
- Peptide Label: isoform X1
- UniProtKB: A0A2R9CDZ2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034788100   ⟸   XM_034932209
- Peptide Label: isoform X3
RefSeq Acc Id: XP_034788098   ⟸   XM_034932207
- Peptide Label: isoform X3
Ensembl Acc Id: ENSPPAP00000040161   ⟸   ENSPPAT00000063075
RefSeq Acc Id: XP_054950121   ⟸   XM_055094146
- Peptide Label: isoform X2
- UniProtKB: A0A2R9CDZ2 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000042738 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000063075.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/TrEMBL
  Cytochrome_P450_fam2 UniProtKB/TrEMBL
NCBI Gene LOC100973299 ENTREZGENE
PANTHER CYTOCHROME P450 508A4-RELATED UniProtKB/TrEMBL
  VITAMIN D 25-HYDROXYLASE UniProtKB/TrEMBL
Pfam p450 UniProtKB/TrEMBL
PRINTS EP450I UniProtKB/TrEMBL
  P450 UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/TrEMBL
UniProt A0A2R9CDZ2 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:83031 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-02-25 CYP2R1  cytochrome P450 family 2 subfamily R member 1  LOC100973299  vitamin D 25-hydroxylase  Symbol and/or name change 5135510 APPROVED